Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 285, Issue -, Pages 137-142Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2015.06.003
Keywords
Polyinosinic-polycytidylic acid; Inflammation; Hippocampus; Complement system; Transcriptome; Immunofluorescence
Categories
Funding
- National Institutes of Health/National Institute of General Medical Sciences [U54GM104942]
Ask authors/readers for more resources
Peripheral challenge with a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces hippocampal hyperexcitability in mice. Here, we characterized this hippocampal response through a whole genome transcriptome analysis. Intraperitoneal injection of PIC resulted in temporal dysregulation of 625 genes in the hippocampus, indicating an extensive genetic reprogramming. The bioinformatics analysis of these genes revealed the complement pathway to be the most significantly activated. The gene encoding complement factor B (CfB) exhibited the highest response, and its upregulation was commensurate with the development of hyperexcitability. Collectively, these results suggest that the induction of hippocampal hyperexcitability may be mediated by the alternative complement cascades. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available