Article
Biochemistry & Molecular Biology
Jingqian Su, Siyuan Chen, Jianbin Xiao, Zhihua Feng, Shan Hu, Qiaofen Su, Qi Chen, Duo Chen
Summary: This study explores the therapeutic potential of aloe-emodin (AE) in the treatment of CLP-induced sepsis, demonstrating its ability to mitigate systemic inflammation and regulate the gut microbiota. The study provides novel insights into the molecular mechanisms underlying the anti-inflammatory effects of AE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Bin Zhang, Feng Zheng, Anpeng Liu, Zhen Li, Fei Zheng, Qiangsheng Liu, Liu Yang, Kai Chen, Yanlin Wang, Zongze Zhang, Qianwen He, Jia Zhan
Summary: Activation of CB2 receptors plays a protective role in sepsis by inhibiting pyroptosis and reducing the release of inflammatory mediators. The protective effect depends on the presence of endogenous CB2 receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pratsanee Hiengrach, Peerapat Visitchanakun, Pakteema Tongchairawewat, Ponphisudti Tangsirisatian, Thitiphat Jungteerapanich, Patcharee Ritprajak, Dhammika Leshan Wannigama, Pattarin Tangtanatakul, Asada Leelahavanichkul
Summary: BAM15 shows potential as an adjuvant therapy against sepsis hyperinflammation by attenuating multiple aspects of septic conditions, such as survival, organ damage, apoptosis, and brain injury, as well as regulating mitochondrial functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Cheng-Long Ge, Wei Chen, Li-Na Zhang, Yu-Hang Ai, Yu Zou, Qian-Yi Peng
Summary: Our study reveals the important role of the HPC-PFC pathway in improving cognitive dysfunction in a mouse model of CLP sepsis and provides a novel pathogenetic mechanism for SAE.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Mingke Ni, Yanhui Li, Jinhong Wei, Zhenpeng Song, Hui Wang, Jinjing Yao, Yong-Xiang Chen, Darrell Belke, John Paul Estillore, Ruiwu Wang, Alexander Vallmitjana, Raul Benitez, Leif Hove-Madsen, Wei Feng, Ju Chen, Thomas M. M. Roston, Shubhayan Sanatani, Anna Lehman, S. R. Wayne Chen
Summary: A loss-of-function RyR2-I4855M(+/-) mutation is associated with left ventricular noncompaction (LVNC), which is characterized by increased Ca2+ release and elevated end-diastolic Ca2+ levels. This mutation may contribute to the development of RyR2-associated LVNC.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Donghwan Park, MyungJa Ro, A-Jin Lee, Dong-Wook Kwak, Yunro Chung, Jae-Hong Kim
Summary: The study found that BLT2, a receptor for leukotriene B-4 with low affinity, plays a role in sepsis, a systemic inflammatory response syndrome caused by infection. Levels of BLT2 ligands and synthesizing enzymes for LTB4 and 12(S)-HETE were significantly increased in lung and liver tissues in a septic mouse model. Blocking BLT2 suppressed the production of sepsis-associated cytokines and alleviated lung inflammation in the sepsis group, suggesting that BLT2 may be a potential therapeutic target for sepsis patients.
MOLECULES AND CELLS
(2021)
Article
Physiology
Jose Maria Moreno-Navarrete, Ferran Comas, Vincent de Jager, Jose Manuel Fernandez-Real, Hjalmar R. Bouma
Summary: The study found that sepsis reduces the expression of adipogenesis-related genes in white adipose tissue while promoting inflammation in adipose tissue. In contrast, sepsis increases inflammation in brown adipose tissue without affecting the expression of thermogenic genes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: Sepsis affects drug metabolism and the expression of cytochrome P450s. The study shows that cecal ligation and puncture (CLP) induces the expression of proinflammatory cytokines and leads to decreased survival in IL-6(-/-) mice. CLP also downregulates the expression of Cyp2c and Cyp3a11 genes, but this effect is abolished by IL-6 depletion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Claudia V. de Araujo, Frederik Denorme, W. Zac Stephens, Qing Li, Mark J. Cody, Jacob L. Crandell, Aaron C. Petrey, Kimberly A. Queisser, John L. Rustad, Judah L. Evangelista, Michael S. Kay, Joshua D. Schiffman, Robert A. Campbell, Christian C. Yost
Summary: Neutrophil extracellular traps (NETs) can contribute to host inflammatory tissue damage during sepsis. This study investigated a novel therapeutic agent, neonatal NET-Inhibitory Factor (nNIF), and found that nNIF inhibited NET formation and improved survival in a mouse model of sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Changnan Wang, Jihong Yuan, Jiankui Du
Summary: The study showed that resveratrol could alleviate sepsis-induced acute lung injury/acute respiratory distress syndrome by regulating mitochondrial function and mitophagy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amy D. Hanna, Chang Seok Lee, Lyle Babcock, Hui Wang, Joseph Recio, Susan L. Hamilton
Summary: The study indicates that the myopathy associated with the D244G mutation in CASQ1 is driven by CASQ1 mislocalization and aggregation, reduced SR calcium release, leading to ER stress, increased protein aggregation, and other pathological changes in muscle cells.
