Article
Clinical Neurology
You-Fan Peng, Miao Luo, Qing-Song Zhang
Summary: The study found that the monocyte to high-density lipoprotein cholesterol ratio (MHR) is associated with the subtype and clinical severity of Guillain-Barre Syndrome (GBS) patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Mohammed H. Alanazy, Sawsan S. Bakry, Afnan Alqahtani, Norah S. AlAkeel, Naael Alazwary, Afag M. Osman, Rania A. Mustafa, Talal M. Al-Harbi, Sameeh O. Abdulmana, Aimee C. Amper, Yousef Aldughaythir, Abdulrahman S. Ali, Seraj Makkawi, Alaa Maglan, Loujen Alamoudi, Feras Alsulaiman, Majed Alabdali, Aysha A. AlShareef, Ahmad R. Abuzinadah, Ahmed K. Bamaga
Summary: The study described the clinical and laboratory characteristics of GBS in Saudi Arabia and found that the overall prognosis for patients was favorable, with approximately half of patients able to walk independently within 9 months after discharge.
Review
Clinical Neurology
Pei Shang, Mingqin Zhu, Ying Wang, Xiangyu Zheng, Xiujuan Wu, Jie Zhu, Jiachun Feng, Hong-Liang Zhang
Summary: Axonal variants of Guillain-Barre syndrome (GBS) have diverse triggers, but key questions remain unanswered and current therapies have limitations. Autoantibody classification and electrophysiology are crucial for differentiation, with emerging technologies facilitating more accurate diagnosis.
JOURNAL OF NEUROLOGY
(2021)
Article
Rehabilitation
Mirim Lee, Chang Hee Lee, Jun Young Ko, Aram Kim
Summary: This case report describes a patient with acute motor axonal neuropathy associated with systemic lupus erythematosus. It highlights the lack of established therapeutic guidelines for the concurrent management of this condition in the acute phase and the lack of research on physical medicine and rehabilitation in the plateau and recovery phases. The patient showed remarkable recovery in muscle strength and functional status after an intensive inpatient rehabilitation program.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Review
Immunology
Pamela A. A. McCombe, Todd A. A. Hardy, Robert J. J. Nona, Judith M. M. Greer
Summary: Guillain Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are immune mediated neuropathies that are more common in males. There are reported sex differences in immune system elements, which may contribute to the male predominance of these diseases and warrant further study in peripheral nerves.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pediatrics
Xin-Ying Yang, Tong-Li Han, Jun-Lan Lv
Summary: Through analysis of seven patients, we found that when GBS meets RML, the most prominent characteristics were male dominance, multiple factors causing limb weakness, pain and respiratory failure, more severe limb weakness and respiratory muscle paralysis compared to GBS alone, and an increased probability of mechanical ventilation. Neuroelectrophysiological studies revealed axonal lesions. Close monitoring and timely intervention are crucial in remedying potentially fatal complications. With plasma exchange, peritoneal dialysis and supportive treatment, the long-term outcome of most patients was satisfactory.
FRONTIERS IN PEDIATRICS
(2022)
Review
Clinical Neurology
Luis Querol, Cinta Lleixa
Summary: Inflammatory neuropathies are rare diseases of the peripheral nervous system with known etiology and pathophysiological mechanisms partially understood. Treatment involves immunomodulatory and immunosuppressive therapies, but a significant proportion of patients do not respond, indicating the need for research and development of new treatment approaches.
Article
Clinical Neurology
Lay Khoon Loo, Omar Salim, Di Liang, Aimee Goel, Salini Sumangala, Ashwin S. Gowda, Brendan Davies, Yusuf A. Rajabally
Summary: This study suggests that exposure to the first dose of the AstraZeneca SARS-CoV2 vaccine may be a risk factor for acute-onset polyradiculoneuropathy, characterized by more common cranial nerve involvement. There was a significant increase in admissions for acute-onset polyradiculoneuropathy during the studied time frame compared to the previous 3 years.
Review
Behavioral Sciences
Lea M. Gerischer, Franziska Scheibe, Astrid Numann, Martin Kohnlein, Ulrich Stolzel, Andreas Meisel
Summary: Acute hepatic porphyrias (AHP) are rare genetic disorders that can lead to delayed diagnosis and misdiagnosis. Differential diagnosis should pay attention to Guillain-Barre syndrome and autoimmune encephalitis.
