Article
Critical Care Medicine
Jianzhuo He, Xujie Zhao, Xinfeng Lin, Zhixu Yang, Mingyuan Ma, Li Ma, Qun Liang, Lan Li, Yong Ye, Zehuai Wen, Zhanlin Zhang, Minzhou Zhang, Liheng Guo
Summary: The study aimed to evaluate the role of Xinmailong injection (XMLI) in reversing myocardial dysfunction in septic patients. Results showed a significant decrease in the incidence of diastolic SIMD in the XMLI group, with a more pronounced improvement in serum BNP concentration. There was no significant difference in 28-day mortality rates between the two groups.
Article
Cardiac & Cardiovascular Systems
Scott A. Hubers, John A. Schirger, S. Jeson Sangaralingham, Yang Chen, John C. Burnett, David Hodge, Horng H. Chen
Summary: Infusion of B-type natriuretic peptide (BNP) in patients with acute anterior myocardial infarction did not have significant effects on parameters of left ventricular remodeling. However, there was a trend towards reduced left ventricular infarction size in patients with a baseline left ventricular ejection fraction of <40% who were treated with BNP. These results do not support the use of intravenous BNP in patients after recent myocardial infarction.
Article
Medicine, General & Internal
Ranjit Lall, Dipesh Mistry, Emma Skilton, Nafisa Boota, Scott Regan, Julian Bion, Simon Gates, Anthony C. Gordon, Janet Lord, Daniel Francis McAuley, Gavin Perkins, Mervyn Singer, Duncan Young, Tony Whitehouse
Summary: A single-center study in 2013 showed the safe use and potential survival benefit of esmolol in septic shock patients with tachycardia. The role of beta blockers in septic shock, including mechanisms such as cardiac function modulation and immunomodulation, remains poorly understood. The STRESS-L trial aims to investigate the effects of continuous landiolol infusion on patients with septic shock and tachycardia to inform clinical practice guidelines.
Article
Cardiac & Cardiovascular Systems
Tara Perunovic, Jens P. Goetze
Summary: Multiple mechanisms contribute to essential hypertension, and antihypertensive drugs primarily target increased sympathetic nervous system activity, altered production of vasoactive mediators, vascular inflammation, fibrosis, and increased peripheral resistance. C-type natriuretic peptide (CNP) is an endothelium-derived peptide that influences vascular signaling through two receptors, NPR-B and NPR-C. This article summarizes the effects of CNP on the vasculature in relation to essential hypertension and proposes targeting the CNP system as a potential tool for managing long-term essential hypertension.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Lina Zhang, Desheng Qi, Milin Peng, Binbin Meng, Xinrun Wang, Xiaolei Zhang, Zhihong Zuo, Li Li, Zhanwen Wang, Wenxuan Zou, Zhonghua Hu, Zhaoxin Qian
Summary: This study systematically characterizes the molecular, morphological, and functional alterations in CLP-induced cardiac injury and finds that dysregulated cardiac function after sepsis is related to poor long-term outcome and increased mortality.
Article
Critical Care Medicine
John A. Kellum, Claudio Ronco
Summary: Septic shock, caused by bacterial toxins like endotoxin, is a severe disease that can lead to organ failure. It is important to note that endotoxin may play a role in all types of septic shock, including non-bacterial causes such as COVID-19. Diagnosis relies on measuring endotoxin activity in addition to clinical assessment. Treatment options are limited, with immune modulating therapies and extracorporeal blood purification still being investigated.
Article
Infectious Diseases
Pedro Martinez-Paz, Marta Aragon-Camino, Esther Gomez-Sanchez, Mario Lorenzo-Lopez, Estefania Gomez-Pesquera, Alejandra Fadrique-Fuentes, Pilar Liu, Alvaro Tamayo-Velasco, Christian Ortega-Loubon, Marta Martin-Fernandez, Hugo Gonzalo-Benito, Emilio Garcia-Moran, Maria Heredia-Rodriguez, Eduardo Tamayo
Summary: The study aims to distinguish between septic shock and non-septic shock in postoperative patients through gene expression signature, providing personalized treatment and avoiding unnecessary antibiotic use and increased healthcare costs.
