Article
Allergy
Charles F. Schuler, Sofija Volertas, Dilawar Khokhar, Huseyin Yuce, Lu Chen, Onur Baser, Jenny M. Montejo, Cem Akin
Summary: Using an insurance claims database and a retrospective study at the University of Michigan, it was found that the prevalence of HVA in the US is lower than previously reported, while the prevalence of mastocytosis in patients with HVA is higher but still lower than previously reported. There was no correlation between tryptase level and reaction severity in patients undergoing VIT.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ali Selcuk, Abdullah Baysan
Summary: Mastocytosis is a rare group of disorders characterized by abnormal accumulation of mast cells, particularly in patients with systemic mastocytosis, who are at increased risk of severe anaphylaxis, often triggered by hymenoptera venom allergy. Immunotherapy is an effective and safe treatment option, but can lead to systemic side effects during up-dosing, making progression to maintenance challenging.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Matija Rijavec, Jezerka Inkret, Urska Bidovec-Stojkovic, Tanja Carli, Nina Frelih, Andreja Kukec, Peter Korosec, Mitja Kosnik
Summary: Hymenoptera venom-induced anaphylaxis is a common and potentially fatal allergic reaction, with mastocytosis being an important risk factor. Undiagnosed underlying clonal mast cell disorder (cMCD) was found in some cases of fatal anaphylaxis. Screening high-risk individuals for cMCD using molecular methods is crucial for proper management and prevention of unnecessary deaths.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Health Care Sciences & Services
Kawita Atipas, Dichapong Kanjanawasee, Pongsakorn Tantilipikorn
Summary: This review examines the use of intradermal immunotherapy (IDIT) in the treatment of allergic rhinitis, including its advantages and effects. However, the current evidence on IDIT is conflicting, and further clinical trials are needed to determine its clinical utility and optimal treatment protocols.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Allergy
Wen-Cheng Chao, Wen-Ting Liao, Jing-Rong Wang, Hsiao-Ni Sung, Hsin-Hua Chen, Fang-Ping Lin, Jou-Yu Huang, Kuan-Ting Liu, Tai-Ming Ko
Summary: Through single-cell transcriptomic profiling of HVA patients, we identified previously unknown molecular changes, providing important insights into the mechanism of venom allergy and potential therapeutic targets.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Allergy
Hyun J. Park, Daniel Brooks, Christopher S. Chavarria, Richard L. Wu, Cecilia P. Mikita, Douglas E. Beakes
Summary: This study compares the concordance between ICAP and IDST in patients with a clinical history suggestive of hymenoptera venom systemic reaction (SR). Significant discordance was found between the two tests, suggesting that they are complementary. ICAP testing first followed by IDST for ICAP-negative venoms is proposed as an alternative and efficient diagnostic strategy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Dermatology
Alexandra Moore, Amanda K. Burrows, Wayne S. Rosenkrantz, Rudayna M. Ghubash, Giselle Hosgood
Summary: This study aimed to evaluate the safety of modified rush Venom Immunotherapy (VIT) in dogs. The results showed that most dogs did not experience adverse reactions after receiving rush VIT, indicating that modified rush VIT is a viable treatment option for dogs with Hymenoptera hypersensitivity.
VETERINARY DERMATOLOGY
(2023)
Article
Immunology
Ewa Czerwinska, Marita Nittner-Marszalska, Robert Pawlowicz, Leszek Szenborn
Summary: Simultaneous administration of allergen immunotherapy and seasonal influenza vaccines is safe and well-tolerated, with no increase in adverse reactions. This procedure is feasible in patients with a history of systemic allergic reactions after Hymenoptera stings, and does not lead to an increase in adverse reactions.
Article
Agriculture, Dairy & Animal Science
Ana Rostaher, Nina Maria Fischer, Alessio Vigani, Barbara Steblaj, Franco Martini, Salina Brem, Claude Favrot, Mitja Kosnik
Summary: This study aimed to demonstrate that venom immunotherapy (VIT) is not only safe, but also effective in treating dogs allergic to bee or wasp stings. Out of the 10 dogs treated with VIT, all of them tolerated the therapy and were able to tolerate subsequent stings.
