Article
Biochemistry & Molecular Biology
Ekaterina Mikhailovna Stakhneva, Elena Vladimirovna Kashtanova, Yana Vladimirovna Polonskaya, Eugeniia Vitalievna Striukova, Viktoriya Sergeevna Shramko, Evgeny Viktorovich Sadovski, Alexey Vitalievich Kurguzov, Ivan Sergeevich Murashov, Alexander Mikhailovich Chernyavskii, Yuliya Igorevna Ragino
Summary: Quantitative proteomics studies revealed associations between several blood proteins and the presence of unstable atherosclerotic plaques in the arteries of patients with coronary atherosclerosis, including afamin, attractin, components of the complement system, hemopexin, and haptoglobin. These findings provide insight into the potential roles of these blood proteins in the development of coronary atherosclerosis and their potential as biomarkers for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ekaterina Mikhailovna Stakhneva, Evgeniia Vitalievna Striukova, Yulia Igorevna Ragino
Summary: Proteomic studies play a crucial role in investigating atherosclerotic cardiovascular diseases, identifying potential biomarkers, and offering novel diagnostic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Jian Zhang, Xiangkai Zhao, Yunyun Guo, Zhiping Liu, Shujian Wei, Qiuhuan Yuan, Haixia Shang, Wentao Sang, Sumei Cui, Tonghui Xu, Kehui Yang, Jialin Guo, Chang Pan, Jiali Wang, Jiaojiao Pang, Tianrui Han, Yuguo Chen, Feng Xu
Summary: The ALDH2 rs671 mutation is a risk factor for the development and prognosis of atherosclerotic cardiovascular diseases. This study uncovers the important role of the ALDH2-Rac2 axis in efferocytosis during atherosclerosis, providing a potential direction for therapeutic strategies in cardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Clinical Neurology
Andrea Baragetti, Elisa Mattavelli, Liliana Grigore, Fabio Pellegatta, Paolo Magni, Alberico Luigi Catapano
Summary: A new set of circulating proteins have been identified that may serve as markers for the development of preclinical atherosclerosis. The proteins identified to predict SCA development versus IMT progression showed different etiological factors.
Article
Medicine, Research & Experimental
Aiyang Liu, Ruizhi Li, Farah Zaaboul, Mengxue He, Xue Li, Jiachen Shi, Yuanfa Liu, Yong -Jiang Xu
Summary: This study aimed to investigate the effect of astaxanthin on foam cells and identified the protein expression changes using proteomic approaches. The results showed that total cholesterol and free cholesterol increased in foam cells treated with astaxanthin. Proteomics analysis revealed the involvement of PI3K/CDC42 and PI3K/RAC1/TGF-beta 1 pathways in lipid metabolism and cholesterol efflux, leading to reduced inflammation in foam cells. These findings provide new insights into the mechanism of astaxanthin in regulating lipid metabolism in macrophage foam cells.
Article
Oncology
Han Jin, Pieter Goossens, Peter Juhasz, Wouter Eijgelaar, Marco Manca, Joel M. H. Karel, Evgueni Smirnov, Cornelis J. J. M. Sikkink, Barend M. E. Mees, Olivia Waring, Kim van Kuijk, Gregorio E. Fazzi, Marion J. J. Gijbels, Martina Kutmon, Chris T. A. Evelo, Ulf Hedin, Mat J. A. P. Daemen, Judith C. Sluimer, Ljubica Matic, Erik A. L. Biessen
Summary: The study integrated multiple omics data and identified a protein-gene associated multiomics model with high predictive performance in distinguishing intraplaque hemorrhage and stable plaques, revealing cardiovascular disease features related to plaque vulnerability, and validated the findings in several independent cohorts.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mathias Jensen, Nicoline W. Thorsen, Line A. E. Hallberg, Per Hagglund, Clare L. Hawkins
Summary: Neutrophil extracellular trap (NET) release plays a key role in chronic diseases like atherosclerosis, but the release of macrophage extracellular traps (METs) and their composition are less understood. This study investigated MET release from human THP-1 macrophages exposed to different stimuli and discovered that METs were composed of histones, various proteins involved in different cellular processes, and the absence of proteases. These findings provide new insights into the implications of MET formation in immune defense and pathology.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Neeloffer Mookherjee, Min Hyung Ryu, Mahadevappa Hemshekhar, Juma Orach, Victor Spicer, Christopher Carlsten
Summary: This study details the impact of traffic-related air pollution on the human plasma proteome. It identifies specific proteins related to atherosclerosis that increase in concentration as the level of traffic-related air pollution increases.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biology
Andrew J. Buckler, David Marlevi, Nikolaos T. Skenteris, Mariette Lengquist, Malin Kronqvist, Ljubica Matic, Ulf Hedin
Summary: Computational modeling could potentially be used to tailor treatment for individual patients with atherosclerosis and prevent heart attacks and strokes. In this study, a comprehensive systems biology disease model was developed based on a unique plaque proteomic dataset, and it was used to simulate individualized responses to pharmacotherapy. The simulation results showed improvements in plaque stability, indicating that proteomics-based system biology modeling could be a potential strategy for personalized management of cardiovascular disease patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Hematology
Lasse G. Lorentzen, Gorm M. Hansen, Kasper K. Iversen, Henning Bundgaard, Michael J. Davies
Summary: Proteomic analysis of proteins captured on angioplasty balloons during percutaneous coronary interventions can provide information on coronary artery lesion protein profiles and distinguish between different types of coronary artery disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemical Research Methods
Yanxiang Wu, Lianfeng Chen, Ziyan Xie, Chenyu Wang, Jiahao Zhang, Xiaowei Yan
Summary: This study found that ABCG1 deficiency could lead to changes in the proteomic composition of HDL, particularly under a high-fat diet. Oxysterols have a detrimental impact on HDL composition, which might affect the antiatherosclerotic properties of HDL.
