Article
Hematology
Dennis A. Eichenauer, Horst Muller, Leonard Elger, Helen Goergen, Michael Fuchs, Stefanie Kreissl, Boris Boll, Volker Diehl, Bastian von Tresckow, Peter Borchmann, Andreas Engert
Summary: NHL after cHL is a rare event that primarily affects older individuals, with a five-year event-free survival and overall survival estimates of 36.9% and 44.2% respectively.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Allini Mafra, Mathieu Laversanne, Mary Gospodarowicz, Paulo Klinger, Neimar De Paula Silva, Marion Pineros, Eva Steliarova-Foucher, Freddie Bray, Ariana Znaor
Summary: Global patterns of non-Hodgkin lymphoma (NHL) in 2020 were evaluated using the GLOBOCAN 2020 database. The study found that Eastern Asia, Northern America, and South-Central Asia had the highest number of NHL cases. Incidence rates were higher in men than in women, with the highest rates in Australia, New Zealand, Northern America, Northern Europe, and Western Europe. The highest mortality rates were found in regions in Africa, Western Asia, and Oceania.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Medicine, General & Internal
Pauline Brice, Eric de Kerviler, Jonathan W. Friedberg
Summary: Classical Hodgkin lymphoma is a relatively common lymphoma that is generally considered highly curable with standard first-line chemotherapy and radiotherapy, although some patients may not be cured or may experience late toxic effects leading to premature death. Recent changes in the gold standard of chemotherapy, now often including immunotherapy in relapse settings, have further impacted treatment outcomes.
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: Many studies have found associations between neighborhood deprivation and disease, emphasizing the importance of social determinants of health. However, when studying diseases with long latency periods such as cancers, considering the timing of exposures for deprivation becomes more important.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
H. Dean Hosgood, Meghan Davitt, Richard Cawthon, Stephanie J. Weinstein, Batel Blechter, Jason Y. Y. Wong, Mohammad L. Rahman, Wei Hu, Satu Mannisto, Demetrius Albanes, Nathaniel Rothman, Qing Lan
Summary: This study suggests that a higher fraction of mitochondrial DNA with breaks is associated with an increased risk of non-Hodgkin lymphoma (NHL).
Article
Health Care Sciences & Services
Sonia Guadalupe Barreno-Rocha, Sandra Guzman-Silahua, Ernesto German Cardona-Munoz, Maria Guadalupe Zavala-Cerna, David Eduardo Munoz Gaytan, Carlos Riebeling-Navarro, Benjamin Rubio-Jurado, Arnulfo Hernan Nava-Zavala
Summary: A retrospective cohort study was performed on patients diagnosed with Non-Hodgkin Lymphoma. The presence of autoantibodies was observed in 30 out of 39 patients, while 9 patients did not have autoantibodies. However, there were no statistically significant differences between the two groups in terms of clinical, demographic, staging, and prognosis characteristics. Further research on a broader panel of autoantibodies is needed to explore the relationship between their presence and the clinical outcome of patients.
Review
Veterinary Sciences
Joana N. R. Dias, Ana S. Andre, Sandra I. I. Aguiar, Solange Gil, Luis Tavares, Frederico Aires-da-Silva
Summary: The new era of immune-oncology presents challenges and opportunities, with the use of a canine model in cancer immunotherapy drug development being widely recognized. Comparative research between human and canine NHL can provide valuable insights into treatment strategies. Additionally, the canine model may help bridge the gap between preclinical studies and clinical trials.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: This study assessed the association between historic environmental pollutant emissions and chemical mixtures in house dust with non-Hodgkin lymphoma (NHL). The results showed a significant positive association between RSEI scores and NHL in long-term residents in Detroit, while significant inverse associations were found in two other study centers. These findings highlight the importance of considering historic and cumulative environmental exposures and using residential histories for diseases with long latency periods like NHL.
