Journal
CRITICAL CARE CLINICS
Volume 29, Issue 4, Pages 865-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccc.2013.06.008
Keywords
Severe malaria; Sepsis; Adjunctive therapy; Antimalarials; Fluid management; Respiratory failure; Acidosis
Categories
Funding
- Grand Challenges Canada
- Research Institute of the McGill University Health Centre
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Severe malaria is a medical emergency requiring early intervention to prevent death. This article highlights key aspects of the management of severe malaria syndromes in the intensive care unit, with a focus on individual case management of imported malaria. Key differences in the presentation, management, and outcomes of severe malaria by endemicity and by age group are emphasized. In all groups with severe malaria, intravenous artesunate is the antimalarial agent of choice. This article discusses specific antimalarial therapies, optimal supportive management strategies, differences from strategies for bacterial sepsis, and trials of adjunctive therapy for severe malaria in humans.
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