Article
Critical Care Medicine
Xiancheng Chen, Xiaojing Li, Huimin Lu, Yali Xu, Yu Wei, Ke Cao, Zhanghua Zhu, Ming Chen, Wenkui Yu
Summary: PIICS poses a growing challenge in ICUs, and we established a mouse model to study the disease's pathophysiology and treatment. The model shows two mortality peaks and a protracted course of 14 days, indicating a re-aggravated status compared to previous models.
Article
Biochemistry & Molecular Biology
Ayako Takeuchi, Satoshi Matsuoka
Summary: In this study, the spatial and functional coupling between mitochondrial Na+-Ca2+ exchanger (NCLX) and sarcoplasmic reticulum Ca2+ pump SERCA in cardiomyocytes was investigated. The results demonstrated a close interaction between NCLX and SERCA, indicating their important role in modulating cellular functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: In the study of polymicrobial sepsis, pro-inflammatory cytokines play a vital role in regulating hepatic drug transporter expression. The research found that both CLP and LPS can reduce the expression of drug transporters, but IL-6 is the major factor in the downregulation of hepatic multidrug transporters caused by polymicrobial sepsis.
TOXICOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Deepa Mathew, Julia Barillas-Cerritos, Ana Nedeljkovic-Kurepa, Mabel Abraham, Matthew D. Taylor, Clifford S. Deutschman
Summary: Cecal ligation and puncture (CLP) attenuates the tyrosine phosphorylation of insulin receptor β-subunit (IRβ) and insulin receptor substrate molecules (IRS)-1 and IRS-2.
MOLECULAR MEDICINE
(2023)
Review
Psychology, Developmental
Ines Muerner-Lavanchy, Michael Kaess, Julian Koenig
Summary: There are various diagnostic instruments available for assessing DMDD, with good reliability. However, there is a lack of reporting on psychometric properties. Further research and refinement of recently developed DMDD interviews are needed to establish the validity of the diagnosis.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Julian Koenig, Elisabeth Kohls, Markus Moessner, Sophia Lustig, Stephanie Bauer, Katja Becker, Rainer Thomasius, Heike Eschenbeck, Silke Diestelkamp, Vera Gille, Alisa Hiery, Christine Rummel-Kluge, Michael Kaess
Summary: Based on a study in Germany, the first school-closing during the COVID-19 pandemic did not have an immediate and severe impact on the mental health and well-being of adolescents. Suicide plans and conduct problems decreased during the lockdown, and the influence of socioeconomic status on mental health also decreased. However, the study's scope was limited and long-term consequences cannot be ruled out.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Daniel Graf, Stefan Lerch, Ulrich Boehnke, Corinna Reichl, Jochen Kindler, Julian Koenig, Michael Kaess
Summary: Home treatment can be an effective alternative to inpatient treatment for children and adolescents with acute mental disorders. A pilot project in Switzerland showed that home treatment resulted in significant improvements in psychopathological burden, comparable to inpatient treatment.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Sophia Lustig, Michael Kaess, Nina Schnyder, Chantal Michel, Romuald Brunner, Alexandra Tubiana, Jean-Pierre Kahn, Marco Sarchiapone, Christina W. Hoven, Shira Barzilay, Alan Apter, Judit Balazs, Julio Bobes, Pilar Alejandra Saiz, Doina Cozman, Padraig Cotter, Agnes Kereszteny, Tina Podlogar, Vita Postuvan, Airi Varnik, Franz Resch, Vladimir Carli, Danuta Wasserman
Summary: Early detection and intervention can help prevent mental disorders and risk behaviors among adolescents, but many of them do not seek help. School-based screenings are a promising approach to identify at-risk adolescents and encourage help-seeking behavior. However, this study found that the intervention called ProfScreen did not significantly improve the use of mental health services or reduce the at-risk state among participants compared to the control group.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
C. Michel, S. Lerch, J. R. Buetiger, R. Flueckiger, M. Cavelti, J. Koenig, M. Kaess, J. Kindler
Summary: Among individuals with clinical high risk for psychosis, children/adolescents show more frequent but less stable perceptive symptoms compared to adults. Ecological momentary assessment (EMA) can be used to explore real-time experiences of these symptoms. This study found that perceptive symptoms were more frequently reported but less stable in children/adolescents based on EMA.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Fanny Carina Ossa, Vanessa Jantzer, Franziska Neumayer, Lena Eppelmann, Franz Resch, Michael Kaess
Summary: This study examines the associations between cyberbullying and mental health problems, risk-taking, and self-harm behavior. It finds that cyberbullying has unique associations compared to school bullying and adds an additional burden for students already involved in school bullying.
