Article
Gastroenterology & Hepatology
Hiroyoshi Iwata, Naoto Matsuno, Daisuke Ishii, Asuka Toriumi, Masahide Otani, Mizuho Ohara, Hiromichi Obara, Yuji Nishikawa, Hideki Yokoo
Summary: This study compared the use of University of Wisconsin solution and histidine-tryptophan-ketoglutarate solution as machine perfusion solutions for marginal liver grafts. The results showed that histidine-tryptophan-ketoglutarate solution can decrease vascular resistance, reduce shear stress, and protect sinusoid epithelial cells in split-liver grafts.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Valentina Veloso-Gimenez, Rosalba Escamilla, David Necunir, Rocio Corrales-Orovio, Sergio Riveros, Carlo Marino, Carolina Ehrenfeld, Christian Dani Guzman, Mauricio P. Boric, Rolando Rebolledo, Jose Tomas Egana
Summary: This study aimed to develop a perfusable photosynthetic solution with microalgae embedded to supply oxygen and support ex vivo organ preservation. The research found that the photosynthetic solution did not harm animal cells and provided sufficient oxygen to meet metabolic demands. Experimental validation showed that during organ perfusion, the photosynthetic microorganisms could reach the renal vasculature without causing tissue damage, surviving the process successfully.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemical Research Methods
Shingo Kaneko, Sugiura Hirotaka, Masaru Tsujii, Hisataka Maruyama, Nobuyuki Uozumi, Fumihito Arai
Summary: A novel on-chip method was presented to evaluate the effect of osmotic stress on microorganisms at the single-cell level. It allowed concurrent evaluation of cell viability and water permeability in response to millisecond-order osmotic shock. The results confirmed that cells with higher water permeability were more likely to die after osmotic shock.
Article
Plant Sciences
Marwa Sulaiman Al Hinai, Aman Ullah, Rashid Said Al-Rajhi, Muhammad Farooq
Summary: The study revealed significant differences in the responses of bread wheat genotypes to salt stress, showing a notable decrease in plant growth and carbon assimilation with increasing salinity levels. Some genotypes exhibited strong salt tolerance, which could be beneficial for future breeding programs.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Review
Chemistry, Medicinal
Yi-Feng Wang, Jia-Wei Li, Da-Peng Wang, Ke Jin, Jiao-Jie Hui, Hong-Yang Xu
Summary: Intestinal barrier injury and hyperglycemia are common in patients with sepsis. Hyperglycemia is an independent risk factor for intestinal barrier injury. Some anti-hyperglycemic agents can improve intestinal barrier function and are beneficial in managing sepsis-induced organ dysfunction.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Xina Dou, Lei Qiao, Xiaofan Song, Jiajing Chang, Shanyao Pi, Xinyi Zhang, Xiaonan Zeng, Lixu Zhu, Chunlan Xu
Summary: This study reveals that the protective effects of selenium nanoparticles (SeNPs) against intestinal epithelial barrier dysfunction are associated with mitochondria-lysosomal crosstalk. SeNPs can alleviate intestinal epithelial barrier injury through regulating mitochondrial autophagy. These findings suggest that the protective effect of SeNPs on intestinal epithelial barrier injury is closely associated with the TBC1D15/Rab7-mediated mitochondria-lysosome crosstalk signaling pathway.
Article
Plant Sciences
Tanveer Ahmad Khan, Mohd Saleem, Qazi Fariduddin
Summary: Salinity stress severely affects plant growth and yield, but the application of Melatonin (Mel) has shown promising results in improving salt tolerance in crops. This review systematically discusses how Mel mediates plant responses to salt stress by fine-tuning signaling pathways, interacting with nitric oxide, and acting as a multifaceted antioxidant molecule, thereby enhancing plant tolerance to salt stress.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ebrahim Asadi, Atefeh Najafi, James D. Benson
Summary: This study determined the osmotic tolerance limits (OTLs) of ovarian stromal cells (OSCs) and investigated their relationship with reactive oxygen species (ROS) and mitochondrial respiratory chain activity (MRCA) of OSCs for the first time. The addition of an optimal dose of melatonin was found to expand the OTLs of OSCs and significantly reduce ROS, improve MRCA, total antioxidant capacity (TAC), and viability. The narrow osmotic window of OSCs emphasizes the importance of optimizing ovarian tissue cryopreservation transplantation (OTCT) protocols to maintain enough alive stromal cells, which are essential for follicle development and graft longevity.
Article
Plant Sciences
Muhammad Yousuf Adnan, Tabassum Hussain, Muhammad Zaheer Ahmed, Bilquees Gul, M. Ajmal Khan, Brent L. Nielsen
Summary: The salt resistance strategies of Desmostachya bipinnata involve coordinated organ-specific responses to different concentrations of salt stress, regulating water flux and ion distribution to adapt to hyperosmotic conditions. Decreases in biomass under saline treatments are considered a survival strategy for energy reallocation in harsh environments. Organ-specific responses to salinity concentrations suggest that different organs work together to achieve better yields in moderately saline areas.
