Review
Biology
Swetha Mohan, Zavier Yongxuan Lim, Kai Siang Chan, Vishal G. G. Shelat
Summary: Obesity is associated with increased risk of intra-abdominal hypertension and abdominal compartment syndrome. This study aims to determine the impact of obesity on the clinical outcomes of patients with these conditions. A systematic review of nine studies involving 9938 patients showed that obesity was associated with a higher risk of intra-abdominal hypertension and correlated with the need for renal replacement therapy, intensive care unit-acquired infections, systemic inflammatory response syndrome, acute respiratory distress syndrome, length of hospital stay, and mortality.
Review
Critical Care Medicine
Jan J. De Waele
Summary: This review focuses on the developing insights in the epidemiology and treatment of patients with intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). Recent studies have drawn attention to the impact of IAH and ACS on kidney function and other outcomes. New methods for measuring intra-abdominal pressure (IAP) are being developed, and researchers continue to search for biomarkers to detect IAH or ACS. The findings from recent studies allow for better prevention and treatment of these conditions in IAH and ACS patients.
CURRENT OPINION IN CRITICAL CARE
(2022)
Review
Medicine, General & Internal
Narcis Octavian Zarnescu, Ioana Dumitrascu, Eugenia Claudia Zarnescu, Radu Costea
Summary: Abdominal compartment syndrome is a severe complication of acute pancreatitis, characterized by increased intra-abdominal pressure and new organ dysfunction. It leads to multiple organ failure and higher morbidity and mortality rates. Elevated intra-abdominal pressure has detrimental effects on respiratory, cardiovascular, gastrointestinal, neurologic, and renal functions. Around 15% of severe acute pancreatitis patients develop intra-abdominal hypertension or abdominal compartment syndrome, with a mortality rate of approximately 50%. Treatment involves medical intervention, percutaneous drainage, surgical decompression, vacuum-assisted closure therapy, and early abdominal fascia closure.
Review
Critical Care Medicine
Edward J. Kimball
Summary: Recent research has improved our understanding of the prevalence of intra-abdominal hypertension (IAH) and its independent association with organ failure. Studies have also clarified the effects of IAH on individual organ systems and specific disease states, contributing to advancements in diagnosing, monitoring, and treating IAH/ACS. There is a significant focus on the impact of IAH/ACS in the ICU setting, with contributions from specialists in various sub-specialties leading to improvements in treatment algorithms.
CURRENT OPINION IN CRITICAL CARE
(2021)
Article
Surgery
Jordan Bozer, Brandon Rodgers, Naveen Qureshi, Kristine Griffin, Brian Kenney
Summary: This study evaluated the incidence and mortality of pediatric abdominal compartment syndrome (ACS) in multiple children's hospitals in the United States from 2007 to 2019. The annual incidence and mortality of pediatric ACS remained unchanged during the study period, with a high mortality rate, especially in neonatal intensive care unit patients. There were significant variations in hospital-specific incidence and mortality, suggesting inconsistencies in pediatric ACS care between institutions, possibly related to recognition and diagnosis.
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Monica Leon, Luis Chavez, Salim Surani
Summary: Abdominal compartment syndrome (ACS) is characterized by organ failure secondary to an increase in intraabdominal pressure. Common conditions in critically ill patients, such as aggressive fluid resuscitation, can increase abdominal pressure and compromise organ perfusion, leading to renal and respiratory dysfunction. Certain surgical interventions and conditions like ascites and large tumors have also been identified as risk factors for ACS.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Medicine, General & Internal
Rayan Qutob, Alanoud Hassan A. Alkhannani, Turki Yazeed Alassaf, Saad Othman Alhokail, Ghassan Abdullah Bagazi, Abdulmalak Abdullah Alsaleh, Mashael Kamel Alqarni, Yousef Alammari, Khalid Al Harbi, Alyaa Elhazmi, Abdullah Ibrahim Bukhari, Abdullah Alaryni, Abdullah Alghamdi, Osamah A. Hakami
Summary: This study investigated physicians' knowledge and management of intra-abdominal hypertension and abdominal compartment syndrome in Saudi Arabia. The results showed a low level of knowledge among physicians, highlighting the need for increased awareness and education on the proper diagnosis and management of these conditions.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Surgery
Manxu Zhao, Nicola D'Attellis, Dominic Emerson, Vanessa Moll, Fardad Esmailian
Summary: We present a case study where a patient who underwent mechanical circulatory support during complicated orthotopic heart transplantation developed spontaneous retroperitoneal hematoma, resulting in abdominal compartment syndrome and organ failure. The utilization of a novel monitor measuring real-time intra-abdominal pressures and urinary output allowed for early detection of high intra-abdominal pressures, leading to prompt intervention through decompressive laparotomy and subsequent hemodynamic stabilization.
