Article
Multidisciplinary Sciences
Pu Cheng, Haipeng Chen, Fei Huang, Jiyun Li, Hengchang Liu, Zhaoxu Zheng, Zhao Lu
Summary: This study established a prediction model for cancer-specific survival (CSS) of CRC patients with synchronous LM, evaluated by C-index, AUC, and calibration curves, showing good performance in predicting 1-, 3-, and 5-year CSS.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Daniel-Clement Osei-Bordom, Sivesh Kamarajah, Niki Christou
Summary: In the clinical management of liver metastasis of colorectal cancer, surgeons and oncologists categorize the metastasis into resectable and non-resectable groups to initiate tailored therapeutics. The combination of targeted therapies and biotherapies around these two entities is being actively explored to determine the ideal conditions for their application to improve patient survival and quality of life.
Article
Surgery
Byung Min Lee, Jee Suk Chang, Woong Sub Koom, Hwa Kyung Byun, Han Sang Kim, Seung-Hoon Beom, Caleb Oh, Young Joo Suh, Joong Bae Ahn, Sang Joon Shin, Byung Jo Park, Seong Yong Park
Summary: This study aimed to assess the effect of local ablative therapy (LAT) on overall survival in patients with lung metastases from colorectal cancer (CRC). The results showed that patients treated with LAT had significantly higher survival rates compared to those treated with systemic therapy alone.
Review
Oncology
Michael J. Raphael, Paul J. Karanicolas
Summary: Regional therapies, such as hepatic arterial infusion pump chemotherapy and drug-eluting beads, are effective treatment options for patients with unresectable colorectal liver metastases. These therapies allow selective delivery of drugs to tumors while sparing normal liver tissue. However, there is a lack of randomized controlled trial evidence to guide the optimal integration of regional therapies into the management of colorectal liver metastases.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
M. S. Schuurman, M. A. G. Elferink, C. Verhoef, I. H. J. T. de Hingh, V. E. P. P. Lemmens
Summary: In the treatment of elderly patients with synchronous peritoneal metastases colorectal cancer, the number of patients receiving treatment decreases with age, the postoperative mortality decreases in different age groups, but the overall survival rate remains stable.
Review
Oncology
Alexandre Delpla, Thierry de Baere, Eloi Varin, Frederic Deschamps, Charles Roux, Lambros Tselikas
Summary: Thermal ablation plays an important role in managing lung metastases of colorectal cancer, providing good outcomes in terms of local tumor control and survival extension. Factors such as tumor size, proximity to bronchi or vessels, and ablation margin size can influence the efficacy of thermal ablation in treating these metastases.
Article
Oncology
Erwin Tomasich, Ariane Steindl, Christina Paiato, Teresa Hatziioannou, Markus Kleinberger, Luzia Berchtold, Rainer Puhr, Johannes A. Hainfellner, Leonhard Mullauer, Georg Widhalm, Franziska Eckert, Rupert Bartsch, Gerwin Heller, Matthias Preusser, Anna Sophie Berghoff
Summary: This study investigated the expression of HER3 in brain metastases of breast cancer and non-small cell lung cancer, providing a basis for future clinical trial design. Results showed that HER3 is highly expressed in brain metastases of both cancer types, suggesting the need for specific trials targeting HER3 in brain metastases.
