Review
Nutrition & Dietetics
Gabriele Piuri, Monica Zocchi, Matteo Della Porta, Valentina Ficara, Michele Manoni, Gian Vincenzo Zuccotti, Luciano Pinotti, Jeanette A. Maier, Roberta Cazzola
Summary: Magnesium (Mg2+) deficiency is often underestimated in Western countries, especially in obese individuals with type 2 diabetes and metabolic syndrome. Proper intake of Mg2+ can help improve metabolic syndrome by regulating gene expression, proteomic profile, and impacting intestinal microbiota and vitamin metabolism.
Article
Cardiac & Cardiovascular Systems
Jae-Seung Yun, Sang-Hyuk Jung, Manu Shivakumar, Brenda Xiao, Amit V. Khera, Hong-Hee Won, Dokyoon Kim
Summary: This study found that genetic risk for T2D is associated with increased risk of CVD. Engaging in a healthy lifestyle and maintaining metabolic health may reduce the risk of CVD, regardless of genetic risk for T2D.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Marietta Rottenkolber, Christina Gar, Cornelia Then, Lorena Wanger, Vanessa Sacco, Friederike Banning, Anne L. Potzel, Stefanie Kern-Matschilles, Claudia Nevinny-Stickel-Hinzpeter, Harald Grallert, Nina Hesse, Jochen Seissler, Andreas Lechner
Summary: This study re-evaluated the prevailing hypothesis that metabolic syndrome components are central to all cases of T2DM. Results showed that a significant proportion of T2DM cases did not display any components of metabolic syndrome, indicating the existence of a second, unrelated pathophysiology.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Holger Steinbrenner, Leonidas H. H. Duntas, Margaret P. P. Rayman
Summary: This review discusses the role of selenium in T2DM and its metabolic co-morbidities, emphasizing the relevance of inflammation and oxidative stress. It describes the epidemiology of selenium studies in diabetes and explains the interaction between selenium status and glucose control. According to current research, dietary selenium supplementation does not appear to be a major causal factor for the development of T2DM.
Article
Endocrinology & Metabolism
Deborah J. Wexler, Yuchiao Chang, Douglas E. Levy, Bianca Porneala, Jeanna McCarthy, Anthony Rodriguez Romero, Valerie Goldman, Paul M. Copeland, Jeanne Steppel-Reznik, Linda M. Delahanty
Summary: The study compared the effectiveness of lifestyle intervention and medical nutrition therapy in weight loss among individuals with type 2 diabetes. The results showed no significant difference in weight outcomes and glycated hemoglobin levels between the two interventions.
Review
Cell Biology
Andre P. Sousa, Raquel Costa, Marco G. Alves, Raquel Soares, Pilar Baylina, Ruben Fernandes
Summary: Prostate cancer is the second most common cancer in men worldwide and requires new treatment approaches. The development of prostate cancer is complex and involves various mutations and carcinogenic events. Metabolic disorders such as Metabolic Syndrome and Type 2 Diabetes Mellitus are associated with the development of prostate cancer, but their impact is opposite.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Shen Li, Mengxuan Cui, Yingshu Liu, Xuhan Liu, Lan Luo, Wei Zhao, Xiaolan Gu, Linfeng Li, Chao Liu, Lan Bai, Di Li, Bo Liu, Defei Che, Xinyu Li, Yao Wang, Zhengnan Gao
Summary: By studying patients with T2D, we identified 6 prevalent metabolic profiles and found that severe hyperglycemia and moderate dyslipidemia are significant risk markers for DKD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Atieh Amouzegar, Mohammadjavad Honarvar, Safdar Masoumi, Davood Khalili, Fereidoun Azizi, Ladan Mehran
Summary: The severity of metabolic syndrome usually remains stable throughout a ten-year follow-up period and can be used as an indicator of cardiometabolic dysfunction. Individuals with higher severity of metabolic syndrome are at a greater risk of developing diabetes, even if their glucose levels are normal.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Moataz M. Hanafy, Jeremie Z. Lindeque, Shohda A. El-Maraghy, Abdel-Hamid Z. Abdel-Hamid, Nancy N. Shahin
Summary: This study monitored the metabolic profile of diabetic rats using metabolomics and identified urinary metabolic biomarkers to better understand the metabolic disturbances in diabetes, emphasizing the need for additional markers beyond glucose levels for disease prognosis.
