Molecular Pathways Regulating Macrophage Polarization: Implications for Atherosclerosis

Unique Expression of Suppressor of Cytokine Signaling 3 Is Essential for Classical Macrophage Activation in Rodents In Vitro and In Vivo

(2014) Yu Liu et al.   JOURNAL OF IMMUNOLOGY

IL-10: The Master Regulator of Immunity to Infection

(2014) Kevin N. Couper et al.   JOURNAL OF IMMUNOLOGY

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Nuclear Factor of Activated T Cells 5 Regulates Vascular Smooth Muscle Cell Phenotypic Modulation

(2011) Julia A. Halterman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Disruption of Endothelial Peroxisome Proliferator-Activated Receptor γ Accelerates Diet-Induced Atherogenesis in LDL Receptor-Null Mice

(2011) Aijuan Qu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reversal of Hyperlipidemia With a Genetic Switch Favorably Affects the Content and Inflammatory State of Macrophages in Atherosclerotic Plaques

(2011) Jonathan E. Feig et al.   CIRCULATION

LXRα Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8

(2011) Benoit Pourcet et al.   CIRCULATION RESEARCH

Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways

(2011) Giulia Chinetti-Gbaguidi et al.   CIRCULATION RESEARCH

Association Between High-Sensitivity C-Reactive Protein and Coronary Plaque Subtypes Assessed by 64-Slice Coronary Computed Tomography Angiography in an Asymptomatic Population

(2011) Jonathan Rubin et al.   Circulation-Cardiovascular Imaging

Epigenetic control of macrophage polarization

(2011) Osamu Takeuch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR−/− mice

(2011) G Li et al.   GENE THERAPY

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

(2011) S. E. Mullican et al.   GENES & DEVELOPMENT

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate immunity and monocyte-macrophage activation in atherosclerosis

(2011) Joseph Shalhoub et al.   Journal of Inflammation-London

Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function

(2011) Claire S. Whyte et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Obstacles and opportunities for understanding macrophage polarization

(2011) P. J. Murray et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Coronary Atherosclerosis Is Associated With Macrophage Polarization in Epicardial Adipose Tissue

(2011) Yoichiro Hirata et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation

(2011) Ine Wolfs et al.   THROMBOSIS AND HAEMOSTASIS

AAV/hSTAT3-gene delivery lowers aortic inflammatory cell infiltration in LDLR KO mice on high cholesterol

(2010) Junaid A. Khan et al.   ATHEROSCLEROSIS

Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: A crucial role for Krüppel-like factor 2

(2010) L.J.H. van Tits et al.   ATHEROSCLEROSIS

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

(2010) Alexandra Kadl et al.   CIRCULATION RESEARCH

Macrophage Heterogeneity: Relevance and Functional Implications in Atherosclerosis

(2010) J. Stoger et al.   Current Vascular Pharmacology

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Epigenetics in atherosclerosis and inflammation

(2010) Rutger J. Wierda et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of IFN Regulatory Factor-1 Down-Regulate Th1 Cell Function in Patients with Acute Coronary Syndrome

(2010) Min Guo et al.   JOURNAL OF CLINICAL IMMUNOLOGY

CXC Chemokine Ligand 4 Induces a Unique Transcriptome in Monocyte-Derived Macrophages

(2010) C. A. Gleissner et al.   JOURNAL OF IMMUNOLOGY

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Macrophage Plasticity in Experimental Atherosclerosis

(2010) Jamila Khallou-Laschet et al.   PLoS One

Prenatal Exposure to apoE Deficiency and Postnatal Hypercholesterolemia Are Associated with Altered Cell-Specific Lysine Methyltransferase and Histone Methylation Patterns in the Vasculature

(2009) Fanneke E. Alkemade et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppressors of Cytokine Signaling Modulate JAK/STAT-Mediated Cell Responses During Atherosclerosis

(2009) Guadalupe Ortiz-Muñoz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation Imaging in Atherosclerosis

(2009) James H.F. Rudd et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage Diversity and Polarization in Atherosclerosis

(2009) Alberto Mantovani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

Heart Disease and Stroke Statistics—2010 Update

(2009) et al.   CIRCULATION

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

(2009) Francesca De Santa et al.   EMBO JOURNAL

GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

(2009) Andrew J. Fleetwood et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Testing the inflammatory hypothesis of atherothrombosis: scientific rationale for the cardiovascular inflammation reduction trial (CIRT)

(2009) PAUL M. RIDKER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

(2009)   LANCET

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Time for Cardiovascular Inflammation Reduction Trials Has Arrived

(2008) Paul M Ridker   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Low Tissue Inhibitor of Metalloproteinases 3 and High Matrix Metalloproteinase 14 Levels Defines a Subpopulation of Highly Invasive Foam-Cell Macrophages

(2008) Jason L. Johnson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo

(2008) Wah-Seng Lim et al.   CIRCULATION

Hemizygous Deficiency of Krüppel-Like Factor 2 Augments Experimental Atherosclerosis

(2008) G. Brandon Atkins et al.   CIRCULATION RESEARCH

An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation

(2008) Carol Ho Yan Fong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms and consequences of macrophage apoptosis in atherosclerosis

(2008) Tracie Seimon et al.   JOURNAL OF LIPID RESEARCH

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark