Review
Cell Biology
Bhupesh Singla, Ravi Varma Aithabathula, Sonia Kiran, Shweta Kapil, Santosh Kumar, Udai P. Singh
Summary: The lymphatic system plays a crucial role in immune surveillance and tissue homeostasis, and lymphangiogenesis, the formation of new lymphatic vessels, is involved in various physiological and pathological processes. Recent research progress in the molecular mechanisms of lymphangiogenesis has opened up new possibilities for therapeutic approaches in diseases such as neurological disorders, cardiac repair, autoimmune disease, obesity, and atherosclerosis.
Article
Biochemistry & Molecular Biology
Panagiotis F. Christopoulos, Mantas Grigalavicius, Alexandre Corthay, Kristian Berg, Theodossis A. Theodossiou
Summary: Excessive secretion of nitric oxide interferes with oxygen consumption measurements in macrophages, impacting accurate metabolic characterization. Inhibition of nitric oxide production partially restores respiration in activated macrophages, highlighting the importance of controlling reactive nitrogen species in cellular metabolic studies.
Article
Biochemistry & Molecular Biology
Volodymyr Lushchak, Oleh Lushchak
Summary: In living organisms, most oxygen is reduced to water through four-electron reduction, but a small percentage is reduced through one-electron mechanisms to produce reactive oxygen and nitrogen species. These species interact with various components of living organisms, leading to diverse effects on biological systems.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Keisuke Nakagawa, Mayuko Itoya, Nao Takemoto, Yuika Matsuura, Masashi Tawa, Yasuo Matsumura, Mamoru Ohkita
Summary: This study showed that IS increases O-2(-) production in vascular tissues, attenuating ACh- and SNP-induced vasorelaxation via potential NO inactivation. Additionally, IS-promoted O-2(-) production in the presence of vascular endothelium is likely through binding to AhR and activation of NADPH oxidase.
Article
Physiology
Yan Pan, Shuo Sun, Xingxing Wang, Aidong Chen, Xuejie Fei, Wei Wang, Ying Han
Summary: Silencing salusin-beta in SHR rats was shown to improve endothelium-dependent relaxation and vascular remodeling, reduce arterial blood pressure and vasoconstriction, possibly by increasing eNOS activity and NO release.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Plant Sciences
Michal Majewski, Mercedes Klett-Mingo, Carlos M. Verdasco-Martin, Cristina Otero, Mercedes Ferrer
Summary: The study investigated the effect of Spirulina aqueous extract on the vascular function of aged rats, finding that it improved vasomotor responses by increasing NO release, decreasing superoxide production, and enhancing sensitivity to vasodilators. This suggests that Spirulina may be beneficial in protecting against vascular dysfunction.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Orthopedics
Aisha Momin, Simona Perrotti, Stephen D. Waldman
Summary: Chondrocytes are able to sense and respond to external mechanical stimuli. Mechanical stimulation leads to mitochondrial deformation and release of ROS. The study found that mechanical stimulation promotes matrix synthesis in chondrocytes, and this effect is mediated by the activation of the p38 and JNK MAPKs through ROS signaling.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Chemistry, Analytical
Wanchao Yu, Lixia Zhao
Summary: ROS, as important oxidizing species in ecosystems, play various roles and monitoring their concentration is crucial for the environment. The chemiluminescence method has attracted attention for ROS detection due to its high sensitivity and simplicity, showing advances in recent years.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Hui Chen, Yongxiang Qin, Jiawei Pu, Jinxing Hu, Yuezhong Wen
Summary: This study investigated the toxicity of the chiral synthetic auxin herbicide DCPP to Arabidopsis, as well as the mutual regulation of NO, H2O2, O-2, and phytohormones at the enantiomeric level. The results revealed the important role of ROS in the enantioselective effect of DCPP and the potential redistribution of phytohormones between leaves and roots.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Critical Care Medicine
Eric H. Mace, Melissa J. Kimlinger, Tom J. No, Sergey Dikalov, Cassandra Hennessy, Matthew S. Shotwell, Frederic T. Billings, Marcos G. Lopez
Summary: Hyperoxia impairs endothelium-dependent and endothelium-independent vasodilation, but has no effect on the response to heme-independent soluble guanylyl cyclase activation. It increases vascular superoxide production.