Review
Endocrinology & Metabolism
Tina I. I. Bui, Emily A. A. Britt, Gowrishankar Muthukrishnan, Steven R. R. Gill
Summary: The gut microbiota plays a crucial role in regulating host metabolism and immunity through the production of signaling metabolites, such as polyamines. Disruption of the gut microbiome in individuals with metabolic syndrome and obesity-related type 2 diabetes can lead to dysregulation of polyamine synthesis. Restoring the dysbiotic gut microbiota and polyamine synthesis has shown promise in ameliorating metabolic syndrome and enhancing immune responses in individuals with obesity/T2D.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jinbo Hu, Yang Hu, Ellen Hertzmark, Chen Yuan, Gang Liu, Meir J. Stampfer, Eric B. Rimm, Frank B. Hu, Molin Wang, Qi Sun
Summary: This study found a significant association between substantial weight loss and increased mortality among newly diagnosed type 2 diabetes patients, which was abolished by improving lifestyle quality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Andreea Gherasim, Andrei C. Oprescu, Ana Maria Gal, Alexandra Maria Burlui, Laura Mihalache
Summary: Modern lifestyles have resulted in sedentary behavior, unhealthy diets, and increased stress, which have led to lower physical activity levels and negatively affected metabolic parameters in patients with type 2 diabetes. This study identified three dietary patterns and two lifestyle patterns, with the inadequate lifestyle pattern being associated with younger age, hypertension, and diabetic neuropathy, while the traditional lifestyle pattern was related to better postprandial blood glucose control. Sedentary individuals were more likely to be older and have higher glycated hemoglobin levels, while smokers were more likely to have poor glycemic and lipid profiles.
Article
Biochemistry & Molecular Biology
Gratiela Gradisteanu Pircalabioru, Janie Liaw, Ozan Gundogdu, Nicolae Corcionivoschi, Iuliana Ilie, Luciana Oprea, Madalina Musat, Mariana-Carmen Chifiriuc
Summary: This study aims to investigate the role of gut microbiota in the development of metabolic syndrome (MetSyn) and type 2 diabetes mellitus (T2DM). The findings show that MetSyn patients have reduced microbial diversity and loss of butyrate producers in their gut microbiome. Furthermore, T2DM patients with MetSyn exhibit distinct gut microbiota signatures. The study also highlights the impact of metformin treatment on the gut microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
A-Ra Cho, Yu-Jin Kwon, Jong-Koo Kim
Summary: This study aimed to investigate the prevalence of pre-MetSyn and its components, as well as their associations with new-onset T2D or hypertension in Korean men and women aged 40-69 years. The results showed that the prevalence of pre-MetSyn and its components varied by sex and disease, suggesting that specific phenotypes of pre-MetSyn may play a crucial role in predicting and preventing the development of T2D and hypertension.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Health Care Sciences & Services
Vishal A. Salunkhe, Neha Sinha, Emma Ahlqvist, Rashmi B. Prasad, Svetlana Johansson, Birgitta Abrahamsson, Anders H. Rosengren
Summary: We developed a new digital method to promote behavioral change and conducted an empirical study on patients with type-2 diabetes in Sweden. The results showed that patients who received the intervention had significantly improved HbA1c during a medium to long-term follow-up, accompanied by improvements in other physical indicators. The study also found differences in treatment effects for patients with different BMI and insulin resistance levels, as well as for carriers of the FTO gene.
NPJ DIGITAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Paola Caruso, Maurizio Gicchino, Miriam Longo, Lorenzo Scappaticcio, Ferdinando Campitiello, Katherine Esposito
Summary: In this article, a case of a 39-year-old man with diabetes who developed severe soft tissue infection and osteomyelitis after undergoing major amputation for wet gangrene of both the foot and ankle is reported.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Review
Endocrinology & Metabolism
L. Scappaticcio, M. I. Maiorino, S. Iorio, C. Camponovo, A. Piccardo, G. Bellastella, G. Docimo, K. Esposito, P. Trimboli
Summary: Elective thyroid surgery during the COVID-19 pandemic may face delays, but the risk of SARS-CoV-2 transmission post-surgery is relatively low. Complications after surgery include hypoparathyroidism and recurrent laryngeal nerve injury.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
M. Longo, L. Scappaticcio, M. Petrizzo, F. Castaldo, A. Sarnataro, D. Forestiere, F. Caiazzo, G. Bellastella, M. Maiorino, A. Capuano, K. Esposito
Summary: Young home-isolated patients with type 1 diabetes and COVID-19 showed a worsening of glucose control during COVID-19, as compared with age-matched diabetic subjects without the infection.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Review
Nutrition & Dietetics
Giuseppe Bellastella, Lorenzo Scappaticcio, Francesco Caiazzo, Maria Tomasuolo, Raffaela Carotenuto, Mariangela Caputo, Stefania Arena, Paola Caruso, Maria Ida Maiorino, Katherine Esposito
Summary: The aim of this review is to examine the correlation between the Mediterranean diet and thyroid function, and to evaluate the pathophysiological connection between selected food intake and thyroid disorders.