CLINICAL CANCER RESEARCH
(2023)
Review
Medicine, General & Internal
Emmanouil Georgilis, Maria Gavriatopoulou, Diamantis I. Tsilimigras, Panagiotis Malandrakis, Theodosios Theodosopoulos, Ioannis Ntanasis-Stathopoulos
Summary: Although surgical resection is the gold standard for resectable colorectal cancer liver metastases (CRLMs), the management after surgery remains controversial. This systematic review aimed to evaluate the efficacy, tolerability, and safety profile of different chemotherapeutic agents used as adjuvant treatment after surgical resection of CRLMs. The results showed that adjuvant therapy improved regression-free survival (RFS) and disease-free survival (DFS), but did not significantly prolong overall survival (OS), and the choice of therapeutic strategy did not have a differential impact on patient outcomes. More high-quality clinical trials are needed to determine which patients would benefit the most from adjuvant therapy after surgery for CRLMs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Preeti Kanikarla Marie, Cara Haymaker, Edwin Roger Parra, Young Uk Kim, Rossana Lazcano, Swati Gite, Daniele Lorenzini, Ignacio I. Wistuba, Rebecca S. Slack Tidwell, Xiaofei Song, Wai Chin Foo, Dipen M. Maru, Yun Shin Chun, Andy Futreal, Bryan Kee, David Menter, Luisa Solis, Ching-Wei Tzeng, Christine Parseghian, Kanwal Raghav, Van Morris, Chia-Chi Chang, Robert Jenq, Alda Tam, Chantale Bernatchez, Scott Kopetz, Jean-Nicolas Vauthey, Michael J. Overman
Summary: This study investigates the feasibility and safety of combining anti-CTLA-4 and anti-PD-L1 therapy in the preoperative management of resectable colorectal cancer liver metastases. Following treatment, evidence of T- and B-cell activation was seen in some patients, possibly contributing to prolonged relapse-free survival.
CLINICAL CANCER RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Tao Sun, Guangping Zhang, Tingting Ning, Qinjun Chen, Yongchao Chu, Yifan Luo, Haoyu You, Boyu Su, Chao Li, Qin Guo, Chen Jiang
Summary: This versatile tumor-targeting theranostic platform combines photothermal therapy with chemotherapy, activating a photosensitizer and releasing oxaliplatin to enhance antitumor efficacy and reduce systematic toxicity.
Article
Public, Environmental & Occupational Health
Chaofan Li, Mengjie Liu, Jia Li, Weiwei Wang, Cong Feng, Yifan Cai, Fei Wu, Xixi Zhao, Chong Du, Yinbin Zhang, Yusheng Wang, Shuqun Zhang, Jingkun Qu
Summary: This study utilized an artificial intelligence model to predict the survival of BMBC patients and identified potential prognostic factors. Additionally, survival outcomes of breast cancer patients treated with neoadjuvant chemotherapy plus surgical treatment and chemotherapy alone were investigated, showing survival benefits in selected patient subgroups with neoadjuvant chemotherapy plus surgical treatment.
FRONTIERS IN PUBLIC HEALTH
(2022)
Editorial Material
Medicine, General & Internal
Xavier Pivot
Summary: The study confirms the efficacy of pembrolizumab combined with chemotherapy in prolonging overall survival of patients with advanced triple-negative breast cancer, providing a breakthrough therapeutic treatment for this patient population.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Oncology
Yan Zhang, Kaili Wang, Tao Yang, Yibo Cao, Wanling Liang, Xiangdong Yang, Tianbao Xiao
Summary: The meta-analysis in this study suggests that hepatic arterial infusion chemotherapy (HAIC) may be a potential therapeutic regimen that could improve the outcomes of patients with colorectal liver metastases.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lana Bijelic, Isabel Ramos, Diane Goere
