Article
Pharmacology & Pharmacy
Mingqi Wang, Wen Wang, Xue Jia, Qiao He, Shichao Zhu, Yan Kang, Rui Zhang, Yan Ren, Ling Li, Kang Zou, Zhiyong Zong, Xin Sun
Summary: This study conducted a retrospective cohort study to evaluate the effect of pharmacological thromboprophylaxis on ventilator-associated events (VAEs), ICU stays, and ICU mortality among patients receiving mechanical ventilation. The results showed that pharmacological thromboprophylaxis was associated with a lower risk of VAEs and ICU mortality. Anticoagulants, but not antiplatelet agents, were associated with a decreased risk of VAEs, ICU mortality, and shorter ICU stays. The use of antithrombosis agents may also decrease the risk of VAEs in patients with D-dimer >5 mg/LFEU.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
D-L Pen, G-F Yan, L-Y He, W-L Yan, W-M Chen, J. Liu, J-Y Ying, C-Q Wang, G-P Lu
Summary: This study revealed the significant role of bacterial colonization in ventilator circuits in the development of VAP in mechanically ventilated children. Early identification and decontamination of contaminated ventilator circuits may play a crucial role in preventing VAP.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Critical Care Medicine
Saad Nseir, Ignacio Martin-Loeches, Pedro Povoa, Matthieu Metzelard, Damien Du Cheyron, Fabien Lambiotte, Fabienne Tamion, Marie Labruyere, Demosthenes Makris, Claire Boulle Geronimi, Marc Pinetonde Chambrun, Martine Nyunga, Olivier Pouly, Bruno Megarbane, Anastasia Saade, Gemma Goma, Eleni Magira, Jean-Francois Llitjos, Antoni Torres, Iliana Ioannidou, Alexandre Pierre, Luis Coelho, Jean Reignier, Denis Garot, Louis Kreitmann, Jean-Luc Baudel, Guillaume Voiriot, Damien Contou, Alexandra Beurton, Pierre Asfar, Alexandre Boyer, Arnaud W. Thille, Armand Mekontso-Dessap, Vassiliki Tsolaki, Christophe Vinsonneau, Pierre-Edouard Floch, Loic Le Guennec, Adrian Ceccato, Antonio Artigas, Mathilde Bouchereau, Julien Labreuche, Alain Duhamel, Anahita Rouze
Summary: This study found that VAP was significantly associated with increased 28-day mortality in SARS-CoV-2 patients, but SARS-CoV-2 pneumonia did not significantly modify the relationship between VAP and 28-day mortality compared to influenza pneumonia or no viral infection.
Article
Multidisciplinary Sciences
Shadi Ebrahimian, Fatemeh Homayounieh, Marcio A. B. C. Rockenbach, Preetham Putha, Tarun Raj, Ittai Dayan, Bernardo C. Bizzo, Varun Buch, Dufan Wu, Kyungsang Kim, Quanzheng Li, Subba R. Digumarthy, Mannudeep K. Kalra
Summary: The study compared the performance of AI and RALE scores in predicting patient outcomes and the need for mechanical ventilation in COVID-19 pneumonia. Both scores were strongly correlated with patients who had higher scores experiencing higher mortality and need for mechanical ventilation. Improved prediction accuracy was achieved by incorporating additional patient information such as age, gender, WBC count, and oxygen saturation.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
James J. Harrigan, Hatem O. Abdallah, Erik L. Clarke, Arman Oganisian, Jason A. Roy, Ebbing Lautenbach, Emily Reesey, Magda Wernovsky, Pam Tolomeo, Zygmunt Morawski, Jerry Jacob, Michael A. Grippi, Brendan J. Kelly
Summary: Persistent disruption of the lower respiratory tract microbiome, characterized by consecutive days with low Shannon diversity, identifies a high-risk population for lower respiratory tract infection among patients with prolonged critical illness and dependence on mechanical ventilation.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Nutrition & Dietetics
Su Wang, Xin Zhao, Qian Wang, Yongran Wu, Jiaxin Xu, Ruiting Li, Ting Zhou, Zheng Lv, Jihong Yang, Le Yang, Xiaojing Zou
Summary: Early enteral nutrition (EN) can reduce the incidence of ventilator-associated pneumonia and shorten the hospital stay in severely traumatized patients receiving invasive mechanical ventilation. Abdominal trauma, massive blood transfusion, and low albumin are independent risk factors for delayed EN.
