Article
Physiology
Yuika Osada, Shunsaku Nakagawa, Kanako Ishibe, Shota Takao, Aimi Shimazaki, Kotaro Itohara, Satoshi Imai, Atsushi Yonezawa, Takayuki Nakagawa, Kazuo Matsubara
Summary: This study investigated the impact of antibiotic-induced microbiome depletion (AIMD) on renal glucose metabolism in mice, finding that AIMD is associated with decreased pyruvate levels in the kidney and may increase the susceptibility of the kidney to ischemia-reperfusion injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Laurent A. Messonnier, Benjamin Chatel, Chi-An W. Emhoff, Leo Blervaque, Samuel Oyono-Enguelle
Summary: The study found that blood glucose levels remained stable during recovery after short-duration high-intensity exercise, while blood lactate levels displayed a classic biphasic curve. Additionally, the delayed and transitory rebound of glycemia was associated with lactate availability during this period.
FRONTIERS IN NUTRITION
(2021)
Article
Plant Sciences
Wen-Ze Wu, Ting Ling-Hu, Yun-Hao Zhao, Wei-Di Zhao, Cui Ji, Jun-Sheng Tian, Yan Ren, Xue-Mei Qin
Summary: This study explored the antidepressant effect of Xiaoyao San (XYS) from the perspective of glucose catabolism using stable isotope tracing, molecular biology techniques, and transmission electron microscopy. The results showed that XYS could improve the depressive symptoms induced by chronic unpredictable mild stress by modulating the disorders of glucose catabolism in the hippocampus of the rats. Additionally, XYS was found to improve the structural damage of mitochondria and nuclei. The specific targets include lactate dehydrogenase, pyruvate carboxylase, pyruvate dehydrogenase, succinate dehydrogenase, and mitochondrial respiratory chain complex V.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Engineering, Environmental
Seung-Hee Kim, Dong-Hun Lee, Min-Seob Kim, Han-Pil Rhee, Jin Hur, Kyung-Hoon Shin
Summary: In this study, an integrated framework was validated to effectively manage nitrate loading in complex river systems through quantitative estimation of nitrate sources. The isotopic compositions of nitrates showed different ranges among land-use types, reflecting different nitrate sources within watersheds. Hydrological conditions, such as water discharge, partially controlled total nitrate loads. Sewage transport near urban boundaries showed unique enhancement and increased total nitrate load in downstream areas. The isotopic and model-based nitrate fluxes showed good correlation for urban sources but poor correlation for agriculture-dominated land use.
Article
Environmental Sciences
Abdulhalim Zaryab, Hamid Reza Nassery, Kay Knoeller, Farshad Alijani, Eddy Minet
Summary: This study investigates the geochemistry and stable isotope composition of the Kabul urban aquifer, the main source of drinking water for Kabul city's inhabitants. The findings suggest that nitrate pollution in the aquifer primarily originates from sewage rather than artificial fertilizer. The results highlight the importance of improving sewage collection systems in the Kabul Plain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Marine
Qibin Lao, Guoqiang Liu, Jingsong Gao, Youli Shen, Qizhong Su, Chunqing Chen, Fajin Chen
Summary: Isotope measurements in the northeastern Beibu Gulf of China revealed that nitrate sources primarily originated from local pollution sources, with seasonal variations and significant impacts from human activities on the marine ecosystem, resulting in excessive nutrient levels.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Endocrinology & Metabolism
Ningmei Zeng, Jiankang Bao, TingTing Shu, Chuang Shi, Gang Zhai, Xia Jin, Jiangyan He, Qiyong Lou, Zhan Yin
Summary: IGF1 is an essential regulator of somatic growth in mammals. This study used CRISPR/Cas9 to create an igf1-deficient zebrafish model and found growth retardation and upregulation of insulin and igf2/igf3 in both male and female fish. Gender-specific responses were observed, with males showing growth retardation and females displaying hyperglycemia and impaired glucose uptake. This suggests different roles of IGF1 in regulating metabolism and growth in male and female zebrafish.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Gabrielle Yasmin Muller, Felipe de Oliveira Matos, Julio Ernesto Perego Junior, Mirian Ayumi Kurauti, Maria Montserrat Diaz Pedrosa
Summary: This study evaluated the effect of high-intensity interval resistance training on liver gluconeogenesis from lactate. The results showed that mice trained for 6 or 8 weeks had higher glucose and pyruvate production from lactate compared to untrained mice. The content of the key regulatory enzyme PEPCK was also increased in the trained group. These findings suggest that high-intensity training can improve the lactate threshold by enhancing liver gluconeogenesis from lactate.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Environmental Sciences
Wei Guo, Li Luo, Zhongyi Zhang, Nengjian Zheng, Hongwei Xiao, Huayun Xiao
Summary: The study shows that nitrate in southern China, especially during warm months, is mainly derived from the OH radical pathway, while changes in formation pathways and isotopic composition are influenced by air pollution emissions. Higher isotopic values from NOx emissions in northern areas and during cold months lead to higher nitrate isotopic compositions.
