Why we should be wary of single-center trials

Multicenter, randomized, controlled trials evaluating mortality in intensive care: Doomed to fail?

(2009) Gustavo A. Ospina-Tascón et al.   CRITICAL CARE MEDICINE

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Intensive versus Conventional Glucose Control in Critically Ill Patients

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

The costs and cost-effectiveness of an integrated sepsis treatment protocol

(2008) Daniel Talmor et al.   CRITICAL CARE MEDICINE

The new Surviving Sepsis Campaign recommendations on glucose control should be reconsidered

(2008) Marcus J. Schultz et al.   INTENSIVE CARE MEDICINE

Once is not enough: clinical trials in sepsis

(2008) Daniel A. Sweeney et al.   INTENSIVE CARE MEDICINE

Benefits and Risks of Tight Glucose Control in Critically Ill Adults

(2008) Renda Soylemez Wiener et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Improvement in Process of Care and Outcome After a Multicenter Severe Sepsis Educational Program in Spain

(2008) Ricard Ferrer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial

(2008) Timothy D Girard et al.   LANCET

Hydrocortisone Therapy for Patients with Septic Shock

(2008) Charles L. Sprung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis

(2008) Frank M. Brunkhorst et al.   NEW ENGLAND JOURNAL OF MEDICINE

The need to reform our assessment of evidence from clinical trials: A commentary

(2008) Sean M Bagshaw et al.   Philosophy Ethics and Humanities in Medicine