Article
Medicine, General & Internal
George D. Rodriguez, Nathan Warren, Roman Yashayev, Surya Chitra, Maria Amodio-Groton, Kelly Wright
Summary: The 2019 guidelines recommend respiratory fluoroquinolones for treating community-acquired bacterial pneumonia in adults with comorbidities. However, fluoroquinolone use has decreased due to safety warnings. This study assessed the safety and efficacy of omadacycline compared to moxifloxacin for treating adult pneumonia patients with comorbidities. The results showed that omadacycline and moxifloxacin had similar efficacy in patients with comorbidities.
FRONTIERS IN MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Shaowei Mu, Yiwen Zhu, Yu Wang, Shuang Qu, Yichun Huang, Liang Zheng, Shun Duan, Bingran Yu, Meng Qin, Fu-Jian Xu
Summary: A novel cationic polysaccharide conjugate, Dex-g-PSS30, disrupts bacterial membranes and efflux pumps, enhancing antibiotic accumulation and restoring efficacy. In a mouse model, Dex-g-PSS30 reduces inflammatory reactions, showing excellent biological absorption and degradation capabilities, providing a new treatment strategy for multidrug-resistant bacteria.
ADVANCED MATERIALS
(2022)
Article
Microbiology
Sebastian Braetz, Peter Schwerk, Arthur Thompson, Karsten Tedin, Marcus Fulde
Summary: The efficacy of killing by bactericidal antibiotics is largely influenced by ATP levels. This study found that an ATP synthase-deficient strain of Salmonella enterica serovar Typhimurium was more sensitive to the fluoroquinolone antibiotic and showed increased survival or no significant difference when challenged with other antibiotics. The increased cell killing and reduced persistence after fluoroquinolone challenge were a result of metabolic compensation through central carbon metabolism reactions and increased NAD(P)H levels.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Environmental Sciences
Sunidhi Bhatt, Subhankar Chatterjee
Summary: Antibiotics are essential in healthcare, but their widespread use has led to negative environmental effects. Fluoroquinolones, a significant antibiotic group, are found ubiquitously in the environment and contribute to the emergence of antibiotic-resistant bacteria. Various biological and chemical processes have been developed to eliminate these pollutants from the environment.
ENVIRONMENTAL POLLUTION
(2022)
Article
Urology & Nephrology
Riccardo Bartoletti, Francesco Claps, Gabriele Tulone, Alessandro Perotti, Alessandro Zucchi, Niccolo Riccardi, Vincenzo Ficarra, Cosimo De Nunzio, Andrea Tubaro, Alchiede Simonato
Summary: The effects of different antibiotic prophylaxis regimens in DM patients undergoing TRUSPB were investigated. The results showed that fluoroquinolones were effective in antibiotic prophylaxis for diabetic patients undergoing TRUSPB, regardless of the level of bacterial resistance in the community.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Multidisciplinary Sciences
Ember (Yiwei) Lu, Hui-Han Chen, Hongqing Zhao, Sachiko Ozawa
Summary: This study investigated the impact of increasing pneumococcal conjugate vaccine (PCV) coverage on antimicrobial resistance (AMR) in China. Results showed that increasing vaccine coverage significantly reduced resistance against penicillin, amoxicillin, and third-generation cephalosporins, leading to a reduction in costs due to AMR.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Ember (Yiwei) Lu, Hui-Han Chen, Hongqing Zhao, Sachiko Ozawa
Summary: This study examined the impact of increasing pneumococcal conjugate vaccine (PCV) coverage on antimicrobial resistance (AMR) in China. The findings suggest that higher PCV coverage can significantly reduce AMR against commonly used antibiotics and lead to substantial cost savings in terms of direct and indirect costs related to AMR. Understanding the benefits of vaccines in reducing AMR is crucial for driving appropriate investment in this area.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Ioana-Andreea Lungu, Octavia-Laura Moldovan, Victoria Biris, Aura Rusu
Summary: The emergence of bacterial resistance has led to the search for new antibacterial agents, with fluoroquinolones being an important class of drugs due to their broad spectrum of activity. The design of fluoroquinolone hybrids with other antibacterial agents or active compounds has resulted in hybrids with superior antibacterial properties and additional biological effects.
Article
Engineering, Environmental
Laishram Saya, W. Rameshwor Singh, Sunita Hooda
Summary: Given the large amount of harmful pharmaceuticals being released into the water stream, it is crucial to eradicate or reduce these chemicals to a minimum permissible limit. This study reports the fabrication of a magnetic guar gum graphene oxide nano-composite (mGG/GO NC) for the adsorption of ciprofloxacin from wastewater. Various techniques were used to characterize the guar gum and the nanocomposite, and it was found that the adsorption process followed the pseudo second order model and Langmuir isotherm model. The nanocomposite exhibited high adsorption capacity and recyclability, potentially due to a synergistic effect of multiple interactions in the adsorption mechanism.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Review
Infectious Diseases
Alberto Enrico Maraolo, Federica Licciardi, Ivan Gentile, Annalisa Saracino, Alessandra Belati, Davide Fiore Bavaro
Summary: A systematic review was conducted to evaluate the best treatment for Stenotrophomonas maltophilia (SM) infections. The study found that fluoroquinolones (FQs) and possibly tetracycline derivatives (TDs) may be reasonable alternatives to trimethoprim/sulfamethoxazole (TMP/SMX). More clinical trial data is needed to inform therapeutic choices.
Article
Environmental Sciences
Rafael Shinji Akiyama Kitamura, Maiara Vicentini, Maiara Carolina Perussolo, Juliana Roratto Lirola, Camilla Freitas Cirilo dos Santos, Julio Cesar Moreira Brito, Marta Margarete Cestari, Maritana Mela Prodocimo, Marcelo Pedrosa Gomes, Helena Cristina Silva de Assis
Summary: This study investigated the sublethal effects of short-term exposure to different concentrations of Ciprofloxacin on Neotropical catfish. The results showed that Ciprofloxacin caused genotoxicity and adverse effects on hematological and histopathological parameters in the fish. These findings highlight the need for attention and monitoring of Ciprofloxacin concentrations in aquatic environments.
ENVIRONMENTAL POLLUTION
(2022)
Article
Infectious Diseases
Penny A. Asbell, Christine M. Sanfilippo, Francis S. Mah
Summary: The study evaluated antibiotic resistance among intraocular isolates obtained from presumed endophthalmitis cases collected from 2009 through 2020. The results showed widespread antibiotic resistance among various bacteria, providing important implications for infection prophylaxis and treatment of intraocular infections.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Immunology
Melinda M. Pettigrew, Windy Tanner, Anthony D. Harris
Summary: Pneumonia is a heterogeneous and complex disease that remains a leading source of disease and death globally, despite advancements in diagnostics, treatment, and prevention. Current methods for prevention include vaccines and antibiotic treatment, but the threat of antimicrobial resistance poses challenges to these treatments. Additionally, the emergence of SARS-CoV-2 has significantly shifted the epidemiology of pneumonia since December 2019, highlighting the need for a broader conceptual framework to address the pathogenesis of pneumonia.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Urology & Nephrology
Jakhongir F. Alidjanov, Tommaso Cai, Riccardo Bartoletti, Gernot Bonkat, Franck Bruyere, Bela Koves, Ekaterina Kulchavenya, Jose Medina-Polo, Kurt Naber, Tamara Perepanova, Adrian Pilatz, Zafer Tandogdu, Truls E. Bjerklund Johansen, Florian M. Wagenlehner
Summary: The study found that the rates of complications after P-Bx tended to increase over time, as well as the rates of patients seeking additional medical help in the post-P-Bx period. To reduce the risk of infectious complications and to comply with the principles of antibiotic stewardship, clinicians should switch to the transperineal biopsy route.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Pharmacology & Pharmacy
Piotr Serwacki, Mateusz Gajda, Wioletta Swiatek-Kwapniewska, Marta Walaszek, Karolina Nowak, Jadwiga Wojkowska-Mach
Summary: The study aimed to assess the use of fluoroquinolone (FQ) in treatment by analyzing FQ consumption and resistance levels of selected pathogens in EU/EEA countries and Poland between 2016 and 2021. Data from ECDC surveillance systems were used to describe pathogen resistance, and the ESAC-Net project was used to determine FQ consumption. The study found that FQ consumption decreased in most EU/EEA countries, but Poland still had high usage. It recommends withdrawing FQ from empirical treatment in Poland and countries with high FQ-resistant microorganisms.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
