Article
Multidisciplinary Sciences
Zhongwei Zhao, Manqing Sun, Xinmu Cui, Jiaxin Chen, Chunhong Liu, Xuewu Zhang
Summary: Bacillus coagulans MZY531 has a protective effect on intestinal mucosal injury in immunosuppressed mice induced by cyclophosphamide. It promotes the expression of immune proteins, regulates intestinal inflammation and cellular repair. Furthermore, it can modulate the gut microbiota by increasing the abundance of beneficial bacteria. In conclusion, B. coagulans MZY531 has potential immunomodulatory activity.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Hiroyoshi Iwata, Naoto Matsuno, Daisuke Ishii, Asuka Toriumi, Masahide Otani, Mizuho Ohara, Hiromichi Obara, Yuji Nishikawa, Hideki Yokoo
Summary: This study compared the use of University of Wisconsin solution and histidine-tryptophan-ketoglutarate solution as machine perfusion solutions for marginal liver grafts. The results showed that histidine-tryptophan-ketoglutarate solution can decrease vascular resistance, reduce shear stress, and protect sinusoid epithelial cells in split-liver grafts.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aneta Ostrozka-Cieslik
Summary: This article discusses the clinical problem of ischemia-reperfusion injury and the direction for improving preservation solutions. It presents clinical and experimental studies aimed at optimizing these fluids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Valentina Veloso-Gimenez, Rosalba Escamilla, David Necunir, Rocio Corrales-Orovio, Sergio Riveros, Carlo Marino, Carolina Ehrenfeld, Christian Dani Guzman, Mauricio P. Boric, Rolando Rebolledo, Jose Tomas Egana
Summary: This study aimed to develop a perfusable photosynthetic solution with microalgae embedded to supply oxygen and support ex vivo organ preservation. The research found that the photosynthetic solution did not harm animal cells and provided sufficient oxygen to meet metabolic demands. Experimental validation showed that during organ perfusion, the photosynthetic microorganisms could reach the renal vasculature without causing tissue damage, surviving the process successfully.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Noah Joseph Murr, Tyler B. Olender, Margaret R. Smith, Amari S. Smith, Jennifer Pilotos, Lyndsay B. Richard, Chishimba Nathan Mowa, Michael Makokha Opata
Summary: The study revealed that moderately malnourished mice infected with malaria had lower parasite burden at the peak of infection, but showed damaged mucosal epithelial cells, increased intestinal permeability, shortened small intestine, and decreased number of innate immune cells in the large intestine. Despite lower numbers, macrophages in the moderately malnourished mice were highly activated in the small intestine, indicating exacerbation of some abnormalities in the gut induced by the moderate malnutrition.
Review
Chemistry, Medicinal
Yi-Feng Wang, Jia-Wei Li, Da-Peng Wang, Ke Jin, Jiao-Jie Hui, Hong-Yang Xu
Summary: Intestinal barrier injury and hyperglycemia are common in patients with sepsis. Hyperglycemia is an independent risk factor for intestinal barrier injury. Some anti-hyperglycemic agents can improve intestinal barrier function and are beneficial in managing sepsis-induced organ dysfunction.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Nutrition & Dietetics
Mohamad Hizami Mohamad Nor, Nurainina Ayob, Norfilza M. Mokhtar, Raja Affendi Raja Ali, Geok Chin Tan, Zhiqin Wong, Nor Hamizah Shafiee, Yin Ping Wong, Muaatamarulain Mustangin, Khairul Najmi Muhammad Nawawi
Summary: The use of probiotics did not lead to significant clinical improvement in NAFLD patients in terms of hepatic steatosis and fibrosis levels, but at the microenvironment level, probiotics seemed to stabilize mucosal immune function and protect patients against increased intestinal permeability. Further studies with larger sample sizes and different probiotic strains are needed to evaluate the true benefit of probiotics in NAFLD.
Article
Immunology
Yanmei Ma, Zhihua Yin, Li Li, Bingni Chen, Hanying Dai, Dandan Wu, Junxiao Cong, Liang Ye, Chenghui Liao, Lingyun Li, Zhizhong Ye, Zhong Huang
Summary: Food antigens and mucosal barrier injury act synergistically to cause intestinal inflammation; the study suggests that CII-induced enteritis is associated with higher levels of Th1, TLR2 and TLR4, and lower levels of Th2.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Gaelle Noel, Julie G. In, Jose M. Lemme-Dumit, Lauren R. DeVine, Robert N. Cole, Anthony L. Guerrerio, James D. Campbell, Olga Kovbasnjuk, Marcela F. Pasetti
Summary: Breastfeeding provides long-lasting health benefits for infants, promoting cell growth, immune development, and gut protection. Using a human pediatric enteroid model, it was found that breast milk affects epithelial cell maturation and function differently compared to commercial infant formula. This highlights the unique impact of breast milk on human intestinal physiology and immunity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Alexandra Adorno Vita, Heather Zwickey, Ryan Bradley
Summary: The study found significant associations between food-specific IgG antibodies and intestinal permeability biomarkers in adults, particularly antibodies against LPS and occludin. While levels of IgG antibodies and permeability biomarkers did not increase in symptomatic patients, the presence of multiple IgG antibodies and increasing titers can be indicative of higher levels of antibodies.