ACTA PHYSIOLOGIAE PLANTARUM
(2021)
Article
Biochemistry & Molecular Biology
Marcos Elias Duarte, Sung Woo Kim
Summary: This study aimed to investigate the effects of phytobiotics on the intestinal health and growth performance of pigs. The results showed that phytobiotics improved growth performance by reducing oxidative stress and enhancing immune status and jejunal morphology in pigs. However, the combinational use of phytobiotics with antibiotics suppressed their effect.
Article
Medicine, General & Internal
Paolo Murabito, Marinella Astuto, Filippo Sanfilippo, Luigi La Via, Francesco Vasile, Francesco Basile, Alessandro Cappellani, Lucia Longhitano, Alfio Distefano, Giovanni Li Volti
Summary: This study demonstrates that the use of an early warning system coupled with a hemodynamic algorithm can reduce intraoperative hypotension and decrease levels of neuronal specific enolase and oxidative stress.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Nagwa Mohamed, Dalia H. El-Kashef, Ghada M. Suddek
Summary: Flavocoxid demonstrated a potential protective effect in acetic acid-induced colitis model, by attenuating oxidative stress, inflammation, and apoptosis in colonic tissues of rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Agronomy
Seyed Morteza Zahedi, Marjan Sadat Hosseini, Naghmeh Daneshvar Hakimi Meybodi, Javier Abadia, Mateja Germ, Rahmatollah Gholami, Mostafa Abdelrahman
Summary: Drought stress has adverse effects on pomegranate fruit productivity, characteristics, and composition. Different cultivars have different responses to drought stress. Under intense drought, there were significant decreases in fruit yield, number of fruits per tree, fruit weight, and leaf photosynthetic pigments. However, the levels of certain metabolites and activities of antioxidant enzymes increased. Intense drought also caused a decrease in the quality of fruit juice.
AGRICULTURAL WATER MANAGEMENT
(2022)
Article
Plant Sciences
Gustavo Ferreira de Sousa, Maila Adriely Silva, Mariana Rocha de Carvalho, Everton Geraldo de Morais, Pedro Antonio Namorato Benevenute, Gustavo Avelar Zorgdrager Van Opbergen, Guilherme Gerrit Avelar Zorgdrager Van Opbergen, Luiz Roberto Guimaraes Guilherme
Summary: This study aimed to investigate the role of Se supply in improving osmotic stress tolerance in coffee seedlings while also evaluating the best timing for Se application. Results demonstrated that osmotic stress promoted mild stress in the coffee plants and led to starch degradation. Seedlings that received foliar Se application 8 days before the stress exhibited higher antioxidant enzyme activity compared to the control group.
Article
Plant Sciences
Pin-Hua Lin, Yun-Yang Chao
Summary: This experiment investigated the effects of different water supply conditions on the growth of two djulis varieties, showing that drought stress significantly reduced plant growth and relative water content, increased antioxidant enzyme activities, total soluble sugars, and proline content. The study also revealed differences in drought tolerance mechanisms between Chenopodium formosana and Chenopodium quinoa.
Article
Oncology
Mark E. Sherman, Thomas de Bel, Michael G. Heckman, Launia J. White, Joshua Ogony, Melody Stallings-Mann, Tracy Hilton, Amy C. Degnim, Robert A. Vierkant, Tanya Hoskin, Matthew R. Jensen, Laura Pacheco-Spann, Jill E. Henry, Anna Maria Storniolo, Jodi M. Carter, Stacey J. Winham, Derek C. Radisky, Jeroen van der Laak
Summary: Serum hormone levels are associated with quantitative features of normal breast tissue. These associations may be modified by parity and tissue composition.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Editorial Material
Clinical Neurology
Andres A. Maldonado, Ryan F. Planchard, Megan M. Jack, Brandon W. Smith, Jodi M. Carter, Robert J. Spinner
WORLD NEUROSURGERY
(2022)
Article
Genetics & Heredity
Yuanhang Liu, Aditya Bhagwate, Stacey J. Winham, Melissa T. Stephens, Brent W. Harker, Samantha J. McDonough, Melody L. Stallings-Mann, Ethan P. Heinzen, Robert A. Vierkant, Tanya L. Hoskin, Marlene H. Frost, Jodi M. Carter, Michael E. Pfrender, Laurie Littlepage, Derek C. Radisky, Julie M. Cunningham, Amy C. Degnim, Chen Wang
Summary: Failed bioinformatics qc in FFPE samples was associated with low sample-wise correlation, reads mapped to gene regions, and detectable genes. A decision tree model based on RNA concentration and library qubit values achieved a high F score in predicting QC status of FFPE samples. Recommendations include a minimum RNA concentration of 25 ng/ul and pre-capture library output of 1.7 ng/ul for adequate RNA-seq data.
