Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 92, Issue 2, Pages 123-132Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2014.05.009
Keywords
Adrenocortical carcinoma; Therapeutics; Targeted therapies; Metastatic disease
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Funding
- CAPES-CNPq - Brazil
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Adrenocortical cancer is a rare malignancy. While surgery is the cornerstone of the management of localized disease, metastatic disease is hard to treat. Cytotoxic chemotherapy and mitotane have been utilized with a variable degree of benefit and few long-term responses. A growing understanding of the molecular pathogenesis of this malignancy as well as multidisciplinary and multi-institutional collaborative efforts will result in better defined targets and subsequently, effective novel therapies. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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