Article
Clinical Neurology
Xuezhen Shen, Feng Qu, Yilun Pei, Simeng Lei, Suhang Xia, Jing Liang, Shan Li, Xun Sun, Liang Liu
Summary: This study demonstrates that the combined application of functionalized self-assembling peptide gels and chitosan nerve conduits accelerates nerve healing and enhances morphological repair, providing a promising therapy for peripheral nerve regeneration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Robert Trujanovic, Helene Rohrbach
Summary: Analgesia plays an important role in peri-operative protocols for both humans and animals. Ultrasound-guided nerve blocks have been developed to improve the effectiveness of analgesic drugs. In rabbits, a new technique for block of the sciatic and femoral nerves has been successfully tested on cadavers and may be useful in hind limb surgery. Incorporating regional anesthesia can reduce the requirement for systemic drugs and minimize side effects.
Article
Computer Science, Interdisciplinary Applications
Serife G. Caliskan, Mehmet D. Bilgin
Summary: During the early period of rat sciatic nerve crush injury, analyzing sEMG signals using nonlinear techniques can provide insights into the neuroprotective effect of citicoline. Administration of citicoline improves functional recovery in rats, and the nonlinear analysis of sEMG signals correlates with functional recovery and electrophysiological assessments.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2022)
Article
Neurosciences
Kelly A. Rich, Megan G. Pino, Mehmet E. Yalvac, Ashley Fox, Hallie Harris, Maria H. H. Balch, W. David Arnold, Stephen J. Kolb
Summary: KIF5A is a motor protein responsible for axonal transport. Loss of function variants in the N-terminal domain are associated with hereditary spastic paraplegia and hereditary motor neuropathy, while gain of function splice-site variants in the C-terminal domain are associated with ALS.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell Biology
Yu-Song Yuan, Fei Yu, Ya-Jun Zhang, Su-Ping Niu, Hai-Lin Xu, Yu-Hui Kou
Summary: This study investigated the expression levels of various factors in the sciatic nerve after injury, providing insights into the pathophysiology of peripheral nerve repair. The results revealed different trajectories of factors expression, which could potentially aid in the development of clinical treatments for peripheral nerve injury.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yaswanth Kuthati, Vaikar Navakanth Rao, Prabhakar Busa, Chih-Shung Wong
Summary: The study demonstrated that teneligliptin has mild antinociceptive effects against acute pain but remarkable analgesic effects against neuropathic pain. Co-infusion of GLP-1R antagonist with teneligliptin partially reversed allodynia but not tail-flick latency. Immunofluorescence examination revealed that teneligliptin decreased the immunoreactivity of GFAP in the spinal cord, suggesting its potential in neuropathic pain management.
Article
Engineering, Biomedical
Injoo Hwang, Eun Ju Lee, Hyomin Park, Dodam Moon, Jong Nam Park, Keun Cheon Kim, Areum Cha, Hyunji Yun, Jaewon Lee, Hwan-Woo Park, Mi-Sook Chang, Hyo-Soo Kim
Summary: The application of EDN1 in treating hMSC organotypic spinal cord slice cultures enhances neuronal outgrowth through whole-genome demethylation and euchromatin. APOBEC1 is identified as a key player in global demethylation and OCT4 gene activation induced by EDN1, suggesting a potential novel therapeutic target for improving hMSC regenerative capability.
Article
Nanoscience & Nanotechnology
Cheuk Sun Edwin Lai, Viridiana Leyva-Aranda, Victoria H. Kong, Tania L. Lopez-Silva, Adam C. Farsheed, Carlo D. Cristobal, Joseph W. R. Swain, Hyun Kyoung Lee, Jeffrey D. Hartgerink
Summary: This study introduces multidomain peptide hydrogels as conduits for bridging sciatic nerve defects and evaluates their efficacy in functional recovery. The results show that conduits filled with anionic peptides may improve postoperative functional recovery, while conduits filled with cationic peptides exhibit poor outcomes.
