Article
Multidisciplinary Sciences
Ran Pang, Lei Dong, Jingfeng Liu, Xiaojun Ji, Haizhou Zhuang, Meili Duan
Summary: The current study suggests that sepsis induces autophagy in renal endothelial cells, and upregulation of autophagy in these cells can alleviate endothelial injury and AKI. In addition, the kidney-specific protein BAMBI is induced by sepsis and may play a role in regulating endothelial stability in septic AKI.
Article
Environmental Sciences
Rong Jiang, Lei Han, Qianqian Gao, Jie Chao
Summary: The study revealed that ZC3H4 plays a regulatory role in silica-induced EndoMT, mediating the process through ER stress and autophagy. This suggests that ZC3H4 may serve as a potential novel target for pulmonary fibrosis treatment.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Cell Biology
Jennifer S. Fang, Nan W. Hultgren, Christopher C. W. Hughes
Summary: Endothelial cells have the ability to undergo complete endothelial-to-mesenchymal transition to generate mesenchymal cells. Research indicates that endothelial cells can also undergo partial transition to generate cells with intermediate characteristics, which is temporary, reversible, and supports developmental and pathological angiogenesis. Possible regulatory mechanisms that control the transition program and potential therapeutic targets in cancer are discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Geoffrey Newcomb, Laszlo Farkas
Summary: Our understanding of the pathophysiology of pulmonary arterial hypertension (PAH) has evolved over recent years, highlighting the importance of endothelial cell dysfunction and inflammation. Pulmonary vascular endothelial cells play a unique role in maintaining vascular integrity and function, and their dysregulated response to injury contributes to the development of PAH. Recent research has shown the presence of multiple distinct subpopulations of endothelial cells and their involvement in aberrant endothelial injury repair. Factors such as clonal expansion, immune dysregulation, and genetic mutations also play a role in the pathogenesis of PAH.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sara Shoeibi, Elahe Mahdipour, Shabnam Mohammadi, Mohsen Moohebati, Majid Ghayour-Mobarhan
Summary: Transplantation of EPCs overexpressing DDAH2 may enhance the repair of injured endothelium by reducing inflammation and restoring endothelial function, making it a potentially valuable tool for the treatment of atherosclerosis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Tianshi Sun, Dengke Wu, Youwen Deng, Dongshan Zhang
Summary: In this study, it was found that EGFR plays a crucial role in rhabdomyolysis-induced acute kidney injury by promoting autophagy and kidney cell apoptosis via the STAT3/Atg7 axis. Additionally, gefitinib represents a potential therapeutic option for acute kidney injury.
Article
Biochemistry & Molecular Biology
Jihoon Kim, Chisato Shimizu, Ming He, Hao Wang, Hal M. Hoffman, Adriana H. Tremoulet, John Y. -J. Shyy, Jane C. Burns
Summary: In this study, RNA sequencing of endothelial cells cultured with sera from KD, MIS-C, and healthy controls revealed differential gene expression patterns, including increased TNFa/NF?B pathway genes and decreased genes related to EC homeostasis and endothelial-mesenchymal transition (EndoMT) in MIS-C. Further analysis identified differentially expressed genes between MIS-C and KD, indicating increased pro-survival transcripts and genes influencing autophagy in MIS-C, while transcripts related to EndoMT and EC homeostasis were reduced. These findings suggest that the endothelial cell response may contribute to the different cardiovascular outcomes in KD and MIS-C.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Chak Kwong Cheng, Xiao Lin, Yujie Pu, Joyce Ka Yu Tse, Yu Wang, Cheng-Lin Zhang, Xiaoyun Cao, Chi Wai Lau, Juan Huang, Lei He, Jiang-Yun Luo, Yu-Tsung Shih, Song Wan, Chi Fai Ng, Li Wang, Ronald Ching Wan, Jeng-Jiann Chiu, Ting Fung Chan, Xiao Yu Tian, Yu Huang
Summary: This study utilized single-cell RNA sequencing to explore the transcriptional landscape and heterogeneity of dysfunctional endothelial cells in atherosclerotic aortae. SOX4 was identified as a novel marker for atherosclerosis and was shown to promote atherogenesis and endothelial-to-mesenchymal transition. Hyperlipidemia-associated cytokines and oscillatory blood flow were found to upregulate SOX4 expression, while the anti-diabetic drug metformin suppressed SOX4 levels in endothelial cells.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Geriatrics & Gerontology
Y. Li, W. Cui, B. Song, X. Ye, Z. Li, C. Lu
Summary: This study found that SIRT1 activator has a negative regulatory effect on weight, blood lipid levels, and lesion conditions in AS mice, and reduces the CD34+/VEGFR2+ density in aortic tissues. In in vitro experiments, the SIRT1 activator promotes the proliferation and migration of EPCs and acts through the wnt/beta-catenin/GSK3 beta signaling pathway.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Biochemistry & Molecular Biology
Sawssen Ben Fraj, Sina Naserian, Bileyle Lorenzini, Sylvie Goulinet, Philippe Mauduit, Georges Uzan, Houda Haouas
Summary: Circulating endothelial progenitor cells (EPCs) play a pivotal role in angiogenesis-related diseases. However, their clinical use is limited due to storage conditions and immune rejection. EPC-derived extracellular vesicles (EPC-EVs) may be an alternative, as they enhance EPC regenerative functions without altering their endothelial identity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Huiling Liu, Zhou Huang, Hong Jiang, Ke Su, Zilin Si, Wenhui Wu, Hanyu Wang, Dongxue Li, Ninghua Tan, Zhihao Zhang
Summary: This study found that dihydroartemisinin can improve renal aging and injury by activating autophagy. It suggests that activation of autophagy and elimination of senescent cells may be an effective strategy for preventing kidney damage and fibrosis.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Review
Biochemistry & Molecular Biology
Kondababu Kurakula, Valerie F. E. D. Smolders, Olga Tura-Ceide, J. Wouter Jukema, Paul H. A. Quax, Marie-Jose Goumans
Summary: This review highlights the crucial role of endothelial cell dysfunction in pulmonary arterial hypertension (PAH) and its contribution to the progression of the disease. The activation of various cellular signaling pathways due to endothelial cell dysfunction ultimately leads to pulmonary artery remodeling and occlusion. Understanding the molecular signals orchestrating endothelial cell dysfunction in PAH is essential for exploring therapeutic interventions targeting this process.
Article
Pharmacology & Pharmacy
Muthu Kumar Krishnamoorthi, Rajarajan A. A. Thandavarayan, Keith A. A. Youker, Arvind Bhimaraj
Summary: Endothelial cells can undergo a transition called endothelial-to-mesenchymal (EndoMT) in response to external stimuli, which is characterized by a change in phenotype. This process has been recognized in both developmental and pathological contexts, including fibrotic diseases. The study presents an in vitro method using L-NAME and Ang II to induce and reversibility of EndoMT in Human umbilical vascular endothelial cells (HUVECs). This method may be useful for drug discovery and development targeting the EndoMT process.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Paul-Lennard Mendez, Leon Obendorf, Jerome Jatzlau, Wiktor Burdzinski, Maria Reichenbach, Vanasa Nageswaran, Arash Haghikia, Verena Stangl, Christian Hiepen, Petra Knaus
Summary: This study investigates the role of Endoglin in regulating SMAD1/5 activation under physiological flow conditions and identifies Caveolin-1-positive early endosomes as a novel flow-regulated signaling compartment for BMP9-ALK1-Endoglin signaling axis in atheroprone flow conditions.
Article
Biochemistry & Molecular Biology
Dunpeng Cai, Shi-You Chen
Summary: This study found that endothelial cell dysfunction is a key factor in pulmonary hypertension induced by chronic hypoxia and concluded that endothelial to mesenchymal transition (EndoMT) plays an important role in this process. The delivery of nanoparticle-mediated endothelial-specific overexpression of PGC-1 alpha can attenuate the progression of PH, restore endothelial function, and reduce vascular remodeling.