Biomarkers for glioma immunotherapy: the next generation

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

(2015) Michael S. Rooney et al.   CELL

Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

(2015) Laura A. Johnson et al.   Science Translational Medicine

Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

(2015) Paul A. Clark et al.   NEOPLASIA

Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens

(2014) Torsten Nielsen et al.   BMC CANCER

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors—Response

(2014) Jaikumar Duraiswamy et al.   CANCER RESEARCH

The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression

(2014) A. M. Sonabend et al.   CANCER RESEARCH

 -Galactosylceramide but Not Phenyl-Glycolipids Induced NKT Cell Anergy and IL-33-Mediated Myeloid-Derived Suppressor Cell Accumulation via Upregulation of egr2/3

(2014) J.-R. Huang et al.   JOURNAL OF IMMUNOLOGY

IDH1 mutation and MGMT methylation status predict survival in patients with anaplastic astrocytoma treated with temozolomide-based chemoradiotherapy

(2014) Giuseppe Minniti et al.   JOURNAL OF NEURO-ONCOLOGY

Validation of a prognostic multi-gene signature in high-risk neuroblastoma using the high throughput digital NanoString nCounter™ system

(2014) Thomas P. Stricker et al.   Molecular Oncology

A vaccine targeting mutant IDH1 induces antitumour immunity

(2014) Theresa Schumacher et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

EGFRvIII-Specific Chimeric Antigen Receptor T Cells Migrate to and Kill Tumor Deposits Infiltrating the Brain Parenchyma in an Invasive Xenograft Model of Glioblastoma

(2014) Hongsheng Miao et al.   PLoS One

miR-135b Contributes to the Radioresistance by Targeting GSK3β in Human Glioblastoma Multiforme Cells

(2014) Songhua Xiao et al.   PLoS One

MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma

(2014) B. J. Gill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Fiery Side of HIV-Induced T Cell Death

(2014) G. D. Gaiha et al.   SCIENCE

Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes

(2014) Lidia Robert et al.   OncoImmunology

Cytokine responsiveness of CD8+ T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients

(2014) Richard G Everson et al.   Journal for ImmunoTherapy of Cancer

The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma

(2014) Minghui Li et al.   Journal for ImmunoTherapy of Cancer

Exploration of the gene fusion landscape of glioblastoma using transcriptome sequencing and copy number data

(2013) Nameeta Shah et al.   BMC GENOMICS

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy

(2013) V. Chandramohan et al.   CLINICAL CANCER RESEARCH

Biomarkers for Immunostimulatory Monoclonal Antibodies in Combination Strategies for Melanoma and Other Tumor Types

(2013) P. A. Ascierto et al.   CLINICAL CANCER RESEARCH

EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss

(2013) J. H. Sampson et al.   CLINICAL CANCER RESEARCH

Anti-programmed death-1 and anti-programmed death-ligand 1 antibodies in cancer therapy

(2013) Omid Hamid et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner

(2013) S. H. Stricker et al.   GENES & DEVELOPMENT

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

(2013) Johannes vom Berg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours

(2013) Jérôme Galon et al.   JOURNAL OF PATHOLOGY

Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma

(2013) Yasufumi Katanasaka et al.   Molecular Cancer

Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer

(2013) Charles G. Drake et al.   Nature Reviews Clinical Oncology

Identification of prognostic gene signatures of glioblastoma: a study based on TCGA data analysis

(2013) Y.-W. Kim et al.   NEURO-ONCOLOGY

Gefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastoma

(2013) J. J. Parker et al.   NEURO-ONCOLOGY

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

(2013) Omid Hamid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Frequency of ICOS+ CD4 T Cells as a Pharmacodynamic Biomarker for Anti-CTLA-4 Therapy

(2013) D. Ng Tang et al.   Cancer Immunology Research

Immune monitoring using the predictive power of immune profiles

(2013) Michael P Gustafson et al.   Journal for ImmunoTherapy of Cancer

Rational combinations of immunotherapeutics that target discrete pathways

(2013) Stefani Spranger et al.   Journal for ImmunoTherapy of Cancer

Tumor-Associated Macrophages in Glioma: Friend or Foe?

(2013) Benjamin C. Kennedy et al.   Journal of Oncology

α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial

(2012) Yasuto Akiyama et al.   BMC CANCER

Immune genes are associated with human glioblastoma pathology and patient survival

(2012) Elodie Vauléon et al.   BMC Medical Genomics

Exploiting the glioblastoma peptidome to discover novel tumour-associated antigens for immunotherapy

(2012) Valérie Dutoit et al.   BRAIN

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma

(2012) Surasak Phuphanich et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-term Tumor Regression

(2012) X. Liang et al.   CANCER RESEARCH

STATs Shape the Active Enhancer Landscape of T Cell Populations

(2012) Golnaz Vahedi et al.   CELL

Individual Patient-Specific Immunity against High-Grade Glioma after Vaccination with Autologous Tumor Derived Peptides Bound to the 96 KD Chaperone Protein