ENVIRONMENTAL RESEARCH
(2023)
Article
Dermatology
A. Goyal, D. O'Leary, K. Goyal, N. Rubin, M. Janakiram
Summary: Patients with mycosis fungoides (MF) have an increased risk of developing various types of cancers, with those developing non-Hodgkin lymphoma (NHL), lung cancer, and bladder cancer tending to be diagnosed at earlier stages and showing better 5-year overall survival. Regular pigmented-lesion-focused skin examinations are recommended for MF patients, along with smoking cessation counseling and ensuring up-to-date cancer screenings. Regular imaging and lab testing for second malignancy screening require further study and expert consensus.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Oncology
Liwei Lv, Yuanbo Liu
Summary: Non-Hodgkin lymphoma (NHL) is a common hematological malignant tumor that can be diagnosed through invasive tissue biopsies, which have limitations in clinical applications. To overcome these limitations, liquid biopsies (LBs) have been proposed and shown to be applicable for diagnosis, treatment, prognosis, and monitoring of NHL.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Saba Omer, Suhrud Pathak, Rishi Nadar, Dylan Bowen, Maninder Sandey, Muralikrishnan Dhanasekaran, Satyanarayana Pondugula, Mohammed Mansour, Dawn Boothe
Summary: The study demonstrated the anti-lymphoma pharmacodynamic actions of endocannabinoids on canine and human NHL cells, validated the expression of CB1 and CB2 receptors in canine NHL cells, and showed differential effects on B-cell lymphoma cells compared to T-cell lymphoma cells. The endocannabinoids altered markers of oxidative stress, inflammation, and mitochondrial function in canine NHL cells without affecting apoptotic markers.
Article
Immunology
Laura E. Martinez, Larry I. Magpantay, Yu Guo, Priya Hegde, Roger Detels, Shehnaz K. Hussain, Marta Epeldegui
Summary: The study revealed significantly higher levels of EVs bearing PD-L1, CD40, TNF-RII, and/or IL-6R alpha in AIDS-NHL cases compared to controls. EVs carrying these molecules were found to be significantly and positively associated with AIDS-NHL risk, suggesting their potential as biomarkers for early detection of NHL in PLWH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Tycel Phillips, Henry Chan, Constantine S. Tam, Alessandra Tedeschi, Patrick Johnston, Sung Yong Oh, Stephen Opat, Hyeon-Seok Eom, Heather Allewelt, Jennifer C. Stern, Ziwen Tan, William Novotny, Jane Huang, Judith Trotman
Summary: The study demonstrates favorable outcomes for patients with relapsed/refractory marginal zone lymphoma and follicular lymphoma treated with the selective Bruton's tyrosine kinase inhibitor zanubrutinib. The results support zanubrutinib as a potentially meaningful addition to available therapies for these patients.
Article
Oncology
Cecilia Marini, Vanessa Cossu, Francesco Lanfranchi, Sonia Carta, Francesca Vitale, Francesca D'Amico, Matteo Bauckneht, Silvia Morbelli, Maria Isabella Donegani, Silvia Chiola, Stefano Raffa, Luca Sofia, Tania Di Raimondo, Filippo Ballerini, Chiara Ghiggi, Paolo Durando, Silvia Ravera, Mattia Riondato, Anna Maria Orengo, Silvia Bruno, Sabrina Chiesa, Gianmario Sambuceti
Summary: Previous studies have found redox stress in PBMCs of HL patients, indicating ER oxidative damage. This study aimed to investigate whether this stress also occurs in non-HL patients. The results showed that HL patients had increased mitochondrial ROS generation, MDA levels, and H6PD activity in PBMCs. FDG uptake in the myocardium was also increased in HL patients. These findings suggest that HL is associated with ER redox stress involving PBMCs and the myocardium.