Summary: Important studies suggest that surgical resection of colorectal PM can be considered as a therapeutic option in appropriately selected patients, using standardized prognostic variables for evaluation. Current evidence does not support the use of specific HIPEC procedures in certain situations.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Junge Bai, Ming Yang, Zheng Liu, Sergey Efetov, Cuneyt Kayaalp, Audrius Dulskas, Darcy Shaw, Xishan Wang
Summary: Colorectal cancer is a major cause of cancer-related death globally, with distant metastatic lesions, primarily in the liver, being found in 20% of patients. Collaboration between interventional radiologists, medical oncologists, and surgeons is crucial for optimal treatment. The effectiveness of primary tumor resection (PTR) in improving overall survival and quality of life is still controversial. This minireview focuses on the treatment options for hepatic colorectal metastatic illness, specifically discussing the advancements and risks of PTR in stage IV CRC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
D. Moschovis, E. Vasilaki, M. Tzouvala, G. Karamanolis, H. Katifelis, E. Legaki, A. Vezakis, G. Aravantinos, M. Gazouli
Article
Oncology
Aristotelis Bamias, Vasilios Karavasilis, Nikolaos Gavalas, Kimon Tzannis, Epaminontas Samantas, Gerasimos Aravantinos, Angelos Koutras, Ioannis Gkerzelis, Euthymios Kostouros, Konstantinos Koutsoukos, Flora Zagouri, George Fountzilas, Meletios-Athanasios Dimopoulos
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Health Care Sciences & Services
Georgiops Tsironis, Konstantinos Koutsoukos, Konstantinos Athanasakis, Anna Tsiara, Kimon Tzannis, Margarita Gerolympou, Anastasios Visvikis, Georgios Oikonomopoulos, Alexandra Kollia, Efstathia Giannopoulou, Marialena Dimitra, Efthymios Kostouros, Athanasios Papatsoris, Athanasios Dellis, Konstantinos Stravodimos, Ioannis Varkarakis, Epaminontas Samantas, Gerasimos. Aravantinos, Nikolaos Kentepozidis, Christos Christodoulou, Vasiliki Bozionelou, Meletios Athanasios. Dimopoulos, Aristotle Bamias
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2019)
Article
Oncology
Dimitra-Ioanna Lampropoulou, Gerasimos Aravantinos, Hector Katifelis, Foivos Lazaris, Konstantinos Laschos, Theodosios Theodosopoulos, Christos Papadimitriou, Maria Gazouli
Article
Oncology
Panagiota Economopoulou, Vassiliki Kotoula, Georgia-Angeliki Kaliou, Kyriaki Papadopoulou, Christos Christodoulou, George Pentheroudakis, Georgios Lazaridis, Petroula Arapantoni-Dadioti, Angelos Koutras, Dimitris Bafaloukos, Pavlos Papakostas, Helen Patsea, Kitty Pavlakis, Dimitrios Pectasides, Athanasios Kotsakis, Evangelia Razis, Gerasimos Aravantinos, Epaminondas Samantas, Konstantine T. Kalageras, Theofanis Economopoulos, Amanta Psyrri, George Fountzilas
TRANSLATIONAL ONCOLOGY
(2019)
Article
Oncology
Ignace Vergote, Giovanni Scambia, David M. O'Malley, Ben Van Calster, Sang-Yoon Park, Josep M. del Campo, Werner Meier, Aristotelis Bamias, Nicofetta Colombo, Robert M. Wenham, Al Covens, Christian Marth, Mansoor Raza Mirza, Judith R. Kroep, Haijun Ma, Cheryl A. Pickett, Bradley J. Monk
Review
Oncology
Dimitra Ioanna Lampropoulou, Konstantinos Laschos, Anna-Lea Amylidi, Ariadni Angelaki, Nikolaos Soupos, Sotirios Boumpoucheropoulos, Eirini Papadopoulou, Evgenia Nanou, Vasilios Zidianakis, George Nasioulas, George Fildissis, Gerasimos Aravantinos
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2020)
Review
Ophthalmology
Ariadni Angelaki, Dimitra Ioanna Lampropoulou, Gerasimos Aravantinos
CUTANEOUS AND OCULAR TOXICOLOGY
(2020)
Article
Gastroenterology & Hepatology
Dimitra-Ioanna Lampropoulou, Gerasimos Aravantinos, Konstantinos Laschos, Theodosis Theodosopoulos, Christos Papadimitriou, Maria Gazouli
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2019)
Article
Medicine, General & Internal
Barbara Burtness, Kevin J. Harrington, Richard Greil, Denis Soulieres, Makoto Tahara, Gilberto de Castro, Amanda Psyrri, Neus Baste, Prakash Neupane, Ase Bratland, Thorsten Fuereder, Brett G. M. Hughes, Ricard Mesia, Nuttapong Ngamphaiboon, Tamara Rordorf, Wan Zamaniah Wan Ishak, Ruey-Long Hong, Rene Gonzalez Mendoza, Ananya Roy, Yayan Zhang, Burak Gumuscu, Jonathan D. Cheng, Fan Jin, Danny Rischin
