Article
Immunology
Arthur VanValkenburg, Vaishnavi Kaipilyawar, Sonali Sarkar, Subitha Lakshminarayanan, Chelsie Cintron, Senbagavalli Prakash Babu, Selby Knudsen, Noyal Mariya Joseph, C. Robert Horsburgh, Jerrold J. Ellner, Prakash Babu Narasimhan, W. Evan Johnson, Natasha S. Hochberg, Padmini Salgame
Summary: This study found that malnourished individuals with latent tuberculosis infection (LTBI) exhibit increased activation of inflammatory pathways and higher expression of risk signatures associated with progression to TB, compared to control individuals. These findings suggest the potential for TB risk biomarkers to identify malnourished LTBI individuals for targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Weiwei Ma, Wenwen Li, Shuang Yu, Hongsheng Bian, Yanyan Wang, Yang Jin, Zhenhua Zhang, Qing Ma, Lili Huang
Summary: This study investigates the immunomodulatory effects of complex probiotics on immunosuppressed mice induced by cyclophosphamide. The results showed that the complex probiotics significantly improved immune indices, intestinal barrier, leukocyte and lymphocyte counts, splenic lymphocyte subpopulations, cytokine levels, and gut microbiota in the immunosuppressed mice. This study provides theoretical support for the immune-enhancing function of complex probiotics and their potential pharmacological development and utilization.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Paipai Guo, Zhen Wang, Zhengwei Zhou, Yu Tai, Aijun Zhang, Wei Wei, Qingtong Wang
Summary: Extensive research has identified the core components of Hippo signaling in Drosophila and mammals. The Hippo pathway controls tissue homeostasis by regulating cell proliferation and apoptosis, and may have a potential role in autoimmune disease. Understanding the role of Hippo signaling pathways in immune regulation is crucial for exploring novel therapeutic targets in AID.
IMMUNOLOGY LETTERS
(2021)
Review
Microbiology
Caitlin S. Pepperell
Summary: Mycobacterium tuberculosis, a globally distributed lethal pathogen, has developed antiphagocytic defenses and effector systems for adaptation. While losing the ability for lateral gene transfer, it retains the adaptability characteristic of mycobacteria. Studies of its evolution have provided important insights into the formation of new pathogens.
ANNUAL REVIEW OF MICROBIOLOGY
(2022)
Review
Immunology
Norio Chihara, Takashi Yamamura
Summary: Neuromyelitis optica (NMO) is an inflammatory disease similar to multiple sclerosis (MS), characterized by relapsing optic neuritis and myelitis. Autoantibodies against NMO play a crucial role in the inflammatory pathology involving proinflammatory cytokines and various inflammatory cells. Recent clinical trials have shown the efficacy of specific antibodies in preventing NMO relapses.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Immunology
Vasti Lozano-Ordaz, Yadira Rodriguez-Miguez, Angel E. Ortiz-Cabrera, Sujhey Hernandez-Bazan, Dulce Mata-Espinosa, Jorge Barrios-Payan, Rafael Saavedra, Rogelio Hernandez-Pando
Summary: This study compared the contribution of Treg cells, IDO, and HO-1 in mice infected with Mtb strains of different virulences. It found that these factors were detrimental for immune protection in mild virulence infection, but beneficial in highly virulent infection by regulating excessive inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Taif Shah, Zahir Shah, Nafeesa Yasmeen, Zulqarnain Baloch, Xueshan Xia
Summary: This article examines the pathogenesis and impact of coinfection between COVID-19 and TB, highlighting the diagnostic challenges associated with this dual infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Biying Xu, Jihong Tang, Cancan Lyu, Wambui S. Wandu, Deborah J. Stumpo, Mary J. Mattapallil, Reiko Horai, Igal Gery, Perry J. Blackshear, Rachel R. Caspi
Summary: TTP Delta ARE mice are resistant to experimental autoimmune uveitis, producing lower levels of pro-inflammatory cytokines and antibodies, and higher levels of anti-inflammatory cytokines and regulatory T-cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Qianting Yang, Furong Qi, Taosheng Ye, Jinpei Li, Gang Xu, Xiaomeng He, Guofang Deng, Peize Zhang, Mingfeng Liao, Kun Qiao, Zheng Zhang
Summary: Using single-cell RNA sequencing, this study found that Mtb infection leads to significant changes in the composition of immune cells in the lung, specifically in three subsets of macrophages associated with TB infection. One of these subsets, MM-CCL23, derived from monocytes after stimulation with Mtb, showed high levels of chemokine production and may serve as a marker for Mtb infection. The MM-CCL23 population primarily recruits CD8-CCR6 T cells through CCL20/CCR6, which is associated with protective immunity in LTBI.