Article
Hematology
Miguel Alcoceba, Maria Garcia-Alvarez, M. Carmen Chillon, Cristina Jimenez, Alejandro Medina, Alicia Anton, Oscar Blanco, Luis G. Diaz, Pilar Tamayo, Veronica Gonzalez-Calle, Maria Jesus Vidal, Rebeca Cuello, Francisco Javier Diaz Galvez, Jose Antonio Queizan, Alejandro Martin, Marcos Gonzalez, Ramon Garcia-Sanz, M. Eugenia Sarasquete
Summary: The study utilizing liquid biopsy with ctDNA revealed genetic features of HL patients, identifying several genes related to poor prognosis. The number of variants in high-quality ctDNA samples was associated with disease severity in patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Delphine Casabonne, Yolanda Benavente, Julia Seifert, Laura Costas, Maria Armesto, Maria Arestin, Caroline Besson, Fatemeh S. Hosnijeh, Eric J. Duell, Elisabete Weiderpass, Giovanna Masala, Rudolf Kaaks, Federico Canzian, Maria-Dolores Chirlaque, Vittorio Perduca, Francesca R. Mancini, Valeria Pala, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Maria-Jose Sanchez, Rosario Tumino, Marc J. Gunter, Pilar Amiano, Salvatore Panico, Carlotta Sacerdote, Julie A. Schmidt, Heiner Boeing, Matthias B. Schulze, Aurelio Barricarte, Elio Riboli, Anja Olsen, Anne Tjonneland, Roel Vermeulen, Alexandra Nieters, Charles H. Lawrie, Silvia de Sanjose
INTERNATIONAL JOURNAL OF CANCER
(2020)
Review
Oncology
Jon Frias-Gomez, Yolanda Benavente, Jordi Ponce, Joan Brunet, Raquel Ibanez, Paula Peremiquel-Trillas, Nuria Baixeras, Alba Zanca, Josep Maria Piulats, Alvaro Aytes, Xavier Matias-Guiu, Francesc Xavier Bosch, Silvia de Sanjose, Laia Alemany, Laura Costas
CANCER CYTOPATHOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Ariadna Garcia-Saenz, Alejandro Sanchez de Miguel, Ana Espinosa, Laura Costas, Nuria Aragones, Cathryn Tonne, Victor Moreno, Beatriz Perez-Gomez, Antonia Valentin, Marina Pollan, Gemma Castano-Vinyals, Martin Aube, Manolis Kogevinas
Article
Oncology
Jon Frias-Gomez, Eva Tovar, August Vidal, Lluis Murgui, Raquel Ibanez, Paula Peremiquel-Trillas, Sonia Paytubi, Nuria Baixeras, Alba Zanca, Jordi Ponce, Marta Pineda, Joan Brunet, Silvia de Sanjose, Francesc Xavier Bosch, Xavier Matias-Guiu, Laia Alemany, Laura Costas
Summary: The study aimed to estimate the sensitivity of cervical cytology in detecting endometrial cancer, finding a low sensitivity in diagnosing endometrial cancer and suggesting the potential role of genomics and epigenomics in improving sensitivity.
Article
Environmental Sciences
Paula Peremiquel-Trillas, Jon Frias-Gomez, Laia Alemany, Alberto Ameijide, Mireia Vilardell, Rafael Marcos-Gragera, Sonia Paytubi, Jordi Ponce, Jose Manuel Martinez, Marta Pineda, Joan Brunet, Xavier Matias-Guiu, Maria Carulla, Jaume Galceran, Angel Izquierdo, Josep M. Borras, Laura Costas, Ramon Cleries
Summary: This study predicts a decline in ovarian cancer incidence and mortality rates in Catalonia by 2030, particularly among women aged 45 years and above. The risk of developing ovarian cancer decreases with later birth year, though there is a rebound among women born in the 1980s. Decreased mortality rates were observed during the period of diagnosis and death, but older women still have higher ovarian cancer mortality compared to other age groups.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Sergi Fernandez-Gonzalez, Jordi Ponce, Maria Angeles Martinez-Maestre, Marc Barahona, Natalia R. Gomez-Hidalgo, Berta Diaz-Feijoo, Andrea Casajuana, Myriam Gracia, Jon Frias-Gomez, Yolanda Benavente, Laura Costas, Lola Marti, Lidia Melero, Jose Manuel Silvan, Eva Beiro, Ignacio Lobo, Jesus De la Rosa, Pluvio J. Coronado, Antonio Gil-Moreno
Summary: In this study, the impact of surgical practice on oncological outcomes among women who underwent robot-assisted radical hysterectomy for early-stage cervical cancer was assessed. Factors such as higher surgical volume, participation in clinical trials, use of MRI for diagnosis, sentinel lymph node biopsies, and a favorable learning curve were found to significantly affect oncological outcomes. These findings suggest that surgical practice plays a crucial role not only in robot-assisted surgery but also in laparoscopic and open surgeries for the treatment of cervical cancer.
