Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 288, Issue -, Pages 34-39Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2015.08.013
Keywords
MicroRNA19b; Myasthenia gravis; Thymoma; Th17 cell; TSLP
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Funding
- military medical science youth funding [13QNP086]
- 309 Hospital [2013ZD-001]
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Myasthenia gravis (MG) is an organ-specific autoimmune disease. The imbalance of T helper type 17 cells (Th17) plays a key role in the pathogenesis of thymomatous MG. But the regulatory mechanism for Th17 cell development in MG-related thymoma remains undefined. Here we demonstrated that thymic stromal lymphopoietin (TSLP) is significantly decreased in thymomas. We also proved that TSLP was post-trancriptionally regulated by microRNA-19b. The expression of microRNA-19b was negatively correlated with the expression of TSLP mRNA and protein in thymomas. This study indicated that the elevation of microRNA-19b suppressed TSLP expression and then influenced T cell development in thymomatous MG. (C) 2015 Elsevier B.V. All rights reserved.
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