Review
Cell Biology
Francesca Fagiani, Marieva Vlachou, Daniele Di Marino, Ilaria Canobbio, Alice Romagnoli, Marco Racchi, Stefano Govoni, Cristina Lanni
Summary: Pin1 functions as a key regulator of vascular homeostasis by modulating nitric oxide bioavailability and influencing various pathways involved in vascular diseases. Understanding the role of Pin1 in vascular endothelium could provide new insights for potential therapeutic strategies in vascular pathologies and neurodegenerative diseases.
Article
Multidisciplinary Sciences
Shaimaa M. M. Saleh, A. Bakr Mahmoud, M. Bassam Al-Salahy, Fatma Ahmed Mohamed Moustafa
Summary: This study aimed to determine the effect of gallic acid (GA) on ameliorating bisphenol A (BPA) nephrotoxicity in male rat kidneys. The results revealed morphological, immunohistochemical, and biochemical alterations in the kidney. Most of these changes showed a satisfactory improvement of kidney damage when BPA-administered rats were treated with GA at both doses.
SCIENTIFIC REPORTS
(2023)
Article
Peripheral Vascular Disease
Kristen J. Bubb, Owen Tang, Carmine Gentile, Seyed M. Moosavi, Thomas Hansen, Chia-Chi Liu, Belinda A. Di Bartolo, Gemma A. Figtree
Summary: FXYD1 plays a crucial role in protecting eNOS from oxidative stress and contributes to cardiovascular health; FXYD1 regulates oxidative dysregulation within caveolae where it is colocalized; In addition to impacting eNOS function, FXYD1 is closely associated with hypertension and diabetic vascular oxidative stress.
Article
Biochemistry & Molecular Biology
Albino Carrizzo, Concetta Iside, Angela Nebbioso, Vincenzo Carafa, Antonio Damato, Sebastiano Sciarretta, Giacomo Frati, Flavio Di Nonno, Valentina Valenti, Michele Ciccarelli, Eleonora Venturini, Mariarosaria Scioli, Paola Di Pietro, Tommaso Bucci, Valentina Giudice, Marianna Storto, Bianca Serio, Annibale Alessandro Puca, Giuseppe Giugliano, Valentina Trimarco, Raffaele Izzo, Bruno Trimarco, Carmine Selleri, Lucia Altucci, Carmine Vecchione
Summary: In addition to well-known risk factors, cardiovascular events may also be associated with epigenetic and genetic alterations. This study found that the MTHFR C677T gene variant is related to increased cardiovascular risk. Interestingly, even with normal homocysteine levels, heterozygous carriers of this gene variant have an augmented risk of cardiovascular accidents, suggesting the presence of additional deregulated processes. The study suggests that targeting SIRT1 activation could be a new therapeutic strategy to control cardiovascular risk in MTHFR carriers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yuxuan Ma, Zhangwei Lu, Bin Jia, Ye Shi, Jun Dong, Shuoxing Jiang, Zhe Li
Summary: This study introduces a targeted treatment for rheumatoid arthritis (RA) using folic acid-modified triangular DNA origami nanostructures (FA-tDONs). The FA-tDONs can efficiently scavenge reactive oxygen species (ROS) and nitric oxide (NO), leading to the transition of pro-inflammatory macrophages to an anti-inflammatory phenotype. In an RA mouse model, FA-tDONs treatment effectively alleviates synovial inflammation and cartilage damage, attenuating disease progression.
