Article
Surgery
Byung Min Lee, Jee Suk Chang, Woong Sub Koom, Hwa Kyung Byun, Han Sang Kim, Seung-Hoon Beom, Caleb Oh, Young Joo Suh, Joong Bae Ahn, Sang Joon Shin, Byung Jo Park, Seong Yong Park
Summary: This study aimed to assess the effect of local ablative therapy (LAT) on overall survival in patients with lung metastases from colorectal cancer (CRC). The results showed that patients treated with LAT had significantly higher survival rates compared to those treated with systemic therapy alone.
Review
Medicine, General & Internal
Emmanouil Georgilis, Maria Gavriatopoulou, Diamantis I. Tsilimigras, Panagiotis Malandrakis, Theodosios Theodosopoulos, Ioannis Ntanasis-Stathopoulos
Summary: Although surgical resection is the gold standard for resectable colorectal cancer liver metastases (CRLMs), the management after surgery remains controversial. This systematic review aimed to evaluate the efficacy, tolerability, and safety profile of different chemotherapeutic agents used as adjuvant treatment after surgical resection of CRLMs. The results showed that adjuvant therapy improved regression-free survival (RFS) and disease-free survival (DFS), but did not significantly prolong overall survival (OS), and the choice of therapeutic strategy did not have a differential impact on patient outcomes. More high-quality clinical trials are needed to determine which patients would benefit the most from adjuvant therapy after surgery for CRLMs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Elodie Peraudeau, Brigitte Renoux, Sheik Emambux, Pauline Poinot, Remi Chatre, Fabien Thoreau, Benjamin Riss Yaw, David Tougeron, Jonathan Clarhaut, Sebastien Papot
Summary: Combining bevacizumab (Bev) with a beta-glucuronidase-responsive albumin-binding prodrug of monomethyl auristatin E (MMAE) has shown to be an effective therapeutic strategy for colorectal cancer in mice.
MOLECULAR PHARMACEUTICS
(2023)
Article
Oncology
Pina Ziranu, Paolo Albino Ferrari, Francesco Guerrera, Pietro Bertoglio, Alessandro Tamburrini, Andrea Pretta, Paraskevas Lyberis, Giulia Grimaldi, Eleonora Lai, Massimiliano Santoru, Fabio Bardanzellu, Laura Riva, Francesca Balconi, Eleonora Della Beffa, Marco Dubois, Matteo Pinna-Susnik, Clelia Donisi, Enrico Capozzi, Valeria Pusceddu, Alessandro Murenu, Marco Puzzoni, Federico Mathieu, Sabrina Sarais, Aiman Alzetani, Luca Luzzi, Piergiorgio Solli, Piero Paladini, Enrico Ruffini, Roberto Cherchi, Mario Scartozzi
Summary: This study analyzed the data of 260 colorectal cancer patients with lung metastases and established the Meta-Lung Score, which can provide valuable prognostic information and guide surgical selection and prognosis assessment.
Article
Gastroenterology & Hepatology
Yoshikuni Kawaguchi, Scott Kopetz, Elena Panettieri, Hyunsoo Hwang, Xuemei Wang, Hop S. Tran Cao, Ching-Wei D. Tzeng, Yun Shin Chun, Thomas A. Aloia, Jean-Nicolas Vauthey
Summary: Survival in patients undergoing resection of colorectal liver metastases has improved over the past 20 years, associated with the introduction of irinotecan- and/or oxaliplatin-containing regimens, molecular targeted therapy, and multigene alteration testing. Liver resectability indications expanded over time, with a significantly better 5-year overall survival rate in 2006-2014 compared to 2001-2005. RAS alteration was associated with worse survival outcomes, while multigene alteration testing proved useful for prognostication and identification of potential therapeutic targets.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Oncology
Shahid Ahmed, Nicholas Bosma, Michael Moser, Shahida Ahmed, Bryan Brunet, Janine Davies, Corinne Doll, Dorie-Anna Dueck, Christina A. Kim, Shuying Ji, Duc Le, Richard Lee-Ying, Howard Lim, John Paul McGhie, Karen Mulder, Jason Park, Deepti Ravi, Daniel J. Renouf, Devin Schellenberg, Ralph P. W. Wong, Adnan Zaidi
Summary: The Western Canadian Gastrointestinal Cancer Consensus Conference discussed the use and optimal sequence of systemic therapy in patients with resectable metastatic colorectal cancer. Healthcare professionals from four Western Canadian provinces participated in the conference.
