Critical appraisal of inflammatory markers in cardiovascular risk stratification

Executive Summary: Heart Disease and Stroke Statistics—2014 Update

(2014) Alan S. Go et al.   CIRCULATION

Varespladib and Cardiovascular Events in Patients With an Acute Coronary Syndrome

(2014) Stephen J. Nicholls et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Relation of Fibrinogen Level With Cardiovascular Events in Patients With Coronary Artery Disease

(2013) Gjin Ndrepepa et al.   AMERICAN JOURNAL OF CARDIOLOGY

Meta-Analysis of Impact of Different Types and Doses of Statins on New-Onset Diabetes Mellitus

(2013) Eliano Pio Navarese et al.   AMERICAN JOURNAL OF CARDIOLOGY

Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease

(2013) Maria Sabater-Lleal et al.   CIRCULATION

Change in Growth Differentiation Factor 15 Concentrations over Time Independently Predicts Mortality in Community-Dwelling Elderly Individuals

(2013) K. M. Eggers et al.   CLINICAL CHEMISTRY

Incremental Prognostic Value of Biomarkers beyond the GRACE (Global Registry of Acute Coronary Events) Score and High-Sensitivity Cardiac Troponin T in Non-ST-Elevation Acute Coronary Syndrome

(2013) C. Widera et al.   CLINICAL CHEMISTRY

The Story of Growth Differentiation Factor 15: Another Piece of the Puzzle

(2013) B. Lindahl   CLINICAL CHEMISTRY

The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1

(2013) Klaus Unsicker et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Lipoprotein-Associated Phospholipase A2 (Lp-PLA2): A Novel and Promising Biomarker for Cardiovascular Risks Assessment

(2013) Anping Cai et al.   DISEASE MARKERS

American Association of Clinical Endocrinologists' Guidelines for Management of Dyslipidemia and Prevention of Atherosclerosis

(2013) Paul Jellinger et al.   Endocrine Practice

How to use C-reactive protein in acute coronary care

(2013) L. M. Biasucci et al.   EUROPEAN HEART JOURNAL

High-sensitivity C-reactive protein and atherosclerotic disease: From improved risk prediction to risk-guided therapy

(2013) Wolfgang Koenig   INTERNATIONAL JOURNAL OF CARDIOLOGY

Classical and Novel Biomarkers for Cardiovascular Risk Prediction in the United States

(2013) Aaron R. Folsom   JOURNAL OF EPIDEMIOLOGY

Identifying novel biomarkers for cardiovascular disease risk prediction

(2013) Y. Ge et al.   JOURNAL OF INTERNAL MEDICINE

Effect of Treatment for 12 Weeks With Rilapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, on Arterial Inflammation as Assessed With 18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging

(2013) Ahmed Tawakol et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Growth Differentiation Factor‐15 Deficiency Inhibits Atherosclerosis Progression by Regulating Interleukin‐6–Dependent Inflammatory Response to Vascular Injury

(2013) Gabriel A. Bonaterra et al.   Journal of the American Heart Association

Changes in Lipoprotein‐Associated Phospholipase A2 Activity Predict Coronary Events and Partly Account for the Treatment Effect of Pravastatin: Results From the Long‐term Intervention with Pravastatin in Ischemic Disease Study

(2013) Harvey D. White et al.   Journal of the American Heart Association

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE−/− mice from the development of atherosclerosis

(2012) Heiko Johnen et al.   CARDIOVASCULAR PATHOLOGY

Clinical Utility of Lipoprotein-Associated Phospholipase A2 for Cardiovascular Disease Prediction in a Multiethnic Cohort of Women

(2012) N. R. Cook et al.   CLINICAL CHEMISTRY

Clinical and Genetic Correlates of Growth Differentiation Factor 15 in the Community

(2012) J. E. Ho et al.   CLINICAL CHEMISTRY

Relationship of Lipoprotein-Associated Phospholipase A2 Mass and Activity with Incident Vascular Events among Primary Prevention Patients Allocated to Placebo or to Statin Therapy: An Analysis from the JUPITER Trial

(2012) P. M. Ridker et al.   CLINICAL CHEMISTRY

Lipoprotein-Associated Phospholipase A2 Measurements: Mass, Activity, but Little Productivity

(2012) E. A. Stein   CLINICAL CHEMISTRY

Quantifying the Accuracy of a Diagnostic Test or Marker

(2012) K. Linnet et al.   CLINICAL CHEMISTRY

Quantifying the Added Value of a Diagnostic Test or Marker

(2012) K. G. M. Moons et al.   CLINICAL CHEMISTRY

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) * Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

(2012) et al.   EUROPEAN HEART JOURNAL

Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction

(2012) Iwona Swiatkiewicz et al.   INFLAMMATION RESEARCH

Lp-PLA2—A novel marker of atherosclerosis: To treat or not to treat?

