Article
Medicine, General & Internal
Jamal S. Rana, Salim S. Virani, Howard H. Moffet, Jennifer Y. Liu, Landis A. Coghlan, Jitesh Vasadia, Christie M. Ballantyne, Andrew J. Karter
Summary: The study aimed to evaluate the association between outpatient LDL-C testing and subsequent statin adherence and intensification in patients after an ASCVD event. The results showed that LDL-C testing was associated with improved statin adherence and higher rates of treatment intensification.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Oncology
Yuri Cho, Eun Ju Cho, Jeong-Ju Yoo, Young Chang, Goh Eun Chung, Su-Min Jeong, Sang-Hyun Park, Kyungdo Han, Dong Wook Shin, Su Jong Yu
Summary: Cholesterol plays a crucial role in cell structure and proliferation, with altered lipid metabolism linked to hepatocellular carcinoma (HCC) development. A large-scale study in Korea found that low lipid levels were significantly associated with an increased risk of developing HCC, serving as both an independent risk factor and preclinical marker for the disease.
Review
Agriculture, Multidisciplinary
Fan Zhang, Junhua Li, Cuihua Chang, Luping Gu, Wen Xiong, Yujie Su, Yanjun Yang
Summary: This review discusses the contradictory conclusions about the relationship between egg consumption and cardiovascular disease (CVD) risk, as well as the effects of egg cholesterol intake on cholesterol homeostasis. The study finds that moderate egg consumption has no substantial overall impact on cholesterol homeostasis in healthy individuals. However, excessive cholesterol intake is not recommended for individuals with metabolic disorders. In the future, the impact of egg consumption on CVD risk should be considered from different perspectives.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Chenglong Yu, Andrew Bakshi, Gerald F. Watts, Alan E. Renton, Brian Fulton-Howard, Alison M. Goate, Pradeep Natarajan, Daniel I. Chasman, Liubov Robman, Robyn L. Woods, Robyn Guymer, Rory Wolfe, Le Thi Phuong Thao, John J. Mcneil, Andrew M. Tonkin, Stephen J. Nicholls, Paul Lacaze
Summary: The study identified genetic variants in the CETP gene region associated with cardiovascular resilience during aging, individuals carrying these variants had better lipid profiles and reduced risk of ASCVD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Qin Luo, Jingfei Chen, Yingjie Su, Panyun Wu, Jiangang Wang, Zhenfei Fang, Fei Luo
Summary: This study investigated the relationship between serum sASGR1 concentration and LDL-C levels, and found a positive correlation between them. Furthermore, the effect of serum sASGR1 on LDL-C levels was significantly influenced by hypertension status. LDL-C and white blood cell count were identified as independent influencing factors for serum sASGR1 levels.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Multidisciplinary Sciences
Gozde Erturk Zararsiz, Serkan Bolat, Ahu Cephe, Necla Kochan, Serra Ilayda Yerlita, Halef Okan Dogan, Gokmen Zararsiz
Summary: Multiple studies have shown a high prevalence of dyslipidemia in children, emphasizing the importance of early recognition to prevent future coronary heart disease. Among the various equations for estimating LDL-C, the extended Martin-Hopkins formula was found to provide the most reliable results in a large pediatric population.
Review
Hematology
Gissette Reyes-Soffer, Henry N. Ginsberg, Lars Berglund, P. Barton Duell, Sean P. Heffron, Pia R. Kamstrup, Donald M. Lloyd-Jones, Santica M. Marcovina, Calvin Yeang, Marlys L. Koschinsky
Summary: High levels of Lp(a) are an independent and causal risk factor for atherosclerotic cardiovascular diseases. Genetic factors determine 70% to 90% of interindividual heterogeneity in Lp(a) levels. There is a lack of standardized assays, diagnostic guidelines, and targeted treatments for lowering Lp(a). Understanding the genetic and biological basis for variation in Lp(a) levels in different populations is crucial.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yvette L. Schooneveldt, Corey Giles, Michael F. Keating, Natalie A. Mellett, Aaron W. Jurrjens, Sudip Paul, Anna C. Calkin, Peter J. Meikle
Summary: The study found that altering cholesterol conditions affects the lipidome of liver cells, including increased levels of lipids containing arachidonic acid and decreases in phosphatidylinositol species. The PI(36:2)/PC(18:0_20:4) ratio responds to changes in intracellular cholesterol abundance, likely through a flux of the n-6 fatty acid pathway and altered phosphatidylinositol synthesis.
