Review
Allergy
Alexandra F. Santos, Oral Alpan, Hans-Jurgen Hoffmann
Summary: The basophil activation test (BAT) measures the degree of degranulation of basophils following stimulation with allergen, and it can be used as a more specific diagnostic tool for allergic diseases. Clinical application of BAT requires clinical validation, quality assurance, and efforts are ongoing to establish a platform for laboratories to ensure reproducibility and reliability of results.
Article
Critical Care Medicine
Paul E. Pfeffer, Ian S. Mudway, Jonathan Grigg
Summary: There is global concern about the harmful impact of polluted air on respiratory health of asthma patients. Despite multiple epidemiologic studies showing ongoing associations, inconsistent findings suggest a need for experimental studies to clarify the mechanistic basis of the effects of ambient pollution on the lungs.
Article
Allergy
Karen M. Anstey, Lulu Tsao, Iris M. Otani
Summary: Drug allergy delabeling programs are important for antibiotic stewardship and involve patient selection, design, stakeholder engagement, team assembly, implementation, and outcome evaluation. Current programs focus on removing inaccurate antibiotic allergy labels for patients with beta-lactam allergies and high-risk populations likely to need beta-lactam antibiotics. Inpatients, pediatric patients, and telehealth programs have successfully implemented beta-lactam delabeling programs. This review also highlights delabeling programs for high-risk populations, such as perioperative, prenatal, and immunocompromised patients. Successful delabeling strategies and future innovation areas are discussed.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Arindam Chakravorty, Elene Binder, Matthew Rawlins, Michelle Trevenen, Paul R. Ingram, Anna McKeogh, Kevin Murray, John Dyer, Michaela Lucas
Summary: This study aimed to evaluate the impact of antimicrobial allergy labels (AAL) on antibiotic prescribing, patient mortality, hospital length of stay, readmission, and rates of multidrug-resistant infections. The results showed that patients with AAL had lower adherence to antibiotic guidelines, but there was no significant association with adverse outcomes.
INTERNAL MEDICINE JOURNAL
(2022)
Review
Allergy
Annabelle Arnold, Linda L. Coventry, Mandie J. Foster, Jennifer J. Koplin, Michaela Lucas
Summary: This systematic review summarizes the impact of patient-reported antibiotic allergy on clinical outcomes and explores various strategies for effectively assessing and removing these allergy labels to improve patient care.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Immunology
Christie M. Bertram, Michael Postelnick, Christian M. Mancini, Xiaoqing Fu, Yuqing Zhang, Lucas T. Schulz, Tanaya Bhowmick, Francesca Lee, Kimberly G. Blumenthal
Summary: The study found that using alternative antibiotics for surgical prophylaxis poses an increased risk of adverse events and surgical site infection compared to cefazolin. Additionally, patients with documented beta-lactam allergy were more likely to be prescribed clindamycin instead of cefazolin.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Kyra Y. L. Chua, Sara Vogrin, Susan Bury, Abby Douglas, Natasha E. Holmes, Nixon Tan, Natasha K. Brusco, Rebecca Hall, Belinda Lambros, Jacinta Lean, Wendy Stevenson, Misha Devchand, Kent Garrett, Karin Thursky, M. Lindsay Grayson, Monica A. Slavin, Elizabeth J. Phillips, Jason A. Trubiano
Summary: This study showed that the program of inpatient delabeling for low-risk penicillin allergies using a combination of direct delabeling and oral penicillin challenge led to increased usage of narrow-spectrum penicillins, improved appropriate antibiotic prescribing, and reduced usage of restricted antibiotics.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Allergy
Theresa B. Dunham, Rebecca M. Gardner, Elizabeth A. Lippner, Danielle E. Fasani, Elwyn Moir, Bonnie Halpern-Felsher, Vandana Sundaram, Anne Y. Liu
Summary: A digital decision support tool was found to improve antibiotic selection and increase confidence in managing b-lactam allergies among non-allergist providers.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Immunology