FRONTIERS IN SURGERY
(2022)
Article
Medicine, General & Internal
Dan Nicolae Paduraru, Octavian Andronic, Florentina Musat, Alexandra Bolocan, Mihai Cristian Dumitrascu, Daniel Ion
Summary: Compartment syndrome occurs when increased pressure compromises tissue perfusion, necessitating rapid surgical decompression. Clinical debate exists on the timing of decompression laparotomy, with urgency and appropriate timing influenced by different diseases.
Review
Biology
Rita Jacobs, Robert D. Wise, Ivan Myatchin, Domien Vanhonacker, Andrea Minini, Michael Mekeirele, Andrew W. Kirkpatrick, Bruno M. Pereira, Michael Sugrue, Bart De Keulenaer, Zsolt Bodnar, Stefan Acosta, Janeth Ejike, Salar Tayebi, Johan Stiens, Colin Cordemans, Niels Van Regenmortel, Paul W. G. Elbers, Xavier Monnet, Adrian Wong, Wojciech Dabrowski, Philippe G. Jorens, Jan J. De Waele, Derek J. Roberts, Edward Kimball, Annika Reintam Blaser, Manu L. N. G. Malbrain
Summary: This review summarizes the current knowledge on the association between fluid administration and intra-abdominal pressure in patients at risk of intra-abdominal hypertension and abdominal compartment syndrome. Most studies confirm the association between fluid resuscitation and intra-abdominal hypertension, but optimal fluid management strategies for these patients remain controversial.
Article
Pediatrics
Paul Wiegandt, Thomas Jack, Alexander von Gise, Kathrin Seidemann, Martin Boehne, Harald Koeditz, Philipp Beerbaum, Michael Sasse, Torsten Kaussen
Summary: The survey reveals inconsistent acceptance of definitions and guidelines among pediatric intensivists in Germany regarding IAH and ACS. The awareness and knowledge of valid definitions of ACS have improved, but a significant number of physicians still have not diagnosed IAH/ACS and have never measured intra-abdominal pressure (IAP).
Article
Surgery
Samuel Ersryd, Hassan Baderkhan, Khatereh Djavani Gidlund, Martin Bjorck, Peter Gillgren, Linda Bilos, Anders Wanhainen
Summary: The study found that abdominal compartment syndrome after ruptured abdominal aortic aneurysms repair is mainly associated with physiological factors, such as pre-operative hypotension, use of aortic balloon occlusion, or intraoperative transfusions. Treatment outside the instructions for use or any other morphological factors were not associated with a risk of ACS.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Review
Urology & Nephrology
Sidar Copur, Metehan Berkkan, Nuri B. Hasbal, Carlo Basile, Mehmet Kanbay
Summary: Abdominal compartment syndrome is organ dysfunction caused by intra-abdominal hypertension, which may lead to high morbidity and mortality if diagnosis is delayed. Acute kidney injury is a common complication associated with intra-abdominal hypertension, although research on its pathophysiology is limited. However, treatment and reversal of intra-abdominal hypertension are feasible.
JOURNAL OF NEPHROLOGY
(2022)
Article
Biology
Liat Iacubovici, Dana Karol, Yuval Baar, Avi Beri, Haim Herzberg, Shiri Zarour, Or Goren, Barak Cohen
Summary: This study aimed to test the accuracy of a novel continuous intra-abdominal pressure (IAP) monitor. The results showed a positive correlation between the novel monitor and the gold-standard foley manometer. Good agreement was found between the two methods, with small mean bias and standard deviation. However, further studies are needed to validate the performance in a wider range of pressures.
