Article
Chemistry, Medicinal
Dorota Dobler, Thomas Schmidts, Michael Merzhaeuser, Peggy Schlupp, Frank Runkel
Summary: Novel compounds with improved functionality and safety, such as Ionic Liquids (ILs) containing salicylate anions, have potential as multifunctional components in dermal formulations. The alkyl chain length of the cation in ILs directly impacts their surface activity, antimicrobial activity, and cytotoxicity. Different ILs show variations in antimicrobial activity, with N-hexyl nicotinamide salicylate exhibiting higher activity and good skin tolerance, making it a potential candidate as an emulsifier/co-emulsifier in dermal formulations.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Kawther Aabed, Afrah E. Mohammed
Summary: The latest advancements in green nanoparticle synthesis present a promising approach to preserving natural resources and reducing environmental pollution. This study on silver nanoparticles (AgNPs) synthesized from aqueous extracts of medicinal plants showed significant antibacterial and cytotoxic potential. The AgNPs exhibited strong antibacterial effects against various microbes and demonstrated synergistic interactions with antibiotics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Immunology
Xizi Song, Rujin Tian, Kai Liu
Summary: Airborne transmission is an unpredictable route of infection that has become more prevalent due to complex air environments. Traditional air purification methods are ineffective against active microorganisms like bacteria, viruses, and fungi. Effective filtration materials with antimicrobial activity, such as ionic liquids (ILs), are needed to solve this problem. ILs are stable salts that remain liquid at room temperature and have a wide range of potential applications. This study focuses on the antimicrobial activity and safety of new types of ILs for air purification and discusses their synthesis and potential applications in medical instruments and indoor environments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Chemistry, Physical
Zari Fallah, Ehsan Nazarzadeh Zare, Moonis Ali Khan, Sidra Iftekhar, Matineh Ghomi, Esmaeel Sharifi, Mahmood Tajbakhsh, Nasser Nikfarjam, Pooyan Makvandi, Eric Lichtfouse, Mika Sillanpaa, Rajender S. Varma
Summary: Efforts to broaden the applications of ionic liquids have advanced in the past two decades. Ionic liquids show promise as antimicrobial systems, as they can be tailored in various sizes, morphologies, and surface charges. Common methods for preparing ionic liquid-based materials include crosslinking, loading, grafting, and combining with other polymeric materials. Recent research focuses on tuning the biological properties of these materials for antimicrobial applications in water treatment, air filtration, food packaging, and anticorrosion.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Physical
Saffron J. Bryant, Stuart J. Brown, Andrew Martin, Radhika Arunkumar, Rekha Raju, Aaron Elbourne, Gary Bryant, Calum J. Drummond, Tamar L. Greaves
Summary: The study found that protic ionic liquids have potential as effective cryoprotective agents, with ethylammonium acetate showing promising results and being safer than the common cryoprotectant, dimethylsulfoxide. The results of this research will inform the development of a suite of potential new ionic liquid-based cryoprotectants that could potentially allow the cryopreservation of new cell types.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ana R. P. Goncalves, Xavier Paredes, A. F. Cristino, F. J. V. Santos, Carla S. G. P. Queiros
Summary: Ionic liquids were initially touted as environmentally friendly replacements for traditional solvents, but research on their interactions with organisms is lacking. Lipophilicity and the type of cation play key roles in toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mohsen Naghmachi, Abdoshakoor Raissi, Payam Baziyar, Farhad Homayoonfar, Farzane Amirmahani, Marzieh Danaei
Summary: In this study, silver nanoparticles (AgNPs) were synthesized using a green method for the first time using the extract of terebinth. Various analyses were conducted to confirm the formation of AgNPs and study their antioxidant, antibacterial, and anticancer activities. The biogenic AgNPs showed a spherical shape with a diameter of 32 nm and exhibited significant antimicrobial and anticancer properties.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Jakub Michalski, Cezary Odrzygozdz, Patrick Mester, Dorota Narozna, Tomasz Clapa
