Article
Allergy
Didier G. Ebo, Leander P. De Puysseleyr, Athina L. Van Gasse, Jessy Elst, Marie-Line Van der Poorten, Margaretha A. Faber, Christel Mertens, Michel Van Houdt, Margo M. Hagendorens, Luc Sermeus, Joana Vitte, Michel Moise, Lene H. Garvey, Mariana C. Castells, Charles Tacquard, Paul-Michel Mertes, Lawrence B. Schwartz, Vito Sabato
Summary: Perioperative hypersensitivity reactions pose a challenge in clinical diagnosis. The study found that a consensus formula for detection of mast cell activation in POH was effective, and a baseline tryptase level higher than 8 ng/mL was associated with anaphylaxis occurrence.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Matthew P. Giannetti, Grace Godwin, Emily Weller, Joseph H. Butterfield, Mariana Castells
Summary: Patients with hereditary alpha-tryptasemia (H alpha T) and symptoms of mast cell activation do not have elevated levels of mast cell urinary metabolites, suggesting that granule- and membrane-derived mediators may not play a role in driving symptoms in H alpha T.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Julij Selb, Matija Rijavec, Renato Erzen, Mihaela Zidarn, Peter Kopac, Matevz Skerget, Nissera Bajrovic, Ajda Demsar Luzar, Young Hwan Park, Yihui Liu, Vladka Curin Serbec, Samo Zver, Mitja Kosnik, Jonathan J. Lyons, Peter Korosec
Summary: The study found that routine screening for KIT p.D816V can identify clonal diseases in high-risk patients with HVA who are often missed when only BST levels are used for diagnosis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Fabrizio Salvucci, Roberto Codella, Adriana Coppola, Irene Zacchei, Gabriella Grassi, Maria Luisa Anti, Nicolita Nitisoara, Livio Luzi, Carmine Gazzaruso
Summary: In patients with long-COVID, treatment with histamine receptor blockers improves symptoms and leads to complete resolution in some cases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Allergy
Allyson Mateja, Qinlu Wang, Jack Chovanec, Jiwon Kim, Kenneth J. Wilson, Lawrence B. Schwartz, Sarah C. Glover, Melody C. Carter, Dean D. Metcalfe, Erica Brittain, Jonathan J. Lyons
Summary: Based on the variability of BST, an acute tryptase/BST ratio exceeding 1.685 is the optimized diagnostic rule for distinguishing baseline variability from anaphylaxis, improving specificity among individuals with H alpha T and ISM while maintaining high sensitivity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Allergy
Mark Kacar, Matija Rijavec, Julij Selb, Peter Korosec
Summary: The association between Hymenoptera venom-triggered anaphylaxis and clonal mast cell-related disorders (cMCD) has been known for decades. Recent studies have revealed a high prevalence of the KIT p.D816V missense variant in patients with severe Hymenoptera venom-triggered anaphylaxis, suggesting that the impact of cMCD on anaphylaxis may be underestimated. Moreover, the discovery of hereditary alpha-tryptasemia (H alpha T) as a genetic modifier of anaphylaxis has provided further insights into the pathogenesis of these conditions.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Immunology
Kanokvalai Kulthanan, Martin K. Church, Eva Maria Grekowitz, Tomasz Hawro, Lea Alice Kiefer, Kanyalak Munprom, Yanisorn Nanchaipruek, Chuda Rujitharanawong, Dorothea Terhorst-Molawi, Marcus Maurer
Summary: The study systematically reviewed a large number of literature and found that histamine plays a key role in the pathogenesis of chronic inducible urticaria, but it is not the sole mediator.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Allergy
Theo Gulen, Cem Akin
Summary: The systematic review aims to present proposed theories of pathogenesis for idiopathic anaphylaxis (IA), discuss its classification, diagnostic approach, and management. Recent findings show that IA represents a major diagnostic challenge and certain conditions such as mastocytosis and red meat allergy may overlap with its symptomatology. Patients with IA should always carry an epinephrine autoinjector for prompt treatment and prophylaxis.