Article
Psychology, Clinical
Leonie Fleck, Anna Fuchs, Eva Moehler, Katharina Williams, Julian Koenig, Franz Resch, Michael Kaess
Summary: Research has shown that borderline personality disorder (BPD) can be diagnosed in adolescence. However, there is limited understanding of BPD traits in school-age children and how they compare to those seen in adolescents. This study compared the prevalence of BPD traits in 14-year-old adolescents and 9-year-old children, finding no significant differences between the two groups. BPD traits were associated with comorbidity, emotional and behavioral problems, and lower quality of life in both cohorts, but showed weaker associations with the mother-child relationship in children compared to adolescents.
PERSONALITY DISORDERS-THEORY RESEARCH AND TREATMENT
(2023)
Letter
Neurosciences
Julian Koenig, Michael Kaess
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2023)
Article
Public, Environmental & Occupational Health
Lorna Staines, Colm Healy, Paul Corcoran, Helen Keeley, Helen Coughlan, Elaine McMahon, Padraig Cotter, David Cotter, Ian Kelleher, Camilla Wasserman, Romuald Brunner, Michael Kaess, Marco Sarchiapone, Christina W. Hoven, Vladimir Carli, Danuta Wasserman, Mary Cannon
Summary: In this study, a secondary data analysis was conducted on a clustered-randomized control trial to investigate the effectiveness of school-based interventions in reducing and preventing psychotic experiences. The findings suggest that a screening and referral intervention significantly reduced the occurrence of psychotic experiences in adolescents. This study provides the first evidence for such school-based interventions.
Article
Clinical Neurology
Ines Murner-Lavanchy, Johannes Josi, Julian Koenig, Corinna Reichl, Romuald Brunner, Michael Kaess
Summary: This study investigated the relationship between treatment response and resting-state functional brain connectivity (RSFC) in adolescents engaging in non-suicidal self-injury (NSSI). The findings suggest that lower baseline RSFC is associated with better clinical outcomes, while both lower and higher baseline RSFC are associated with symptomatology and severity, independent of time and treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Tania Moretta, Michael Kaess, Julian Koenig
Summary: Major depressive disorder (MDD) is associated with autonomic nervous system (ANS) dysfunction, characterized by decreased parasympathetic (PNS) and increased sympathetic (SNS) activity. This study aimed to assess the ANS activity in adolescents with MDD and found that patients with MDD showed decreased PNS activity, as indicated by reduced heart rate variability (HRV), while no significant differences were found in SNS activity between groups. The findings suggest that ANS dysfunction in adolescent MDD may be predominantly driven by decreased PNS activity.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Christine Sigrist, Hannah Jakob, Christoph J. Beeretz, Stefanie J. Schmidt, Michael Kaess, Julian Koenig
Summary: Heart rate (HR) and vagally mediated heart rate variability (HRV) are distinct biomarkers of cardiac autonomic activity. Decreased HRV has been linked with impairments in stress and emotion regulation, which are also observed in individuals engaging in non-suicidal self-injury (NSSI). This study examined diurnal variations of HR and HRV in female adolescents with NSSI disorder and found altered patterns compared to healthy controls. The findings highlight the potential of diurnal rhythms of cardiac autonomic activity as objective indicators of disordered stress and emotion regulation in developmental psychopathology.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jasper Voeckel, Christine Sigrist, Michael Kaess, Julian Koenig
Summary: This study aimed to identify predictors of treatment non-response in female adolescents with depression. The results showed that greater symptom severity, higher frequency of self-injury, history of suicide attempts, and history of childhood trauma were consistently associated with treatment non-response. Only a lower number of siblings was robustly associated with treatment non-response based on self-reports.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Chiara E. G. Castiglione-Fontanellaz, Samira Schaufler, Salome Wild, Christoph Hamann, Michael Kaess, Leila Tarokh
Summary: Current evidence suggests that sleep is important for the physical and mental health of adolescents. Most studies have focused on the association between sleep duration/quality and health. Recent research has found that regularity in the timing of sleep also plays a role in well-being. This study investigated the variability of sleep and its relationship with depressive symptoms/mental health in adolescents. The results showed that regular sleep timing was associated with longer duration and higher quality sleep, and may be protective of adolescent mental health.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Emilia L. Mielke, Julian Koenig, Sabine C. Herpertz, Sylvia Steinmann, Corinne Neukel, Pelin Kilavuz, Patrice van der Venne, Katja Bertsch, Michael Kaess
Summary: Interpersonal dysfunction is a core symptom of borderline personality disorder (BPD), and recent research suggests that low levels of oxytocin in plasma may be related to this disorder. This study examined plasma oxytocin levels in 131 female BPD patients, finding that they had reduced levels compared to non-BPD controls, and this was independent of age. Plasma oxytocin was also negatively associated with the number of BPD symptoms, and there was a mediating effect of adverse childhood experiences on the relationship between BPD symptoms and oxytocin levels.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)