EMERGING MICROBES & INFECTIONS
(2023)
Review
Microbiology
Julio Flores, Juan Carlos Cancino, Leslie Chavez-Galan
Summary: LAM has been suggested as a potential biomarker for the development of new point-of-care tests for TB diagnosis. This glycolipid can be easily detected in urine samples, making it a prominent candidate for such diagnostic tests.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Immunology
Paolo D'Avino, Gloria Serena, Victoria Kenyon, Alessio Fasano
Summary: Celiac disease is a unique autoimmune disease triggered by the ingestion of gluten, with a well-described genetic background. Understanding the pathogenesis of CD can shed light on the rise of autoimmune diseases in general.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Soo-Na Cho, Ji-Ae Choi, Junghwan Lee, Sang-Hun Son, Seong-Ahn Lee, Tam-Doan Nguyen, Song-Yi Choi, Chang-Hwa Song
Summary: The study revealed that Ang II-induced hypertension promotes cell death and lipid accumulation in the lungs during Mycobacterium tuberculosis infection, leading to severe pathogenesis of tuberculosis.
Article
Materials Science, Multidisciplinary
Xing Wang, Lianhua Qin, Weijun Fang, Dong Lin, Xiaolong Li, Beatrice Aramini, Ruijuan Zheng, Jiang Fan
Summary: This study aims to identify novel DNA methylation sites associated with endobronchial tuberculosis (EBTB) and understand their underlying pathological mechanisms. By performing genome-wide DNA methylation and mRNA expression profiling, the researchers identified 1258 DNA methylation regions (DMRs) associated with EBTB and established regulatory chains between DNA methylation and mRNA expression. The findings provide valuable resources for epigenetics studies in EBTB and enhance our understanding of the role of DNA methylation in EBTB pathology.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Materials Science, Biomaterials
Haoran Zhu, Yang Liu, Xinfeng Yi, Chuyun Zhu, Yuanyue Fu, Zerong Huang, Kairui Zhu, Wencai Zhang, Huige Hou, Chenghong Sun, Cheng Zhong, Wei Liu, Zhizhong Li, Baocheng Wang, Jin Wo
Summary: A novel biomimetic nanoparticle system was designed to enhance both targeted chemotherapy and immune response in solid tumor therapy. In vitro and in vivo experiments demonstrated that this system effectively promoted antitumor efficiency and increased CD8+ T cell activation and cytokine production, while reducing myeloid-derived suppressor cell (MDSC) levels in tumors.
BIOMATERIALS ADVANCES
(2023)
Article
Biochemistry & Molecular Biology
Ajit Kumar, Priyanka Sharma, Akanksha Arun, Laxman S. Meena
Summary: Tuberculosis is a fast spreading, transmissible disease with a high death rate due to a lack of appropriate treatment and preventative measures. Researchers have developed a multi-epitope vaccine against Mycobacterium tuberculosis and conducted validation studies, which show that the vaccine is stable and effective in the biological environment.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Critical Care Medicine
Kevin P. Fennelly, Edward C. Jones-Lopez, Irene Ayakaka, Soyeon Kims, Harriet Menyha, Bruce Kirenga, Christopher Muchwa, Moses Joloba, Scott Dryden-Peterson, Nancy Reilly, Alphonse Okwera, Alison M. Elliott, Peter G. Smith, Roy D. Mugerwa, Kathleen D. Eisenach, Jerrold J. Ellner
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2012)
Article
Infectious Diseases
Sam Ogwang, Benon B. Asiimwe, Hamidou Traore, Francis Mumbowa, Alphonse Okwera, Kathleen D. Eisenach, Susan Kayes, Edward C. Jones-Lopez, Ruth McNerney, William Worodria, Irene Ayakaka, Roy D. Mugerwa, Peter G. Smith, Jerrold Ellner, Moses L. Joloba
BMC INFECTIOUS DISEASES
(2009)
Article
Cell Biology
Hiroe Shiratsuchi, Jerrold J. Ellner, Marc D. Basson
CELL AND TISSUE RESEARCH
(2008)
Article
Immunology
Beth Temple, Irene Ayakaka, Sam Ogwang, Helen Nabanjja, Susan Kayes, Susan Nakubulwa, William Worodria, Jonathan Levin, Moses Joloba, Alphonse Okwera, Kathleen D. Eisenach, Ruth McNerney, Alison M. Elliott, Peter G. Smith, Roy D. Mugerwa, Jerrold J. Ellner, Edward C. Jones-Lopez
CLINICAL INFECTIOUS DISEASES
(2008)
Review
Medicine, Research & Experimental
Jerrold J. Ellner
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2008)
Review
Medicine, Research & Experimental
Jerrold J. Ellner
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2009)
Article
Immunology
Katherine C. Tang, Katarzyna A. Trzaska, Sergey V. Smirnov, Sergei V. Kotenko, Stephan K. Schwander, Jerrold J. Ellner, Pranela Rameshwar
JOURNAL OF IMMUNOLOGY
(2008)
Article
Immunology
Payam Nahid, Peter S. Kim, Carlton A. Evans, David Alland, Michael Barer, Jane Diefenbach, Jerrold Ellner, Richard Hafner, Carol Dukes Hamilton, Michael F. Iademarco, Gregory Ireton, Michael E. Kimerling, Christian Lienhardt, William R. MacKenzie, Megan Murray, Mark D. Perkins, Jamie E. Posey, Teri Roberts, Christine Sizemore, Wendy S. Stevens, Laura Via, Sharon D. Williams, Wing W. Yew, Susan Swindells
JOURNAL OF INFECTIOUS DISEASES
(2012)
Article
Immunology
Maria Teresa Herrera, Martha Torres, Denarra Nevels, Carlos Nunez Perez-Redondo, Jerrold J. Ellner, Eduardo Sada, Stephan K. Schwander
Review
Immunology
Wasiulla Rafi, Rodrigo Ribeiro-Rodrigues, Jerrold J. Ellner, Padmini Salgame
CURRENT OPINION IN HIV AND AIDS
(2012)
Article
Medicine, General & Internal
Edward C. Jones-Lopez, Irene Ayakaka, Jonathan Levin, Nancy Reilly, Francis Mumbowa, Scott Dryden-Peterson, Grace Nyakoojo, Kevin Fennelly, Beth Temple, Susan Nakubulwa, Moses L. Joloba, Alphonse Okwera, Kathleen D. Eisenach, Ruth McNerney, Alison M. Elliott, Jerrold J. Ellner, Peter G. Smith, Roy D. Mugerwa
Article
Immunology
Tom H. M. Ottenhoff, Jerrold J. Ellner, Stefan H. E. Kaufmann
Article
Respiratory System
Esmeralda Juarez, Carlos Nunez, Eduardo Sada, Jerrold J. Ellner, Stephan K. Schwander, Martha Torres
RESPIRATORY RESEARCH
(2010)
Article
Respiratory System
Esmeralda Juarez, Carlos Nunez, Eduardo Sada, Jerrold J. Ellner, Stephan K. Schwander, Martha Torres
RESPIRATORY RESEARCH
(2010)