Review
Gastroenterology & Hepatology
Prashant Nasa, Gunjan Chanchalani, Deven Juneja, Manu L. N. G. Malbrain
Summary: Intra-abdominal hypertension and abdominal compartment syndrome have a significant impact on the pathophysiology of severe acute pancreatitis and contribute to organ failure. The optimal management involves a multi-disciplinary approach. High-quality evidence on patient selection, timing, and modalities of surgical decompression are lacking.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Medicine, General & Internal
T. S. Meyhoff, P. B. Hjortrup, J. Wetterslev, P. Sivapalan, J. H. Laake, M. Cronhjort, S. M. Jakob, M. Cecconi, M. Nalos, M. Ostermann, M. Malbrain, V Pettila, M. H. Moller, M-B N. Kjaer, T. Lange, C. Overgaard-Steensen, B. A. Brand, M. Winther-Olesen, J. O. White, L. Quist, B. Westergaard, A. B. Jonsson, C. J. S. Hjortso, N. Meier, T. S. Jensen, J. Engstrom, L. Nebrich, N. C. Andersen-Ranberg, J. Jensen, N. A. Joseph, L. M. Poulsen, L. S. Herlov, C. G. Solling, S. K. Pedersen, K. K. Knudsen, T. S. Straarup, M. L. Vang, H. Bundgaard, B. S. Rasmussen, S. R. Aagaard, T. Hildebrandt, L. Russell, M. H. Bestle, M. Schonemann-Lund, A. C. Brochner, C. F. Elvander, S. K. L. Hoffmann, M. L. Rasmussen, Y. K. Martin, F. F. Friberg, H. Seter, T. N. Aslam, S. Adnoy, P. Seidel, K. Strand, B. Johnstad, E. Joelsson-Alm, J. Christensen, C. Ahlstedt, C. A. Pfortmueller, M. Siegemund, M. Greco, J. Radej, M. Kriz, D. W. Gould, K. M. Rowan, P. R. Mouncey, A. Perner
Summary: The study found that restricting intravenous fluid therapy in adult patients with septic shock in the ICU did not lead to fewer deaths at 90 days compared to standard intravenous fluid therapy. Other survival indicators during ICU stay and at 90 days were similar in both groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Anesthesiology
Anneleen S. Staelens, Ann Heymans, Sigrid Christiaens, Niels Van Regenmortel, Wilfried Gyselaers, Manu L. N. G. Malbrain
Summary: Rectal measurement of intra-abdominal pressure is not feasible and lacks reliability for obtaining accurate readings and validations.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ashish K. Khanna, Phillipe Rola, Manu L. N. G. Malbrain
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Article
Biology
Salar Tayebi, Robert Wise, Ali Pourkazemi, Johan Stiens, Manu L. N. G. Malbrain
Summary: In this pre-clinical validation study, the SERENNO system showed excellent agreement and correlation with other continuous techniques and the gold standard method, demonstrating its ability to accurately track changes in intra-abdominal pressure.
Editorial Material
Critical Care Medicine
Xavier Monnet, Manu L. N. G. Malbrain, Michael R. Pinsky
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Prashant Nasa, Robert Wise, Paul W. G. Elbers, Adrian Wong, Wojciech Dabrowski, Niels Regenmortel, Xavier Monnet, Sheila N. Myatra, Manu L. N. G. Malbrain
Summary: According to a cross-sectional survey, there is a wide difference in the knowledge and prescription of intravenous fluids among healthcare professionals (HCP). The majority of respondents reported the absence of internal guidelines on IV fluids in hospitals or intensive care units. The average score on knowledge assessment questions was found to be low. This highlights the urgent need for education on the use of IV fluids.
JOURNAL OF CRITICAL CARE
(2022)
Article
Medicine, Research & Experimental
Wojciech Dabrowski, Mariusz Gagos, Dorota Siwicka-Gieroba, Mariusz Piechota, Jan Siwiec, Magdalena Bielacz, Katarzyna Kotfis, Andrzej Stepulak, Luiza Grzycka-Kowalczyk, Andrzej Jaroszynski, Manu L. N. G. Malbrain
Summary: This study analyzed the effect of Xn on the inflammatory response and clinical outcomes of COVID-19 patients. The results showed that compared to the control group, patients receiving Xn treatment had a significantly lower mortality rate and shorter clinical course. Xn treatment also significantly reduced plasma IL-6 concentration, D-dimer levels, and neutrophil-to-lymphocyte ratio (NLR).