Article
Endocrinology & Metabolism
Lorenzo Scappaticcio, Pierpaolo Trimboli, Sergio Iorio, Maria Ida Maiorino, Miriam Longo, Laura Croce, Marcello Filograna Pignatelli, Sonia Ferrandes, Immacolata Cozzolino, Marco Montella, Andrea Ronchi, Renato Franco, Mario Rotondi, Giovanni Docimo, Katherine Esposito, Giuseppe Bellastella
Summary: This study examined the inter-observer agreement between high-volume and low-volume institutions in thyroid cytology and explored the distribution of discordant FNAC reports in the European Thyroid Imaging and Reporting Data System (EU-TIRADS) categories. The study found significant differences in FNAC reports between the high-volume and low-volume institutions, and poor inter-observer agreement.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Paola Caruso, Maria Ida Maiorino, Lorenzo Scappaticcio, Chiara Porcellini, Rita Matrone, Paolo Cirillo, Margherita Macera, Maurizio Gicchino, Maria Teresa Vietri, Giuseppe Bellastella, Nicola Coppola, Katherine Esposito
Summary: This study aimed to evaluate PTH levels in individuals with diabetic foot ulcers (DFU) and investigate the relationship between PTH levels and osteomyelitis (OM) in this population. The results showed that PTH levels were lower in DFU patients with OM compared to those without OM, and alkaline phosphatase levels were higher in the OM group. OM and alkaline phosphatase levels were independent predictors of PTH levels in this selected population.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Bellastella, Paolo Cirillo, Carla Carbone, Lorenzo Scappaticcio, Antonietta Maio, Graziella Botta, Maria Tomasuolo, Miriam Longo, Alessandro Pontillo, Antonio Bellastella, Katherine Esposito, Annamaria De Bellis
Summary: This review discusses the neuroimmune endocrinological aspects of SARS-CoV-2 infection. The virus targets the central nervous system, affecting the hypothalamic-pituitary axis and potentially causing autoimmune processes and satellite gland disorders. However, further research is needed to understand the short- and long-term effects on the endocrine system.
Editorial Material
Endocrinology & Metabolism
Paola Caruso, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito, Dario Giugliano
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Michele Cerasuolo, Irene Di Meo, Maria Chiara Auriemma, Francesca Trojsi, Maria Ida Maiorino, Mario Cirillo, Fabrizio Esposito, Rita Polito, Anna Maria Colangelo, Giuseppe Paolisso, Michele Papa, Maria Rosaria Rizzo
Summary: Neurodegeneration is a complex process involving multiple mechanisms, with diseases like Parkinson's, multiple sclerosis, Alzheimer's, prion diseases, and ALS being examples. Iron overload has been identified as a potential cause of neurodegeneration, with dysregulated iron metabolism and increased oxidative stress being common in these diseases. Alzheimer's, in particular, shows increased iron content in vulnerable brain regions, leading to mitochondrial alterations and lack of antioxidant defenses. Iron metabolism and ferroptosis play a significant role in diabetes-induced cognitive decline, and iron chelators offer a promising therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Dario Giugliano, Miriam Longo, Lorenzo Scappaticcio, Paola Caruso, Maurizio Gicchino, Michela Petrizzo, Giuseppe Bellastella, Maria Ida Maiorino, Katherine Esposito
Summary: The study aimed to assess the metabolic benefits of simplifying complex insulin regimens in patients with inadequately controlled type 2 diabetes. Results showed that simplification of treatment might be a durable option for at least half of patients.
Review
Public, Environmental & Occupational Health
Giuseppe Bellastella, Raffaela Carotenuto, Francesco Caiazzo, Miriam Longo, Paolo Cirillo, Lorenzo Scappaticcio, Carla Carbone, Davide Arcaniolo, Maria Ida Maiorino, Katherine Esposito
Summary: Varicocele can affect hormone production and fertility in males, but the relationship between clinical varicocele and hormonal alterations is not fully understood. More research is needed to clarify this relationship and improve the clinical management of varicocele patients.
FRONTIERS IN REPRODUCTIVE HEALTH
(2022)
Review
Geriatrics & Gerontology
Tahir Masud, Giulia Ogliari, Eleanor Lunt, Adrian Blundell, Adam Lee Gordon, Regina Roller-Wirnsberger, Michael Vassallo, Daniela Mari, Marina Kotsani, Katrin Singler, Roman Romero-Ortuno, Alfonso J. Cruz-Jentoft, Andreas E. Stuck
Summary: This scoping review aims to summarize recent developments in Geriatric Medicine for informing the updating of undergraduate medical curricula. Based on the analysis of 367 records, six major themes emerged, including curriculum, topics, teaching methods, teaching settings, medical students' skills, and attitudes. The review suggests the inclusion of new topics, different teaching methods and settings, as well as a focus on communication skills and empathy in the future curricula.
EUROPEAN GERIATRIC MEDICINE
(2022)
