Article
Clinical Neurology
Adrien ter Schiphorst, Roxane Peres, Cyril Dargazanli, Raphael Blanc, Benjamin Gory, Sebastien Richard, Gaultier Marnat, Igor Sibon, Benoit Guillon, Romain Bourcier, Christian Denier, Laurent Spelle, Julien Labreuche, Arturo Consoli, Bertrand Lapergue, Vincent Costalat, Michael Obadia, Caroline Arquizan
Summary: This study found that EVT is effective in improving cerebral recanalization in patients with acute ischemic stroke due to CICAO, with a 40% rate of favorable outcome at 3 months. However, there is a high rate of procedural complications, and further randomized controlled trials are needed to evaluate the superiority of EVT in CICAO patients.
JOURNAL OF NEUROLOGY
(2022)
Letter
Clinical Neurology
Sven Poli, Joshua Mbroh
Summary: In this article, the authors express their interest in the study on normobaric oxygen therapy in acute ischemic stroke by Li et al. They also provide additional vital information that may be beneficial for enthusiasts of this therapy.
Letter
Clinical Neurology
Umberto Pensato, Michele Romoli, Andrea Zini
Summary: Li et al. investigated the role of normobaric hyperoxia (NBO) in patients with anterior circulation ischemic stroke eligible for endovascular therapy. They demonstrated the feasibility, safety, and efficacy of NBO in a pilot randomized controlled trial, showing a smaller median final infarct volume and infarct volume growth in the treatment arm.
Letter
Clinical Neurology
Weili Li, Zhifeng Qi, Xunming Ji, Ke Jian Liu
Summary: This article agrees with Dr. Pensato's opinion and proposes two practical approaches to save the ischemic penumbra, with a focus on normobaric hyperoxia plus endovascular therapy. The author emphasizes the importance of real-time imaging techniques to track the reversion of the ischemic core and achieve better clinical outcomes, calling for the development of new imaging techniques or refinement of existing ones.
Letter
Clinical Neurology
Weili Li, Zhifeng Qi, Xunming Ji, Ke Jian Liu
Summary: This article agrees with Dr. Pensato's opinion that saving the ischemic penumbra can be achieved through two practical approaches: shortening the time to complete recanalization and minimizing penumbra loss through neuroprotection strategies. The article suggests that real-time imaging techniques should be developed and implemented to track the reversion of the ischemic core in patients undergoing normobaric hyperoxia (NBO) therapy, in order to demonstrate better clinical outcomes. The article also highlights the importance of accurately reflecting the size of the ischemic core through new imaging techniques or refined CT perfusion thresholds in the era of neuroprotection in the ischemic penumbra.
Letter
Clinical Neurology
Aravind Ganesh, Steven Galetta
Summary: This study investigated the safety and efficacy of combining normobaric hyperoxia (NBO) with endovascular treatment (EVT) for acute ischemic stroke. The researchers found that NBO resulted in smaller infarct volume and lower mRS at 90 days. In response to comments, the authors suggested that a single round of hyperbaric oxygen therapy (HBOT) with EVT may be optimal, highlighting the ease of delivery of NBO compared to HBOT.
Letter
Clinical Neurology
Weili Li, Zhifeng Qi, Xunming Ji, Ke Jian Liu
Summary: New imaging techniques or refined CT perfusion thresholds are urgently needed to accurately reflect the size of the ischemic core for neuroprotection in the ischemic penumbra.
Article
Neurosciences
Shuai Liu, Fengli Li, Jie Yang, Dongjie Xie, Chengsong Yue, Weidong Luo, Jinrong Hu, Jiaxing Song, Linyu Li, Jiacheng Huang, Chenhao Zhao, Zili Gong, Qingwu Yang, Wenjie Zi
Summary: This study found that combining NBP with EVT in patients with AIS due to LVO can improve functional outcomes, reduce mortality risk, and does not increase the risk of sICH.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Lucie A. van den Berg, Olvert A. Berkhemer, Puck S. S. Fransen, Debbie Beumer, Hester Lingsma, Charles B. M. Majoie, Diederik W. J. Dippel, Aad van der Lugt, Robert J. van Oostenbrugge, Wim H. van Zwam, Yvo B. Roos, Marcel G. W. Dijkgraaf
Summary: This study aimed to evaluate whether endovascular therapy plus usual care is cost-effective compared to usual care alone in acute ischemic stroke patients. The results showed that endovascular treatment added to usual care is clinically effective and cost-saving in comparison to usual care alone for patients with acute ischemic stroke.
Article
Cell Biology
Hongchen Zhao, Yiwei Feng, Xiaoming Rong, Yiting Mao, Zigao Wang, Yifeng Ling, Qiang Dong, Wenjie Cao
Summary: In this meta-analysis, tirofiban was found to improve patient independence and functional outcomes without increasing the risk of intracranial hemorrhage or mortality in acute ischemic stroke with large vessel occlusion. The dosing regimen of tirofiban may impact its effectiveness in improving the functional outcomes of endovascular therapy.
Review
Clinical Neurology
Sushanth Rao Aroor, Kaiz S. Asif, Jennifer Potter-Vig, Arun Sharma, Bijoy K. Menon, Violiza Inoa, Cynthia B. Zevallos, Jose G. Romano, Santiago Ortega-Gutierrez, Larry B. Goldstein, Dileep R. Yavagal
Summary: Mechanical thrombectomy (MT) is the most effective treatment for acute ischemic stroke patients with emergent large vessel occlusions (LVOs). However, there are barriers to access, including delays in evaluation and diagnosis, logistical delays, and financial hurdles. Regional data collection and a measurable access score could help address these challenges.
Article
Clinical Neurology
Fouzi Bala, Nicolas Bricout, Nasreddine Nouri, Charlotte Cordonnier, Hilde Henon, Barbara Casolla
Summary: This study aimed to evaluate the safety and outcomes of endovascular treatment in patients with very severe and severe neurological deficits. Results showed that in patients with very severe deficits, successful recanalization was strongly associated with better functional outcomes at 90 days.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Adriaan C. G. M. van Es, Maayke A. W. Hunfeld, Ido van den Wijngaard, Ulrike Kraemer, Marc Engelen, Boudewijn A. A. M. van Hasselt, Puck S. S. Fransen, Diederik W. J. Dippel, Charles B. L. M. Majoie, Aad van der Lugt, Bart J. Emmer
Summary: This study retrospectively assessed the safety and efficacy of EVT in children with acute ischemic stroke, showing promising results. More research is needed to confirm the findings and better understand the risk-benefit profile of this treatment.
Review
Clinical Neurology
Femke Kremers, Esmee Venema, Martijne Duvekot, Lonneke Yo, Reinoud Bokkers, Geert Lycklama A. Nijeholt, Adriaan van Es, Aad van der Lugt, Charles Majoie, James Burke, Bob Roozenbeek, Hester Lingsma, Diederik Dippel
Summary: This study provides an overview and validation of prediction models for functional outcome after endovascular treatment in acute ischemic stroke patients. The results show that the THRIVE-c score and MR PREDICTS score have good performance in predicting functional outcome.
Article
Clinical Neurology
Fernando Gongora-Rivera, Alejandro Gonzalez-Aquines, Juan Manuel Marquez-Romero
Summary: Access to endovascular treatment (EVT) for acute ischemic stroke (AIS) in Mexico faces barriers such as lack of health coverage, high costs of medical supplies, and general population's inadequate knowledge of stroke symptoms. Efforts from government and society are needed to address these obstacles, such as increasing public funding for EVT coverage and implementing continuous stroke education campaigns to reduce inequities in access to EVT in Mexico.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Andre Miranda, Ramy Abdelnaby, Andre Araujo, Marta Rodrigues, Valeria Battistella, Jose Mario Roriz, Carmelia Rodrigues, Martin Wiesmann, Jorg B. Schulz, Omid Nikoubashman, Arno Reich, Manuel Ribeiro, Joao Pinho
Summary: The presence of the meniscus sign does not appear to influence angiographic or clinical outcomes in acute ischemic stroke patients with anterior circulation large vessel occlusion who undergo endovascular treatment.
CLINICAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
F. Gottmann, O. Nikoubashman, A. Hoellig, A. Reich, M. Wiesmann
Summary: Temporary stent-assisted coiling is a safe and effective treatment method for intracranial wide-neck aneurysms, with comparable procedural safety and less need for posttreatment antiplatelet therapy compared to other alternatives.
CLINICAL NEURORADIOLOGY
(2023)
Review
Clinical Neurology
Ramy Abdelnaby, Khaled Ashraf Mohamed, Anas ELgenidy, Yousef Tarek Sonbol, Mahmoud Mostafa Bedewy, Aya Moustafa Aboutaleb, Khaled Tarek Dardeer, Hamed Amr Heikal, Hazem Maher Gawish, Omid Nikoubashman, Arno Reich, Joao Pinho
Summary: This study evaluated the outcomes of iPCAO patients who underwent endovascular treatment (EVT). The results showed that while EVT is feasible and safe in iPCAO, it does not have an outcome benefit compared to best medical treatment.
CLINICAL NEURORADIOLOGY
(2023)
Editorial Material
Cell Biology
Muthuraman Muthuraman, Mohammadsaleh Oshaghi, Vinzenz Fleischer, Dumitru Ciolac, Ahmed Othman, Sven G. Meuth, Gabriel Gonzalez-Escamilla, Sergiu Groppa
NEURAL REGENERATION RESEARCH
(2023)
Article
Clinical Neurology
Sarah Lee, Michael Mlynash, Soren Christensen, Bin Jiang, Max Wintermark, Ronald Straeter, Gabriel Broocks, Astrid Grams, Omid Nikoubashman, Andrea Morotti, Johannes Trenkler, Markus Moehlenbruch, Jens Fiehler, Moritz Wildgruber, Andre Kemmling, Marios Psychogios, Peter B. Sporns
Summary: The aim of this study was to determine whether contrast perfusion imaging delayed time to treatment in children with large vessel occlusion stroke, and assess perfusion profiles. The results showed that perfusion imaging is feasible and does not delay time to treatment in children.