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Anesthesiology
Wojciech Dabrowski, Philippe Rola, Manu L. N. G. Malbrain
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Multidisciplinary Sciences
Lore Huwel, Joke Van Eessen, Jan Gunst, Manu L. N. G. Malbrain, Veerle Bosschem, Tom Vanacker, Sofie Verhaeghe, Dominique D. Benoit
Summary: This study aims to explore when healthcare professionals consider intensive care as appropriate care. Despite previous attempts to conceptualize appropriate care, there is a lack of understanding on its meaning and implementation. This is important as inappropriate care in the ICU is regularly reported by healthcare professionals, patients, and relatives.
Article
Anesthesiology
Kay Choong See, Salar Tayebi, Chew Lai Sum, Jason Phua, Johan Stiens, Robert Wise, Amartya Mukhopadhyay, Manu L. N. G. Malbrain
Summary: This study aimed to validate a novel non-invasive ultrasonographic approach to intra-abdominal pressure (IAP) measurement and compare it with the gold standard intra-bladder pressure (IBP) method. The results showed that the ultrasound-based IAP method displayed good correlation and agreement with IBP up to 15 mmHg, providing a reliable solution for quick decision-making in critically ill patients.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Anesthesiology
Guy Fishman, Eilon Ram, Dan Gorfil, Yigal Kassif, Rachel David, Tzlil Hershko, Manu L. N. G. Malbrain, Pierre Singer, Daniel I. I. Sessler
Summary: The study aimed to validate a new automatic urine output monitoring device by comparing it to the standard urometer. The device showed good agreement with camera measurements and was more accurate than hourly nursing assessments. It provided accurate and continuous assessments of urine output.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Chemistry, Analytical
Salar Tayebi, Tim McKinney, Cynthia McKinney, Dipak Delvadia, Marc-Alan Levine, Edward S. Spofford, Luca Malbrain, Johan Stiens, Wojciech Dabrowski, Manu L. N. G. Malbrain
Summary: Continuous intra-abdominal pressure (IAP) monitoring is crucial for early detection and prevention of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). This study evaluated a novel triple balloon, air-filled TraumaGuard (TG) catheter system and found it to be effective in porcine and cadaver models, with results consistent with existing guidelines.
Review
Critical Care Medicine
Manu L. N. G. Malbrain, Pietro Caironi, Robert G. Hahn, Juan V. Llau, Marcia Mcdougall, Luis Patrao, Emily Ridley, Alan Timmins
Summary: This article discusses the importance of fluid management during hospitalization and the issues that exist, and provides specific strategies and recommendations to improve the quality and consistency of fluid management.
ANNALS OF INTENSIVE CARE
(2023)
Article
Medicine, General & Internal
Salar Tayebi, Robert Wise, Ashkan Zarghami, Luca Malbrain, Ashish K. Khanna, Wojciech Dabrowski, Johan Stiens, Manu L. N. G. Malbrain
Summary: This study aimed to validate a new continuous intra-abdominal pressure (IAP) monitoring device, TraumaGuard, and compare different measurement technologies. The results showed that TraumaGuard can measure IAP in an empty bladder, and all the studied devices demonstrated excellent IAP monitoring ability, with intra-vesical measurement methods appearing to be more reliable. TraumaGuard, Accuryn, and Serenno showed better accuracy and smaller percentage errors compared to intra-gastric measurement devices.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Jeroen Walpot, Paul Van Herck, Caroline M. Van de Heyning, Johan Bosmans, Samia Massalha, Manu L. N. G. Malbrain, Hein Heidbuchel, Joao R. Inacio
Summary: Over the last two decades, the potential role of epicardial adipocyte tissue (EAT) as a marker for major adverse cardiovascular events has been extensively studied. EAT, unlike other visceral adipocyte tissues, shares the same microcirculation with the myocardium and secretes adipocytokines that directly interact with the heart. This article discusses the three available imaging modalities for evaluating EAT and summarizes the current knowledge on its association with coronary artery disease, high-risk plaque features, atrial fibrillation, aortic stenosis, mitral annular calcification, and heart failure. The potential role of EAT in critically ill patients admitted to the intensive care unit is also discussed.
ANAESTHESIOLOGY INTENSIVE THERAPY
(2023)