FRONTIERS IN NUTRITION
(2023)
Review
Infectious Diseases
Mariachiara Ippolito, Giovanni Misseri, Giulia Catalisano, Claudia Marino, Giulia Ingoglia, Marta Alessi, Elisa Consiglio, Cesare Gregoretti, Antonino Giarratano, Andrea Cortegiani
Summary: This systematic review and meta-analysis aimed to estimate the occurrence of ventilator-associated pneumonia (VAP) among COVID-19 patients in the ICU and the mortality rate of those who developed VAP. The results showed that the estimated occurrence of VAP in COVID-19 patients was 45.4%, the mortality rate was 42.7%, and the mean ICU length of stay was approximately 28.58 days.
Review
Public, Environmental & Occupational Health
Istvan Ruzsics, Peter Matrai, Peter Hegyi, David Nemeth, Judit Tenk, Alexandra Csenkey, Balint Eross, Gabor Varga, Marta Balasko, Erika Petervari, Gabor Veres, Robert Sepp, Rakonczay Zoltan, Aron Vincze, Andras Garami, Zoltan Rumbus
Summary: Noninvasive ventilation (NIV) decreases mortality and reduces the need for intubation in pneumonia-associated respiratory failure, particularly in populations that include patients with COPD.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Ayse Akbiyik, Ziynet Hepcivici, Ismet Eser, Mehmet Uyar, Perihan Cetin
Summary: The study aimed to investigate the impact of oropharyngeal aspiration on ventilator-associated pneumonia (VAP) incidence prior to changing patient position. It found that performing oropharyngeal aspiration before patient position changes could effectively prevent the development of VAP. The experimental group had a significantly lower rate of VAP incidence compared to the control group, suggesting the potential benefits of this preventive measure.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Laura Pasin, Dario Gregori, Tommaso Pettenuzzo, Alessandro De Cassai, Annalisa Boscolo, Nicolo Sella, Giulia Lorenzoni, Federico Geraldini, Elisa Pistollato, Vito Marco Ranieri, Giovanni Landoni, Paolo Rosi, Paolo Navalesi
Summary: This study compared the outcomes of COVID-19 patients with hypoxemic acute respiratory failure (hARF) who received either non-invasive ventilation (NIV) or direct intubation. The results showed that attempting a trial of NIV prior to intubation in COVID-19 patients significantly reduced in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Mirella van Duijnhoven, Manon Fleuren-Janssen, Frits van Osch, Jos L. M. L. Lenoble
Summary: The study investigated the incidence and recurrence of ventilator-associated pneumonia (VAP) in patients with COVID-19 and found a high rate of VAP occurrence and recurrence. The most commonly cultured microorganisms in VAP were Pseudomonas, Klebsiella, Escherichia coli, and Staphylococcus aureus. VAP recurrences were frequent, mainly relapses. Extended antibiotic therapy and therapeutic drug monitoring should be considered for VAP caused by Gram-negative microorganisms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Infectious Diseases
Shao-Huan Lan, Shun-Hsing Hung, Shen-Peng Chang, Li-Chin Lu, Chih-Cheng Lai, Wei-Ting Lin
Summary: This study suggests that pro-, pre- and synbiotics can prevent ventilator-associated pneumonia (VAP) and reduce the duration of mechanical ventilation and stay in the intensive care unit for critically ill patients.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Medicine, General & Internal
Elise Beijer, Stefan F. van Wonderen, Wietse P. Zuidema, Marieke C. Visser, Michael J. R. Edwards, Michael H. J. Verhofstad, Tjarda N. Tromp, Charissa E. van den Brom, Esther M. M. van Lieshout, Frank W. Bloemers, Leo M. G. Geeraedts Jr
Summary: This study identified an association between sex and outcomes in severe traumatic brain injury (TBI) patients, particularly favoring older females by indicating shorter hospital stays.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Sheng-Huei Wang, Kuang-Yao Yang, Chau-Chyun Sheu, Yu-Chao Lin, Ming-Cheng Chan, Jia-Yih Feng, Chia-Min Chen, Chih-Yu Chen, Zhe-Rong Zheng, Yu-Ching Chou, Chung-Kan Peng
Summary: This study investigated the prevalence of CSO AB pneumonia and compared the presentation and outcome with CRAB-associated pneumonia. The prevalence of CSO AB among CRAB pneumonia cases was 13.74%. CSO AB and CRAB groups had similar demographic characteristics and disease severities at initial presentation, but CSO AB group had better clinical outcomes at day 7 with longer ICU stay.
