Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 9, Pages 2297-2300Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00290
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Funding
- Institute of Natural Medicine at the University of Toyama
- Uehara Medical Foundation
- Grants-in-Aid for Scientific Research [15H05268] Funding Source: KAKEN
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Axonal regeneration might contribute to the restoration of damaged neuronal networks and improvement of memory deficits in a murine Alzheimer's,disease (AD) model. A search for axonal regenerative drugs was performed to discover novel therapeutic options for AD. In this study, an aqueous extract of Drynaria fortunei rhizomes reversed A beta(25-35)-induced axonal atrophy in cultured cortical neurons of mice. Bioassay-guided fractionation of this extract led to the isolation and identification of compounds 1-5. Among them, (2S)-neoeriocitrin (2) and caffeic acid 4-O-glucoside (4) showed significant axonal elongation effects on A beta(25-35)-induced atrophy.
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