JOURNAL OF INFECTION
(2021)
Article
Cardiac & Cardiovascular Systems
Keyvan Razazi, Vincent Labbe, Laurent Laine, Alexandre Bedet, Guillaume Carteaux, Nicolas de Prost, Florence Boissier, Francois Bagate, Armand Mekontso Dessap
Summary: The study found that dobutamine improved cardiac function in septic shock patients with myocardial dysfunction, but was poorly tolerated in nearly two thirds of patients, especially those with severe acidosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Veterinary Sciences
Mingzhen Fan, Yuyang Miao, Yutong Yan, Kunyuan Zhu, Xiaoe Zhao, Menghao Pan, Baohua Ma, Qiang Wei
Summary: The study found that C-type natriuretic peptide regulates the expression and secretion of S100A7 in goat mammary epithelial cells through the NPR-B/JNK/c-Jun signaling pathway, playing an important role in mammary gland innate immunity.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pediatrics
Emile Simard, Christophe Morin, David Coquerel, Frederic Chagnon, Charlene Nadeau, Nathalie Samson, Jean-Paul Praud, Olivier Lesur, Etienne Fortin-Pellerin
Summary: This study aimed to assess the hemodynamic impacts of Apelin-13 in a neonatal lamb septic shock model. The results showed that Apelin-13 increased mean arterial pressure but also increased systemic vascular resistances.
PEDIATRIC RESEARCH
(2023)
Review
Cell Biology
Federico Carbone, Luca Liberale, Alberto Preda, Thomas Hellmut Schindler, Fabrizio Montecucco
Summary: The onset of cardiomyopathy in sepsis is a common feature that affects its pathophysiology and clinical care. However, there is a lack of consensus in the definition of sepsis-induced cardiomyopathy, and the wide range of ultrasonographic findings may not fully reflect the understanding of the condition. This review explores the current state of research on sepsis-related cardiomyopathy, highlighting the shortcomings in its definition and discussing the dynamic changes in cardiac performance in response to different hemodynamic clusters. The review also addresses the molecular mechanisms leading to myocardial dysfunction and their similarities to myocardial hibernation.
Review
Biochemistry & Molecular Biology
Debra M. Foster, John A. Kellum
Summary: Endotoxin, also known as lipopolysaccharide (LPS), induces inflammatory response and can lead to sepsis and septic shock. Quantifying endotoxin and removing it using extracorporeal methods may be beneficial for patients with endotoxic septic shock.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Pamela Nogueira Cavalcante, Gabriel Kanhouche, Vitor Emer Egypto Rosa, Carlos M. Campos, Mariana Pezzute Lopes, Maria Antonieta Albanez A. de M. Lopes, Roney Orismar Sampaio, Fabio Sandoli de Brito Jr, Flavio Tarasoutchi, Alexandre Antonio Cunha Abizaid
Summary: B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro BNP) are cardiac biomarkers released in response to increased ventricular and atrial wall stress. Studies have shown that elevated levels of these biomarkers are correlated with the severity of aortic stenosis (AS) and can predict the need for intervention. They play a crucial role in risk stratification and predicting cardiovascular outcomes of patients with severe AS. This paper aims to summarize the evidence of the role of BNP and NT-pro BNP in AS, before and after intervention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemical Research Methods
Meysam Gachpazan, Arash Mohammadinejad, Amin Saeidinia, Hamid Reza Rahimi, Majid Ghayour-Mobarhan, Farveh Vakilian, Majid Rezayi
Summary: Heart disease poses a serious threat to human health globally, leading to rising mortality rates. B-type natriuretic peptide is a crucial biomarker for diagnosis of heart failure, but faces challenges such as low concentration and short half-life in blood.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Vittoriano Della Corte, Gaetano Pacinella, Federica Todaro, Rosaria Pecoraro, Antonino Tuttolomondo
Summary: Natriuretic peptides are a complex molecular network with pleiotropic effects on various organs and tissues, primarily maintaining cardiovascular homeostasis and regulating water-salt balance. Increasing knowledge of their receptors, molecular mechanisms, and discovery of new peptides has led to a better understanding of their physiological and pathophysiological roles, with potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Lukas Hobohm, Ioannis T. Farmakis, Karsten Keller, Barbara Scibior, Anna C. Mavromanoli, Ingo Sagoschen, Thomas Muenzel, Ingo Ahrens, Stavros Konstantinides
Summary: This study systematically investigated the composition and clinical value of multidisciplinary pulmonary embolism response teams (PERTs). The results showed that PERT implementation led to greater use of advanced therapies and shorter in-hospital stay, but did not show a survival benefit in patients with PE.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Thomas Muenzel, Andreas Daiber
Summary: Cardiovascular disease and drug-induced health side effects are often associated with an imbalance between reactive oxygen and nitrogen species (RONS) and antioxidants. This review focuses on dysfunctional eNOS caused by RONS in the context of transportation noise exposure or chronic treatment with nitroglycerin (GTN). It also discusses various redox switches involved in the uncoupling process of eNOS.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Psychiatry
Matthias Michal, Andreas Schulz, Philipp S. Wild, Thomas Koeck, Thomas Muenzel, Alexander K. Schuster, Konstantin Strauch, Karl Lackner, Sigurd D. Suessmuth, Heiko G. Niessen, Andreas Borta, Kelly A. Allers, Daniela Zahn, Manfred E. Beutel
Summary: Previous studies have shown altered tryptophan catabolite concentrations in major depression, suggesting their potential as biomarkers and treatment targets. However, these studies had small sample sizes, limiting their generalizability. In this population-based study with 3,389 participants, we found that clinically significant depression was associated with lower levels of kynurenine and kynurenic acid. However, the correlation between tryptophan catabolites and depression severity was very small, and they could not be used to diagnose depression.
Editorial Material
Cardiac & Cardiovascular Systems
Thomas Muenzel, Andreas Daiber, Omar Hahad
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Karsten Keller, Volker H. Schmitt, Ingo Sagoschen, Thomas Muenzel, Christine Espinola-Klein, Lukas Hobohm
Summary: This study used the German nationwide inpatient sample and found that the CRB-65 score is helpful in identifying high-risk patients with PE and predicting adverse in-hospital events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Berit Hackenberg, Julia Doege, Karoline O'Brien, Andrea Bohnert, Karl J. J. Lackner, Manfred E. E. Beutel, Matthias Michal, Thomas Muenzel, Philipp S. Wild, Norbert Pfeiffer, Andreas Schulz, Irene Schmidtmann, Christoph Matthias, Katharina Bahr
Summary: The aim of this study was to investigate the correlation between tinnitus, depression, anxiety, and somatic symptom disorders in a large population. The study found that participants with tinnitus had a higher prevalence of depression, anxiety, and somatic symptom disorders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Recha Blessing, Ioannis Drosos, Thomas Muenzel, Philip Wenzel, Tommaso Gori, Zisis Dimitriadis
Summary: This study aimed to evaluate the changes in right atrial function after revascularization of right coronary artery chronic total occlusion (CTO). Transthoracic echocardiography with strain imaging was used to assess right atrial function in 55 patients undergoing CTO recanalization. The results showed that successful revascularization improved right atrial function.
BMC CARDIOVASCULAR DISORDERS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas Muenzel, Omar Hahad, Andreas Daiber
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas Muenzel, Mette Sorensen, Omar Hahad, Mark Nieuwenhuijsen, Andreas Daiber
Summary: Large epidemiological and health impact assessment studies indicate that chronic non-communicable diseases caused the majority of global deaths in 2020, with expectations for this number to increase by 2030. The exposome concept, established in 2005, focuses on the effects of various environmental exposures on health, such as pollution and climate change, and their contribution to adverse health effects and premature deaths. This Review discusses the exposome concept in relation to cardiovascular disease burden and highlights its relevance for future health research and preventive medicine.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Karsten Keller, Ioannis T. Farmakis, Luca Valerio, Sebastian Koelmel, Johannes Wild, Stefano Barco, Frank P. Schmidt, Christine Espinola-Klein, Stavros Konstantinides, Thomas Muenzel, Ingo Sagoschen, Lukas Hobohm
Summary: In Germany, 15.4% of hospitalized COVID-19 patients received ICU treatment in 2020. Male sex, cardiovascular diseases, and cardiovascular risk-factors were independent risk-factors for ICU admission.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Hiroaki Yokoyama, Tobias Friedrich Ruf, Martin Geyer, Alexander R. R. Tamm, Jaqueline Grace Da Rocha E. Silva, Theresa Ann Maria Goessler, Julia Zirbs, Ben Schwidtal, Thomas Muenzel, Ralph Stephan von Bardeleben
Summary: In this study, the effect of COMBO-TMVr on the left cardiac chambers was evaluated, including survival rate and other clinical data. The results showed that the combination therapy can support reverse remodeling of left cardiac chambers in high-risk patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Peripheral Vascular Disease
Omar Hahad, Sanjay Rajagopalan, Jos Lelieveld, Mette Sorensen, Marin Kuntic, Andreas Daiber, Mathias Basner, Mark Nieuwenhuijsen, Robert D. Brook, Thomas Muenzel
Summary: Traffic noise and air pollution are significant risk factors for cardiovascular events, with various mediating pathways involved. Existing evidence suggests that interventions targeting these environmental stressors can alleviate the adverse effects on blood pressure and intermediate pathways, providing support for a causal link. However, there are still gaps in our understanding of the underlying mechanisms, highlighting the need for further research.
Review
Peripheral Vascular Disease
Omar Hahad, Sanjay Rajagopalan, Jos Lelieveld, Mette Sorensen, Katie Frenis, Andreas Daiber, Mathias Basner, Mark Nieuwenhuijsen, Robert D. Brook, Thomas Muenzel
Summary: Traffic noise and air pollution are major environmental risk factors that often occur together in urban settings. Both noise and air pollution have been found to have independent effects on blood pressure, causing endothelial dysfunction, oxidative stress, vascular inflammation, circadian dysfunction, and activation of the autonomic nervous system, all of which contribute to the development of hypertension. It is important to increase the recognition of these environmental risk factors as modifiable cardiovascular risk factors in order to reduce the burden of cardiovascular disease.
Article
Biochemistry & Molecular Biology
Janina Krug, Magdalena L. Bochenek, Rajinikanth Gogiraju, Dagmar Laubert-Reh, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild, Christine Espinola-Klein, Katrin Schaefer
Summary: This study found that circulating sEPCR levels may serve as biomarkers of endothelial dysfunction, including angiogenesis, in individuals older than 35 years, and progressive loss of endothelial protein C receptors might be involved in the development and progression of PAD.
Article
Cardiac & Cardiovascular Systems
Sabrina Kopp, Marie-Kristin Tilch, Ingo Sagoschen, Joachim Kaes, Malte Kuniss, Thomas Neumann, Yang Yang, Katharina Schnitzler, Kai-Helge Schmidt, Thomas Rostock, Thomas Muenzel, Stavros Konstantinides, Johannes Wild, Lukas Hobohm
Summary: Pulmonary vein stenosis (PVS) is a serious complication after radiofrequency energy-mediated percutaneous pulmonary vein isolation for atrial fibrillation. It can result in nonspecific symptoms and may lead to pulmonary hypertension. We report a case of a 59-year-old female who developed progressive dyspnea after pulmonary vein ablation.
PULMONARY CIRCULATION
(2023)