(2012) C. A. Crane et al.   CLINICAL CANCER RESEARCH

Tim-3, a negative regulator of anti-tumor immunity

(2012) Ana Carrizosa Anderson   CURRENT OPINION IN IMMUNOLOGY

Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma

(2012) Richard A. Morgan et al.   HUMAN GENE THERAPY

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes

(2012) Evan W. Newell et al.   IMMUNITY

T Cells Redirected to EphA2 for the Immunotherapy of Glioblastoma

(2012) Kevin KH Chow et al.   MOLECULAR THERAPY

Phase II trial of continuous low-dose temozolomide for patients with recurrent malignant glioma

(2012) Antonio Omuro et al.   NEURO-ONCOLOGY

Immunotherapy for Glioma

(2012) Seunggu J. Han et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

A Pilot Study of IL-2Rα Blockade during Lymphopenia Depletes Regulatory T-cells and Correlates with Enhanced Immunity in Patients with Glioblastoma

(2012) John H. Sampson et al.   PLoS One

Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

(2012) D. Singh et al.   SCIENCE

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

(2011) O. M. Pello et al.   BLOOD

The Present and Future of Peptide Vaccines for Cancer

(2011) Craig L. Slingluff   CANCER JOURNAL

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

(2011) S.-R. Woo et al.   CANCER RESEARCH

Clinical Application of a Dendritic Cell Vaccine Raised Against Heat-Shocked Glioblastoma

(2011) X. Jie et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

(2011) T. R. Sippel et al.   CLINICAL CANCER RESEARCH

Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide

(2011) Stuart A. Grossman et al.   CLINICAL CANCER RESEARCH

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes

(2011) R. L. Warren et al.   GENOME RESEARCH

A phase I/II clinical trial investigating the adverse and therapeutic effects of a postoperative autologous dendritic cell tumor vaccine in patients with malignant glioma

(2011) Chen-Nen Chang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Mechanisms of necroptosis in T cells

(2011) Irene L. Ch’en et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defining the critical hurdles in cancer immunotherapy

(2011) Bernard A Fox et al.   Journal of Translational Medicine

Vaccination Alters the Balance between Protective Immunity, Exhaustion, Escape, and Death in Chronic Infections

(2011) P. L. F. Johnson et al.   JOURNAL OF VIROLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural Phenotype

(2011) Liang Lei et al.   PLoS One

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer

(2011) Cathy A. Andorfer et al.   TRENDS IN MOLECULAR MEDICINE

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors

(2010) N. Ahmed et al.   CLINICAL CANCER RESEARCH

Temozolomide Versus Procarbazine, Lomustine, and Vincristine in Recurrent High-Grade Glioma

(2010) Michael Brada et al.   JOURNAL OF CLINICAL ONCOLOGY

Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

(2010) John H. Sampson et al.   JOURNAL OF CLINICAL ONCOLOGY

Rebound tumour progression after the cessation of bevacizumab therapy in patients with recurrent high-grade glioma

(2010) Richard M. Zuniga et al.   JOURNAL OF NEURO-ONCOLOGY

Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy

(2010) Xinmei Zhu et al.   JOURNAL OF NEURO-ONCOLOGY

Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma

(2010) S. Kunwar et al.   NEURO-ONCOLOGY

The paradoxical effect of bevacizumab in the therapy of malignant gliomas

(2010) E. M. Thompson et al.   NEUROLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance

(2010) V. A. Pedicord et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets

(2010) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a Long-Time Survival in Murine Model of Glioma

(2010) Marie-Denise Poirier et al.   Journal of Oncology

The EGFRvIII variant in glioblastoma multiforme

(2009) Hui K. Gan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

Expression of Tolerance Associated Gene-1, a Mitochondrial Protein Inhibiting T Cell Activation, Can Be Used to Predict Response to Immune Modulating Therapies

(2009) K. Keeren et al.   JOURNAL OF IMMUNOLOGY

Intralesional Lymphokine-activated Killer Cells as Adjuvant Therapy for Primary Glioblastoma

(2009) Robert Owen Dillman et al.   JOURNAL OF IMMUNOTHERAPY

Poor drug distribution as a possible explanation for the results of the PRECISE trial

(2009) John H. Sampson et al.   JOURNAL OF NEUROSURGERY

Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection

(2009) J. N. Blattman et al.   JOURNAL OF VIROLOGY

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

DC vaccination with anti-CD25 treatment leads to long-term immunity against experimental glioma

(2009) Wim Maes et al.   NEURO-ONCOLOGY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

TGF-β and tumors—an ill-fated alliance

(2008) Niki M Moutsopoulos et al.   CURRENT OPINION IN IMMUNOLOGY

Recommendations for the assessment of progression in randomised cancer treatment trials

(2008) J.E. Dancey et al.   EUROPEAN JOURNAL OF CANCER

EGF receptor variant III as a target antigen for tumor immunotherapy

(2008) Gordon Li et al.   Expert Review of Vaccines

Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma

(2008) Teri N. Kreisl et al.   JOURNAL OF CLINICAL ONCOLOGY

An exploratory survival analysis of anti-angiogenic therapy for recurrent malignant glioma

(2008) Andrew D. Norden et al.   JOURNAL OF NEURO-ONCOLOGY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Direct multiplexed measurement of gene expression with color-coded probe pairs

(2008) Gary K Geiss et al.   NATURE BIOTECHNOLOGY

K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer

(2008) Christos S. Karapetis et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE