Review
Obstetrics & Gynecology
Marina Ilicic, Tamas Zakar, Amy Gregson, Waleed M. Hussein, Roger Smith, Jonathan W. Paul
Summary: The article summarizes the crucial role of myometrial phenotypic transformation during pregnancy to facilitate childbirth, and the involvement of protein acetylation in this process. Studies show that histone deacetylase inhibitors have significant relaxation effects on pregnant human myometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Agronomy
Sasipriya Sasikumar, Banur Marulasiddappa Dushyanthakumar, Shankarappa Sridhara, Nagarajappa Adivappar, Harish Babu Bheemanapalli Nagraja, Ahmed M. El-Shehawi, Salman Aloufi, Mohammed Alqurashi, Hosam O. Elansary, Khalid M. Elhindi, Eman A. Mahmoud
Summary: This study investigated the effects of Trichostatin A (TSA) on the morphological variations in okra. The results showed that TSA treatment had a negative impact on the growth and development of okra, including inhibited seedling emergence, malformed plants, abnormal flower development, and pollen sterility. However, under specific doses and incubation periods, TSA treatment can induce epigenetic variations in okra without significantly compromising its growth and vigor parameters.
Article
Agriculture, Multidisciplinary
Sharmin Hossain, Zhenhua Liu, Richard J. Wood
Summary: The study found that colon cancer cells respond differently to dietary components under different conditions. The effects of vitamin D and SFN on gene expression in colorectal cancer are selective and gene-specific.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Cell Biology
Kenny Man, Mathieu Y. Brunet, Maria Fernandez-Rhodes, Soraya Williams, Liam M. Heaney, Lee A. Gethings, Angelica Federici, Owen G. Davies, David Hoey, Sophie C. Cox
Summary: EVs, as acellular tools, show promise in tissue engineering by overcoming limitations of cell-based therapies. This study demonstrates that altering osteoblasts' epigenome with the HDAC inhibitor TSA enhances their osteogenic capacity and the therapeutic efficacy of EVs, promoting bone regeneration. The findings suggest a novel approach of harnessing epigenetic regulation to improve EVs' potency in bone repair.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Biochemistry & Molecular Biology
Yanjie Kong, Wenlong Ren, Huan Fang, Naseer Ali Shah, Yujie Shi, Dingyun You, Chengang Zhou, Dewei Jiang, Chuanyu Yang, Huichun Liang, Wenjin Liu, Luzhen Wang, Wenqiang Gan, Xing Wan, Fubing Li, Zhen Li, Ceshi Chen, Ni Xie
Summary: This study reveals a novel mechanism by which histone deacetylase inhibitors suppress basal-like breast cancer (BLBC) by promoting proteasomal degradation of KLF5 protein through ubiquitination. The acetylation of KLF5 at lysine 369 decreases its binding with deubiquitinase BAP1, leading to decreased BLBC cell viability and proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Danhui Liu, Yuzhen Liu, Bo Qi, Chengwei Gu, Shuhua Huo, Baosheng Zhao
Summary: Recent studies have shown that HDAC inhibitors promote cancer cell migration. However, inhibition of Slug or PAI-1 can reduce HDAC inhibitor-induced cancer cell migration. In addition, blocking ERK1/2 activation can also inhibit HDAC inhibitor-induced cancer cell migration.
Article
Multidisciplinary Sciences
Sean M. Callahan, Trevor J. Hancock, Ryan S. Doster, Caroline B. Parker, Mary E. Wakim, Jennifer A. Gaddy, Jeremiah G. Johnson
Summary: Histone modifications are involved in many processes in eukaryotes, including inflammation. Some bacterial pathogens use sirtuins to alter host histones and induce responses that promote infection. In this study, a Campylobacter jejuni deacetylase with sirtuin activities was found to contribute to activation of human neutrophils. This bacterial sirtuin is secreted into neutrophils, deacetylates host histones, and promotes neutrophil activation and extracellular trap production. The study also showed that this bacterial sirtuin is responsible for the inflammation and pathology observed during campylobacteriosis.
Article
Obstetrics & Gynecology
Marina Paul, Anna Paredes Barreda, Amy Gregson, Richard Kahl, Madeline King, Waleed M. Hussein, Frederick R. Walker, Roger Smith, Tamas Zakar, Jonathan W. Paul
Summary: In this study, the effects of various treatments on AKR1C1 expression in pregnant human myometrium were determined. It was found that culture-induced upregulation of AKR1C1 expression was repressed by histone/protein deacetylase inhibitors, suggesting the importance of histone deacetylase in maintaining progesterone sensitivity in the uterus.
REPRODUCTIVE SCIENCES
(2023)
Review
Cell Biology
Christian Humpel
Summary: Neurodegenerative brain disorders, such as Alzheimer's disease, pose a significant burden on society. Delivery of an amyloid-beta degrading enzyme, neprilysin, through the intranasal pathway has been found to eliminate amyloid-beta plaques in transgenic Alzheimer's disease mice. This method shows promise as an alternative approach for treating Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2022)
Article
Geriatrics & Gerontology
Christian Humpel
Summary: The study aimed to investigate if intranasal delivery of neprilysin can eliminate plaques in a transgenic AD mouse model, and found that collagen and platelets are potential vehicles for delivering neprilysin into the brain.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Cell Biology
Ienglam Lei, Wei Huang, Pierre Emmanuel Noly, Suyash Naik, Miriyam Ghali, Liu Liu, Francis D. Pagani, Ashraf Abou El Ela, Jordan S. Pober, Bertram Pitt, Jeffrey L. Platt, Marilia Cascalho, Zhong Wang, Y. Eugene Chen, Richard M. Mortensen, Paul C. Tang
Summary: Preservation quality is crucial for successful heart transplantation, and prolonged preservation can lead to graft dysfunction. However, geographical limitations and transport time constraints limit donor heart utilization. This study demonstrates that metabolic reprogramming through up-regulation of the IRG1 gene and itaconate improves heart function after prolonged preservation.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Namdoo Kim, Hyuck Jin Lee
Summary: Redox-active metal ions, such as Cu(I/II) and Fe(II/III), play essential roles in normal brain functioning, and their dysregulation can lead to Alzheimer's disease. Regulating the levels of these metal ions is crucial for maintaining normal brain function, while understanding their involvement in the pathogenesis of AD is also important. Multiple metalloenzymes have been identified to play a significant role in the degradation of amyloid-beta in the brain, and their interactions with redox-active metal ions may affect the progression of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Tomoyuki Iwata, Eri Kaneda-Ikeda, Keita Takahashi, Katsuhiro Takeda, Takayoshi Nagahara, Mikihito Kajiya, Shinya Sasaki, Shu Ishida, Minami Yoshioka, Shinji Matsuda, Kazuhisa Ouhara, Tsuyoshi Fujita, Hidemi Kurihara, Noriyoshi Mizuno
Summary: This study aimed to investigate the regulatory mechanism of bone marrow-derived mesenchymal stem cell (BM-MSC) differentiation by humoral factors derived from human periodontal ligament (HPL) cells and human gingival fibroblasts (HGFs). The results showed that histone deacetylase (HDAC) expression and histone H3 acetylation were involved in the regulation of BM-MSC differentiation. In clinical applications, regulation of HDAC expression holds potential for effective periodontal regeneration, particularly bone regeneration.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Toxicology
Shama Bhatia, Yongran Yan, Mina Ly, Peter G. Wells
Summary: Oxoguanine glycosylase 1 (OGG1) is involved in DNA repair and epigenetic modification. This study investigates the effects of in utero ethanol exposure and postnatal treatment with a histone deacetylase inhibitor on behavior in OGG1-deficient mice. The results suggest that ethanol and the inhibitor improve memory and reverse ethanol-induced abnormalities, and the effects are dependent on sex and OGG1. The findings also indicate that the combined treatment reduces nesting material shredding in females and enhances rotarod performance in male OGG1-positive mice. These results suggest that targeting epigenetic modification may be a potential strategy for mitigating neurodevelopmental disorders.
TOXICOLOGY LETTERS
(2022)
Review
Immunology
Greg Lemke, Youtong Huang
Summary: Dense-core plaques, a defining histopathological feature of Alzheimer's disease, are constructed by microglia in the central nervous system rather than forming spontaneously. The process parallels macrophage construction of granulomas in tuberculosis and other settings.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)