ACS APPLIED BIO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Tuchen Guan, Beibei Guo, Wenxue Zhang, Mengwei Qi, Xiaoqian Luo, Zhen Li, Yufang Zhang, Tiancheng Bao, Man Xu, Mei Liu, Yan Liu
Summary: In this study, it was found that gastric inhibitory peptide (GIP) enhances Schwann cell migration and the formation of Schwann cell cords after sciatic nerve injury in rats. Further investigations revealed that mTORC2 activity and Rap1 activation may be involved in GIP/GIPR-mediated cell migration. Additionally, Gli3 and the Sonic hedgehog pathway were found to play a crucial role in GIPR expression.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Anatomy & Morphology
Sarah E. Kinsley, Stephen D. Fernicola, Marvin E. Dingle, Milfred S. Williams, Jody M. Richardson, Dennis Taylor, Jaira F. de Vasconcellos, Timothy R. Malone, Matthew R. Blattner, Jonathan K. Smith, Alli Oliver, Amory L. Koch, Laura E. Riddle, Cara Reiter, William E. Culp, Edward J. Caterson, Leon J. Nesti, Simon G. Talbot
Summary: Animal studies are crucial in biomedical research, with large animal models essential for confirming nerve regeneration effects over longer distances required in humans. This paper presents a novel neurovascular injury model in the Sus scrofa domesticus swine, describing the authors' experience and recommendations for creating an effective model.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Article
Clinical Neurology
Gokhan Gurkan, Mumin Alper Erdogan, Gurkan Yigitturk, Oytun Erbas
Summary: The study demonstrates that gallic acid plays a positive role in the healing of mechanical nerve injuries by reducing latency, increasing nerve growth factor levels, and decreasing fibrosis. This suggests that gallic acid could be used as a supportive treatment for peripheral nerve damage.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2021)
Article
Clinical Neurology
Marzieh Karimi Khezri, Alper Turkkan, Cansu Koc, Berna Salman, Pinar Levent, Aysen Cakir, Ilker Mustafa Kafa, Mehmet Cansev, Ahmet Bekar
Summary: The study demonstrated that uridine treatment in a rat model of sciatic nerve injury can improve morphological and electrophysiological outcomes, leading to long-term functional improvement.
TURKISH NEUROSURGERY
(2022)
Article
Biology
Gulten Bademoglu, Nurten Erdal, Cosar Uzun, Bahar Tasdelen
Summary: This study aims to investigate the effects of PEMF on sciatic nerve regeneration, and the results suggest that PEMF has a beneficial effect during the short-term recovery period, but is not effective for long-periods of application time.
ELECTROMAGNETIC BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Kelly C. S. Roballo, Jason P. Gigley, Tyler A. Smith, George D. Bittner, Jared S. Bushman
Summary: This review discusses the unique functional and immunological properties of live allogeneic peripheral nerves compared to other transplanted tissues. It highlights the effectiveness of live peripheral nerve allografts in promoting recovery after peripheral nerve injury and the potential interest of understanding their immunological peculiarities in the field of transplantation. The review addresses topics such as the utility of peripheral nerve allografts in bridging nerve defects, the host immune response to these grafts, and the potential mechanisms accounting for immunological differences.
NEURAL REGENERATION RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
M. Takiguchi, I Sato, Z. L. Li, H. Miyaso, S. Kawata, M. Itoh
Summary: This study investigated the detailed morphological characteristics of mandibular canal branches (MCBs) using CBCT and observing the distribution of CGRP around the MCB. It found correlations between the structure of MCBs and CGRP distribution, with most MCBs following a clockwise distribution pattern and positive CGRP reactions observed in the no-canal branch group. These findings provide valuable insights for MCB dynamics and clinical dental treatment.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Cell Biology
Valerie Jolivel, Susana Brun, Fabien Biname, Jeremie Benyounes, Omar Taleb, Dominique Bagnard, Jerome De Seze, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan
Summary: Research has shown that the neurosteroid allopregnanolone (ALLO) has a direct impact on the morphology and phagocytic function of microglial cells, potentially contributing to the development of effective strategies against neurological disorders.