ENVIRONMENTAL RESEARCH
(2021)
Article
Medicine, General & Internal
Teemu Zetterman, Ritva Markkula, Eija Kalso
Summary: Fibromyalgia patients showed higher glycaemic response to glucose intake, which may not be directly attributed to fibromyalgia but rather lifestyle factors. Body mass index and smoking rates were higher in fibromyalgia patients, while levels of pyruvate and lactate were similar between the two groups.
Article
Biochemistry & Molecular Biology
Ting Linghu, Yunhao Zhao, Wenze Wu, Yao Gao, Junsheng Tian, Xuemei Qin
Summary: The severe harm of depression to human health and life has attracted global attention, but the exact mechanism is not yet known due to the complicated pathogenesis. This study focuses on mitochondrial dysfunction and reveals a metabolic reprogramming in depressed rats, including decreased TCA cycle and increased gluconeogenesis pathway. The levels of the mitochondrial pyruvate carrier (MPC) decreased significantly, suggesting MPC, PDH and PC as potential therapeutic targets for depression.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Article
Cell Biology
Clara I. Marin-Briggiler, Guillermina M. Luque, Maria G. Gervasi, Natalia Oscoz-Susino, Jessica M. Sierra, Carolina Mondillo, Ana M. Salicioni, Dario Krapf, Pablo E. Visconti, Mariano G. Buffone
Summary: Experimental results show that human sperm exhibit reduced motility and other kinematic parameters under starvation conditions, while treatment with energy recovery restores hyperactivated motility, rapidly increasing ATP and cAMP levels. This suggests that modulating sperm energy levels through such treatment may positively impact human sperm fertilizing ability in vitro.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Leonie K. Stabenow, Darya Zibrova, Claudia Ender, Dario L. Helbing, Katrin Spengler, Christian Marx, Zhao-Qi Wang, Regine Heller
Summary: Vascular aging is associated with endothelial dysfunction, which is influenced by the accumulation of senescent cells in aged tissues and their environment. Senescence is closely linked to changes in cell metabolism, with senescent cells showing enhanced glycolytic and oxidative glucose metabolism.
Article
Biotechnology & Applied Microbiology
A. Yu. Skorokhodova, A. Yu. Gulevich, V. G. Debabov
Summary: The study found that adding nitrate ions to the medium stopped alanine production by E. coli strains, but they retained the functionality of respiratory reduction of endogenous pyruvate to lactate. Additionally, respiratory activity provoked the activation of the oxidative tricarboxylic acid cycle in the strains.
