The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids

Exploiting Cannabinoid-Induced Cytotoxic Autophagy to Drive Melanoma Cell Death

(2015) Jane L. Armstrong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: Novel anti-tumor mechanisms of Cannabidiol in breast cancer

(2015) Mohamad Elbaz et al.   Molecular Oncology

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma

(2015) E Singer et al.   Cell Death & Disease

Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer

(2014) Ryuichi Murase et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Combination of Cannabidiol and  9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

(2014) K. A. Scott et al.   MOLECULAR CANCER THERAPEUTICS

Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1Areceptors without diminishing nervous system function or chemotherapy efficacy

(2013) Sara Jane Ward et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma

(2013) M. Yoshikawa et al.   CANCER RESEARCH

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death

(2013) N Rimmerman et al.   Cell Death & Disease

Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells

(2013) I Dando et al.   Cell Death & Disease

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Cannabidiol as potential anticancer drug

(2012) Paola Massi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cannabidiol inhibits angiogenesis by multiple mechanisms

(2012) M Solinas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Non-THC cannabinoids inhibit prostate carcinoma growthin vitroandin vivo: pro-apoptotic effects and underlying mechanisms

(2012) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target

(2012) L. Soroceanu et al.   CANCER RESEARCH

Redox implications of AMPK-mediated signal transduction beyond energetic clues

(2012) S. Cardaci et al.   JOURNAL OF CELL SCIENCE

COX-2 and PPAR-  Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells

(2012) R. Ramer et al.   MOLECULAR CANCER THERAPEUTICS

The endocannabinoid system and cancer: therapeutic implication

(2011) Josée Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibitor of Differentiation-1 as a Novel Prognostic Factor in NSCLC Patients with Adenocarcinoma Histology and Its Potential Contribution to Therapy Resistance

(2011) M. Ponz-Sarvise et al.   CLINICAL CANCER RESEARCH

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1

(2011) Robert Ramer et al.   FASEB JOURNAL

A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma

(2011) S. Torres et al.   MOLECULAR CANCER THERAPEUTICS

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy

(2011) A. Shrivastava et al.   MOLECULAR CANCER THERAPEUTICS

Crosstalk between Chemokine Receptor CXCR4 and Cannabinoid Receptor CB2 in Modulating Breast Cancer Growth and Invasion

(2011) Mohd W. Nasser et al.   PLoS One

Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism

(2011) M Donadelli et al.   Cell Death & Disease

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

(2010) Sean D. McAllister et al.   BREAST CANCER RESEARCH AND TREATMENT

Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis

(2010) A. Preet et al.   Cancer Prevention Research

Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes

(2010) Susana Mato et al.   GLIA

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

(2010) María M Caffarel et al.   Molecular Cancer

Cannabidiol Enhances the Inhibitory Effects of  9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival

(2010) J. P. Marcu et al.   MOLECULAR CANCER THERAPEUTICS

Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells

(2010) Robert Ramer et al.   PHARMACEUTICAL RESEARCH

Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

(2009) Georg T. Wondrak   ANTIOXIDANTS & REDOX SIGNALING

Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1

(2009) Robert Ramer et al.   BIOCHEMICAL PHARMACOLOGY

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels

(2009) D. Ryan et al.   JOURNAL OF NEUROSCIENCE

Antitumorigenic Effects of Cannabinoids beyond Apoptosis

(2009) N. Freimuth et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer

(2009) Z. Qamri et al.   MOLECULAR CANCER THERAPEUTICS

Cannabinoids for Cancer Treatment: Progress and Promise

(2008) S. Sarfaraz et al.   CANCER RESEARCH

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

(2008) A. Swarbrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

(2008) Antonio Waldo Zuardi   REVISTA BRASILEIRA DE PSIQUIATRIA

The endocannabinoid system in cancer—Potential therapeutic target?

(2008) Jenny Flygare et al.   SEMINARS IN CANCER BIOLOGY

The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids

(2007) M L Holland et al.   BRITISH JOURNAL OF PHARMACOLOGY

5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid

(2007) P. Massi et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1

(2007) Robert Ramer et al.   JNCI-Journal of the National Cancer Institute