Ali Baghersad, Mohammad Hossein Shams, Farhad Shahsavar, Seyyed Mohsen Sohrabi, Ali Mohammad Varzi, Peyman Amanolahi Baharvand, Nahid Eskandari, Nadia Ghasemi Darestani, Hale Abdoli Sereshki, Fatemeh Doosti, Mohammad-Ali Assarehzadegan
Summary: This study investigated the immunochemical characteristics of allergenic proteins in S. alba tree pollen extract and their cross-reaction with pollen allergens of other common allergenic trees. The results showed a high structural homology between the specific IgE-binding proteins in S. alba and P. nigra tree pollens, suggesting their potential diagnostic and therapeutic applications.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Allergy
Chioma Udemgba, Sandeep K. Sarkaria, Patrick Gleeson, Tyra Bryant-Stephens, Princess U. Ogbogu, Paneez Khoury, Andrea J. Apter
Summary: The pandemic, political upheavals, and social justice efforts have drawn attention to persistent health disparities and the urgent need to address them. This scoping review examines published updates on addressing disparities in allergy and immunology, providing insight into how social determinants of health impact patient outcomes and efforts to advance health equity. Steps to improve access to care and promote health equity are outlined, including diversifying trainees, providers, and scientific teams, as well as engaging in advocacy work and public health interventions. Addressing health disparities requires understanding the interplay between social and structural barriers and implementing interventions in key areas to bring about change.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Montserrat Alvaro-Lozano, Monica Sandoval-Ruballos, Mattia Giovannini, Erika Jensen-Jarolim, Umit Sahiner, Vesna Tomic Spiric, Cristina Quecchia, Adam Chaker, Enrico Heffler, Ludger Klimek, Helen Brough, Gunter Sturm, Eva Untersmayr, Mateo Bonini, Oliver Pfaar
Summary: The COVID-19 pandemic has had an impact on the healthcare provided to allergic patients, leading to changes in diagnostic, management, and therapeutic approaches. However, most healthcare professionals have maintained recommended treatments for asthma and allergic rhinitis, as well as the use of biological agents. Remote tools have proven valuable in delivering allergy care.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Infectious Diseases
Joseph Brayson, Scott Barrett, Wasim Baqir, David Campbell, Tamsin Oswald, Simon Ellis, Nikhil Premchand
Summary: The study aimed to develop a transferable process, CATALYST, to assess and challenge penicillin allergy status of inpatients within an NHS Foundation Hospital. Through a multidisciplinary team's collaboration, key steps of CATALYST were identified, including clinical assessment, inclusion/exclusion criteria, consent, direct oral penicillin challenge, and removal of allergy label. The pilot of CATALYST was conducted in 304 patients, with 132 successful allergy challenges and one adverse event of acute kidney injury.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Allergy
Brent Anderson, Lauren Wong, Bahman Adlou, Andrew Long, R. Sharon Chinthrajah
Summary: Oral immunotherapy (OIT) provides an alternative option for pediatric patients with food allergies, showing high efficacy and improving quality of life for patients and their families. Clinical considerations for OIT in pediatrics include efficacy, safety, practical management, and future treatment directions.
JOURNAL OF ASTHMA AND ALLERGY
(2021)
Review
Biology
Clio Dessinioti, Andreas Katsambas
Summary: Antimicrobial resistance is a growing concern in the treatment of acne, which is the most common skin disease worldwide. The bacterium Cutibacterium acnes plays a key role in acne pathogenesis and is part of the skin flora. Overuse of antibiotics and long treatment courses have led to the emergence of resistant strains. It is important to address antimicrobial resistance in acne to preserve the effectiveness of antibiotics and consider non-antibiotic therapies.