(2012) Dimitris Tousoulis et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Utility of 14 novel biomarkers in patients with acute chest pain and undetectable levels of conventional cardiac troponin

(2012) Christophe Meune et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Value of C-Reactive Protein as a Risk Factor for Acute Coronary Syndrome: A Comparison with Apolipoprotein Concentrations and Lipid Profile

(2012) Magdalena Krintus et al.   MEDIATORS OF INFLAMMATION

Value of C-Reactive Protein in Predicting Left Ventricular Remodelling in Patients with a First ST-Segment Elevation Myocardial Infarction

(2012) Iwona Swiatkiewicz et al.   MEDIATORS OF INFLAMMATION

C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Circulating, Imaging, and Genetic Biomarkers in Cardiovascular Risk Prediction

(2012) Yin Ge et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Myeloperoxidase in the diagnosis of acute coronary syndromes: The importance of spectrum

(2011) W. Frank Peacock et al.   AMERICAN HEART JOURNAL

Lipoprotein-associated phospholipase A2 activity improves risk discrimination of incident coronary heart disease among women

(2011) Ida J. Hatoum et al.   AMERICAN HEART JOURNAL

Study design and rationale for the Stabilization of pLaques usIng Darapladib—Thrombolysis in Myocardial Infarction (SOLID-TIMI 52) trial in patients after an acute coronary syndrome

(2011) Michelle L. O'Donoghue et al.   AMERICAN HEART JOURNAL

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Growth-Differentiation Factor-15 Is a Robust, Independent Predictor of 11-Year Mortality Risk in Community-Dwelling Older Adults

(2011) Lori B. Daniels et al.   CIRCULATION

Myeloperoxidase Improves Risk Stratification in Patients with Ischemia and Normal Cardiac Troponin I Concentrations

(2011) F. S. Apple et al.   CLINICAL CHEMISTRY

Risk Prediction with Serial Myeloperoxidase Monitoring in Patients with Acute Chest Pain

(2011) S. J. Nicholls et al.   CLINICAL CHEMISTRY

Association of Growth Differentiation Factor-15 with Coronary Atherosclerosis and Mortality in a Young, Multiethnic Population: Observations from the Dallas Heart Study

(2011) A. Rohatgi et al.   CLINICAL CHEMISTRY

Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies

(2011) H. Grallert et al.   EUROPEAN HEART JOURNAL

Diagnostic efficacy of myeloperoxidase for the detection of acute coronary syndromes

(2011) Marcin Sawicki et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The Cost-Effectiveness of C-Reactive Protein Testing and Rosuvastatin Treatment for Patients With Normal Cholesterol Levels

(2011) Niteesh K. Choudhry et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diagnostic Performance of High-Sensitivity Troponin T, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A Assays for Triage of Patients with Acute Myocardial Infarction

(2011) Dilshad Ahmed Khan et al.   Korean Journal of Laboratory Medicine

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

(2011) Tibor Kempf et al.   NATURE MEDICINE

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease

(2011) S. N. Breit et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Relations of growth-differentiation factor-15 to biomarkers reflecting vascular pathologies in a population-based sample of elderly subjects

(2011) Kai M. Eggers et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Fibrinogen as a key regulator of inflammation in disease

(2011) Dimitrios Davalos et al.   Seminars in Immunopathology

Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality

(2010) Fredrik E. Wiklund et al.   AGING CELL

Study design and rationale for the clinical outcomes of the STABILITY Trial (STabilization of Atherosclerotic plaque By Initiation of darapLadIb TherapY) comparing darapladib versus placebo in patients with coronary heart disease

(2010) Harvey White et al.   AMERICAN HEART JOURNAL

The JUPITER Trial: Responding to the Critics

(2010) Paul M. Ridker et al.   AMERICAN JOURNAL OF CARDIOLOGY

Cholesterol Lowering, Cardiovascular Diseases, and the Rosuvastatin-JUPITER Controversy

(2010) Michel de Lorgeril   ARCHIVES OF INTERNAL MEDICINE

PLA2G7 Genotype, Lipoprotein-Associated Phospholipase A 2 Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry

(2010) Juan P. Casas et al.   CIRCULATION

High Levels of Systemic Myeloperoxidase Are Associated With Coronary Plaque Erosion in Patients With Acute Coronary Syndromes

(2010) Giuseppe Ferrante et al.   CIRCULATION

Fibrinogen Assays for Cardiovascular Risk Assessment

(2010) G. D. O. Lowe   CLINICAL CHEMISTRY

Plasma Myeloperoxidase Predicts Incident Cardiovascular Risks in Stable Patients Undergoing Medical Management for Coronary Artery Disease

(2010) W. H. W. Tang et al.   CLINICAL CHEMISTRY

Assessment of multiple cardiac biomarkers in non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 Trial