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
(2021)
Article
Environmental Sciences
Young-Jae Jeong, Bo-Seong Seo, Nuri Baek, Jin-Hyeob Kwak, Sang-Mo Lee, Hyun-Jin Park, Woo-Jung Choi
Summary: This study proposed methods for determining the δN-15 of multiple nitrogen species. The methods included traditional distillation, direct evaporation, and isotope mass balance equation. The accuracy and precision of the methods were evaluated through a series of experiments, and the influences of different conditions on the analysis results were assessed.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Editorial Material
Peripheral Vascular Disease
F. Simon
Article
Peripheral Vascular Disease
P. Dueppers, N. Floros, A. Oberhuber, H. Schelzig, M. U. Wagenhaeuser, F. Simon
Editorial Material
Peripheral Vascular Disease
M. Forstner, W. Eilenberg, F. Simon, M. Trenner, H. H. Eckstein, L. Maegdefessel, A. Busch
Review
Cell Biology
Florian Simon, Markus Udo Wagenhaeuser, Albert Busch, Hubert Schelzig, Alexander Gombert
Article
Peripheral Vascular Disease
F. Simon, A. Larena-Avellaneda, S. Wipper
Letter
Surgery
Alexander Gombert, Mohammad Barbati, Oliver Hartmann, Janin Schulte, Tim Simon, Florian Simon
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2020)
Editorial Material
Peripheral Vascular Disease
K. Troidl, F. Simon
Article
Peripheral Vascular Disease
M. U. Wagenhaeuser, N. Floros, E. Nikitina, J. Mulorz, K. M. Balzer, S. Goulas, M. Petrich, P. Dueppers, F. Simon, H. Schelzig, A. Oberhuber
Summary: This study analyzed patient outcomes following endovascular aortic aneurysm repair using the AFX stent graft in cases with very narrow aortic bifurcations. The technical success rate was high with no procedure-related deaths, but some patients experienced iliac artery stenosis and endoleak complications. Overall, the use of the AFX stent graft appears safe, although patients with very narrow aortic bifurcations may require additional interventions.
INTERNATIONAL JOURNAL OF VASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Florian Simon, Mansur Duran, Waseem Garabet, Hubert Schelzig, Michael Jacobs, Alexander Gombert
Summary: A decade ago, gene therapy was seen as a potential treatment for chronic limb-threatening ischemia, but its safety and clinical feasibility are still in question. Gene therapy can be achieved through transduction and transfection methods, but there are risks involved, such as increased neo-vascularization in undesired tissue, malignant transformation and inflammation, and arterial thrombosis. Clinical trials of gene therapy in vascular occlusive disease have shown mixed results, leaving the role of gene therapy unclear.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Leon-Gordian Koepke, Edzard Schwedhelm, Wiebke Ibing, Alexander Oberhuber, Guenter Daum, Brigitta Vcelar, Hubert Schelzig, Florian Simon
Summary: This study found that rhEPO and cEPO-Fc have protective effects on the clinical outcome and neuronal tissue of mice after SCI, and that serum S1P levels may predict the severity of impairment after SCI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Panagiotis Doukas, Gabriel Hellfritsch, Hanif Krabbe, Jelle Frankort, Michael J. Jacobs, Alexander Gombert, Florian Simon
Summary: Tissue injury during open thoracoabdominal aortic reconstructions can be predicted by measuring HSP70 serum levels, which is essential for the timely detection and management of abdominal complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Florian Simon, Axel Larena-Avellaneda, Sabine Wipper
Summary: Animal models have played an important role in studying atherosclerosis, but there is no perfect model available. Current research focuses on preventive strategies, including pharmacologic and biologic interventions. Understanding the individual characteristics of natural or stimulated diseases in each species is crucial for proper experimental design and execution.
JOURNAL OF VASCULAR RESEARCH
(2022)
Meeting Abstract
Physiology
S. Sadir, K. Simsek, K. Ates, M. Ozler, B. Uysal, T. Topal, A. Korkmaz, S. Oter
Meeting Abstract
Physiology
K. Simsek, S. Sadir, K. Ates, M. Ozler, T. Topal, B. Uysal, S. Oter, A. Korkmaz
Review
Cell Biology
Florian Simon, Nicolaos Floros, Wiebke Ibing, Hubert Schelzig, Artis Knapsis
NEURAL REGENERATION RESEARCH
(2019)