Review
Allergy
Patrizia Bonadonna, Peter Korosec, Francesca Nalin, David B. K. Golden
Summary: Diagnostic testing for insect venom allergy requires a detailed initial history to assess severity and predict future reactions. Venom skin tests and specific IgE measurement confirm the diagnosis but have limited predictive value. Testing for serum IgE to recombinant venom component allergens can distinguish true allergy from cross reactivity. Basophil activation tests and elevated tryptase levels are useful for detecting and predicting the severity of venom allergy. Bone marrow biopsy is the definitive tool for characterizing mast cell disorders in patients with insect sting allergy. (From J Allergy Clin Immunol Pract 2023;11:2024-31)
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Food Science & Technology
Johannes Grosch, Antoine Lesur, Stephanie Kler, Francois Bernardin, Gunnar Dittmar, Elisabetta Francescato, Simon J. Hewings, Constanze A. Jakwerth, Ulrich M. Zissler, Matthew D. Heath, Markus Ollert, Matthias F. Kramer, Christiane Hilger, Maria Beatrice Bilo, Carsten B. Schmidt-Weber, Simon Blank
Summary: Allergy to Polistes dominula venom is a significant issue in Southern Europe and may become a threat in other regions. Venom immunotherapy (VIT) is an effective treatment for this allergy. This study compared five different VIT preparations for P. dominula venom allergy in Spain and found that the majority of samples contained comparable levels of major allergens.
Article
Food Science & Technology
Ana Navas, Berta Ruiz-Leon, Pilar Serrano, Manuel Marti, M. Luisa Espinazo, Nadine Blanco, Juan Molina, Corona Alonso, Aurora Jurado, Carmen Moreno-Aguilar
Summary: Bee venom immunotherapy (BVIT) is widely used to treat severe bee sting allergy. The study found that BVIT induced both tolerogenic and allergenic responses in patients, and identified potential biomarkers for treatment efficacy.
Article
Allergy
Qing Wang, Nora L. Watson, Douglas E. Beakes, David J. Schwartz
Summary: This study compares the standard and accelerated venom skin test protocols for Hymenoptera venom allergy. The results show that the accelerated method is safer and does not result in adverse reactions. This study provides evidence for using an accelerated approach to reduce testing time and costs.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Jesper Jarkvist, Theo Gulen
Summary: This study investigates the prevalence and clinical features of hypersensitivity reactions to antibiotics in mastocytosis patients. The results suggest a similar prevalence of antibiotic hypersensitivity in these patients compared to the general population, and antibiotics appear to rarely cause anaphylaxis in this population. Therefore, mastocytosis patients without a history of antibiotic hypersensitivity may be safely treated with these drugs.
Review
Allergy
Josefine Gradman, Susanne Halken
Summary: Allergen immunotherapy (AIT) is a disease-modifying treatment that may prevent the progression of allergic rhinitis to asthma in children. It has the potential to delay disease progression and have a preventive effect, especially in children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Nutrition & Dietetics
Alfredo Cordova, Franchek Drobnic, David Noriega-Gonzalez, Alberto Caballero-Garcia, Enrique Roche, Melchor Alvarez-Mon
Summary: Physical activity and sports increase the risk of tendinopathies due to the stress and force generated in the tendon and muscle-tendon unit. Curcumin, a supplement, has been found to have significant anti-pain, anti-inflammatory, and antioxidant effects, and can promote the inflammatory and regenerative response in tendinopathies. Additionally, curcumin can reduce cell infiltration, activation, and production of pro-inflammatory mediators at the site of inflammation.
Article
Pharmacology & Pharmacy
Maria Munoz-Garcia, Hilario Martinez-Barros, Silvia Sanchez-Cuellar, Ana Morales-Tirado, Ana De-Andres-Martin, Gonzalo De-Los-Santos-Granados, Dario Antolin-Amerigo, Enrique Blitz-Castro, Patricia Fernandez-Martin, Alfonso Santamaria-Gadea, Belen De-La-Hoz-Caballer, Ana Maria Alvarez-Diaz, David Gonzalez-De-Olano
Summary: Severe asthma has a significant impact on both patients and healthcare resources. The ASfarMA project aims to understand patients' perspectives and improve the care for severe asthma by defining an ideal Severe Asthma Unit and proposing transformative solutions. The successful implementation of these solutions would optimize patient care, resources, and can be applicable to other similar units or projects involving complex chronic diseases.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Article
Neurosciences
M. A. Alvarez-Mon, Cielo Garcia-Montero, Oscar Fraile-Martinez, Javier Quintero, Sonia Fernandez-Rojo, Fernando Mora, Luis Gutierrez-Rojas, Rosa M. Molina-Ruiz, Guillermo Lahera, Melchor Alvarez-Mon, Miguel A. Ortega
Summary: Research has shown that serotonin and norepinephrine reuptake inhibitors (SNRIs) can have more effective and faster antidepressant effects than other common medications, such as serotonin selective reuptake inhibitors (SSRIs), for major depressive disorder (MDD). The SNRI duloxetine has been found to be favorable in clinical practice for treating MDD, anxiety, and fibromyalgia. Through an online survey, psychiatrists' knowledge and experience, as well as patients' preferences, symptoms, and well-being, were collected and compared with scientific literature, leading to the conclusion that duloxetine is widely accepted due to its tolerability, effectiveness, and versatility in various situations.
Article
Health Care Sciences & Services
Sergio Haro Giron, Jorge Monserrat Sanz, Miguel A. Ortega, Cielo Garcia-Montero, Oscar Fraile-Martinez, Ana M. Gomez-Lahoz, Diego Liviu Boaru, Diego de Leon-Oliva, Luis G. Guijarro, Mar Atienza-Perez, David Diaz, Elisa Lopez-Dolado, Melchor Alvarez-Mon
Summary: The plasma concentration of malondialdehyde (MDA) can be considered as an oxidative stress biomarker to assess the prognosis of chronic spinal cord injury (SCI).
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Isabel Alfonso-Fuertes, Miguel Angel Alvarez-Mon, Rafael Sanchez del Hoyo, Miguel A. Ortega, Melchor Alvarez-Mon, Rosa M. Molina-Ruiz
Summary: This study aims to analyze the relationships between the use of Instagram, both the hours of daily use and the type of content viewed, and self-esteem, tendency to make physical comparisons, and satisfaction with body image. The study found that participants who spent more time on Instagram had higher levels of body dissatisfaction, greater comparisons of physical appearance, and lower self-esteem. There were no significant differences between the types of content viewed.
JMIR FORMATIVE RESEARCH
(2023)
Article
Health Care Sciences & Services
Julia Corominas, Carme Garriga, Antoni Prenafeta, Alexandra Moros, Manuel Canete, Antonio Barreiro, Luis Gonzalez-Gonzalez, Laia Madrenas, Irina Guell, Bonaventura Clotet, Nuria Izquierdo-Useros, Dalia Raich-Regue, Marcal Gallemi, Julia Blanco, Edwards Pradenas, Benjamin Trinite, Julia G. Prado, Oscar Blanch-Lombarte, Raul Perez-Caballero, Montserrat Plana, Ignasi Esteban, Carmen Pastor-Quinones, Xavier Nunez-Costa, Rachel Abu Taleb, Paula McSkimming, Alex Soriano, Jocelyn Nava, Jesse Omar Anagua, Rafel Ramos, Ruth Marti Lluch, Aida Corpes Comes, Susana Otero Romero, Xavier Martinez Gomez, Carla Sans-Pola, Jose Molto, Susana Benet, Lucia Bailon, Jose R. Arribas, Alberto M. Borobia, Javier Queiruga Parada, Jorge Navarro-Perez, Maria Jose Forner Giner, Rafael Orti Lucas, Maria del Mar Vazquez Jimenez, Salvador Ona Compan, Melchor Alvarez-Mon, Daniel Troncoso, Eunate Arana-Arri, Susana Meijide, Natale Imaz-Ayo, Patricia Munoz Garcia, Sofia de la Villa Martinez, Sara Rodriguez Fernandez, Teresa Prat, Elia Torroella, Laura Ferrer
Summary: In the interim results of the Phase IIb HH-2 trial, the SARS-CoV-2 protein-based heterodimer vaccine PHH-1V is shown to have a stronger immunogenicity and higher safety compared to the homologous booster BNT162b2. The PHH-1V booster induces a superior neutralizing antibody response against various SARS-CoV-2 variants and also elicits a strong T-cell response.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Biochemistry & Molecular Biology
Miguel A. Ortega, Cielo Garcia-Montero, Oscar Fraile-Martinez, Diego De Leon-Oliva, Diego Liviu Boaru, Coral Bravo, Juan A. De Leon-Luis, Miguel A. Saez, Angel Asunsolo, Ignacio Romero-Gerechter, Alejandro Sanz-Giancola, Raul Diaz-Pedrero, Laura Lopez-Gonzalez, Luis G. Guijarro, Silvestra Barrena-Blazquez, Julia Bujan, Natalio Garcia-Honduvilla, Melchor Alvarez-Mon, Miguel Angel Alvarez-Mon, Guillermo Lahera
Summary: Psychosis is a mental health condition characterized by a loss of touch with reality. A first-episode psychosis during pregnancy can have adverse effects on both the mother and newborn. This study aimed to analyze the gene and protein expression of oxytocin (OXT), oxytocin receptor (OXTR), vasopressin (AVP), and vasopressin receptor 1a (AVPR1a) in the placental tissue of pregnant women after a first-episode psychosis. The results showed increased gene and protein expression of OXT, AVP, OXTR, and AVPR1A in the placental tissue of these women. This suggests that an abnormal paracrine/endocrine activity of the placenta may be associated with a first-episode psychosis during pregnancy, negatively impacting the well-being of both the mother and fetus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sylwia Smolinska, Dario Antolin-Amerigo, Florin-Dan Popescu, Marek Jutel
Summary: TSLP is a critical cytokine in allergy and asthma development, primarily produced by epithelial cells. It functions as a potent immune system activator through interaction with its receptor complex. Understanding the interplay between TSLP and dysfunctional epithelium provides insights into allergy and asthma pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Maria Lozano-Espinosa, Dario Antolin-Amerigo, Jordi Riera, Federico Gordo Vidal, Santiago Quirce, Joaquin Alvarez Rodriguez
Summary: The treatment of choice for severe asthma exacerbations with respiratory failure includes ventilatory support and different kinds of asthma medication. Mortality rate in these patients has decreased due to advances in pharmacological treatment. In invasive cases, extracorporeal membrane oxygenation (ECMO) or extracorporeal CO2 removal (ECCO2R) may be necessary. ECMO can minimize lung injury and enable diagnostic and therapeutic maneuvers, while ECCO2R is more widely used. This article aims to review the evidence for the usefulness of extracorporeal respiratory support in severe asthma exacerbations.
RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Maria Consuelo Pintado, Inmaculada Lasa Unzue, Remedios Gomez Sanz, Manuel Diez Alonso, Miguel A. Ortega, Melchor Alvarez de Mon, Emilio Nevado Losada, Alberto Gutierrez Calvo
Summary: This study found that 77.1% of patients undergoing CRS and HIPEC developed hematological complications during the postoperative period. These complications were mostly not severe and resolved spontaneously, without an effect on patient mortality or hospital stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Luis G. Guijarro, Francisco Javier Justo Bermejo, Diego Liviu Boaru, Patricia De Castro-Martinez, Diego De Leon-Oliva, Oscar Fraile-Martinez, Cielo Garcia-Montero, Melchor Alvarez-Mon, Maria del Val Toledo-Lobo, Miguel A. Ortega
Summary: IRS4 is a protein associated with insulin and IGF1 signaling pathways, with limited research but increased expression in various cancers. It not only connects different signaling pathways, but also activates multiple oncogenes, potentially serving as a meeting point for them.
Review
Medicine, General & Internal
Miguel A. Ortega, Oscar Fraile-Martinez, Cielo Garcia-Montero, Sergio Haro, Miguel angel Alvarez-Mon, Diego De Leon-Oliva, Ana M. Gomez-Lahoz, Jorge Monserrat, Mar Atienza-Perez, David Diaz, Elisa Lopez-Dolado, Melchor Alvarez-Mon
Summary: Spinal cord injury (SCI) is a devastasting and disabling medical condition caused by traumatic event, which leads to local and systemic consequences in the body. Psychoneuroimmunoendocrinology (PNIE) is an area of research that explores the interactions between different systems of the human organism, considering mind and body as a whole. This review examines the local and systemic consequences of SCI from a PNIE perspective and presents potential clinical approaches for integrative therapies.
MILITARY MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Luis M. Garcia-Puente, Oscar Fraile-Martinez, Cielo Garcia-Montero, Julia Bujan, Juan A. De Leon-Luis, Coral Bravo, Patrocinio Rodriguez-Benitez, Pilar Pintado, Francisco Javier Ruiz-Labarta, Melchor alvarez-Mon, Natalio Garcia-Honduvilla, Maria J. Cancelo, Miguel A. Saez, Miguel A. Ortega
Summary: Pre-eclampsia is a harmful condition during pregnancy, characterized by hypertension and proteinuria. Inflammation in the placenta may play a role in its development, and this study suggests that the NLRP3 inflammasome is potentially involved in the pathophysiology of late-onset pre-eclampsia.
Article
Allergy
Sylwia Smolinska, Florin-Dan Popescu, Elena Izquierdo, Dario Antolin-Amerigo, Oliver J. Price, Alberto Alvarez-Perea, Ibon Eguiluz Gracia, Nikolaos G. Papadopoulos, Oliver Pfaar, Filippo Fassio, Karin Hoffmann-Sommergruber, Stephanie Dramburg, Ioana Agache, Marek Jutel, Helen A. Brough, Joao A. Fonseca, Elizabeth Angier, Cristina Boccabella, Matteo Bonini, Audrey Dunn Galvin, Peter G. Gibson, Radoslaw Gawlik, Farah Hannachi, Oemer Kalayci, Ludger Klimek, Rebecca Knibb, Paolo Matricardi, Tomas Chivato
Summary: This article aims to describe effective telemedicine communication between healthcare professionals and patients. The article discusses the terminology, important forms, and applications of telemedicine in asthma and allergies. It concludes that telemedicine reduces costs and time but cannot fully replace face-to-face visits. Additionally, confidentiality and information security are important from an ethical perspective.
Review
Medicine, General & Internal
Diego De Leon-Oliva, Silvestra Barrena-Blazquez, Laura Jimenez-Alvarez, Oscar Fraile-Martinez, Cielo Garcia-Montero, Laura Lopez-Gonzalez, Diego Torres-Carranza, Luis M. Garcia-Puente, Sara T. Carranza, Miguel Angel Alvarez-Mon, Melchor Alvarez-Mon, Raul Diaz, Miguel A. Ortega
Summary: The RANK-RANKL-OPG system is a crucial signaling pathway in bone metabolism, mammary epithelial cell development, immune function, and cancer. RANKL binds to RANK on osteoclasts, dendritic cells, T cells, and other cells, promoting osteoclast differentiation and activation, resulting in bone resorption. OPG acts as a decoy receptor to inhibit RANKL signaling. Increased RANKL expression in cancer cells can lead to enhanced bone resorption and bone metastases. RANKL-neutralizing antibodies, like denosumab, have shown efficacy in treating skeletal-related events and cancer.
MEDICINA-LITHUANIA
(2023)