BRAIN AND BEHAVIOR
(2021)
Article
Geriatrics & Gerontology
Jiajia Yao, Yin Liu, Shuping Liu, Zuneng Lu
Summary: The epidemiological features of Guillain-Barre syndrome (GBS) vary among different regions in China, including the age distribution of patients, seasonal outbreaks, preceding events, and the proportion of different axonal subtypes.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Zaheer Qureshi, Sameer Kandhi, Neeti Prasai, Faryal Altaf, Manjeet Dhallu
Summary: Novel outbreaks with COVID-19 can lead to various systemic manifestations, including autoimmune diseases. Respiratory complications are the most apparent symptoms. Guillain-Barre syndrome has emerged as a potentially severe complication of COVID-19. This study reports the first case of COVID-19-induced acute motor axonal neuropathy variant of Guillain-Barre syndrome from New York, USA.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Immunology
Felix Kohle, Robin Ackfeld, Franziska Hommen, Ines Klein, Martin K. R. Svacina, Christian Schneider, Gereon R. R. Fink, Mohammed Barham, David Vilchez, Helmar C. C. Lehmann
Summary: This study evaluated the neuro-regenerative effects of the small molecule kinesin-5 inhibitor monastrol in a rodent model of acute autoimmune neuropathies. The results showed that treatment with monastrol improved the functional and histological recovery of neuropathies and promoted the regeneration of nerve terminals, possibly through accelerated motor neurite outgrowth.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Endocrinology & Metabolism
Uddalak Chakraborty, Arkapravo Hati, Atanu Chandra
Summary: This study analyzed the clinical presentations and outcomes of eight cases with COVID-19 associated GBS. Results showed that among the eight patients, three were diagnosed with AIDP, three had AMAN, and two had AMSAN. Early diagnosis is crucial for better outcome in patients with GBS associated with COVID-19.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Review
Immunology
N. Gavrilova, E. Kamaeva, M. Ignatova, V. Ryabkova, M. Lukashenko, L. Soprun, L. P. Churilov, Y. Shoenfeld
Summary: Intravenous immunoglobulin (IVIg) treatment is considered promising in autoimmune disease therapy, but its mechanism of action and recommended dosage require further study. This review summarizes the effectiveness of IVIg in primary autoimmune neuropathies and neurological complications of systemic diseases, as well as its side effects and clinical use, with a focus on doses and treatment protocols in dysautonomia.
CLINICAL IMMUNOLOGY
(2022)
Article
Clinical Neurology
Eman M. Khedr, Ahmed Shoyb, Khaled O. Mohamed, Ahmed A. Karim, Mostafa Saber
Summary: GBS cases associated with COVID-19 infection exhibit unique clinical features, such as rapid onset, cranial nerve involvement, etc. Some patients achieved full or partial recovery after receiving plasmapheresis treatment.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Laura Clarke, Wajih Bukhari, Cullen M. O'Gorman, Elham Khalilidehkordi, Simon Arnett, Mark Woodhall, Kerri M. Prain, John D. E. Parratt, Michael H. Barnett, Mark P. Marriott, Pamela A. McCombe, Ian Sutton, Mike Boggild, Wallace Brownlee, William M. Carroll, Suzanne Hodgkinson, Richard A. L. Macdonell, Deborah F. Mason, Jennifer Pereira, Mark Slee, Chandi Das, Andrew P. D. Henderson, Allan G. Kermode, Jeannette Lechner-Scott, Patrick Waters, Jing Sun, Simon A. Broadley
Summary: This retrospective observational study evaluated the treatment response of rituximab and traditional immunosuppressive therapy in patients with AQP4 antibody positive NMOSD. The results showed that rituximab had a lower risk of first relapse and a non-significant reduction in annualized relapse rates compared to no treatment. beta-interferon and cyclophosphamide were associated with increased relapse rates. Both rituximab and traditional immunosuppressive therapy were associated with lower final EDSS compared to beta-interferon.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Psychiatry
Nicola Warren, Karen Freier, Dan Siskind, Cullen O'Gorman, Stefan Blum, David Gillis, James G. Scott
Summary: Glutamic acid decarboxylase antibodies were found to be uncommon in consumers with psychosis, and there was no significant difference in prevalence compared to controls. No cases of encephalitis were identified. Targeted antibody testing guidelines should be further considered.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
M. Lefort, S. Sharmin, J. B. Andersen, S. Vukusic, R. Casey, M. Debouverie, G. Edan, J. Ciron, A. Ruet, J. De Seze, E. Maillart, H. Zephir, P. Labauge, G. Defer, C. Lebrun-Frenay, T. Moreau, E. Berger, P. Clavelou, J. Pelletier, B. Stankoff, O. Gout, E. Thouvenot, O. Heinzlef, A. Al-Khedr, B. Bourre, O. Casez, P. Cabre, A. Montcuquet, A. Wahab, J. P. Camdessanche, A. Maurousset, H. Ben Nasr, K. Hankiewicz, C. Pottier, N. Maubeuge, C. Nifle, D. A. Laplaud, D. Horakova, D. Dimitri-Boulos, E. K. Havrdova, R. Alroughani, G. Izquierdo, S. Eichau, S. Ozakbas, F. Patti, M. Onofrj, A. Lugaresi, M. Terzi, P. Grammond, F. Grand'Maison, B. Yamout, A. Prat, M. Girard, P. Duquette, C. Boz, M. Trojano, P. McCombe, M. Slee, J. Lechner-Scott, R. Turkoglu, P. Sola, D. Ferraro, F. Granella, V Shaygannejad, J. Prevost, D. Maimone, O. Skibina, K. Buzzard, A. Van der Walt, R. Karabudak, B. Van Wijmeersch, T. Csepany, D. Spitaleri, S. Vucic, N. Koch-Henriksen, F. Sellebjerg, P. S. Soerensen, C. C. Hilt Christensen, P. Rasmussen, M. B. Jensen, J. L. Frederiksen, S. Bramow, H. K. Mathiesen, K. Schreiber, H. Butzkueven, M. Magyari, T. Kalincik, E. Leray
Summary: This study provides valuable insights into the impact of methodological decisions on the results of comparative effectiveness studies. The results suggest that there are no substantial differences in the conclusions obtained with propensity scores matching or propensity scores weighting, given that the study is sufficiently powered, models are correctly specified, and the positivity assumption is fulfilled.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Clinical Neurology
Sifat Sharmin, Francesca Bovis, Charles Malpas, Dana Horakova, Eva Kubala Havrdova, Guillermo Izquierdo, Sara Eichau, Maria Trojano, Alexandre Prat, Marc Girard, Pierre Duquette, Marco Onofrj, Alessandra Lugaresi, Francois Grand'Maison, Pierre Grammond, Patrizia Sola, Diana Ferraro, Murat Terzi, Oliver Gerlach, Raed Alroughani, Cavit Boz, Vahid Shaygannejad, Vincent van Pesch, Elisabetta Cartechini, Ludwig Kappos, Jeannette Lechner-Scott, Roberto Bergamaschi, Recai Turkoglu, Claudio Solaro, Gerardo Iuliano, Franco Granella, Bart Van Wijmeersch, Daniele Spitaleri, Mark Slee, Pamela McCombe, Julie Prevost, Radek Ampapa, Serkan Ozakbas, Jose Luis Sanchez-Menoyo, Aysun Soysal, Steve Vucic, Thor Petersen, Koen de Gans, Ernest Butler, Suzanne Hodgkinson, Youssef Sidhom, Riadh Gouider, Edgardo Cristiano, Tamara Castillo-Trivino, Maria Laura Saladino, Michael Barnett, Fraser Moore, Csilla Rozsa, Bassem Yamout, Olga Skibina, Anneke van der Walt, Katherine Buzzard, Orla Gray, Stella Hughes, Angel Perez Sempere, Bhim Singhal, Yara Fragoso, Cameron Shaw, Allan Kermode, Bruce Taylor, Magdolna Simo, Neil Shuey, Talal Al-Harbi, Richard Macdonell, Jose Andres Dominguez, Tunde Csepany, Carmen Adella Sirbu, Maria Pia Sormani, Helmut Butzkueven, Tomas Kalincik
Summary: This study identifies the clinicodemographic characteristics of 6-month confirmed disability progression events in multiple sclerosis (MS) patients, which can help identify those at high risk of sustained long-term disability. This knowledge will improve the assessment of therapy effects on long-term disability accrual in future trials.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Pamela A. McCombe
Summary: This review summarizes the data on sex differences and pregnancy in multiple sclerosis (MS), and discusses the possible mechanisms behind these effects. Practical suggestions for addressing these issues are also provided.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2022)
Article
Clinical Neurology
Marianna Vitkova, Ibrahima Diouf, Charles Malpas, Dana Horakova, Eva Kubala Havrdova, Francesco Patti, Serkan Ozakbas, Guillermo Izquierdo, Sara Eichau, Vahid Shaygannejad, Marco Onofrj, Alessandra Lugaresi, Raed Alroughani, Alexandre Prat, Catherine Larochelle, Marc Girard, Pierre Duquette, Murat Terzi, Cavit Boz, Francois Grand'Maison, Patrizia Sola, Diana Ferraro, Pierre Grammond, Helmut Butzkueven, Katherine Buzzard, Olga Skibina, Bassem Yamout, Rana Karabudak, Oliver Gerlach, Jeannette Lechner-Scott, Davide Maimone, Roberto Bergamaschi, Vincent Van Pesch, Gerardo Iuliano, Elisabetta Cartechini, Maria Jose Sa, Radek Ampapa, Michael Barnett, Stella E. Hughes, Cristina M. Ramo-Tello, Suzanne Hodgkinson, Daniele L. A. Spitaleri, Thor Petersen, Ernest Gerard Butler, Mark Slee, Chris McGuigan, Pamela Ann McCombe, Franco Granella, Edgardo Cristiano, Julie Prevost, Bruce Taylor, Josaa Luis Sanchez-Menoyo, Guy Laureys, Liesbeth Van Hijfte, Steve Vucic, Richard A. Macdonell, Orla Gray, Javier Olascoaga, Norma Deri, Yara Dadalti Fragoso, Cameron Shaw, Tomas Kalincik
Summary: This study investigated the association between latitude of residence, UVB exposure, and the severity of multiple sclerosis (MS). The findings revealed that in temperate zones, latitude is associated with the severity of MS, and this association is mainly driven by UVB exposure.