Article
Multidisciplinary Sciences
Eirini Papadopoulou, Nikolaos Tsoulos, Katerina Tsantikidi, Vasiliki Metaxa-Mariatou, Pinelopi Eleftheria Stamou, Athina Kladi-Skandali, Evgenia Kapeni, Georgios Tsaousis, George Pentheroudakis, Dimitrios Petrakis, Dimitra Ioanna Lampropoulou, Gerasimos Aravantinos, Ioannis Varthalitis, George Kesisis, Ioannis Boukovinas, Pavlos Papakotoulas, Nikolaos Katirtzoglou, Elias Athanasiadis, Flora Stavridi, Christos Christodoulou, Anna Koumarianou, Yesim Eralp, George Nasioulas
Article
Oncology
Elena Fountzilas, Alexia Eliades, Georgia-Angeliki Koliou, Achilleas Achilleos, Charalambos Loizides, Kyriakos Tsangaras, Dimitrios Pectasides, Joseph Sgouros, Pavlos Papakostas, Grigorios Rallis, Amanda Psyrri, Christos Papadimitriou, Georgios Oikonomopoulos, Konstantinos Ferentinos, Anna Koumarianou, George Zarkavelis, Christos Dervenis, Gerasimos Aravantinos, Dimitrios Bafaloukos, Paris Kosmidis, George Papaxoinis, Maria Theochari, Ioannis Varthalitis, Nikolaos Kentepozidis, Georgios Rigakos, Zacharenia Saridaki, Adamantia Nikolaidi, Athina Christopoulou, Florentia Fostira, Epaminontas Samantas, Elena Kypri, Marios Ioannides, George Koumbaris, George Fountzilas, Philippos C. Patsalis
Summary: Limited data exists on the prognostic and predictive value of germline cancer predisposing pathogenic/likely pathogenic variants (P/LPVs) in patients with pancreatic ductal adenocarcinoma. This study examined germline testing of 62 cancer susceptibility genes in 549 unselected patients with pancreatic cancer, revealing a significant proportion of patients carrying P/LPVs in clinically relevant genes. While the presence of any P/LPVs was associated with improved overall survival, its independent prognostic significance was not retained in multivariate analysis, and P/LPVs in homologous recombination repair genes did not predict benefit from platinum-based treatment. The results suggest the need for further validation through universal genetic testing and consideration of newer treatments for patients with pancreatic cancer.
Article
Infectious Diseases
Dimitra Ioanna Lampropoulou, Vanessa Meletia Bala, Eleni Zerva, Evangelia Pliakou, Dimitrios Filippou, Maria Gazouli, Gerasimos Aravantinos
Summary: This article examines the potential benefits of poly(ADP-ribose)-polymerase inhibitors and vascular endothelial growth factor blockade in the management of severe SARS-CoV-2 infection, highlighting the need for further research to support these hypotheses.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Oncology
Michalis Liontos, Eleni Timotheadou, Emmanuel I. Papadopoulos, Zafeiris Zafeiriou, Dimitra Ioanna Lampropoulou, Gerasimos Aravantinos, Dimitrios Mavroudis, Christos Christodoulou, Adamantia Nikolaidi, Alvertos Somarakis, Christos Papadimitriou, Christos Papandreou, Aristotelis Bamias
Summary: This study investigated the implementation of new treatment modalities in routine clinical practice for ovarian cancer in Greece. The findings revealed that the majority of patients undergo debulking surgery at diagnosis, with platinum-based chemotherapy being predominantly used in the first-line setting. The study also highlighted the prevalence of BRCA mutations testing among patients and the shift towards non-platinum-based chemotherapy in later lines of treatment.
Article
Oncology
G. Mountzios, Vassiliki Kotoula, Georgia-Angeliki Kolliou, Kyriaki Papadopoulou, Georgios Lazaridis, Christos Christodoulou, George Pentheroudakis, Maria Skondra, Angelos Koutras, Helena Linardou, Evangelia Razis, Pavlos Papakostas, Sofia Chrisafi, Gerasimos Aravantinos, Irene Nicolaou, Anna Goussia, Konstantine Kalogeras, Dimitrios Pectasides, George Fountzilas
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)