Article
Clinical Neurology
Maximilian Einsiedler, Paul Voulleminot, Stanislas Demuth, Pauline Kalaaji, Thomas Bogdan, Lucas Gauer, Cecile Reschwein, Aleksandra Nadaj-Pakleza, Jerome de Seze, Laurent Kremer, Ivana Schroder, Kevin Bigaut
Summary: This study highlights an increased incidence of neurological complications related to nitrous oxide abuse during the recent COVID-19 lockdown. Patients with compatible neurological symptoms and elevated homocysteinemia should be tracked down and supplemented with vitamin B-12 upon diagnosis.
JOURNAL OF NEUROLOGY
(2022)
Letter
Clinical Neurology
Stanislas Demuth, Thomas Bogdan, Laurent Kremer, Livia Lanotte, Nicolas Collongues, Jerome de Seze, Kevin Bigaut
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Alice Gravier-Dumonceau, Roxana Ameli, Veronique Rogemond, Anne Ruiz, Bastien Joubert, Sergio Muniz-Castrillo, Alberto Vogrig, Geraldine Picard, Aditya Ambati, Marie Benaiteau, Florence Rulquin, Jonathan Ciron, Kumaran Deiva, Thomas de Broucker, Laurent Kremer, Philippe Kerschen, Francois Sellal, Bastien Bouldoires, Roxana Genet, Julien Biberon, Adrien Bigot, Fanny Duval, Nahema Issa, Elena-Camelia Rusu, Mathilde Goudot, Anais Dutray, Jean Louis Devoize, Lucie Hopes, Anne-Laure Kaminsky, Marion Philbert, Eve Chanson, Amelie Leblanc, Erwan Morvan, Daniela Andriuta, Philippe Diraison, Gabriel Mirebeau, Celine Derollez, Veronique Bourg, Quentin Bodard, Clementine Fort, Irina Grigorashvili-Coin, Guillaume Rieul, Daniela Molinier-Tiganas, Mickael Bonnan, Thierry Tchoumi, Jerome Honnorat, Romain Marignier
Summary: This French cohort study reported the clinical, biological, and imaging features of patients with glial fibrillary acidic protein (GFAP) autoantibodies. The majority of patients presented with acute/subacute meningoencephalomyelitis and had good outcomes despite severe clinical presentations. Tumors and T-cell dysfunction were common triggers for GFAP autoimmunity.
Article
Biochemistry & Molecular Biology
Youssef El Khoury, Marie Gebelin, Jerome de Seze, Christine Patte-Mensah, Gilles Marcou, Alexandre Varnek, Ayikoe-Guy Mensah-Nyagan, Petra Hellwig, Nicolas Collongues
Summary: Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are autoimmune inflammatory and demyelinating diseases of the central nervous system. Differentiating between NMOSD and MS is crucial for the timely and appropriate treatment. In this study, infrared spectroscopy combined with machine learning successfully distinguished NMOSD and MS patients with 100% sensitivity and specificity. The method shows promise as a cost-effective and rapid diagnostic tool to help save valuable treatment time for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Maximilian Einsiedler, Laurent Kremer, Marie Fleury, Nicolas Collongues, Jerome De Seze, Kevin Bigaut
Summary: This study describes a cohort of progressive MS patients treated with ocrelizumab or rituximab in a real-world setting. The results confirm the tolerability of these treatments in a real-world setting and suggest that standardized clinical assessments could improve early detection of worsening patients.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
R. J. Nona, J. M. Greer, R. D. Henderson, P. A. McCombe
Summary: This systematic review and meta-analysis examines the association between HLA and ALS. The study finds three alleles of interest, but does not confirm all previously reported associations. The study also identifies methodological limitations and calls for further modern research to validate the results.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Review
Clinical Neurology
Sandra Vukusic, Clarisse Carra-Dalliere, Jonathan Ciron, Elisabeth Maillart, Laure Michel, Emmanuelle Leray, Anne-Marie Guennoc, Bertrand Bourre, David Laplaud, Geraldine Androdias, Caroline Bensa, Kevin Bigaut, Damien Biotti, Pierre Branger, Olivier Casez, Mikael Cohen, Elodie Daval, Romain Deschamps, Cecile Donze, Anne-Laure Dubessy, Cecile Dulau, Francoise Durand-Dubief, Maxime Guillaume, Benjamin Hebant, Laurent Kremer, Arnaud Kwiatkowski, Julien Lannoy, Adil Maarouf, Eric Manchon, Guillaume Mathey, Xavier Moisset, Alexis Montcuquet, Julie Pique, Thomas Roux, Romain Marignier, Christine Lebrun-Frenay
