Article
Medicine, General & Internal
Paul F. Pinsky, Howard Parnes
Summary: Screening for prostate cancer should take into consideration the risks and benefits. PSA screening can reduce prostate cancer deaths, but the reduction is small. Follow-up tests such as biopsy and MRI may be needed for individuals with elevated PSA levels. Patients with low-risk or favorable intermediate-risk prostate cancer may choose active surveillance over immediate curative treatment. Surgery and radiation therapy have good outcomes but can lead to complications.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Monica Zuradelli, Massimo Lazzeri, Egesta Lopci, Paolo Andrea Zucali, Luca Balzarini, Giorgio Guazzoni, Piergiuseppe Colombo, Marta Scorsetti, Ciro Franzese, Rosanna Asselta, Giulia Solda, Stefano Duga
Summary: Understanding the individual patient is more crucial than understanding the disease itself, reflecting the importance of personalized medicine in risk stratification and treatment programs. This report highlights the author's personal experience as a patient with aggressive prostate cancer, benefiting from cutting-edge medical care and molecular profiling.
NPJ PRECISION ONCOLOGY
(2021)
Article
Oncology
Christine C. Moon, Kenneth Mah, Ashley Pope, Nadia Swami, Breffni Hannon, Jenny Lau, Ernie Mak, Ahmed Al-Awamer, Subrata Banerjee, Laura A. Dawson, Amna Husain, Gary Rodin, Lisa W. Le, Camilla Zimmermann
Summary: Most patients with advanced cancer have not received palliative care from a family physician. Accessibility, availability, and equity are important factors to consider when encouraging and facilitating the involvement of family physicians in palliative care.
Article
Medicine, General & Internal
Jonas Hugosson, Marianne Mansson, Jonas Wallstrom, Ulrika Axcrona, Sigrid V. Carlsson, Lars Egevad, Kjell Geterud, Ali Khatami, Kimia Kohestani, Carl-Gustaf Pihl, Andreas Socratous, Johan Stranne, Rebecka Arnsrud Godtman, Mikael Hellstrom
Summary: MRI-directed targeted biopsy for prostate cancer screening reduces the risk of overdiagnosis by half compared to systematic biopsy, but may delay the detection of intermediate-risk tumors in a small proportion of patients.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Psychiatry
Shijiao Yan, Xin Shen, Rixing Wang, Zhiqian Luo, Xiaotong Han, Yong Gan, Chuanzhu Lv
Summary: This study found that 14.9% of emergency physicians in China experience a high level of burnout, mainly due to factors such as individual, work environment, and health status. In order to improve the work enthusiasm of emergency physicians and maintain the quality of emergency medical services, positive measures need to be taken to reduce burnout.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonas Wallstrom, Kjell Geterud, Kimia Kohestani, Stephan E. Maier, Marianne Mansson, Carl-Gustaf Pihl, Andreas Socratous, Rebecka Arnsrud Godtman, Mikael Hellstrom, Jonas Hugosson
Summary: This study found that biparametric MRI was non-inferior to multiparametric MRI for cancer detection in prostate cancer screening, with fewer false positive results.
EUROPEAN RADIOLOGY
(2021)
Article
Business
Xin Pan, Xuanjin Chen, Shumin Qiu
Summary: This study investigates the impact of family management on digitalization by exploring the relationship between family management and digitalization. It finds that family small and medium enterprises are more likely to embrace digitalization. The relationship between family management and digitalization exhibits an inverted U-shaped pattern, with moderate levels being the most conducive. Male successors intensify this relationship. This study expands the understanding of the family's role in digitalization.
IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT
(2023)
Article
Biochemistry & Molecular Biology
Linda Kachuri, Thomas J. Hoffmann, Yu Jiang, Sonja I. Berndt, John P. Shelley, Kerry R. Schaffer, Mitchell J. Machiela, Neal D. Freedman, Wen-Yi Huang, Shengchao A. Li, Ryder Easterlin, Phyllis J. Goodman, Cathee Till, Ian Thompson, Hans Lilja, Stephen K. Van Den Eeden, Stephen J. Chanock, Christopher A. Haiman, David V. Conti, Robert J. Klein, Jonathan D. Mosley, Rebecca E. Graff, John S. Witte
Summary: Prostate-specific antigen (PSA) screening for prostate cancer remains controversial due to overdiagnosis and overtreatment. However, accounting for genetic determinants of PSA variation may improve screening accuracy.