Article
Pharmacology & Pharmacy
Cristina Miralpeix, Ana Cristina Reguera, Anna Fosch, Maria Casas, Jaume Lillo, Gemma Navarro, Rafael Franco, Josefina Casas, Stephen P. H. Alexander, Nuria Casals, Rosalia Rodriguez-Rodriguez
Summary: The study found that CPT1C interacts with ABHD6 and negatively regulates its hydrolase activity, thereby regulating 2-AG downstream signalling. Brain tissues of CPT1C-KO mice showed increased ABHD6 activity. CPT1C malonyl-CoA sensing was key to the regulatory role on ABHD6 activity and CB1 receptor signalling.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rut Fado, Rosalia Rodriguez-Rodriguez, Nuria Casals
Summary: Malonyl-CoA plays a crucial role in regulating various functions in the brain, influencing food intake, energy balance, cognition, and brain development. Recent studies have shown that CPT1 proteins sense and regulate malonyl-CoA, impacting neuronal functions and revealing the effects of nutrients and metabolic disorders on cognition.
PROGRESS IN LIPID RESEARCH
(2021)
Article
Acoustics
Amparo Ferrer-Vilanova, Yasmine Alonso, Jiri Dietvorst, Marta Perez-Montero, Rosalia Rodriguez-Rodriguez, Kristina Ivanova, Tzanko Tzanov, Nuria Vigues, Jordi Mas, Gonzalo Guirado, Xavier Munoz-Berbel
Summary: This technology utilizes sonochemical coating to create robust blue-colored textiles with bacterial sensing capability, enabling on-site detection of live bacteria. The textiles are sensitive to both Gram-positive and Gram-negative bacteria, recover their original blue color through oxidation-reduction reactions, and can be applied to various materials for controlling and preventing microbial infections in hospitals, industries, schools, and homes.
ULTRASONICS SONOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Anna Fosch, Sebastian Zagmutt, Nuria Casals, Rosalia Rodriguez-Rodriguez
Summary: SF1 neurons in the ventromedial hypothalamus play a crucial role in sensing glucose levels and mediating insulin and leptin signaling, as well as in energy expenditure and glucose homeostasis, particularly in the early stages of obesity. While studies have provided insight into the central role of these neurons in whole-body energy homeostasis, they have also raised new questions regarding the existence of neuronal sub-populations and the complexity of neurocircuitry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Cristina Miralpeix, Ana Cristina Reguera, Anna Fosch, Sebastian Zagmutt, Nuria Casals, Daniela Cota, Rosalia Rodriguez-Rodriguez
Summary: The hypothalamus plays a crucial role in the pathogenesis of obesity, with disrupted endocannabinoid system considered a landmark indicator. Recent research has expanded knowledge of the complex endocannabinoid system, focusing on CB receptors, ligands, non-CB receptors, and metabolizing enzymes, particularly in the hypothalamus. The insights gained have provided promising targets for tackling obesity and related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Rosalia Rodriguez-Rodriguez, Cristina Miralpeix
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Rosalia Rodriguez-Rodriguez, Sabina Quader
Review
Nutrition & Dietetics
Carmen M. Claro-Cala, Francesc Jimenez-Altayo, Sebastian Zagmutt, Rosalia Rodriguez-Rodriguez
Summary: Dietary components, specifically olive oil triterpenes, have potential protective effects against obesity and related metabolic and cardiovascular disorders. This review focuses on understanding the molecular mechanisms and targets of these triterpenic compounds in improving glucose and insulin homeostasis, lipid metabolism, adiposity, and cardiovascular dysfunction in obesity. The study highlights the potential of olive oil as a dietary component for long-term management of obesity and metabolic syndrome in humans.
Article
Biochemistry & Molecular Biology
Jose Fernando Rinaldi de Alvarenga, Mar Garcia-Aloy, Marynka Ulaszewska, Sebastian Zagmutt, Marta Perez-Montero, Urska Vrhovsek, Rosa M. Lamuela-Raventos, Rosalia Rodriguez-Rodriguez
Summary: This study investigates the impact of sofrito, a tomato and olive oil-based sauce, on energy metabolism in obese rats. The results show that sofrito intake promotes lipid oxidation, ketogenesis activation, and alters the lipidomic profile in fat depots. These findings provide further evidence for the beneficial effects of sofrito and components of the Mediterranean diet against obesity.