CURRENT ALLERGY AND ASTHMA REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Clayton Webster Jackson, Cristina Marie Pratt, Chase Preston Rupprecht, Debendra Pattanaik, Guha Krishnaswamy
Summary: Mast cells are derived from hematopoietic stem cell precursors and play a crucial role in allergic responses and various disorders. Some disorders are associated with specific genetic mutations, while others may be genetic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Charles F. Schuler, Sofija Volertas, Dilawar Khokhar, Huseyin Yuce, Lu Chen, Onur Baser, Jenny M. Montejo, Cem Akin
Summary: Using an insurance claims database and a retrospective study at the University of Michigan, it was found that the prevalence of HVA in the US is lower than previously reported, while the prevalence of mastocytosis in patients with HVA is higher but still lower than previously reported. There was no correlation between tryptase level and reaction severity in patients undergoing VIT.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Hematology
Melody C. Carter, Dean D. Metcalfe
Summary: Historically, understanding of human mast cells has lagged behind other cell lineages, and there is currently no identified pharmacological agent that can completely and selectively inhibit human MC function. Mast cell diseases are categorized as intrinsic or extrinsic to the MC compartment, with mediators playing a key role in MC activation disorders.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Pathology
Matthew J. Hamilton, Melissa Zhao, Matthew P. Giannetti, Emily Weller, Raied Hufdhi, Peter Novak, Lybil B. Mendoza-Alvarez, Jason Hornick, Jonathan J. Lyons, Sarah C. Glover, Mariana C. Castells, Olga Pozdnyakova
Summary: This study found that patients with the H alpha T mutation have increased numbers of MCs in the duodenum, which may contribute to the prevalent gastrointestinal manifestations seen in individuals with this genetic trait.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Review
Allergy
A. Matito, M. M. Escribese, N. Longo, C. Mayorga, O. Luengo-Sanchez, M. Perez-Gordo, V Matheu, M. Labrador-Horrillo, M. Pascal, M. E. Seoane-Reula
Summary: The diagnosis of MCAS relies on typical clinical signs and symptoms, rapid increase in tryptase level, and response to antimediator therapy. The Spanish Network on Mastocytosis score serves as a predictive model for selecting MCAS candidates for bone marrow studies based on the probability of an underlying clonal mast cell disorder.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Anne Tranberg Madsen, Helle Pilgaard Kristiansen, Anne Winther-Larsen
Summary: Serum tryptase is a tightly regulated biomarker with very low within-subject variation, no significant day-to-day variation, and only minor semidiurnal variation, making it suitable for monitoring purposes.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Sherin Saheera, Ajay Godwin Potnuri, Ashrith Guha, Suresh S. Palaniyandi, Rajarajan A. Thandavarayan
Summary: Understanding the role of mast cells and histamine in cardiovascular diseases, particularly in cardiac hypertrophy, can lead to better disease management. Research on histamine receptors has shown improvement in cardiac function, suggesting potential for novel therapies in the future.