Review
Oncology
Junge Bai, Ming Yang, Zheng Liu, Sergey Efetov, Cuneyt Kayaalp, Audrius Dulskas, Darcy Shaw, Xishan Wang
Summary: Colorectal cancer is a major cause of cancer-related death globally, with distant metastatic lesions, primarily in the liver, being found in 20% of patients. Collaboration between interventional radiologists, medical oncologists, and surgeons is crucial for optimal treatment. The effectiveness of primary tumor resection (PTR) in improving overall survival and quality of life is still controversial. This minireview focuses on the treatment options for hepatic colorectal metastatic illness, specifically discussing the advancements and risks of PTR in stage IV CRC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Aina Kunitomo, Akira Ouchi, Koji Komori, Takashi Kinoshita, Yusuke Sato, Tetsuya Abe, Seiji Ito, Tsuyoshi Sano, Yasuhiro Shimizu
Summary: This study aimed to evaluate the clinical significance of surgical intervention for isolated peritoneal metastases (PM) from colorectal cancer (CRC), with a particular focus on the timing of PM. The results showed that patients who underwent radical resection of PM had better survival compared with those who received palliative chemotherapy, especially for metachronous PM. Therefore, surgical intervention should be considered for isolated metachronous PM when radical resection is feasible.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Daniel-Clement Osei-Bordom, Sivesh Kamarajah, Niki Christou
Summary: In the clinical management of liver metastasis of colorectal cancer, surgeons and oncologists categorize the metastasis into resectable and non-resectable groups to initiate tailored therapeutics. The combination of targeted therapies and biotherapies around these two entities is being actively explored to determine the ideal conditions for their application to improve patient survival and quality of life.
Article
Primary Health Care
Claire Elizabeth Powers Smith, Vinayak Prasad
Summary: Targeted cancer therapies involve attacking specific genetic biomarkers found in certain cancers, and includes monoclonal antibodies, small molecule inhibitors, antibody-drug conjugates, and immunotherapy. While these therapies have improved survival for some incurable cancers, only a small percentage of patients qualify for targeted oncology medications and fewer actually benefit.
AMERICAN FAMILY PHYSICIAN
(2021)
Review
Biochemistry & Molecular Biology
Lifu Long, Zhenjie Yi, Yu Zeng, Zhixiong Liu
Summary: The incidence of brain metastases has been increasing and poses a significant challenge in the medical field. Currently available therapies, such as systemic chemotherapy, targeted therapy, and immunotherapy, face difficulties like drug resistance and low permeability of the blood-brain barrier. Recent research shows that malignant tumor cells can manipulate the brain microenvironment, leading to a pro-tumoral environment. This review compares the characteristics of the brain microenvironment in brain metastases with other sites or primary tumors and evaluates microenvironment-targeted therapies for brain metastases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Oncology
Xiaofei Zhang, Wenjun Zhang, Pingan Cao
Summary: As the population ages in China, the incidence of colorectal cancer is on the rise, with CpG island methylator phenotype (CIMP) playing an important role in its development. Recent studies have shown a close relationship between CIMP and specific clinicopathological phenotypes and multiple molecular phenotypes in colorectal cancer. This paper introduces the latest progress on CIMP colorectal cancer in terms of chemotherapeutic drugs, targeted agents, and small molecular methylation inhibitors, aiming to provide potential clinical treatment strategies for personalized and precise treatment of colorectal cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Rossella Reddavid, Simona Dagatti, Caterina Franco, Lucia Puca, Mariano Tomatis, Simona Corso, Silvia Giordano, Maurizio Degiuli
Summary: Despite the addition of molecular therapy in the clinical treatment of advanced and metastatic gastric cancer, the survival benefits of these novel therapies remain rather unclear, possibly due to inaccurate patient selection.
