Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 2, Pages 250-257Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500824f
Keywords
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Funding
- CONICET [Resol. 1675/12]
- SeCyT-UNC [05/C608]
- FONCYT [PICT 2775, 0694]
- CONICET (Argentina)
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Eleven new withanolides (1-11) were isolated and characterized from the aerial parts of Nicandra john-tyleriana. Five of these withanolides have an unmodified skeleton (1-5), two are acnistins (6, 7), and four are withajardins (8-11). These new isolates were fully characterized using a combination of spectroscopic techniques (including multidimensional NMR) and mass spectrometry. All compounds were evaluated for their antibacterial activity against Bacillus, Enterococcus, Escherichia, Listeria, Pseudomonas, and Staphylococcus strains.
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