Article
Biochemistry & Molecular Biology
Anna Fosch, Maria Rodriguez-Garcia, Cristina Miralpeix, Sebastian Zagmutt, Maite Larranaga, Ana Cristina Reguera, Jesus Garcia-Chica, Laura Herrero, Dolors Serra, Nuria Casals, Rosalia Rodriguez-Rodriguez
Summary: Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance and disruption leads to obesity. The effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and underlying mechanisms were investigated. Unsaturated LCFA increased BAT thermogenesis through CPT1C-mediated FA metabolism shift, while saturated LCFA did not. These findings provide new insight into neuronal circuitries activated by LCFA to drive thermogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Rosalia Rodriguez-Rodriguez, Anna Fosch, Jesus Garcia-Chica, Sebastian Zagmutt, Nuria Casals
Summary: Tackling obesity requires uncovering new molecular pathways. The brain, especially the hypothalamus, plays a major role in regulating metabolic signals that control feeding behavior and energy expenditure. Hypothalamic lipid metabolism, particularly the CPT1 isoforms, are potential targets for obesity treatment.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Review
Cell Biology
Rut Fado, Sebastian Zagmutt, Laura Herrero, Helena Muley, Rosalia Rodriguez-Rodriguez, Huichang Bi, Dolors Serra, Nuria Casals
Summary: There is a need for reliable genetic biomarkers in the diagnosis, prognosis, and treatment of different tumor types. One potential biomarker is CPT1C, a neuronal protein involved in cancer cell adaptation to nutrient depletion and hypoxia. However, its molecular role in cancer cells is controversial. This review discusses the evidence on CPT1C in neurons and its potential role in lipid metabolism and cell adaptation to stressors in cancer cells.
CELL DEATH & DISEASE
(2023)
Editorial Material
Physiology
Julien V. Brugniaux, Rosalia Rodriguez-Rodriguez, Ali Dabiri, Kivilcim Kilic, Calum Wilson, Alexey Goltsov, Antonio Colantuoni
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Materials Science, Biomaterials
Jesus Garcia-Chica, West Kristian Dizon Paraiso, Sebastian Zagmutt, Anna Fosch, Ana Cristina Reguera, Sara Alzina, Laura Sanchez-Garcia, Shigeto Fukushima, Kazuko Toh, Nuria Casals, Dolors Serra, Laura Herrero, Jordi Garcia, Kazunori Kataoka, Xavier Ariza, Sabina Quader, Rosalia Rodriguez-Rodriguez
Summary: Targeting brain lipid metabolism is a promising strategy for regulating energy balance and combating metabolic diseases. However, it is difficult to selectively deliver drugs to the hypothalamus, which plays a crucial role in controlling metabolism. This study proposes the use of a nanomedicine that can effectively deliver a CPT1A inhibitor to the hypothalamus, leading to the modulation of food intake and peripheral metabolism in mice.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
West Kristian D. Paraiso, Jesus Garcia-Chica, Xavier Ariza, Sebastian Zagmutt, Shigeto Fukushima, Jordi Garcia, Yuki Mochida, Dolors Serra, Laura Herrero, Hiroaki Kinoh, Nuria Casals, Kazunori Kataoka, Rosalia Rodriguez-Rodriguez, Sabina Quader
Summary: The study demonstrates the use of PIC micelles as a promising delivery platform for specific CPT1A inhibitors in glioma cells and neurons, resulting in a significant reduction in ATP synthesis and subsequent inhibition of fatty acid oxidation, with a lowered IC50 after long-term incubation.
BIOMATERIALS SCIENCE
(2021)