Summary: The objective of this study was to develop evidence-based recommendations on pregnancy management for persons with multiple sclerosis (MS). A total of 104 proposed recommendations were reached through a thorough review of literature and expert consensus. These recommendations cover various aspects including pregnancy planning, follow-up, delivery routes, anesthesia, prevention of relapses, breastfeeding, vaccinations, etc. These recommendations are expected to harmonize counseling and treatment practices, and provide better and individualized choices for individuals with MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Review
Immunology
Pamela A. A. McCombe, Todd A. A. Hardy, Robert J. J. Nona, Judith M. M. Greer
Summary: Guillain Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are immune mediated neuropathies that are more common in males. There are reported sex differences in immune system elements, which may contribute to the male predominance of these diseases and warrant further study in peripheral nerves.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pamela A. McCombe, Judith M. Greer
Summary: This article reviews the effects of biological sex and pregnancy on the clinical features and pathophysiology of experimental autoimmune encephalomyelitis (EAE), a widely used animal model for multiple sclerosis (MS). It highlights the importance of understanding the specific model used in EAE studies and the need for further research to better understand the mechanisms underlying sex differences.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Cell Biology
Judith M. Greer
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Review
Neurosciences
Michel Maitre, Helene Jeltsch-David, Nwife Getrude Okechukwu, Christian Klein, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of toxic A beta peptide oligomers, plaques, and tangles containing tau protein, resulting in neuronal and synaptic losses. Sporadic AD, the more common form, is believed to be caused by chronic neuroinflammation and mitochondriopathies, leading to the accumulation of free radicals. Mutations in DNA and unfolded proteins in aging brains contribute to chronic amyloidosis, which affects myelin sheath and axons and ultimately leads to cognitive deficits and dementia. This study explores the potential role of early myelin alterations in the development of neuronal alterations and symptom onset, suggesting that structural and metabolic disorders in myelination/demyelination processes may play a crucial role in certain pathophysiological and clinical forms of the disease.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Aakanksha Dixit, Hannah S. Savage, Judith M. Greer
Summary: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative condition affecting the central nervous system (CNS). Although therapeutic approaches have become available over the last 20 years that markedly slow the progression of disease, there is no cure for MS. Furthermore, the capacity to repair existing CNS damage caused by MS remains very limited.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Editorial Material
Cell Biology
Adrian Liston, Anne C. La Flamme, Gabrielle T. Belz, Christopher R. Parish, Judith M. Greer
Summary: This editorial recounts the history of Immunology & Cell Biology journal, from its founding in 1924 to its current focus on immunology research.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Editorial Material
Cell Biology
Judith M. Greer
Summary: This article focuses on the contributions of two long-serving Editors-in-Chief, Mark Mitchell and Derrick Rowley, during the 100-year publication history of Immunology & Cell Biology. It highlights the growth and consolidation of the journal during this period, as well as notable works published in the journal.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