SCIENTIFIC REPORTS
(2023)
Article
Nursing
Eman Arafa Hassan, Suad Elsayed Abdelmotalb Elsaman
Summary: Compliance with the ventilator bundle was found to be associated with a decreased risk of ventilator-associated events (VAEs) occurrence. Mechanically ventilated patients had a lower likelihood of experiencing VAEs when receiving the ventilator bundle.
Article
Medicine, General & Internal
Emilie Javelle, Aurelie Mayet, Rodrigue S. Allodji, Catherine Marimoutou, Chrystel Lavagna, Jerome Desplans, Matthieu Million, Didier Raoult, Gaetan Texier
Summary: This study evaluated the impact of doxycycline (DOXY) on body weight in military international travelers. The results showed that DOXY did not cause significant weight gain in soldiers. However, other factors such as fatty food, sedentary lifestyle, and strain-specific probiotics may contribute to weight gain.
Article
Virology
Philippe Colson, Philippe Gautret, Jeremy Delerce, Herve Chaudet, Pierre Pontarotti, Patrick Forterre, Raphael Tola, Marielle Bedotto, Lea Delorme, Wahiba Bader, Anthony Levasseur, Jean-Christophe Lagier, Matthieu Million, Nouara Yahi, Jacques Fantini, Bernard La Scola, Pierre-Edouard Fournier, Didier Raoult
Summary: This study investigated the dynamics of the French variant Marseille-4 of SARS-CoV-2 over a 10-month period, identifying two subvariants and analyzing their mutations and lifetimes. The findings suggest that beneficial mutations can initiate new outbreaks, while the accumulation of other mutations can result in the disappearance of lineages.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Alissa Hammoud, Meriem Louni, Florence Fenollar, Hubert Bassene, Masse Sambou, Nathalie Duclos, Georges Diatta, Cheikh Sokhna, Anthony Levasseur, Didier Raoult, Oleg Mediannikov
Summary: The current paradigm of trench fever transmission by body lice is challenged by the isolation of identical strains of Bartonella quintana from patients and head lice. Confirmation of head lice as a vector will have implications for the treatment and prevention of louse-borne diseases. This study provides evidence of head lice vectorial capacity by detecting live B. quintana in head lice and finding genetic identity between strains from patients' blood and head lice during an outbreak.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Imene Ikram Hassani, Ines Quadri, Archana Yadav, Sonia Bouchard, Didier Raoult, Hocine Hacene, Christelle Desnues
Summary: This study analyzed and compared the diversity of halophilic archaea in Zehrez-Chergui (Saharian chott), Algeria, using both PCR amplification and cultivation approaches. A total of 45 distinct strains were characterized, indicating their membership in the class Halobacteria. Phylogenetic analysis revealed that 23 strains were related to 6 genera of halophilic archaea, including Halopiger which was dominant in this hypersaline environment. The molecular analysis identified a diverse range of archaeological species, highlighting the importance of combining both methods to obtain comprehensive information.