Article
Public, Environmental & Occupational Health
Laura Costas, Jon Frias-Gomez, Yolanda Benavente Moreno, Paula Peremiquel-Trillas, Alvaro Carmona, Javier de Francisco, Victor Cano, Sonia Paytubi, Beatriz Pelegrina, Jose Manuel Martinez, Marta Pineda, Joan Brunet, August Vidal, Xavier Matias-Guiu, Xavier Bosch, Jordi Ponce, Manolis Kogevinas, Silvia De Sanjose, Laia Alemany
Summary: After adjusting for potential confounders, an inverse but not statistically significant association was found between night shift work and endometrial cancer (OR=0.64; 95% CI=0.35 to 1.16). The associations were independent of shift type (permanent or rotating nights) or duration of night work. No statistically significant association was observed between endometrial cancer and sleep duration, while inconsistent patterns were seen for chronotype and endometrial cancer risk.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Oncology
Laura Ciria-Suarez, Laura Costas, Aida Flix-Valle, Maria Serra-Blasco, Joan C. Medina, Cristian Ochoa-Arnedo
Summary: Providing an early holistic health educational platform for breast cancer patients within a digital cancer ecosystem can improve their quality of life, reduce emotional distress, and possibly impact survival rates. Digital health education interventions can reach a larger number of cancer patients, promoting equity in access to cancer information and prevention, and improving efficiency.
Article
Health Care Sciences & Services
Paula Peremiquel-Trillas, Sonia Paytubi, Beatriz Pelegrina, Jon Frias-Gomez, Alvaro Carmona, Jose Manuel Martinez, Javier de Francisco, Yolanda Benavente, Marc Barahona, Ferran Brianso, Julia Canet-Hermida, Victor Cano, August Vidal, Alba Zanca, Nuria Baixeras, Axel Rodriguez, Sergi Fernandez-Gonzalez, Nuria Duenas, Laura Cardenas, Alvaro Aytes, Ilaria Bianchi, Miquel Angel Pavon, Jaume Reventos, Gabriel Capella, David Gomez, Mireia Diaz, Jordi Ponce, Joan Brunet, Xavier Matias-Guiu, Francesc Xavier Bosch, Silvia de Sanjose, Laia Alemany, Marta Pineda, Fatima Marin, Laura Costas
Summary: Screenwide is a four-year case-control study aimed at evaluating potential risk factors for endometrial and ovarian cancers, as well as developing early detection strategies. The results of the study showed that genetic variants in the samples could be detected through various methods for early detection, suggesting the potential application of this approach in clinical practice.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Chiara Herzog, Fatima Marin, Allison Jones, Iona Evans, Daniel Reisel, Elisa Redl, Lena Schreiberhuber, Sonia Paytubi, Beatriz Pelegrina, Alvaro Carmona, Paula Peremiquel-Trillas, Jon Frias-Gomez, Marta Pineda, Joan Brunet, Jordi Ponce, Xavier Matias-Guiu, Silvia de Sanjose, Laia Alemany, Adeola Olaitan, Michael Wong, Davor Jurkovic, Emma J. Crosbie, Adam N. Rosenthal, Line Bjorge, Michal Zikan, Lukas Dostalek, David Cibula, Karin Sundstrom, Joakim Dillner, Laura Costas, Martin Widschwendter
Summary: The study developed a noninvasive triage test for women with suspected endometrial cancer symptoms, aiming to improve early diagnosis and reduce the need for in-person visits. The test showed high sensitivity and specificity in detecting EC cases in different sample types and settings.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Joy Shi, Peter Kraft, Bernard A. Rosner, Yolanda Benavente, Amanda Black, Louise A. Brinton, Chu Chen, Megan A. Clarke, Linda S. Cook, Laura Costas, Luigino Dal Maso, Jo L. Freudenheim, Jon Frias-Gomez, Christine M. Friedenreich, Montserrat Garcia-Closas, Marc T. Goodman, Lisa Johnson, Carlo La Vecchia, Fabio Levi, Jolanta Lissowska, Lingeng Lu, Susan E. McCann, Kirsten B. Moysich, Eva Negri, Kelli O'Connell, Fabio Parazzini, Stacey Petruzella, Jerry Polesel, Jeanette Ponte, Timothy R. Rebbeck, Peggy Reynolds, Fulvio Ricceri, Harvey A. Risch, Carlotta Sacerdote, Veronica W. Setiawan, Xiao-Ou Shu, Amanda B. Spurdle, Britton Trabert, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Wang Hong Xu, Hannah P. Yang, Herbert Yu, Mengmeng Du, Immaculata De Vivo
