Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 4, Pages 639-644Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500773s
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Funding
- Grants-in-Aid for Scientific Research [14J03069] Funding Source: KAKEN
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Four maleic anhydride derivatives, tricladolides A-D (1-4), and three alkylidene succinic acid derivatives, tricladic acids A-C (5-7), were isolated from the aquatic hyphomycete Tricladium castaneicola. The structures of these compounds were determined by spectroscopic analysis, and all were found to be novel. The compounds exhibited inhibitory activity against fungi, particularly Phytophthora sp., a plant pathogen of oomycetes. The inhibitory activity of these metabolites revealed the importance of the cyclic anhydride structure and the lipophilicity of the alkyl side chain. On the other hand, the cytotoxicity of the compounds against B16 melanoma cells indicated that the cyclic anhydride structure was not essential.
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