DRUG DISCOVERY TODAY
(2022)
Article
Critical Care Medicine
Loren C. Denlinger, Tonya S. King, Juan Carlos Cardet, Timothy Craig, Fernando Holguin, Daniel J. Jackson, Monica Kraft, Stephen P. Peters, Kristie Ross, Kaharu Sumino, Homer A. Boushey, Nizar N. Jarjour, Michael E. Wechsler, Sally E. Wenzel, Mario Castro, Pedro C. Avila
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)
Review
Allergy
Matthew P. Giannetti, Juan C. Cardet
CURRENT ALLERGY AND ASTHMA REPORTS
(2016)
Article
Critical Care Medicine
Samuel Y. Ash, Farbod N. Rahaghi, Carolyn E. Come, James C. Ross, Alysha G. Colon, Juan Carlos Cardet-Guisasola, Eleanor M. Dunican, Eugene R. Bleecker, Mario Castro, John Fahy, Sean B. Fain, Benjamin M. Gaston, Eric A. Hoffman, Nizar N. Jarjour, David T. Mauger, Sally E. Wenzel, Bruce D. Levy, Raul San Jose Estepar, Elliot Israel, George R. Washko
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Review
Biotechnology & Applied Microbiology
Shiven S. Patel, Thomas B. Casale, Juan Carlos Cardet
EXPERT OPINION ON BIOLOGICAL THERAPY
(2018)
Article
Allergy
Juan Carlos Cardet, Margee Louisias, Tonya S. King, Mario Castro, Christopher D. Codispoti, Ryan Dunn, Linda Engle, B. Louise Giles, Fernando Holguin, John J. Lima, Dayna Long, Njira Lugogo, Sharmilee Nyenhuis, Victor E. Ortega, Sima Ramratnam, Michael E. Wechsler, Elliot Israel, Wanda Phipatanakul
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
Tanya M. Laidlaw, Katherine N. Cahill, Juan Carlos Cardet, Katherine Murphy, Jing Cui, Brittney Dioneda, Parul Kothari, Benjamin A. Raby, Elliot Israel, Joshua A. Boyce
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Allergy
W. Gerald Teague, Brenda R. Phillips, John V. Fahy, Sally E. Wenzel, Anne M. Fitzpatrick, Wendy C. Moore, Annette T. Hastie, Eugene R. Bleecker, Deborah A. Meyers, Stephen P. Peters, Mario Castro, Andrea M. Coverstone, Leonard B. Bacharier, Ngoc P. Ly, Michael C. Peters, Loren C. Denlinger, Sima Ramratnam, Ronald L. Sorkness, Benjamin M. Gaston, Serpil C. Erzurum, Suzy A. A. Comhair, Ross E. Myers, Joe Zein, Mark D. DeBoer, Anne-Marie Irani, Elliot Israel, Bruce Levy, Juan Carlos Cardet, Wanda Phipatanakul, Jonathan M. Gaffin, Fernando Holguin, Merritt L. Fajt, Shean J. Aujla, David T. Mauger, Nizar N. Jarjour
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2018)
Article
Respiratory System
Fernando Holguin, Juan Carlos Cardet, Kian Fan Chung, Sarah Diver, Diogenes S. Ferreira, Anne Fitzpatrick, Mina Gaga, Liz Kellermeyer, Sandhya Khurana, Shandra Knight, Vanessa M. McDonald, Rebecca L. Morgan, Victor E. Ortega, David Rigau, Padmaja Subbarao, Thomy Tonia, Ian M. Adcock, Eugene R. Bleecker, Chris Brightling, Louis-Philippe Boulet, Michael Cabana, Mario Castro, Pascal Chanez, Adnan Custovic, Ratko Djukanovic, Urs Frey, Betty Frankemoelle, Peter Gibson, Dominique Hamerlijnck, Nizar Jarjour, Satoshi Konno, Huahao Shen, Cathy Vitary, Andy Bush
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Medicine, General & Internal
Jennifer K. Carroll, Paulina Arias Hernandez, Alicia Brooks-Greisen, Juan Carlos Cardet, Jing Cui, Brianna Ericson, Maureen Fagan, Merritt L. Fajt, Victoria E. Forth, Anne L. Fuhlbrigge, Margie Lorenzi, Jacqueline Rodriguez-Louis, Nancy E. Maher, Brian K. Manning, Wilson D. Pace, Joel B. Shields, Elliot Israel
Summary: This study describes the socioeconomic and healthcare-related effects of the COVID-19 pandemic, as well as the willingness to receive a free COVID-19 vaccine, among African American/Black and Hispanic/Latinx adults with asthma.