FRONTIERS IN NUTRITION
(2022)
Article
Plant Sciences
Muhammad Yousuf Adnan, Tabassum Hussain, Muhammad Zaheer Ahmed, Bilquees Gul, M. Ajmal Khan, Brent L. Nielsen
Summary: The salt resistance strategies of Desmostachya bipinnata involve coordinated organ-specific responses to different concentrations of salt stress, regulating water flux and ion distribution to adapt to hyperosmotic conditions. Decreases in biomass under saline treatments are considered a survival strategy for energy reallocation in harsh environments. Organ-specific responses to salinity concentrations suggest that different organs work together to achieve better yields in moderately saline areas.
ACTA PHYSIOLOGIAE PLANTARUM
(2021)
Article
Biochemistry & Molecular Biology
Jianping Li, Xia Liu, Yuzhen Wu, Wei Ji, Qinghua Tian, Shichen Li
Summary: This study found that aerobic exercise can improve the intestinal mucosal barrier dysfunction in diabetic rats by inhibiting LPS release, TLR4/MyD88/NF-kB signaling pathway, and pro-inflammatory cytokines expression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Jun-Ke Wang, Wei Wei, Dong-Yan Zhao, Hui-Fen Wang, Yan-Li Zhang, Jie-Ping Lei, Shu-Kun Yao
Summary: The intestinal mucosal barrier in patients with functional constipation (FC) exhibits a compensatory increase in goblet cells and integral intercellular junctions without activation of mucosal immunity or increased gut permeability.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Fisheries
Jayne E. Wiarda, Hannah R. Watkins, Nicholas K. Gabler, Christopher L. Anderson, Crystal L. Loving
Summary: This study expands on the analysis of porcine intestinal T-IELs, identifying non-conventional CD8 alpha(+)CD8 beta(-) alpha beta T-IELs that are most prevalent in the distal intestine and primarily CD16+CD27-. The comparison of T-IEL and mucosal microbial community structures reveals location- and age-specific differences, with the largest shifts occurring in the large intestine for the microbiota and in the small intestine for T-IELs between 5 and 7 weeks of age. These findings have important implications for understanding intestinal health in pigs.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Materials Science, Biomaterials
Marlon Lemos Dias, Bruno Andrade Paranhos, Juliana Ribeiro Pinheiro Ferreira, Roberto Jose Castro Fonseca, Cintia Marina Paz Batista, Ricardo Martins-Santos, Cherley Borba Vieira de Andrade, Lanuza Alaby Pinheiro Faccioli, Alexandre Cerqueira da Silva, Faio Cear Souza Nogueira, Gilberto Barbosa Domont, Regina Coeli dos Santos Goldenberg
Summary: Organ decellularization is a promising approach in tissue engineering to overcome the shortage of organs for transplantation. However, its lack of hemocompatibility hinders its clinical application. This study shows that Custodiol solution can improve the hemocompatibility of decellularized liver scaffolds, inhibiting blood coagulation and allowing successful transplantation.
BIOMATERIALS ADVANCES
(2022)
Article
Oncology
Lixuan Wei, Huanyao Gao, Jia Yu, Huan Zhang, Thanh Thanh L. Nguyen, Yayun Gu, Marie R. Passow, Jodi M. Carter, Bo Qin, Judy C. Boughey, Matthew P. Goetz, Richard M. Weinshilboum, James N. Ingle, Liewei Wang
Summary: Androgen receptor (AR) is expressed in the majority of estrogen receptor a-positive (ER+) breast cancers. The efficacy of AR-targeting therapies, including both AR agonists and AR inhibitors, is dependent on the levels of AR and ERa. ENZ functions as an ERa antagonist in low AR expression breast cancer, while RAD140 activates AR signaling and suppresses AR-high tumor growth. Overall, this study provides insights into the clinical application of AR-targeting therapy based on the AR/ER ratio in ER+ breast cancers.