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2022)
Review
Allergy
Aleena Banerji, Roland Solensky, Elizabeth J. Phillips, David A. Khan
Summary: This article presents the updated practice parameter for the diagnosis and management of drug hypersensitivity reactions. It includes significant updates on the diagnosis of antibiotic allergies and provides new guidance on the management of patients with different phenotypes of aspirin and nonsteroidal anti-inflammatory drug hypersensitivity reactions. The article also discusses approaches to delayed drug hypersensitivity and the management of patients with reactions to chemotherapeutics and biologics.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Ophthalmology
Liisa Kautto, Terry Nguyen-Khuong, Arun Everest-Dass, Andrea Leong, Zhenjun Zhao, Mark D. P. Willcox, Nicolle H. Packer, Robyn Peterson
EXPERIMENTAL EYE RESEARCH
(2016)
Article
Clinical Neurology
Zhenjun Zhao, Michael S. Johnson, Biyi Chen, Michael Grace, Jaysree Ukath, Vivienne S. Lee, Lucinda S. McRobb, Lisa M. Sedger, Marcus A. Stoodley
JOURNAL OF NEUROSURGERY
(2016)
Article
Ophthalmology
Simin Masoudi, Zhenjun Zhao, Fiona Stapleton, Mark Willcox
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2017)
Meeting Abstract
Clinical Neurology
S. Subramanian, Z. Zhao, L. McRobb, V. Moutrie, S. Marcus
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2017)
Article
Biology
Lucinda S. McRobb, Vivienne S. Lee, Margaret Simonian, Zhenjun Zhao, Santhosh George Thomas, Markus Wiedmann, Jude V. Amal Raj, Michael Grace, Vaughan Moutrie, Matthew J. Mckay, Mark P. Molloy, Marcus A. Stoodley
RADIATION RESEARCH
(2017)
Article
Biology
Newsha Raoufi Rad, Lucinda S. McRobb, Zhenjun Zhao, Vivienne S. Lee, Nirav J. Patel, Anas Sarwar Qureshi, Michael Grace, Joshua J. McHattan, Jude V. Amal Raj, Hong Duong, Saleh R. Kashba, Marcus A. Stoodley
RADIATION RESEARCH
(2017)
Article
Hematology
S. Subramanian, S. O. Ugoya, Z. Zhao, L. S. McRobb, G. E. Grau, V. Combes, D. W. Inglis, A. J. Gauden, V. S. Lee, V. Moutrie, E. D. Santos, M. A. Stoodley
THROMBOSIS RESEARCH
(2018)
Article
Multidisciplinary Sciences
Wei Deng, Wenjie Chen, Sandhya Clement, Anna Guller, Zhenjun Zhao, Alexander Engel, Ewa M. Goldys
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Newsha Raoufi-Rad, Lucinda S. McRobb, Vivienne S. Lee, David Bervini, Michael Grace, Jaysree Ukath, Joshua Mchattan, Varun K. A. Sreenivasan, Hong Duong, Zhenjun Zhao, Marcus A. Stoodley
Article
Biochemistry & Molecular Biology
Lucinda S. McRobb, Matthew J. McKay, Andrew J. Gauden, Vivienne S. Lee, Sinduja Subramanian, Santhosh George Thomas, Markus K. H. Wiedmann, Vaughan Moutrie, Michael Grace, Zhenjun Zhao, Mark P. Molloy, Marcus A. Stoodley
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Clinical Neurology
Andrew J. Gauden, Lucinda S. McRobb, Vivienne S. Lee, Sinduja Subramanian, Vaughan Moutrie, Zhenjun Zhao, Marcus A. Stoodley
TRANSLATIONAL STROKE RESEARCH
(2020)
Article
Hematology
Sinduja Subramanian, Zhenjun Zhao, Fahimeh Faqihi, Georges E. Grau, Valery Combes, David W. Inglis, Vaughan Moutrie, Marcus A. Stoodley, Lucinda S. McRobb
THROMBOSIS RESEARCH
(2020)
Meeting Abstract
Clinical Neurology
Andrew Gauden, Vivienne Lee, Sinduja Subramanian, Vaughan Moutrie, Zhenjun Zhao, Lucinda McRobb, Marcus Stoodley
JOURNAL OF NEUROSURGERY
(2018)
Article
Ophthalmology
Simin Masoudi, Zhenjun Zhao, Mark Willcox
CURRENT EYE RESEARCH
(2017)
Article
Cell Biology
Lucinda S. McRobb, Matthew J. McKay, Jennifer R. Gamble, Michael Grace, Vaughan Moutrie, Estevam D. Santos, Vivienne S. Lee, Zhenjun Zhao, Mark P. Molloy, Marcus A. Stoodley