Article
Medicine, General & Internal
Estefania Nunez, Valentin Fuster, Maria Gomez-Serrano, Jose Manuel Valdivielso, Juan Miguel Fernandez-Alvira, Diego Martinez-Lopez, Jose Manuel Rodriguez, Elena Bonzon-Kulichenko, Enrique Calvo, Alvaro Alfayate, Marcelino Bermudez-Lopez, Joan Carles Escola-Gil, Leticia Fernandez-Friera, Isabel Cerro-Pardo, Jose Maria Mendiguren, Fatima Sanchez-Cabo, Javier Sanz, Jose Maria Ordovas, Luis Miguel Blanco-Colio, Jose Manuel Garcia-Ruiz, Borja Ibanez, Enrique Lara-Pezzi, Antonio Fernandez-Ortiz, Jose Luis Martin-Ventura, Jesus Vazquez
Summary: This study identified circulating proteins that are associated with subclinical atherosclerosis and can predict the disease. These proteins offer potential for improving primary prevention strategies in areas where cardiovascular imaging is not available.
Article
Cardiac & Cardiovascular Systems
Mihaela Ioana Dregoesc, Adrian Bogdan Tigu, Siroon Bekkering, Charlotte D. C. C. van der Heijden, Sorana Daniela Bolboaca, Leo A. B. Joosten, Frank L. J. Visseren, Mihai G. Netea, Niels P. Riksen, Adrian Corneliu Iancu
Summary: This study examined the relationship between plasma proteomics analysis and the risk of cardiovascular events in patients with stable CAD. Five novel biomarkers were identified as independent risk factors for adverse outcomes in these patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Viorel Suica, Elena Uyy, Luminita Ivan, Raluca M. Boteanu, Aurel Cerveanu-Hogas, Rune Hansen, Felicia Antohe
Summary: Increased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. This study suggests that a specific panel of stress-sensing molecules (alarmins) may indicate the persistence of residual risk in silent atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Hematology
Natalia Eberhardt, Chiara Giannarelli
Summary: The development of innovative single-cell technologies has allowed for in-depth analysis of the transcriptomic and proteomic profiling of individual blood and tissue cells. Recent single-cell studies have revealed the cellular heterogeneity of atherosclerotic plaque tissue and provided a better understanding of the immune functional states in the context of atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Urology & Nephrology
Maria Luz Sanchez-Tocino, Emilio Gonzalez-Parra, Blanca Miranda Serrano, Carolina Gracia-Iguacel, Ana Maria De-Alba-Penaranda, Antonio Lopez-Gonzalez, Marcos Garcia Olegario, Alberto Ortiz, Sebastian Mas-Fontao
Summary: The study found that sarcopaenia remains stable in stable very elderly persons on haemodialysis, while those who completed a lower limb exercise programme showed significant improvement in the five times sit-to-stand test and frailty scale. This suggests that short-term intradialytic exercise programmes can effectively improve physical function in this population.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Nutrition & Dietetics
Cristina Valle-Hita, Andres Diaz-Lopez, Nerea Becerra-Tomas, Miguel A. Martinez-Gonzalez, Veronica Ruiz Garcia, Dolores Corella, Albert Goday, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Luis Serra-Majem, Naomi Cano-Ibanez, Josep A. Tur, Maria Rubin-Garcia, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia-Martin, Josep Vidal, Sebastian Mas Fontao, Lidia Daimiel, Emilio Ros, Estefania Toledo, Jose Sorli, C. Roca, Iztiar Abete, Anai Moreno-Rodriguez, Edelys Crespo-Oliva, Inmaculada Candela-Garcia, Marga Morey, Antonio Garcia-Rios, Rosa Casas, Jose Carlos Fernandez-Garcia, Jose Manuel Santos-Lozano, Javier Diez-Espino, Carolina Ortega-Azorin, M. Comas, M. Angeles Zulet, Carolina Sorto-Sanchez, Miguel Ruiz-Canela, Montse Fito, Jordi Salas-Salvado, Nancy Babio
Summary: Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Lucas Opazo-Rios, Manuel Soto-Catalan, Iolanda Lazaro, Aleix Sala-Vila, Luna Jimenez-Castilla, Macarena Orejudo, Juan Antonio Moreno, Jesus Egido, Sebastian Mas-Fontao
