Review
Otorhinolaryngology
Nadim Khoueir, Michel G. Khalaf, Ralph Assily, Simon Rassi, Walid Abou Hamad
Summary: This systematic review and meta-analysis examined the effects of intranasal antihistamines (INAH) on idiopathic rhinitis (IR). The study found that INAH had a beneficial effect on improving nasal symptoms compared to placebo. No significant difference in efficacy was observed between different types of INAH. The most commonly reported adverse event was bitter taste sensation.
Article
Health Care Sciences & Services
Elena Russo, Francesco Giombi, Giovanni Paoletti, Enrico Heffler, Giorgio Walter Canonica, Francesca Pirola, Giuseppe Mercante, Giuseppe Spriano, Luca Malvezzi, Enrico Keber, Corrado SGCP, Corrado Giua
Summary: This observational study reveals that medication overuse is an increasing global problem, particularly for rhinology diseases managed with over-the-counter drugs. The study found that the two most frequent age groups purchasing topical decongestants were 18-30 years old and 60-75 years old. It was also discovered that a significant proportion of patients using sympathomimetic amines exceeded the recommended dosage and duration. This study highlights the need for greater attention to social education and surveillance in addressing the prolonged use of sympathomimetic amines in patients with rhinology diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Otorhinolaryngology
Jean Kim, Darryn W. Waugh, Benjamin F. Zaitchik, Amber Luong, Regan Bergmark, Kent Lam, Lauren Roland, Joshua Levy, Jivianne T. Lee, Do-Yeon Cho, Murugappan Ramanathan Jr, Fuad Baroody, Mas Takashima, Daniel O'Brien, Sandra Y. Lin, Stephanie Joe, Mohamad R. Chaaban, Anna Butrymowicz, Stephanie Smith, Warren Mullings
Summary: Climate change has a negative impact on our environment, leading to an increased morbidity of rhinologic diseases. A systematic approach is needed to improve healthcare infrastructure and funding, and promote diverse scientific collaboration to address these healthcare needs.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Behavioral Sciences
Ruaywan Suntiwes, Vilawan Chirdkiatgumchai, Rawiwan Roongpraiwan, Teeradej Kuptanon, Komsan Kiatrungrit, Wiparat Manuyakorn
Summary: This study found that treating chronic rhinitis can improve ADHD symptoms in children and adolescents with ADHD. The treatment was associated with decreased inattentive, hyperactive/impulsive, and total ADHD symptom scores. There was also a positive correlation between improvement in ADHD symptom scores and improvement in quality of life related to sleep problems.
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2023)
Article
Medicine, Research & Experimental
Randall A. Ow, Ellen M. O'Malley, Joseph K. Han, Kent K. Lam, David M. Yen
Summary: The study assessed the long-term safety and effectiveness of cryoablation of the posterior nasal nerve for chronic rhinitis. Significant improvements in rhinitis symptoms and quality of life were observed, with durable outcomes through 24 months post-treatment. The majority of treatment-related adverse events were transient and resolved with little to no intervention.
Article
Immunology
Ling Jin, Kai Fan, Shiwang Tan, Shangxi Liu, Qin Ge, Yang Wang, Zisheng Ai, Shaoqing Yu
Summary: This study investigated the beneficial effects of hydrogen-rich saline irrigation as an anti-inflammatory therapy for chronic rhinitis (CR). Compared to saline irrigation, hydrogen-rich saline nasal irrigation was found to significantly reduce nasal symptoms and eosinophilic protein levels, especially in patients with allergic rhinitis (AR).
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Allergy
Di Wu, Bing Yan, Yang Wang, Chengshuo Wang, Luo Zhang
Summary: This study found that cystatin SN levels in nasal secretions are strongly associated with the uncontrolled status of CRSwNP patients, with higher concentrations indicating a lower risk of uncontrolled status. Enhanced medical treatment for patients with high cystatin SN levels can delay the onset of uncontrolled status.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yara Zoabi, Francesca Levi-Schaffer, Ron Eliashar
Summary: Allergic rhinitis is a common nasal disorder affecting up to 30% of adults. Mast cells play a crucial role in allergic inflammation and are involved in the development of symptoms. This review provides a comprehensive summary of mast cells' involvement in allergic rhinitis and the modulation of mast cells by current and emerging therapies.