(2010) Benjamin M. Scirica et al.   EUROPEAN HEART JOURNAL

Multiple marker approach to risk stratification in patients with stable coronary artery disease

(2010) Renate B. Schnabel et al.   EUROPEAN HEART JOURNAL

Early C-reactive protein in the prediction of long-term outcomes after acute coronary syndromes: a meta-analysis of longitudinal studies

(2010) L.-p. He et al.   HEART

Simvastatin Reduces Lipoprotein-associated Phospholipase A2 in Lipopolysaccharide-stimulated Human Monocyte–derived Macrophages Through Inhibition of the Mevalonate–Geranylgeranyl Pyrophosphate–RhoA-p38 Mitogen-activated Protein Kinase Pathway

(2010) Jun-Xian Song et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Lipoprotein-associated phospholipase A2 activity and mass in relation to vascular disease and nonvascular mortality

(2010)   JOURNAL OF INTERNAL MEDICINE

2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults

(2010) Philip Greenland et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myeloperoxidase and C-Reactive Protein Have Combined Utility for Long-Term Prediction of Cardiovascular Mortality After Coronary Angiography

(2010) Claire L. Heslop et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lp-PLA2 and risk of atherosclerotic vascular disease

(2010) Robert S Rosenson   LANCET

Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies

(2010)   LANCET

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies

(2010) The Emerging Risk Factors Collaboration   LANCET

Evaluating the Quality of Research into a Single Prognostic Biomarker: A Systematic Review and Meta-analysis of 83 Studies of C-Reactive Protein in Stable Coronary Artery Disease

(2010) Harry Hemingway et al.   PLOS MEDICINE

Lipoprotein-associated phospholipase A2 (Lp-PLA2) and risk of cardiovascular disease in older adults: Results from the Cardiovascular Health Study

(2009) Nancy Swords Jenny et al.   ATHEROSCLEROSIS

Reference change values and determinants of variability of NT-proANP and GDF15 in stable chronic heart failure

(2009) Lutz Frankenstein et al.   BASIC RESEARCH IN CARDIOLOGY

Does fibrinogen add to prediction of cardiovascular disease? Results from the Scottish Heart Health Extended Cohort Study

(2009) Mark Woodward et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Report Card on Growth Differentiation Factor 15

(2009) Anand Rohatgi et al.   Circulation-Cardiovascular Genetics

Growth-Differentiation Factor-15 for Long-Term Risk Prediction in Patients Stabilized After an Episode of Non–ST-Segment–Elevation Acute Coronary Syndrome

(2009) Kai M. Eggers et al.   Circulation-Cardiovascular Genetics

Number Needed to Treat With Rosuvastatin to Prevent First Cardiovascular Events and Death Among Men and Women With Low Low-Density Lipoprotein Cholesterol and Elevated High-Sensitivity C-Reactive Protein

(2009) Paul M Ridker et al.  

C-reactive protein improves risk prediction in patients with acute coronary syndromes

(2009) F. Schiele et al.   EUROPEAN HEART JOURNAL

Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease

(2009) Paul Elliott   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Use of Biochip Cardiac Array Technology for Early Diagnosis of Acute Coronary Syndromes

(2009) Grazyna Sypniewska et al.   Journal of Medical Biochemistry

Myeloperoxidase, Subclinical Atherosclerosis, and Cardiovascular Disease Events

(2009) Nathan D. Wong et al.   JACC-Cardiovascular Imaging

Growth-Differentiation Factor-15 in Heart Failure

(2009) Tibor Kempf et al.   Heart Failure Clinics

Influence of postprandial triglyceride-rich lipoproteins on lipid-mediated gene expression in smooth muscle cells of the human coronary artery

(2008) B. Bermudez et al.   CARDIOVASCULAR RESEARCH

C-Reactive Protein and Reclassification of Cardiovascular Risk in the Framingham Heart Study

(2008) Peter W.F. Wilson et al.  

Effect of Collection Tube Type and Preanalytical Handling on Myeloperoxidase Concentrations

(2008) J. Shih et al.   CLINICAL CHEMISTRY

Assessment of the Multiple-Biomarker Approach for Diagnosis of Myocardial Infarction in Patients Presenting with Symptoms Suggestive of Acute Coronary Syndrome

(2008) F. S. Apple et al.   CLINICAL CHEMISTRY

Lipoprotein-Associated Phospholipase A2 Is an Independent Predictor of Incident Coronary Heart Disease in an Apparently Healthy Older Population

(2008) Lori B. Daniels et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myeloperoxidase: A New Biomarker of Inflammation in Ischemic Heart Disease and Acute Coronary Syndromes

(2008) Valentina Loria et al.   MEDIATORS OF INFLAMMATION

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE