Article
Biochemistry & Molecular Biology
Li-Chung Chiu, Li-Pang Chuang, Shaw-Woei Leu, Yu- Lin, Chee-Jen Chang, Hsin-Hsien Li, Feng-Chun Tsai, Chih-Hao Chang, Chen-Yiu Hung, Shih-Wei Lin, Han-Chung Hu, Chung-Chi Huang, Huang-Pin Wu, Kuo-Chin Kao
Summary: For patients with severe ARDS, early initiation of ECMO may increase the likelihood of survival, especially for those with more severe conditions. Research has shown a significantly lower hospital mortality rate among patients treated with ECMO compared to those who did not receive ECMO treatment.
Article
Medicine, General & Internal
Thomas Schmitz, Muriel Doret-Dion, Loic Sentilhes, Olivier Parant, Olivier Claris, Laurent Renesme, Julie Abbal, Aude Girault, Heloise Torchin, Marie Houllier, Nolwenn Le Sache, Alexandre J. Vivanti, Daniele De Luca, Norbert Winer, Cyril Flamant, Claire Thuillier, Pascal Boileau, Julie Blanc, Veronique Brevaut, Pierre-Emmanuel Bouet, Geraldine Gascoin, Gael Beucher, Valerie Datin-Dorriere, Stephane Bounan, Pascal Bolot, Christophe Poncelet, Corinne Alberti, Moreno Ursino, Camille Aupiais, Olivier Baud
Summary: Comparison between a full dose and a half dose of antenatal betamethasone for preterm delivery showed that the half dose was not non-inferior to the full dose in terms of preventing respiratory distress syndrome. Therefore, reducing the dose of antenatal betamethasone is not recommended.
Article
Medicine, General & Internal
Natalia Saldana-Garcia, Maria Gracia Espinosa-Fernandez, Celia Gomez-Robles, Antonio Javier Postigo-Jimenez, Nicholas Bello, Francisca Rius-Diaz, Tomas Sanchez-Tamayo
Summary: A single dose of betamethasone up to 3 h before delivery may reduce the rate of serious outcomes and the severity of neonatal RDS, especially in non-tertiary hospitals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Anoopindar K. Bhalla, Margaret J. Klein, Guillaume Emeriaud, Yolanda M. Lopez-Fernandez, Natalie Napolitano, Analia Fernandez, Awni M. Al-Subu, Rainer Gedeit, Steven L. Shein, Ryan Nofziger, Deyin Doreen Hsing, George Briassoulis, Stavroula Ilia, Florent Baudin, Byron Enrique Pineres-Olave, Ledys Maria Izquierdo, John C. Lin, Ira M. Cheifetz, Martin C. J. Kneyber, Lincoln Smith, Robinder G. Khemani, Christopher J. L. Newth
Summary: The study described mechanical ventilation management in pediatric acute respiratory distress syndrome and found that nonadherence to lung-protective ventilation principles is common, potentially impacting outcomes. Modifiable factors exist that may improve adherence.
CRITICAL CARE MEDICINE
(2021)
Article
Cell Biology
Qinjie Liu, Jie Wu, Xufei Zhang, Xuanheng Li, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: The STING pathway and its induction of autophagy play a crucial role in immune defense response against pathogenic DNA, but excessive activation of STING can exacerbate organ damage. Increased circulating mtDNA levels and STING activation in sALI patients contribute to lung injury by triggering an inflammatory response and disrupting autophagy. STING activation interferes with lysosomal acidification in an IFN-dependent manner, worsening sepsis.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Jie Zhu, Shuyue Li, Ying Zhao, Yu Xiong
Summary: Twin pregnancy is associated with higher rates of adverse outcomes, largely due to increased risk of preterm birth. Antenatal corticosteroids are commonly used to reduce neonatal morbidity and mortality. However, there are ongoing controversies and uncertainties regarding their use in twin gestations, such as timing, dosage, and administration intervals.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
An-Min Hu, Xiong-Xiong Zhong, Zhen Li, Zhong-Jun Zhang, Hui-Ping Li
Summary: The study compared the outcomes of ARDS patients treated with midazolam, propofol, and dexmedetomidine, finding that patients treated with dexmedetomidine had a lower in-hospital mortality rate, while those treated with midazolam were less likely to be discharged home.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Natalia Saldana-Garcia, Maria Gracia Espinosa-Fernandez, Jose David Martinez-Pajares, Elias Tapia-Moreno, Maria Moreno-Samos, Celia Cuenca-Marin, Francisca Rius-Diaz, Tomas Sanchez-Tamayo
Summary: This retrospective cohort study compared the effects of administering two doses of betamethasone 12 hours apart to the traditional regimen in preterm infants. The results showed that the shorter interval between doses did not increase the incidence of morbidity and had similar outcomes in terms of mortality and severe morbidities. There were no adverse effects on neurodevelopment at 24 months of corrected age.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Liu Wang, Yan-Fen Tian, Wen-Qing Deng
Summary: This study conducted a systematic review and meta-analysis to evaluate the effects of metformin on ARDS. The results showed that metformin can inhibit pulmonary inflammation and oxidative stress, and improve lung injury and survival rates. More randomized controlled trials are needed to confirm these findings.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Katherine E. Eddy, Joshua P. Vogel, Nick Scott, Dagnachew Fetene, Tom Tidhar, Olufemi T. Oladapo, Gilda Piaggio, My Huong Nguyen, Fernando Althabe, Rajiv Bahl, Suman P. N. Rao, Ayesha Dc Costa, Shuchita Gupta, Abdullah H. Baqui, Mohammod Shahidullah, Saleha Begum Chowdhury, Salahuddin Ahmed, Saima Sultana, Iffat Ara Jaben, Shivaprasad S. Goudar, Sangappa M. Dhaded, Yeshita Pujar, Sunil S. Vernekar, Saraswati Welling, Geetanjali M. Katageri, Muttappa R. Gudadinni, Saumya Nanda, Zahida Qureshi, Harriet Tunu Baraka, Alfred Osoti, George Gwako, John Kinuthia, Samuel Ojo, Adesina Olubukola Adeponle, Ayede Adejumoke Idowu, Ebunoluwa Aderonke Adejuyigbe, Oluwaferni Kuti, Bankole Peter Kuti, Francis Bola Akinkunmi, Weyinmi Emmanuel Kubeyinje, Hadijat Olaide Raji, Olusanya Abiodun, Anthony Dennis Isah, Shabina Ariff, Sajid Bashir Soofi, Lumaan Sheikh, Almas Aamir, Farrukh Raza
Summary: The use of antenatal corticosteroids for preterm birth in low-resource countries has been found to be effective and cost-saving, providing a cost-effective solution for pregnant women at risk of preterm birth in reasonably equipped hospitals.
LANCET GLOBAL HEALTH
(2022)
Article
Critical Care Medicine
Christophe Le Terrier, Florian Sigaud, Said Lebbah, Luc Desmedt, David Hajage, Claude Guerin, Jerome Pugin, Steve Primmaz, Nicolas Terzi
Summary: Prone positioning (PP) is frequently used as a main treatment for intubated ICU patients with COVID-19-induced ARDS. However, early PP within 24 hours of ICU admission does not show a survival benefit compared to PP after day-1.
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Jun Hu, Lian Liu, Xianghu Zeng, Ke Wang, Hao Wang, Zijian Zeng, Yufang Cao, Lijuan Gao, Mengxin Cheng, Tao Wang, Fuqiang Wen
Summary: The study revealed that ANGPTL4 levels were elevated in patients with ARDS and significantly correlated with disease severity and mortality, suggesting that ANGPTL4 may serve as a novel prognostic biomarker in ARDS.
Article
Pharmacology & Pharmacy
Jia-Wei Yang, Ping Jiang, Wen-Wen Wang, Zong-Mei Wen, Bei Mao, Hai-Wen Lu, Li Zhang, Yuan-Lin Song, Jin-Fu Xu
Summary: Appropriate dosages of corticosteroids may improve oxygenation and moderately inhibit inflammation in ARDS patients. However, the risks associated with high-dose corticosteroid treatment should be carefully considered.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