Review
Cardiac & Cardiovascular Systems
Kexin Wang, Rui Wang, Jiaxin Yang, Xiaoli Liu, Hua Shen, Yan Sun, Yujie Zhou, Zhe Fang, Hailong Ge
Summary: This review aims to summarize the evidence of elevated remnant cholesterol and its risks in atherosclerotic cardiovascular disease (ASCVD) and to provide further guidance for clinical therapy. Remnant cholesterol is considered an important indicator for predicting the incidence of ASCVD, especially when LDL-C levels have been controlled to recommended levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hui Min Chen, Kar Yan Li, Tian Le Li, Elaine Kwong, Gloria Hoi Yan Wong, Colman McGrath, Hui Chen
Summary: This study aimed to investigate the role of HDL-C concentration among older adults and its contribution to the link between tooth loss and cognitive impairment. The results showed a significant association between tooth loss, decreased cognitive function scores, and decreased HDL-C levels. The study suggests that the preservation of natural dentition may serve as a preventive measure against cognitive impairment, possibly mediated by abnormal lipid metabolism.
JOURNAL OF DENTISTRY
(2023)
Review
Endocrinology & Metabolism
Chunyu Li, Fei Wang, Lili Cui, Shaoxin Li, Junyu Zhao, Lin Liao
Summary: Metabolic reprogramming is a characteristic of tumors, with lipid metabolism playing a significant role. Abnormal lipid metabolism is associated with various diseases, and the number of people with such abnormalities is increasing. Lipid metabolism regulates oncogenic signaling pathways and is involved in the occurrence, development, invasion, and metastasis of tumors. Factors such as tumor origin, lipid metabolism pathway regulation, and diet contribute to the differences in lipid metabolism among different tumors. This article provides a review of lipid synthesis and regulatory pathways, highlighting the research progress on cholesterol, triglycerides, sphingolipids, lipid rafts, adipocytes, lipid droplets, and lipid-lowering drugs in relation to tumors and their drug resistance. It also identifies current research limitations and potential targets for tumor treatment within the lipid metabolism pathway. Studying and intervening in lipid metabolism abnormalities may offer new insights into tumor treatment and survival prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medical Laboratory Technology
Chun Gu, Na Wang, Peng Ren, Xuemei Wu, Bo Pang, Shuying Zhang, Xueyun Hou, Dan Xu, Yuliang Yuan, Guijian Liu
Summary: The study shows that postprandial lipoprotein subclass concentrations can effectively stratify cardiovascular disease risk. In the intermediate/high-risk FRS group, levels of fasting and postprandial VLDL1 + 2 and RLP, as well as postprandial LDL4 and VLDL3, were significantly higher than in the low-risk group.
CLINICAL BIOCHEMISTRY
(2021)
Article
Hematology
Mary Hoekstra, Hao Yu Chen, Jian Rong, Line Dufresne, Jie Yao, Xiuqing Guo, Michael Y. Tsai, Sotirios Tsimikas, Wendy S. Post, Ramachandran S. Vasan, Jerome I. Rotter, Martin G. Larson, George Thanassoulis, James C. Engert
Summary: This study identified a novel locus APOH influencing Lp(a) levels in individuals of European ancestry and confirmed previous associations at LPA, APOE, and CETP. Further research is needed to determine the precise role of beta 2GPI in influencing Lp(a) levels and its potential as a therapeutic target.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Nestor Vasquez, Colby R. Ayers, Jaideep Patel, Ananya Hooda, Amit Khera, Roger S. Blumenthal, Michael D. Shapiro, Carlos J. Rodriguez, Michael Y. Tsai, Laurence S. Sperling, Salim S. Virani, Michael J. Blaha, Parag H. Joshi
Summary: Elevated lipoprotein(a) and coronary artery calcium are independently associated with ASCVD risk, and may be concurrently useful in guiding primary prevention therapy decisions, as demonstrated in the MESA and DHS cohorts.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Iokfai Cheang, Xu Zhu, Shi Shi, Yuan Tang, Xin Yue, Shengen Liao, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yanxiu Li, Xinli Li
Summary: This study investigated the association between target lipid parameters (RC and NHDL-C) and the risk of cardiovascular mortality in the general population. The results showed that high RC levels were associated with an increased risk of CV mortality, while NHDL-C and ApoB did not show association.
