Article
Plant Sciences
Jung-Eun Lee, Young-Whan Choi, Dong-Soon Im
Summary: The aim of this study was to identify an active phytochemical from Schisandra chinensis and evaluate its effects on AD-like symptoms. The results showed that alpha-cubebenoate, an active phytochemical in Schisandra chinensis, significantly improved AD-like symptoms by reducing skin hypertrophy and mast cell accumulation, as well as decreasing pro-inflammatory chemokine and cytokine levels. This study provides evidence for the therapeutic efficacy of alpha-cubebenoate in the treatment of AD symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Yi Zhang, Chenglin Niu
Summary: The study suggests that CDC42 may be associated with the progression and cognitive decline in Alzheimer's disease, and has the potential to serve as a biomarker for estimating AD risk and progression.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yumei Zhou, Linhan Hu, Honglei Zhang, Haiyun Zhang, Juntong Liu, Xiaoshan Zhao, Ji Wang, Qi Wang
Summary: The study found that GMK achieves a similar effect as dexamethasone in controlling symptoms of allergic asthma and inhibiting inflammation, reconstructs the immune balance of Th1/Th2 and Treg/Th17 cells, and impacts asthma treatment by altering gut microbiota. Metabolome results reveal specific substances associated with Th1/Th2 and Treg/Th17 cell balance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Xiao-Di Chen, Jing Xie, Yong Wei, Ji-Feng Yu, Ye Cao, Lu Xiao, Xue-Jing Wu, Cong-Jian Mao, Run-Min Kang, Yong-Gang Ye
Summary: Despite long-term control efforts, hepatic coccidiosis caused by Eimeria stiedai infection remains persistent in rabbits in China. This study provides the first evidence of changes in Th1/Th2/Treg/Th17/Th9/Th21 cells in rabbits infected with E. stiedai, offering insights into immune regulation mechanisms and potential vaccine development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Microbiology
Ekaterina Martynova, Albert Rizvanov, Richard A. Urbanowicz, Svetlana Khaiboullina
Summary: This review focuses on the mechanisms of inflammasome activation and their role in the development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines released from activated inflammasomes to the immune response is summarized, along with the discussion of the role of cytokines released from tissue cells in promoting lymphocyte differentiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Le Lv, Ziyang Chen, Wenhui Bai, Jiahui Hao, Zhengang Heng, Caijin Meng, Lin Wang, Xianglan Luo, Xinmiao Wang, Yanjun Cao, Jiao He
Summary: This study aimed to explore the efficacy of THDCA on ulcerative colitis and to reveal its mechanisms of action. The results showed that THDCA can significantly alleviate colitis and exert its effects by regulating the Th1/Th2 and Th17/Treg balance.
Review
Immunology
Hannes Lindahl, Tomas Olsson
Summary: IL-22 is a significant interleukin that plays a crucial role in the immune system and tissue repair, particularly in T cell-driven inflammatory diseases. Its influence on T cells has not been fully understood so far, and further research is needed to explore its role in promoting regulatory T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Stefano Piazza, Marco Fumagalli, Giulia Martinelli, Carola Pozzoli, Nicole Maranta, Marco Angarano, Enrico Sangiovanni, Mario Dell'Agli
Summary: Plants rich in hydrolyzable tannins have traditionally been used for the treatment of chronic inflammatory disorders. However, limited knowledge of their immunological targets hinders their rational use in phytotherapy. Recent advances in understanding the pathogenesis of inflammatory-based diseases provide an opportunity to elucidate the pharmacological mechanisms of these plant-derived metabolites with immunomodulatory activity. This review summarizes recent articles on the role of hydrolyzable tannins and their gut metabolites in various inflammatory responses.
Article
Oncology
Zhiguo Peng, Xinyue Dong, Miao He, Yajing Zhao, Yujia Liu, Mo Li, Guosheng Li, Xiuwen Wang, Li Li, Yu Hu
Summary: This study found that the expression levels of Th22, Th17, Th1, and Th2 cell subsets were significantly increased in breast cancer patients. Th22 cells were found to be associated with molecular classification and clinical outcomes of breast cancer. These cell subsets may play a critical role in the development of breast cancer and have the potential to be used as clinical markers.
Article
Immunology
Haiyan Bian, Lisheng Wang, Chengwen Gao, Zhihe Liu, Yang Sun, Minghui Hu, Yujing Xiao, Fengyun Hao, Yushuo Ma, Xia Zhao
Summary: This study explores the expression and clinical significance of Th1/Th2/Th17 cytokines and lymphocyte subsets in patients with Primary central nervous system lymphoma (PCNSL). The results show significant differences in cytokines and lymphocyte subsets between PCNSL patients, diffuse large B-cell lymphoma (DLBCL) patients, and healthy controls. These findings provide valuable information for the diagnosis, treatment, and prognosis of PCNSL.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Immunology
Yan Qin, Chong Gao, Jing Luo
Summary: The abnormal number and function of immune cells are the basis for various diseases. Recent studies have shown that the altered metabolic state of immune cells exists in autoimmune diseases and affects the occurrence and development of inflammation. This review summarizes the biology and function of Th17 and Treg cells in autoimmune diseases, with emphasis on the regulatory role of energy metabolism in the activation, differentiation, and physiological function of these cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xia Ke, Ziqi Chen, Xiaoqiang Wang, Houyong Kang, Suling Hong
Summary: In this study, the effects of quercetin on the balance of Th1/Th2 and Treg/Th17 ratios in allergic rhinitis were explored. By orally administering different doses of quercetin to mice, nasal symptoms were observed and immunoglobulin levels, Treg/Th17-related factors, and pro-inflammatory factors were examined. The results showed that quercetin alleviated allergic rhinitis symptoms by balancing the Th1/Th2 and Treg/Th17 ratios and inhibiting the NF-kappa B pathway.
Article
Medicine, General & Internal
Andrea Itano, Douglas Maslin, Kritika Ramani, Golbarg Mehraei, Nancy Carpenter, Taylor Cormack, Mahdi Saghari, Matthijs Moerland, Erin Troy, Will Caffry, Leslie Wardwell-Scott, Stuart Abel, Duncan McHale, Mark Bodmer
Summary: This study introduces EDP1815, a non-colonizing pharmaceutical preparation derived from a single strain of Prevotella histicola. The research demonstrates that EDP1815 can regulate inflammatory responses throughout the body when taken orally and restricted to the gut.
FRONTIERS IN MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Yee Huang, Li Nan, Chenwen Xiao, Jie Dong, Ke Li, Jvfen Cheng, Quanan Ji, Qiang Wei, Guolian Bao, Yan Liu
Summary: The study successfully developed GAN-OMV, which can stimulate Th1/Th2/Th17 immune responses against Bb and provide a promising strategy for novel vaccine development against the microbial pathogen. GAN-OMV showed a stable core-shell structure and effectively internalized into macrophages through multiple endocytotic pathways, promoting cell proliferation, cytokine secretion, and M1 polarization. Subcutaneous GAN-OMV vaccination significantly enhanced specific antibody production, lymphocyte proliferation, and the production of Th1/Th2/Th17 cytokines.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)