Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 83, Issue 3, Pages 393-406Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2011.11.004
Keywords
Sarcoma in irradiated tissue; Radiation-induced sarcoma; Radiogenic; Second cancer; Signature; Response
Categories
Ask authors/readers for more resources
Background: Sarcomas in irradiated tissue (SITs) are often considered with second cancers, although they usually present distinct dose response, genetic and clinical patterns. The contribution of radiation in SIT development is likely, but remains unproven in many cases. Materials and methods: We reviewed the literature for published data on SITs. Results: SITs incidence ranged between 0.03% and 0.2%. Median latency was 15 years. Angiosarcoma was the second most common subtype after undifferentiated sarcomas of malignant fibrous histiocytoma (MFH). C-Myc overexpression can be used to identify radiation-induced angiosarcoma, and a recently described transcriptomic signature of genes involved in chronic oxidative stress and mitochondrial dysfunction may indicate radiation causality. Osteosarcomas were often associated with genetic predisposition. Five-year survival rates rarely exceeded 30% because the therapeutic possibilities were often limited by the first cancer. Chemotherapy response may differ from that of de novo sarcomas. Conclusion: SITs present different characteristics from non-sarcomatoid second cancers. Reporting of SIT cases and the establishment of tissue and serum banks is necessary to better understand and validate the recently discovered radiation signature. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available