Summary: This study characterized the pathophysiological mechanism involved in the development of MAFLD using the BTBR ob/ob mouse model. The results showed that BTBR ob/ob mice exhibited MAFLD features similar to humans, with overactivation of inflammatory response, oxidative stress, and de novo lipogenesis signaling pathways. This research is important for understanding the transition from steatosis to steatohepatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Lucas Opazo-Rios, Antonio Tejera-Munoz, Manuel Soto Catalan, Vanessa Marchant, Carolina Lavoz, Sebastian Mas Fontao, Juan Antonio Moreno, Marta Fierro Fernandez, Ricardo Ramos, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Jesus Egido, Raul R. Rodrigues-Diez
Summary: The study analyzed the differential expression of miRNA in the kidneys of BTBR ob/ob mice using Next-Generation Sequencing and found 99 miRNAs significantly increased in diabetic kidneys, with none being significantly decreased. These miRNAs may be associated with inflammatory and immune processes, highlighting the importance of inflammation in the pathogenesis of diabetic nephropathy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
M. Luz Sanchez-Tocino, Blanca Miranda-Serrano, Antonio Lopez-Gonzalez, Silvia Villoria-Gonzalez, Monica Pereira-Garcia, Carolina Gracia-Iguacel, Isabel Gonzalez-Ibarguren, Alberto Ortiz-Arduan, Sebastian Mas-Fontao, Emilio Gonzalez-Parra
Summary: This study demonstrates an association between sarcopenia defined by the Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria and mortality in very elderly hemodialysis patients at 24 months.
Article
Nutrition & Dietetics
Laura Diez-Ricote, Rodrigo San-Cristobal, M. Jose Concejo, Miguel a Martinez-Gonzalez, Dolores Corella, Jordi Salas-Salvado, Albert Goday, J. Alfredo Martinez, angel M. Alonso-Gomez, Julia Waernberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Lluis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Jose J. Gaforio, Pilar Matia-Martin, Josep Vidal, Sebastian Mas Fontao, Emilio Ros, Zenaida Vazquez-Ruiz, Carolina Ortega-Azorin, Jesus F. Garcia-Gavilan, Mireia Malcampo, Diego Martinez-Urbistondo, Lucas Tojal-Sierra, Antonio Garcia Rodriguez, Nuria Gomez-Bellvert, Alice Chaplin, Antonio Garcia-Rios, Rosa M. Bernal-Lopez, Jose M. Santos-Lozano, Javier Basterra-Gortari, Jose Sorli, Michelle Murphy, Griselda Gasulla, Victor Mico, Itziar Salaverria-Lete, Estibaliz Goni Ochandorena, Nancy Babio, Xavier Herraiz, Jose M. Ordovas, Lidia Daimiel
Summary: This study found that increasing dietary intake of choline or betaine was associated with improvements in cardiometabolic parameters and slight improvements in markers of renal function.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Patricia Branco, Ana Rita Martins, Rita Calca, Catarina Mateus, Maria Joao Jervis, Anabela Rodrigues, Sofia Azeredo Lopes, Ester Civantos, Sebastian Mas-Fontao, Augusta Gaspar, Sancia Ramos, Judit Morello, Daniel Pinto Gomes, Sofia Azeredo Pereira
Summary: This study found that some patients already have fibrosis of the peritoneal membrane before starting dialysis, while others do not. The results suggest that alpha-Klotho may be implicated in fibrosis of the peritoneal membrane.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Andrea Kallmeyer, Ana Maria Pello Lazaro, Luis M. Blanco-Colio, Alvaro Acena, Oscar Gonzalez-Lorenzo, Nieves Tarin, Carmen Cristobal, Carlos Gutierrez-Landaluce, Ana Huelmos, Jairo Lumpuy-Castillo, Marta Lopez-Castillo, Juan Manuel Montalvo, Joaquin J. Alonso Martin, Lorenzo Lopez-Bescos, Jesus Egido, Oscar Lorenzo, Jose Tunon
Summary: This study found that the absence of high Lp(a) levels and high HDL-c levels were independent predictors of the absence of coronary artery disease in patients with myocardial infarction. High Lp(a) levels were also an independent predictor of ischemic events or death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Patricia Branco, Rita Calca, Ana Rita Martins, Catarina Mateus, Maria Joao Jervis, Daniel Pinto Gomes, Sofia Azeredo-Lopes, Antonio Ferreira Junior De Melo, Catia Sousa, Ester Civantos, Sebastian Mas-Fontao, Augusta Gaspar, Sancia Ramos, Judit Morello, Fernando Nolasco, Anabela Rodrigues, Sofia Azeredo Pereira