Article
Otorhinolaryngology
Denna Zebda, Zi Yang Jiang, Micah M. Gibson, Chauchau Pham, Sorour Ahmadi, Samuel Floren, William C. Yao, Martin J. Citardi, Amber U. Luong
Summary: This study evaluated the therapeutic action of intranasal capsaicin in managing nonallergic rhinitis symptoms and its effect on optical rhinometry readings. The results showed that intranasal capsaicin not only improved rhinitic symptoms but also objectively reduced nasal reactivity and congestion, with a 40% responder rate at 12 weeks based on optical rhinometry.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Article
Health Care Sciences & Services
Eugenio De Corso, Silvia Baroni, Stefano Settimi, Maria Elisabetta Onori, Rodolfo Francesco Mastrapasqua, Eliana Troiani, Giacomo Moretti, Donatella Lucchetti, Marco Corbo, Claudio Montuori, Alessandro Cantiani, Davide Paolo Porru, Simone Lo Verde, Giuseppe Alberto Di Bella, Cristiano Caruso, Jacopo Galli
Summary: This study evaluated the inflammatory load and cytokine profiles in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Two distinct clusters were identified based on cytokine levels and eosinophil count, with IL-5 being the most reliable biomarker for differentiation. This research highlights the potential role of type 2 biomarkers, particularly IL-5, in identifying patients with a more severe phenotype.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Georg Karl Ludwig Burghardt, Mandy Cuevas, Rumi Sekine, Thomas Hummel
Summary: This study compared nasal trigeminal sensitivity in patients with allergic rhinitis (AR), chronic rhinosinusitis with nasal polyps (CRSwNP), and healthy controls (HC). The results showed that AR patients had increased sensitivity to trigeminal stimuli, while CRSwNP patients had decreased sensitivity.
Article
Otorhinolaryngology
Yi-Tsen Lin, Chih-Feng Lin, Chun-Kang Liao, Bor-Luen Chiang, Te-Huei Yeh
Summary: Central-compartment-type chronic rhinosinusitis is associated with hyposmia or anosmia, higher levels of eosinophils in tissue and serum, and elevated levels of IL-5 and IL-13 in middle turbinate tissues. Allergen sensitization status showed no significant difference between the central-compartment type and other types of CRS patients.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Article
Otorhinolaryngology
Sarina Katrin Mueller, Olaf Wendler, Susanne Mayr, Maximilian Traxdorf, Michael Koch, Konstantinos Mantsopoulos, Matti Sievert, Philipp Grundtner, Heinrich Iro, Benjamin S. Bleier
Summary: This study analyzed the advantages and disadvantages of mucus and serum for biomarker analysis. The results showed that periostin and IgE in mucus, and periostin in serum were the most reliable biomarkers for tracking disease severity and predicting recurrences.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Medicine, Research & Experimental
Carl Philpott, Tanya Ta, Claire Hopkins, Jaydip Ray, Shazhada Ahmed, Robert Almeyda, Naveed Kara, Sean Carrie, Sally E. Erskine, Russell Cathcart, Vishnu Sunkaraneni, Alasdair Robertson, Shahram Anari, Balasubrahmanyam Nirmal Kumar, Allan Clark
Summary: The study found that patients with chronic rhinosinusitis with nasal polyps (CRSwNP) are more likely to have asthma, but less likely to experience upper respiratory tract infections (URTIs). On the other hand, patients with CRSwNP tend to have worse body pain scores. Other than that, there were no significant socioeconomic, comorbidity, lifestyle, or quality of life differences between the two phenotypes.
Article
Otorhinolaryngology
Chadi A. Makary, Jeffrey Falco, Sarah Sussman, Lindsey Ryan, Camilo Reyes, Hassan Ramadan, Stilianos E. Kountakis
Summary: This study evaluated disease presence in the central compartment (CC) in patients with eosinophilic chronic rhinosinusitis (CRS) and found that CC involvement is more significant in AERD patients. This suggests that the CC could represent a source of inflammatory load in patients with AERD.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)