Article
Neurosciences
A. Lee, S. Klinkradt, P. A. McCombe, D. Pow
Summary: In this study, a novel splice variant of glutamate transporter 1, named GLT-1d/EAAT2d, was cloned from human and rodent brains. The splice variant was found to be abundantly expressed in the brain, spinal cord, retina, liver, and testis, and functions as a glutamate transporter. These findings suggest that it may play a functional role in glutamate homeostasis in the nervous system of rodents and humans.
NEUROSCIENCE LETTERS
(2022)
Review
Clinical Neurology
R. J. Nona, J. M. Greer, R. D. Henderson, P. A. McCombe
Summary: This systematic review and meta-analysis examines the association between HLA and ALS. The study finds three alleles of interest, but does not confirm all previously reported associations. The study also identifies methodological limitations and calls for further modern research to validate the results.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Matthew Katz, Fleur C. Garton, Mark Davis, Robert D. Henderson, Pamela A. McCombe
Summary: This study reports on two unrelated patients with Limb girdle muscular dystrophy who were found to have novel variants in ANO5. The findings expand the genotypic spectrum of ANO5 disease and support the utility of next generation sequencing in the diagnosis of patients with Limb girdle muscular dystrophy phenotype.
FRONTIERS IN NEUROLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Matthew R. Nangle, Nithin Manchery, Andrew Swayne, Helen Boocock, Stefan Blum, Julie D. Henry
Summary: This study aims to test whether individuals with relapsing-remitting MS have poorer oral health-related quality of life (OHRQoL) than demographically matched controls, and to determine the variables associated with worse OHRQoL.
JOURNAL OF ORAL REHABILITATION
(2023)
Article
Clinical Neurology
James Broadley, Robb Wesselingh, Paul Beech, Udaya Seneviratne, Chris Kyndt, Katherine Buzzard, Cassie Nesbitt, Wendyl D'Souza, Amy Brodtmann, Richard Macdonell, Tomas Kalincik, Terence J. O'Brien, Helmut Butzkueven, Mastura Monif
Summary: The utility of neuroimaging characteristics as biomarkers of prognosis in seropositive autoimmune encephalitis (AE) was examined in this study. MRI and PET imaging were assessed, and abnormalities were found in 35.1% and 46.4% of patients, respectively. Initial whole brain and hippocampal volumes were below the 5th and 20th percentile compared to a healthy database. After a median follow-up of 715 days, 85.2% had good functional outcome. Structural and inflammatory changes of the MTL were associated with prognosis in seropositive AE.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Dennis Yeow, Matthew Katz, Robert Henderson, Sandhir Prasad, Russell Denman, Stefan Blum, Mark Davis, Thomas Robertson, Pamela McCombe
Summary: The DES gene encodes desmin, an important protein in skeletal, cardiac, and smooth muscle. Mutations in the DES gene can lead to a range of muscular disorders known as desminopathies. We present three cases of desminopathy that demonstrate the phenotypic diversity of this disorder, and discuss factors that contribute to clinical differences between patients with different desmin variants and within families.
FRONTIERS IN NEUROLOGY
(2023)
Letter
Clinical Neurology
Shadi El-Wahsh, Rajiv Wijesinghe, Jessica Qiu, Rob Heard, Marion Stoll, Stephen Reddel
Meeting Abstract
Clinical Neurology
T. Hardy, P. Aouad, M. Barnett, S. Blum, S. Broadley, W. Carroll, D. Crimmins, D. Griffiths, S. Hodgkinson, J. Lechner-Scott, A. Lee, R. Malhotra, P. McCombe, J. Parratt, C. Plummer, A. van der Walt, K. Martel, R. Walker
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Todd A. Hardy, John Parratt, Heidi Beadnall, Stefan Blum, Richard Macdonell, Roy G. Beran, Neil Shuey, Andrew Lee, William Carroll, Cameron Shaw, Richard Worrell, Jana Moody, Mamdouh Sedhom, Michael Barnett, Steve Vucic
Summary: In this study of Australian patients with RRMS initiated on teriflunomide, high treatment satisfaction and adherence were reported at 24 and 48 weeks. Patient-reported disability remained low, with improvements in work capacity and daily life activity observed, while most patients remained relapse-free.
BMJ NEUROLOGY OPEN
(2022)