Article
Oncology
Megan Hansen, Nadine M. Hamieh, Sarah C. Markt, Jane B. Vaselkiv, Claire H. Pernar, Amparo G. Gonzalez-Feliciano, Samuel Peisch, Ilkania M. Chowdhury-Paulino, Emily M. Rencsok, Timothy R. Rebbeck, Elizabeth A. Platz, Edward L. Giovannucci, Kathryn M. Wilson, Lorelei A. Mucci
Summary: In the Health Professionals Follow-up Study (HPFS), African American men have a higher risk of prostate cancer and higher mortality rates compared to White men. Asian American men have a lower risk of prostate cancer, but similar risk of fatal disease compared to White men. Racial disparities in prostate cancer incidence and mortality cannot be fully explained by differences in lifestyle, diet, family history, or PSA screening.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anwar R. R. Padhani, Ivo G. G. Schoots
Summary: This article comprehensively reviews the integration of MRI as a diagnostic tool in prostate cancer screening and provides practical recommendations for optimizing its use. To strike a balance between the benefits of early detection and minimizing harm, understanding the context of MRI use is crucial. Patient selection and MRI-targeted biopsies are key to optimization, along with screening-specific MRI protocols and accuracy levels. Automation, image quality monitoring, post-processing, radiologist certification, and deep-learning computer-aided software contribute to improved readings. The optimal utilization of MRI involves integrating it into a multi-step diagnostic pathway with quality-assured, cost-effective infrastructure ensuring community-wide access.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Jukka K. Salminen, Viivu Kuoppamaki, Kirsi Talala, Kimmo Taari, Jussi Makinen, Jukka Peltola, Teuvo L. J. Tammela, Anssi Auvinen, Teemu J. Murtola
Summary: The study found that men using antiepileptic drugs had a decreased overall risk of prostate cancer compared to non-users. This risk reduction was similar among users of HDAC inhibitors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Urology & Nephrology
Mark N. Brook, Holly Ni Raghallaigh, Koveela Govindasami, Tokhir Dadaev, Reshma Rageevakumar, Diana Keating, Nafisa Hussain, Andrea Osborne, Artitaya Lophatananon, Kenneth R. Muir, Zsofia Kote-Jarai, Rosalind A. Eeles
Summary: A family history of prostate cancer is associated with an increased risk of developing the disease. This study examines how the number, degree, and age of relatives with prostate cancer are related to overall survival and prostate cancer-specific survival in prostate cancer patients.
Article
Medicine, General & Internal
Martin Eklund, Fredrik Jaderling, Andrea Discacciati, Martin Bergman, Magnus Annerstedt, Markus Aly, Axel Glaessgen, Stefan Carlsson, Henrik Groenberg, Tobias Nordstroem
Summary: In the context of organized prostate cancer screening, MRI with targeted and standard biopsy was shown to be noninferior to standard biopsy for detecting clinically significant prostate cancer, while also resulting in less detection of clinically insignificant cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Hojun Kim, Sungwook Park, In Gab Jeong, Sang Hoon Song, Youngdo Jeong, Choung-Soo Kim, Kwan Hyi Lee
Summary: The study introduces a method of precision screening for prostate cancer using a urinary multimarker biosensor combined with machine learning analysis. The research shows that under the best combination of biomarkers, this method can screen prostate cancer patients with more than 99% accuracy using 76 urine specimens.
Article
Oncology
Tomi Pakarainen, Jaakko Nevalainen, Kirsi Talala, Kimmo Taari, Jani Raitanen, Paula Kujala, Ulf-Hakan Stenman, Teuvo L. J. Tammela, Anssi Auvinen
Summary: The European Randomized Study of Screening for Prostate Cancer has shown that PSA-based screening can reduce prostate cancer mortality by 20% and lower the risk of advanced PC. Screening participation was found to increase the incidence of low-risk PC with the number of screens, while no clear relation was observed in intermediate and high-risk cases. Repeated screening is necessary to achieve the benefits of screening.