Summary: This study investigated the predictors of long-term peritoneal dialysis (PD) outcomes, including peritoneal membrane status, clinical data, and aging-related molecules. It found that fibrosis of the peritoneal membrane was associated with major cardiovascular events (MACE) occurrence, while serum alpha-Klotho below 742 pg/mL was related to submesothelial thickness. Uremic levels of galectin-3 were associated with PD failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
M. L. Sanchez-Tocino, S. Mas-Fontao, C. Gracia-Iguacel, M. Pereira, I. Gonzalez-Ibarguren, A. Ortiz, M. D. Arenas, E. Gonzalez Parra
Summary: This study aimed to develop a sarcopenia index based on malnutrition parameters for screening muscle wasting in elderly hemodialysis patients. The results showed that the combination of loss of strength, loss of muscle mass, and low physical performance correlated with malnutrition. Regression equations were developed to predict the severity of sarcopenia, and easily accessible anthropometric and nutritional parameters were used for screening.
Article
Nutrition & Dietetics
Octavian Parascinet, Sebastian Mas, Tianyu Hang, Carolina Llavero, Oscar Lorenzo, Jaime Ruiz-Tovar
Summary: This pilot study suggests that the administration of a multi-strain probiotic containing lactobacillus and bifidobacterium species can help reduce body weight and cardiovascular risk factors in obese patients. This effect may be related to the production of short-chain fatty acids.
Article
Medicine, General & Internal
Rafael Gabriel, Nisa Boukichou-Abdelkader, Aleksandra Gilis-Januszewska, Konstantinos Makrilakis, Ricardo Gomez-Huelgas, Zdravko Kamenov, Bernhard Paulweber, Ilhan Satman, Predrag Djordjevic, Abdullah Alkandari, Asimina Mitrakou, Nebojsa Lalic, Jesus Egido, Sebastian Mas-Fontao, Jean Henri Calvet, Jose Carlos Pastor, Jaana Lindstrom, Marcus Lind, Tania Acosta, Luis Silva, Jaakko Tuomilehto
Summary: The objective of this study was to compare the impact of glucose-lowering drugs on peripheral nerve and kidney function in prediabetes. The results showed that the use of metformin alone, linagliptin alone, or the combination of both reduced the risk of small fiber peripheral neuropathy and slowed down the decrease in estimated glomerular filtration rate compared to the placebo. These findings suggest that treatment with metformin and linagliptin, either alone or in combination, can effectively protect prediabetes patients from developing peripheral nerve diseases and maintain kidney function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Belen Picatoste, Isabel Cerro-Pardo, Luis M. Blanco-Colio, Jose L. Martin-Ventura
Summary: This review discusses the impact of diabetes mellitus (DM) on abdominal aortic aneurysms (AAA). It suggests that DM may have a protective role, potentially through factors such as hyperglycemia or insulin resistance, as well as through the effect of prescribed DM drugs. The review also summarizes the potential cellular and molecular pathways involved in the vascular effects of DM and provides an overview of current antidiabetic therapies that could be beneficial for AAA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Marcelino Cortes, Oscar Lorenzo, Jairo Lumpuy-Castillo, Sacramento Martinez-Albaladejo, Mikel Taibo-Urquia, Ana Maria Pello, Antonio Jose Bollas, Miguel Orejas, Miguel angel Navas, Ester Macia, Maria Esther Martinez, Andrea Rueda, Jose Tunon
Summary: This study analyzed the effect of dapagliflozin on cardiac structure and function in patients with normal ejection fraction. The results showed that the use of SGLT2i was associated with improvements in both structural and functional aspects of the heart in diabetic patients with normal ejection fraction.
JOURNAL OF CLINICAL MEDICINE
(2023)