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
(2022)
Article
Allergy
Juan Carlos Cardet, Ku-Lang Chang, Benjamin J. Rooks, Jennifer K. Carroll, Juan Carlos Celedon, Tamera Coyne-Beasley, Jing Cui, Brianna Ericson, Victoria E. Forth, Maureen Fagan, Anne L. Fuhlbrigge, Paulina Arias Hernandez, Jean Kruse, Margee Louisias, Nancy E. Maher, Brian Manning, Wilson D. Pace, Wanda Phipatanakul, Jacqueline Rodriguez-Louis, Joel B. Shields, Elliot Israel, Juan P. Wisnivesky
Summary: This study found that low socioeconomic status is directly and indirectly associated with asthma morbidity among African American/Black and Hispanic/Latinx adults. Stress partially mediates this relationship. Identifying stressors and implementing relevant management strategies may help reduce asthma-related morbidity in these populations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Juan Carlos Cardet, Donghwa Kim, Eugene R. Bleecker, Thomas B. Casale, Elliot Israel, David Mauger, Deborah A. Meyers, Elizabeth Ampleford, Gregory A. Hawkins, Yaping Tu, Stephen B. Liggett, Victor E. Ortega
Summary: RGS2 promoter variation enhances bronchoconstrictive stimulation in human airway smooth muscle and is associated with asthma severity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Juan Carlos Cardet, Kartik Shenoy, Ahmet Baydur, Jennifer K. Carroll, Juan Carlos Celedon, Jing Cui, Prajwal Dara, Brianna Ericson, Victoria E. Forth, Maureen Fagan, Anne L. Fuhlbrigge, Rohit Gupta, Mary K. Hart, Michelle L. Hernandez, Paulina Arias Hernandez, Jean Kruse, Nancy E. Maher, Brian K. Manning, Victor M. Pinto-Plata, Janet Robles, Jacqueline Rodriguez-Louis, Joel B. Shields, Bonnie S. Telon Sosa, Michael E. Wechsler, Elliot Israel
Summary: This study found significant disparities in asthma morbidity among Hispanic/Latinx adult subgroups, with Puerto Ricans experiencing higher rates of exacerbations, emergency department visits, hospitalizations, and healthcare utilization compared to other Hispanic/Latinx groups. These findings highlight the need for targeted interventions to reduce asthma morbidity in this highly impacted population.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Editorial Material
Allergy
Juan Carlos Cardet, Natalia Weare-Regales, Richard F. Lockey
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Juan Carlos Cardet, Paula J. Busse, Jennifer K. Carroll, Thomas B. Casale, Tamera Coyne-Beasley, Sherrie Dixon-Williams, Maureen Fagan, Victoria E. Forth, Anne L. Fuhlbrigge, Michelle L. Hernandez, David Kaelber, Barbara Kaplan, Margarita Lorenzi, Suzanne Madison, Nancy E. Maher, Karen Majewski, Brian Manning, Melissa D. McKee, Sylvette Nazario, Wilson D. Pace, Michael J. Pencina, Cynthia S. Rand, Jacqueline Rodriguez-Louis, Lilin She, Joel Shields, Jessica E. Teng, Michael E. Wechsler, Juan P. Wisnivesky, Barbara P. Yawn, Elliot Israel
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2020)
Article
Critical Care Medicine
Loren C. Denlinger, Brenda R. Phillips, Sinna Ramratnam, Kristie Ross, Nirav R. Bhakta, Juan Carlos Cardet, Mario Castro, Stephen P. Peters, Wanda Phipatanakul, Shean Aujle, Leonard B. Bacharier, Eugene R. Bleecker, Suzy A. A. Comhair, Andrea Coverstone, Mark DeBoer, Serpil C. Erzurum, Sean B. Fain, Merritt Fajt, Anne M. Fitzpatrick, Jonathan Gaffin, Benjamin Gaston, Annette T. Hastie, Gregory A. Hawkins, Fernando Holguin, Anne-Marie Irani, Elliot Israel, Bruce D. Levy, Ngoc Ly, Deborah A. Meyers, Wendy C. Moore, Ross Myers, Maria Theresa D. Opina, Michael C. Peters, Mark L. Schiebler, Ronald L. Sorkness, W. Gerald Teague, Sally E. Wenzel, Prescott G. Woodruff, David T. Mauger, John V. Fahy, Nizar N. Jarjour
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)