Summary: To mitigate the burden of endometrial cancer, risk stratification can help target interventions. The study developed risk prediction models using data from postmenopausal White women aged 45-85 years. The models based on epidemiologic factors alone successfully identified women at high risk of endometrial cancer, with limited improvements from genetic factors.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Chiara Herzog, Karin Sundstrom, Allison Jones, Iona Evans, James E. Barrett, Jiangrong Wang, Elisa Redl, Lena Schreiberhuber, Laura Costas, Sonia Paytubi, Lukas Dostalek, Michal Zikan, David Cibula, Gaby Sroczynski, Uwe Siebert, Joakim Dillner, Martin Widschwendter
Summary: This study developed an automatable triage test for cervical screening that is highly sensitive and specific in predicting the risk of progression to CIN3+ in HPV+ patients. The test demonstrated a sensitivity of 100% for detecting invasive cancer and 78% for detecting CIN3, with a specificity of 90%. It also identified 52% of women aged 30 and above with a negative cytology index sample who were later diagnosed with CIN3 within 1-4 years.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Laura Costas, Irene Onieva, Beatriz Pelegrina, Fatima Marin, Alvaro Carmona, Marta Lopez-Querol, Jon Frias-Gomez, Paula Peremiquel-Trillas, Jose Manuel Martinez, Eduard Dorca, Joan Brunet, Marta Pineda, Jordi Ponce, Xavier Matias-Guiu, Silvia de Sanjose, Francesc Xavier Bosch, Laia Alemany, Sonia Paytubi
Summary: This study evaluated the use of urine samples for the detection and molecular classification of endometrial cancer. Mutations in DNA from urine supernatant samples were identified in 100% of endometrial cancer cases, while only one control showed variants at a low frequency. The results suggest that urine samples may offer a user-friendly and reliable tool for endometrial cancer detection and classification.
CLINICAL CANCER RESEARCH
(2023)
Article
Pathology
Julia Canet-Hermida, Fatima Marin, Eduard Dorca, Nuria Duenas, Laura Costas, Monica Salinas, Angela Velasco, Paula Peremiquel-Trillas, Sonia Paytubi, Jordi Ponce, Sergi Fernandez, Jose Manuel Martinez, Laura Cardenas, Anna Taltavull, Laia Alemany, Cristina Melendez, Gloria Oliveras, August Vidal, Gabriel Capella, Eugeni Lopez-Bonet, Joan Brunet, Xavier Matias-Guiu, Marta Pineda
Summary: The study explored the utility of highly sensitive MSI assessment in endometrial aspirates for individualized gynecologic surveillance in Lynch syndrome carriers. The results showed that hs-MSI assessment can detect cellular abnormalities in LS carriers in premalignant lesions, malignant lesions, and normal endometrium, and is associated with loss of mismatch repair proteins.
Article
Geriatrics & Gerontology
Jon Frias-Gomez, Paula Peremiquel-Trillas, Laia Alemany, Alberto Ameijide, Rafael Marcos-Gragera, Jordi Ponce, Joan Brunet, Xavier Matias-Guiu, Jaume Galceran, Angel Izquierdo, Josep M. Borras, Laura Costas, Ramon Cleries
Summary: This study analyzed and predicted the incidence and mortality rates of endometrial cancer in Catalonia by 2030, with the findings showing a decrease in incidence rates for women under 65 and an increase for those aged 65-74, while mortality rates for women aged 65 and above are likely to rise.
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