Review
Pharmacology & Pharmacy
Ilana Schlam, Paolo Tarantino, Stefania Morganti, Filipa Lynce, Dario Trapani, Erica L. Mayer, Ana C. Garrido-Castro, Ada Waks, Sara M. Tolaney
Summary: Breast cancer is a common and deadly disease in the US, and recent advancements in treatment for early-stage breast cancer include the use of immune checkpoint inhibitors for triple-negative breast cancer and CDK4/6 inhibitors for hormone receptor-positive disease. Additionally, adjuvant olaparib has shown significant improvement in outcomes for patients with BRCA1/2 mutations and high-risk HER2-negative breast cancer.
Article
Oncology
C. Villard, M. Habib, C. Nordenvall, P. J. Nilsson, C. Jorns, E. Sparrelid
Summary: Conversion therapy can offer a survival benefit in selected patients, but the majority of patients still cannot undergo liver resection treatment.
Article
Oncology
Elisabetta Fenocchio, Federica Colombi, Maria Grazia Calella, Roberto Filippi, Ilaria Depetris, Giovanna Chila, Pasquale Lombardi, Donatella Marino, Celeste Cagnazzo, Renato Ferraris, Marco Vaira, Massimo Aglietta, Francesco Leone
Article
Oncology
Eleonora Ghisoni, Gaia Giannone, Valentina Tuninetti, Sofia Genta, Giulia Scotto, Massimo Aglietta, Dario Sangiolo, Gloria Mittica, Giorgio Valabrega
Meeting Abstract
Oncology
P. Lombardi, L. Marandino, E. De Luca, C. Zichi, D. Pignataro, R. Di Stefano, E. Ghisoni, A. Mariniello, M. Reale, E. Trevisi, L. Gianmarco, L. Muratori, A. La Salvia, C. Sonetto, F. Leone, M. Aglietta, S. Novello, G. Scagliotti, F. Perrone, M. Di Maio
ANNALS OF ONCOLOGY
(2019)
Article
Hematology
Eleonora Ghisoni, Laura Marandino, Pasquale Lombardi, Alessandro Bonzano, Paolo Becco, Massimo Aglietta, Marco Fizzotti, Francesca Gay, Delia Rota Scalabrini
ACTA HAEMATOLOGICA
(2020)
Article
Oncology
Lorenzo Fornaro, Francesco Leone, Angelique Vienot, Andrea Casadei-Gardini, Caterina Vivaldi, Astrid Lievre, Pasquale Lombardi, Emmanuele De Luca, Dewi Vernerey, Elisa Sperti, Gianna Musettini, Maria Antonietta Satolli, Julien Edeline, Rosella Spadi, Cindy Neuzillet, Alfredo Falcone, Giulia Pasquini, Mario Clerico, Alessandro Passardi, Paola Buscaglia, Aurelia Meurisse, Massimo Aglietta, Clemence Brac, Enrico Vasile, Francesco Montagnani
CLINICAL COLORECTAL CANCER
(2019)
Article
Oncology
Fotios Loupakis, Rossana Intini, Chiara Cremolini, Armando Orlandi, Andrea Sartore-Bianchi, Filippo Pietrantonio, Nicoletta Pella, Andrea Spallanzani, Emanuela Dell'Aquila, Mario Scartozzi, Emmanuele De Luca, Lorenza Rimassa, Vincenzo Formica, Francesco Leone, Lorenzo Calvetti, Giuseppe Aprile, Lorenzo Antonuzzo, Federica Urbano, Hans Prenen, Francesca Negri, Samantha Di Donato, Pasquale Buonandi, Gianluca Tomasello, Antonio Avallone, Fable Zustovich, Roberto Moretto, Carlotta Antoniotti, Lisa Salvatore, Maria Alessandra Calegari, Salvatore Siena, Federica Morano, Elena Ongaro, Stefano Cascinu, Daniele Santini, Pina Ziranu, Marta Schirripa, Federica Buggin, Alessandra Anna Prete, Ilaria Depetris, Paola Biason, Sara Lonardi, Vittorina Zagonel, Matteo Fassan, Massimo Di Maio