Meeting Abstract
Clinical Neurology
Adnan Mujanovic, Omer Eker, Gaultier Marnat, Daniel Strbian, Petra Ijas, Cecile Preterre, Aude Triquenot, Jean-Francois Albucher, Maxime Gauberti, David Weisenburger-Lile, Marielle Sophie, Omid NIkoubashman, Anastasios Mpotsaris, Benjamin Gory, Vi Tuan Hua, Marc Ribo, David S. Liebeskind, Tomas Dobrocky, Thomas Meinel, Lukas Butikofer, Jan Gralla, Urs Fischer, Johannes Kaesmacher
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Antoine Sanner, Ahmed E. Othman
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmed E. Othman, Cecilia Liang, Yasmin Komma, Max Munz, Manuel Kolb, Dominik Rath, Brigitte Gueckel, Rolf Pohmann, Konstantin Nikolaou, Martin Schwartz, Thomas Kuestner, Petros Martirosian, Ferdinand Seith
Summary: This study evaluated the use of pseudo-continuous arterial spin labeling (PCASL) MRI for the detection of acute pulmonary embolism (PE) and its potential as an alternative to CT pulmonary angiography (CTPA). The results showed that PCASL MRI had high image quality, low artifact level, and good diagnostic confidence. It had a sensitivity of 92% and a specificity of 95% in detecting PE. Therefore, PCASL MRI may be a contrast material-free alternative to CTPA.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Razmin Bonsignore, Malte Ottenhausen, Ahmed E. E. Othman
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2023)
Article
Clinical Neurology
Svenja Tafelmeier, Elisabeth Kesseler, Anca-Maria Iancu, Omid Nikoubashman, Martin Wiesmann
Summary: The study aimed to evaluate the total complication rates and types of complications after diagnostic cerebral and spinal catheter angiography. The retrospective analysis of data from 2340 patients over a 10-year period showed that there were 75 clinically noted complications, with groin hematoma being the most common (1.32%). Neurological complications occurred in 0.68% of patients, while technical complications occurred in 2.35% of angiographic procedures.
CLINICAL NEURORADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
C. A. Luisi, A. Amiri, M. Buesen, T. Sichermann, O. Nikoubashman, M. Wiesmann, U. Steinseifer, M. Mueller, M. Neidlin
Summary: This study investigates the hemodynamics of blood flow in cerebral arteries during endovascular aspiration using both experimental and numerical approaches. An in vitro setup was developed to mimic patient-specific cerebral arteries, and measurements of pressure, flow, and velocity were obtained. Numerical simulations showed a strong correlation between flow rates and occlusion severity, as well as good agreement between pressure values.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Medicine, General & Internal
Aynur Goekduman, Ibrahim Yel, Thomas J. Vogl, Mirela Dimitrova, Leon D. Gruenewald, Vitali Koch, Leona S. Alizadeh, Andreas S. Brendlin, Ahmed E. Othman, Simon S. Martin, Tommaso D'Angelo, Alfredo Blandino, Silvio Mazziotti, Christian Booz
Summary: Due to its high morbidity and mortality, rapid diagnosis of myocardial infarction is crucial. This report presents a complex case of acute coronary syndrome, where a triple-rule-out CT examination in DECT mode was able to detect anterior wall infarction. Prompt and appropriate treatment was then initiated, resulting in the patient's survival.
Article
Medicine, General & Internal
Sebastian Altmann, Mario A. Abello A. Mercado, Felix A. Ucar, Andrea Kronfeld, Bilal Al-Nawas, Anirban Mukhopadhyay, Christian Booz, Marc A. Brockmann, Ahmed E. Othman
Summary: This study assesses the benefits of UHR-CT with AiCE in terms of image quality and radiation dose, and compares it to NR-CT. The results show that UHR-CT with AiCE reconstruction leads to significantly improved image quality and lower radiation dose compared to NR-CT.
Article
Multidisciplinary Sciences
Camila Gonzalez, Amin Ranem, Daniel Pinto dos Santos, Ahmed Othman, Anirban Mukhopadhyay
Summary: As the adoption of Deep Learning in medical field increases, researchers and clinicians are exploring safe ways to incorporate image segmentation into clinical practice. The shift from static to continual learning is a challenge when translating research into real-world applications. In this study, we present Lifelong nnU-Net, a standardized framework that allows researchers and clinicians to perform continual segmentation. Using the widely regarded nnU-Net as the base segmenter, our framework offers the necessary modules for sequential training and testing, making it easier to evaluate new methods in a continual manner. The benchmark results across three medical segmentation use cases and five continual learning methods provide a comprehensive understanding of the current state of the field.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Sebastian R. Reder, Steffen Lueckerath, Axel Neulen, Katja U. Beiser, Nils F. Grauhan, Ahmed E. Othman, Marc A. Brockmann, Carolin Brockmann, Andrea Kronfeld
Summary: Predicting clinical outcomes in aSAH and DCI patients by assessing cerebral perfusion using a 2DPA time-contrast agent concentration model.
JOURNAL OF CLINICAL MEDICINE
(2023)