BMC MEDICAL GENOMICS
(2022)
Article
Surgery
Marie Osdoit, Christina Yau, W. Fraser Symmans, Judy C. Boughey, Cheryl A. Ewing, Ron Balassanian, Yunn-Yi Chen, Gregor Krings, Anne M. Wallace, Somaye Zare, Oluwole Fadare, Rachael Lancaster, Shi Wei, Constantine Godellas, Ping Tang, Todd M. Tuttle, Molly Klein, Sunati Sahoo, Tina J. Hieken, Jodi M. Carter, Beiyun Chen, Gretchen Ahrendt, Julia Tchou, Michael Feldman, Eleni Tousimis, Jay Zeck, Nora Jaskowiak, Husain Sattar, Arpana M. Naik, Marie Catherine Lee, Marilin Rosa, Laila Khazai, Mara H. Rendi, Julie E. Lang, Janice Lu, Ossama Tawfik, Smita M. Asare, Laura J. Esserman, Rita A. Mukhtar
Summary: This study analyzed the association of residual ductal carcinoma in situ (DCIS) in surgical specimens after neoadjuvant chemotherapy for breast cancer with survival end points. The results support the definition of pathologic complete response (pCR) as the absence of invasive disease after neoadjuvant chemotherapy regardless of the presence or absence of DCIS.
Article
Oncology
Ishwar N. Kohale, Jia Yu, Yongxian Zhuang, Xiaoyang Fan, Raven J. Reddy, Jason Sinnwell, Krishna R. Kalari, Judy C. Boughey, Jodi M. Carter, Matthew P. Goetz, Liewei Wang, Forest M. White
Summary: Breast cancer is the leading cause of cancer-related deaths in women globally, with triple negative breast cancer (TNBC) known for being highly aggressive and resistant to chemotherapy. In this study, the researchers identified Src family kinases (SFKs) as potential drug targets for chemotherapy-resistant TNBC. However, the prevalence of SFK-driven tumors was found to be low in human tumor tissue specimens. These findings highlight the importance of characterizing phosphotyrosine signaling profiles for patient stratification and therapeutic options.
Article
Oncology
Lixuan Wei, Huanyao Gao, Jia Yu, Huan Zhang, Thanh Thanh L. Nguyen, Yayun Gu, Marie R. Passow, Jodi M. Carter, Bo Qin, Judy C. Boughey, Matthew P. Goetz, Richard M. Weinshilboum, James N. Ingle, Liewei Wang
Summary: Androgen receptor (AR) is expressed in the majority of estrogen receptor a-positive (ER+) breast cancers. The efficacy of AR-targeting therapies, including both AR agonists and AR inhibitors, is dependent on the levels of AR and ERa. ENZ functions as an ERa antagonist in low AR expression breast cancer, while RAD140 activates AR signaling and suppresses AR-high tumor growth. Overall, this study provides insights into the clinical application of AR-targeting therapy based on the AR/ER ratio in ER+ breast cancers.
Article
Multidisciplinary Sciences
Alexander S. Roesler, Smriti Malasi, Lori Koslosky, Peter Hartmayer, Tammey J. Naab, Jodi M. Carter, David Zahrieh, David Hillman, Roberto A. Leon-Ferre, Fergus J. Couch, Matthew P. Goetz, Karen S. Anderson, Barbara A. Pockaj, Michael T. Barrett
Summary: We investigated the prevalence, prognostic value, and enrichment by chemotherapy of the PDJ amplicon in TNBC. Our findings demonstrate that the prevalence of PDJ amplicons in TNBC varies extensively and is associated with poor clinical outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Amy C. Degnim, Brittany L. Siontis, Safia K. Ahmed, Tanya L. Hoskin, Tina J. Hieken, James W. Jakub, Christian L. Baum, Courtney Day, Sarah E. Schrup, Lauren Smith, Jodi M. Carter, Tiffany M. Sae Kho, Katrina N. Glazebrook, Aparna Vijayasekaran, Scott H. Okuno, Ivy A. Petersen
Summary: This study evaluated the impact of trimodality treatment compared to monotherapy or dual therapy for radiation-associated angiosarcoma of the breast (RAASB) after prior breast cancer treatment. The study found that trimodality therapy demonstrated a higher rate of pathological complete response and improved 5-year recurrence-free survival, but had more surgical complications and toxic effects.
CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jodi M. Carter, Saranya Chumsri, Douglas A. Hinerfeld, Yaohua Ma, Xue Wang, David Zahrieh, David W. Hillman, Kathleen S. Tenner, Jennifer M. Kachergus, Heather Ann Brauer, Sarah E. Warren, David Henderson, Ji Shi, Yi Liu, Heikki Joensuu, Henrik Lindman, Roberto A. Leon-Ferre, Judy C. Boughey, Minetta C. Liu, James N. Ingle, Krishna R. Kalari, Fergus J. Couch, Keith L. Knutson, Matthew P. Goetz, Edith A. Perez, E. Aubrey Thompson
Summary: The use of spatial immunobiomarker quantitation is being actively explored in the prognosis and prediction of therapy in triple-negative breast cancer (TNBC). In this study, high-plex quantitative digital spatial profiling was used to analyze the immune protein microenvironments in treatment-naive TNBC. The results show that immune protein profiles differ significantly in intraepithelial and adjacent stromal microenvironments, and the enrichment of certain immune proteins is associated with better outcomes, highlighting the importance of spatial microenvironments in predicting the prognosis of TNBC.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Tufia C. Haddad, Vera J. Suman, Antonino B. D'Assoro, Jodi M. Carter, Karthik V. Giridhar, Brendan P. McMenomy, Katelyn Santo, Erica L. Mayer, Meghan S. Karuturi, Aki Morikawa, P. Kelly Marcom, Claudine J. Isaacs, Sun Young Oh, Amy S. Clark, Ingrid A. Mayer, Khandan Keyomarsi, Timothy J. Hobday, Prema P. Peethambaram, Ciara C. O'Sullivan, Roberto A. Leon-Ferre, Minetta C. Liu, James N. Ingle, Matthew P. Goetz
Summary: This randomized clinical trial found that adding fulvestrant to treatment with alisertib did not increase objective tumor response rates (ORRs) or progression-free survival (PFS) in endocrine-resistant metastatic breast cancer (MBC).
Article
Pathology
William R. Sukov, Jain Zhou, Katherine B. Geiersbach, Gary L. Keeney, Jodi M. Carter, J. Kenneth Schoolmeester
Summary: HER2 overexpression and gene amplification have been well established in several tumors, and HER2 targeted therapy may be effective in these cases. However, interpreting data regarding HER2 in clear cell endometrial carcinoma (CCC) is challenging due to various issues. A study of hysterectomy specimens from CCC patients showed that HER2 overexpression and amplification occur in a subset of cases, suggesting the potential benefit of HER2 targeted therapy in CCC patients.
Article
Oncology
Giulia Ferroni, Soroosh Sabeti, Tasneem Abdus-Shakur, Lorenzo Scalise, Jodi M. Carter, Robert T. Fazzio, Nicholas B. Larson, Mostafa Fatemi, Azra Alizad
Summary: The study aims to develop a non-invasive ultrasound imaging technique for detecting metastatic axillary lymph nodes in breast cancer patients. The results show that this technique can identify metastatic lymph nodes by analyzing vessel morphology features and can improve diagnostic performance when combined with clinical information.
BREAST CANCER RESEARCH
(2023)
Article
Oncology
Xiaojia Tang, Kevin J. Thompson, Krishna R. Kalari, Jason P. Sinnwell, Vera J. Suman, Peter T. Vedell, Sarah A. McLaughlin, Donald W. Northfelt, Alvaro Moreno Aspitia, Richard J. Gray, Jodi M. Carter, Richard Weinshilboum, Liewei Wang, Judy C. Boughey, Matthew P. Goetz
Summary: This study compared pre- and post-chemotherapy TNBC tumor samples and identified biomarkers associated with post-chemotherapy recurrence. The gene expression patterns were significantly altered in the post-treatment samples, indicating potential mechanisms and treatment targets for post-chemotherapy recurrence.
BREAST CANCER RESEARCH
(2023)
Article
Clinical Neurology
Tomas Marek, Robert J. Spinner, Jodi M. Carter, Nikhil K. Murthy, Kimberly K. Amrami, Stephen M. Broski
Summary: Background: Neuromuscular choristoma is a rare peripheral nerve lesion characterized by abnormal presence of muscle within nerve. This study reports the FDG PET characteristics of NMC and NMC-DTF, and suggests that increased FDG activity within NMCs may be associated with subclinical NMC-DTF or NMC-DTF precursor tissue.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Megan M. Jack, Brandon W. Smith, Stepan Capek, Tomas Marek, Jodi M. Carter, Stephen M. Broski, Kimberly K. Amrami, Robert J. Spinner
Summary: Perineural spread of breast cancer to the brachial plexus is a rare but often misdiagnosed complication, characterized by pain, sensory alterations, and upper extremity weakness. This study retrospectively analyzed the clinical, radiological, and pathological data of 19 patients with biopsy-proven perineural spread of breast cancer to the brachial plexus.
JOURNAL OF NEUROSURGERY
(2022)