EUROPEAN JOURNAL OF CANCER
(2019)
Review
Pharmacology & Pharmacy
Roberto Filippi, Pasquale Lombardi, Virginia Quara, Elisabetta Fenocchio, Giacomo Aimar, Michela Milanesio, Francesco Leone, Massimo Aglietta
EXPERT OPINION ON PHARMACOTHERAPY
(2019)
Review
Oncology
Elisabetta Fenocchio, Roberto Filippi, Pasquale Lombardi, Virginia Quara, Michela Milanesio, Giacomo Aimar, Francesco Leone, Massimo Aglietta
Review
Oncology
Gaia Giannone, Laura Attademo, Giulia Scotto, Sofia Genta, Eleonora Ghisoni, Valentina Tuninetti, Massimo Aglietta, Sandro Pignata, Giorgio Valabrega
Review
Oncology
Pasquale Lombardi, Laura Marandino, Emmanuele De Luca, Clizia Zichi, Maria Lucia Reale, Daniele Pignataro, Rosario F. Di Stefano, Eleonora Ghisoni, Annapaola Mariniello, Elena Trevisi, Gianmarco Leone, Leonardo Muratori, Anna La Salvia, Cristina Sonetto, Francesco Leone, Massimo Aglietta, Silvia Novello, Giorgio Scagliotti, Francesco Perrone, Massimo Di Maio
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Massimiliano Salati, Roberto Filippi, Caterina Vivaldi, Francesco Caputo, Francesco Leone, Francesca Salani, Krisida Cerma, Massimo Aglietta, Lorenzo Fornaro, Elisa Sperti, Massimo Di Maio, Cinzia Ortega, Elisabetta Fenocchio, Pasquale Lombardi, Celeste Cagnazzo, Ilaria Depretis, Fabio Gelsomino, Andrea Spallanzani, Daniele Santini, Nicola Silvestris, Giuseppe Aprile, Giandomenico Roviello, Mario Scartozzi, Stefano Cascinu, Andrea Casadei-Gardini
LIVER INTERNATIONAL
(2020)
Article
Oncology
Maria Lucia Reale, Emmanuele De Luca, Pasquale Lombardi, Laura Marandino, Clizia Zichi, Daniele Pignataro, Eleonora Ghisoni, Rosario F. Di Stefano, Annapaola Mariniello, Elena Trevisi, Gianmarco Leone, Leonardo Muratori, Anna La Salvia, Cristina Sonetto, Paolo Bironzo, Massimo Aglietta, Silvia Novello, Giorgio Scagliotti, Francesco Perrone, Massimo Di Maio
Article
Oncology
Fotios Loupakis, Ilaria Depetris, Paola Biason, Rossana Intini, Alessandra Anna Prete, Francesco Leone, Pasquale Lombardi, Roberto Filippi, Andrea Spallanzani, Stefano Cascinu, Luca Reggiani Bonetti, Giulia Maddalena, Nicola Valeri, Andrea Sottoriva, Luis Zapata, Roberta Salmaso, Giada Munari, Massimo Rugge, Angelo Paolo Dei Tos, Justin Golovato, John Z. Sanborn, Andrew Nguyen, Marta Schirripa, Vittorina Zagonel, Sara Lonardi, Matteo Fassan
Correction
Oncology
P. Lombardi, S. Silvestri, D. Marino, M. Santarelli, D. Campra, P. De Paolis, M. Aglietta, F. Leone
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2020)
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)