Article
Multidisciplinary Sciences
Alexander S. Roesler, Smriti Malasi, Lori Koslosky, Peter Hartmayer, Tammey J. Naab, Jodi M. Carter, David Zahrieh, David Hillman, Roberto A. Leon-Ferre, Fergus J. Couch, Matthew P. Goetz, Karen S. Anderson, Barbara A. Pockaj, Michael T. Barrett
Summary: We investigated the prevalence, prognostic value, and enrichment by chemotherapy of the PDJ amplicon in TNBC. Our findings demonstrate that the prevalence of PDJ amplicons in TNBC varies extensively and is associated with poor clinical outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Afton K. Limberg, Christopher G. Salib, Meagan E. Tibbo, Juan S. Vargas-Hernandez, Jacob W. Bettencourt, Banu Bayram, Charlotte E. Berry, Amel Dudakovic, Brad Bolon, Andre J. van Wijnen, Mark E. Morrey, Joaquin Sanchez-Sotelo, Daniel J. Berry, Jodi M. Carter, Matthew P. Abdel
Summary: This study assessed the immune cell microenvironment in arthrofibrosis following total knee arthroplasty, and found increased tissue fibrosis and myofibroblast populations in arthrofibrotic patients compared to non-arthrofibrotic patients. Macrophages were significantly decreased in the fibrotic tissue region of arthrofibrosis patients compared to patients with primary TKA, while CD163 + macrophages were significantly increased in the adipose tissue region of arthrofibrotic specimens compared to non-arthrofibrotic specimens. These findings provide insights into the underlying pathogenetic mechanisms of arthrofibrosis.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Caner Mercan, Maschenka Balkenhol, Roberto Salgado, Mark Sherman, Philippe Vielh, Willem Vreuls, Antonio Polonia, Hugo M. Horlings, Wilko Weichert, Jodi M. Carter, Peter Bult, Matthias Christgen, Carsten Denkert, Koen van de Vijver, John-Melle Bokhorst, Jeroen van der Laak, Francesco Ciompi
Summary: This study investigates the use of deep learning for automated scoring of nuclear pleomorphism in breast cancer. By training a deep regression model, the authors achieved continuous scoring, surpassing top pathologist-level performance in multiple experiments.
Article
Oncology
Amy C. Degnim, Brittany L. Siontis, Safia K. Ahmed, Tanya L. Hoskin, Tina J. Hieken, James W. Jakub, Christian L. Baum, Courtney Day, Sarah E. Schrup, Lauren Smith, Jodi M. Carter, Tiffany M. Sae Kho, Katrina N. Glazebrook, Aparna Vijayasekaran, Scott H. Okuno, Ivy A. Petersen
Summary: This study evaluated the impact of trimodality treatment compared to monotherapy or dual therapy for radiation-associated angiosarcoma of the breast (RAASB) after prior breast cancer treatment. The study found that trimodality therapy demonstrated a higher rate of pathological complete response and improved 5-year recurrence-free survival, but had more surgical complications and toxic effects.
CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jodi M. Carter, Saranya Chumsri, Douglas A. Hinerfeld, Yaohua Ma, Xue Wang, David Zahrieh, David W. Hillman, Kathleen S. Tenner, Jennifer M. Kachergus, Heather Ann Brauer, Sarah E. Warren, David Henderson, Ji Shi, Yi Liu, Heikki Joensuu, Henrik Lindman, Roberto A. Leon-Ferre, Judy C. Boughey, Minetta C. Liu, James N. Ingle, Krishna R. Kalari, Fergus J. Couch, Keith L. Knutson, Matthew P. Goetz, Edith A. Perez, E. Aubrey Thompson
Summary: The use of spatial immunobiomarker quantitation is being actively explored in the prognosis and prediction of therapy in triple-negative breast cancer (TNBC). In this study, high-plex quantitative digital spatial profiling was used to analyze the immune protein microenvironments in treatment-naive TNBC. The results show that immune protein profiles differ significantly in intraepithelial and adjacent stromal microenvironments, and the enrichment of certain immune proteins is associated with better outcomes, highlighting the importance of spatial microenvironments in predicting the prognosis of TNBC.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Tufia C. Haddad, Vera J. Suman, Antonino B. D'Assoro, Jodi M. Carter, Karthik V. Giridhar, Brendan P. McMenomy, Katelyn Santo, Erica L. Mayer, Meghan S. Karuturi, Aki Morikawa, P. Kelly Marcom, Claudine J. Isaacs, Sun Young Oh, Amy S. Clark, Ingrid A. Mayer, Khandan Keyomarsi, Timothy J. Hobday, Prema P. Peethambaram, Ciara C. O'Sullivan, Roberto A. Leon-Ferre, Minetta C. Liu, James N. Ingle, Matthew P. Goetz
Summary: This randomized clinical trial found that adding fulvestrant to treatment with alisertib did not increase objective tumor response rates (ORRs) or progression-free survival (PFS) in endocrine-resistant metastatic breast cancer (MBC).
Article
Pathology
William R. Sukov, Jain Zhou, Katherine B. Geiersbach, Gary L. Keeney, Jodi M. Carter, J. Kenneth Schoolmeester
Summary: HER2 overexpression and gene amplification have been well established in several tumors, and HER2 targeted therapy may be effective in these cases. However, interpreting data regarding HER2 in clear cell endometrial carcinoma (CCC) is challenging due to various issues. A study of hysterectomy specimens from CCC patients showed that HER2 overexpression and amplification occur in a subset of cases, suggesting the potential benefit of HER2 targeted therapy in CCC patients.
Article
Oncology
Giulia Ferroni, Soroosh Sabeti, Tasneem Abdus-Shakur, Lorenzo Scalise, Jodi M. Carter, Robert T. Fazzio, Nicholas B. Larson, Mostafa Fatemi, Azra Alizad
Summary: The study aims to develop a non-invasive ultrasound imaging technique for detecting metastatic axillary lymph nodes in breast cancer patients. The results show that this technique can identify metastatic lymph nodes by analyzing vessel morphology features and can improve diagnostic performance when combined with clinical information.
BREAST CANCER RESEARCH
(2023)
Article
Oncology
Xiaojia Tang, Kevin J. Thompson, Krishna R. Kalari, Jason P. Sinnwell, Vera J. Suman, Peter T. Vedell, Sarah A. McLaughlin, Donald W. Northfelt, Alvaro Moreno Aspitia, Richard J. Gray, Jodi M. Carter, Richard Weinshilboum, Liewei Wang, Judy C. Boughey, Matthew P. Goetz
Summary: This study compared pre- and post-chemotherapy TNBC tumor samples and identified biomarkers associated with post-chemotherapy recurrence. The gene expression patterns were significantly altered in the post-treatment samples, indicating potential mechanisms and treatment targets for post-chemotherapy recurrence.
BREAST CANCER RESEARCH
(2023)
Article
Clinical Neurology
Tomas Marek, Robert J. Spinner, Jodi M. Carter, Nikhil K. Murthy, Kimberly K. Amrami, Stephen M. Broski
Summary: Background: Neuromuscular choristoma is a rare peripheral nerve lesion characterized by abnormal presence of muscle within nerve. This study reports the FDG PET characteristics of NMC and NMC-DTF, and suggests that increased FDG activity within NMCs may be associated with subclinical NMC-DTF or NMC-DTF precursor tissue.
ACTA NEUROCHIRURGICA
(2023)
Article
Biochemistry & Molecular Biology
Kevin J. Thompson, Roberto A. Leon-Ferre, Jason P. Sinnwell, David M. Zahrieh, Vera J. Suman, Filho Otto Metzger, Sarah Asad, Daniel G. Stover, Lisa Carey, William M. Sikov, James N. Ingle, Minetta C. Liu, Jodi M. Carter, Eric W. Klee, Richard M. Weinshilboum, Judy C. Boughey, Liewei Wang, Fergus J. Couch, Matthew P. Goetz, Krishna R. Kalari
Summary: Triple-negative breast cancer (TNBC) is a highly aggressive subtype with limited targeted therapies. Luminal androgen receptor (LAR) is a distinct TNBC subtype that has lower response rates to treatment and distinct changes in the tumor microenvironment. New therapeutic strategies are needed for LAR TNBC.
Article
Oncology
Juanjuan Gu, Redouane Ternifi, Soroosh Sabeti, Nicholas B. B. Larson, Jodi M. M. Carter, Robert T. T. Fazzio, Mostafa Fatemi, Azra Alizad
Summary: The q3D-HDMI technology was successfully used to quantitatively analyze the morphological features of breast tumor microvessels, improving the ability to differentiate breast tumors with high diagnostic performance.
BREAST CANCER RESEARCH
(2022)
Article
Oncology
Joshua Ogony, Thomas de Bel, Derek C. Radisky, Jennifer Kachergus, E. Aubrey Thompson, Amy C. Degnim, Kathryn J. Ruddy, Tracy Hilton, Melody Stallings-Mann, Celine Vachon, Tanya L. Hoskin, Michael G. Heckman, Robert A. Vierkant, Launia J. White, Raymond M. Moore, Jodi Carter, Matthew Jensen, Laura Pacheco-Spann, Jill E. Henry, Anna Maria Storniolo, Stacey J. Winham, Jeroen van der Laak, Mark E. Sherman
Summary: This study found that the number of terminal duct lobular units (TDLUs) in parous women continues to increase, while the average acini area decreases, and immune responses increase significantly within five years after childbirth. The quantitative characteristics of normal breast tissues vary with demographic features and breast cancer risk factors.
BREAST CANCER RESEARCH
(2022)
Letter
Genetics & Heredity
Andres A. Maldonado, Robert J. Spinner, Jodi M. Carter, Christopher J. Klein
HUMAN GENETICS AND GENOMICS ADVANCES
(2022)