Article
Cardiac & Cardiovascular Systems
Rossella Maria Benvenga, Christophe Tribouilloy, Hector I. Michelena, Angelo Silverio, Florent Arregle, Helene Martel, Seyhan Denev, Yohann Bohbot, Sandrine Hubert, Sebastien Renard, Laurence Camoin, Anne Claire Casalta, Jean Paul Casalta, Frederic Gouyier, Alberto Riberi, Hubert Lepidi, Frederic Collart, Didier Raoult, Michel Drancourt, Gennaro Galasso, Daniel C. DeSimone, Rodolfo Citro, Gilbert Habb
Summary: This study aimed to investigate the clinical characteristics of different bicuspid aortic valve (BAV) morphology in infective endocarditis (IE). Patients were divided into two groups based on echocardiographic definition: right-left coronary (RL type) and right noncoronary or left noncoronary (non-RL type) cusp fusion. The study found that patients with BAV and IE may have different clinical and echocardiographic features according to valve morphology, and they tend to be referred late, even with pre-existing BAV disease.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Marine Makoa-Meng, Rayan Semmar, Angeline Antezack, Gwilherm Penant, Bernard La Scola, Virginie Monnet-Corti, Philippe Colson
Summary: This study aimed to detect redondoviruses in the human oral cavity and search for a potential viral host. The results showed that redondovirus DNA was detected in 46% of the 28 saliva samples, and there was a strong correlation between redondovirus DNA and E. gingivalis DNA detections in 93% of the cases. These findings strongly support the presence of redondoviruses in the human oral cavity and their association with E. gingivalis as a likely host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Bekir Celebi, Derya Karatas Yeni, Yusuf Yilmaz, Ferhat Matur, Cahit Babur, Mehmet Ali Oktem, Mustafa Sozen, Ahmet Karatas, Didier Raoult, Oleg Mediannikov, Pierre Edouard Fournier
Summary: This study examined Borrelia species in rodents captured from rural areas of Turkey. Borrelia miyamotoi was discovered in 1.7% of the blood samples collected from wild rodents. This is the first report of B. miyamotoi presence in rodents in Turkey.
TICKS AND TICK-BORNE DISEASES
(2023)
Article
Multidisciplinary Sciences
Afaf Hamame, Reham Magdy Wasfy, Cheikh Ibrahima Lo, Florence Fenollar, Didier Raoult, Pierre-Edouard Fournier, Linda Houhamdi
Summary: Two new bacterial strains, Marseille-P2698(T) and Marseille-P2260(T), were isolated from human stools using the culturomic method. These two strains were fully described using the taxonogenomic approach. Marseille-P2698(T) was identified as a Gram-negative, motile, non-spore-forming, rod-shaped bacterium, while Marseille-P2260(T) was identified as a Gram-positive, motile, spore-forming rod-shaped bacterium.
SCIENTIFIC REPORTS
(2023)
Letter
Infectious Diseases
Philippe Brouqui, Michel Drancourt, Didier Raoult
NEW MICROBES AND NEW INFECTIONS
(2023)
Expression of Concern
Microbiology
T. Adekambi, M. Reynaud-Gaubert, G. Greub, M-J Gevaudan, B. La Scola, D. Raoult, D. Drancourt
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Expression of Concern
Microbiology
Y. Yu, M. Kowalczewska, P. Decloquement, C. Nappez, B. La Scola
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Akiko Hisada, Erino Matsumoto, Ryo Hirano, Mami Konomi, Jacques Yaacoub Bou Khalil, Didier Raoult, Yusuke Ominami
Summary: Rapid determination of drug efficacy against bacterial pathogens is crucial for detecting potentially resistant bacteria and optimizing the use of antimicrobials. This study proposes a simplified method for assessing antimicrobial efficacy by detecting immediate damage to bacterial cells using tabletop SEM. The method involves staining unaffected bacterial cell envelopes and whole affected cells, with brighter images indicating lethal damage. By quantifying single-cell images based on brightness, the efficacy of antimicrobials in causing bacterial-cell-envelope damage can be determined.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Omar Zmerli, Sara Bellali, Gabriel Haddad, Akiko Hisada, Yusuke Ominami, Didier Raoult, Jacques Bou Khalil
Summary: Phosphotungstic acid (PTA) staining is a commonly used negative staining method in scanning electron microscopy (SEM) for assessing the viability of microorganisms. This study demonstrates that PTA staining can effectively differentiate between live and dead bacteria, providing a rapid, cost-effective, and efficient viability assay for microbiome investigations and antimicrobial susceptibility testing.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Correction
Microbiology
Cheikh Ibrahima Lo, Niokhor Dione, Aminata Mbaye, Patricia Fernandez-Mellado Gomez, Issa Isaac Ngom, Camille Valles, Stephane Alibar, Jean-Christophe Lagier, Florence Fenollar, Pierre-Edouard Fournier, Didier Raoult, Seydina M. Diene
FEMS MICROBIOLOGY LETTERS
(2023)