Summary: Emerging antimicrobial resistance and spread of drug-resistant pathogens is currently one of the biggest threats to global health. Ionic liquids, low-melting salts with unique tunable nature and biological activity, are considered as potential candidates to replace current antibiotics. This Review summarizes the effects of ionic liquids on pathogenic and non-pathogenic bacteria and viruses, focusing on their interactions with key cell components, oxidative stress and metabolic dysregulation induced by ionic liquids, interactions with bacterial biofilms, and potential drawbacks of using ionic liquids as antimicrobials.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Engineering, Environmental
Amirah Azzouz, Maan Hayyan
Summary: Deep eutectic solvents (DESs) have attracted significant interest in fields such as nanotechnology due to their beneficial characteristics and potential to replace conventional agents with higher environmental impacts. Research studies have demonstrated the promise of DESs in improving efficiency and sustainability in nano-scale applications. Therefore, a comprehensive review of the recent advances in these fields is crucial.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Juanjuan Xu, Yuanpei Li, Haojie Wang, Mengxi Zhu, Wenpo Feng, Gaofeng Liang
Summary: The study successfully developed an AMP@PDA@AgNPs nanocomposite with excellent biocompatibility and strong antimicrobial activity, capable of disrupting bacterial biofilms. The nanocomposite showed potential in treating bacterial infections by inhibiting the expression of biofilm-related genes. The synergistic strategy of AMPs and AgNPs provided a new perspective for the treatment of bacterial infections.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Polymer Science
Crisiane A. Marangon, Murilo A. Vigilato Rodrigues, Mirella R. Vicente Bertolo, Virginia da C. Amaro Martins, Ana Maria de Guzzi Plepis, Marcia Nitschke
Summary: The study explores the influence of pH and ionic strength on the properties of chitosan/rhamnolipid nanoparticles (C/RL-NPs), showing that adjusting these factors can enhance the colloidal stability and antimicrobial activity of the NPs. The research highlights the importance of investigating size and surface charge to determine the bioactivity properties of hybrid natural-based nanomaterials.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Multidisciplinary Sciences
Madhulata Shukla, Alkadevi Verma, Sunil Kumar, Shaili Pal, Indrajit Sinha
Summary: The stabilization mechanism of silver nanoparticles by 1-butyl-3-methylimidazolium tetrafluoroborate ionic liquid is elucidated through experimental spectroscopic investigations and DFT calculations. The results show that the nanoparticles are surrounded by IL anions, and the attractive binding energy and interaction energy between cluster and IL are considerable. Additionally, DOS calculation indicates a significantly smaller HOMO-LUMO gap in the Ag cluster-IL composite compared to IL alone.
Article
Pharmacology & Pharmacy
Francyelle Borges Rosa de Moura, Bruno Antonio Ferreira, Elusca Helena Muniz, Allisson Benatti Justino, Ana Gabriela Silva, Rosy Iara Maciel de Azambuja Ribeiro, Noelio Oliveira Dantas, Daniele Lisboa Ribeiro, Fernanda de Assis Araujo, Foued Salmen Espindola, Anielle Christine Almeida Silva, Tatiana Carla Tomiosso
Summary: This study demonstrated that Ag-ZnO/AgO nanoparticles have anti-inflammatory and antioxidant properties, and can accelerate wound healing. By reducing the inflammatory response, protecting tissues from damage caused by free radicals, and increasing collagen deposition, this nanocomposite material has the potential to improve the treatment of wounds.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Maksim Rapaic, Jovana Panic, Branislava Teofilovic, Nevena Grujic-Letic, Slobodan Gadzuric, Milan Vranes
Summary: Tetracainium salicylate and tetracainium ibuprofenate, as a combination of local anesthetic drug tetracaine and nonsteroidal anti-inflammatory drugs salicylic acid and ibuprofen, were synthesized as active pharmaceutical ingredient ionic liquids (API-ILs). Spectroscopic investigations confirmed their structures, while thermal behavior and interactions were determined through experimental measurements and theoretical calculations.
Article
Chemistry, Multidisciplinary
Elham Avirdi, Seyyed Emad Hooshmand, Heshmatollah Sepahvand, Venkataraman Vishwanathan, Indra Bahadur, Lebogang Maureen Katata-Seru, Rajender S. Varma
Summary: The synthesis and stabilization of silver nanoparticles in ionic liquids without the need for additional stabilizers showcase the potential of ILs as green media for nanoparticle synthesis.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Engineering, Environmental
Deok Hyun Moon, Yoon-Young Chang, Minho Lee, Agamemnon Koutsospyros, Il-Ha Koh, Won Hyun Ji, Jeong-Hun Park
Summary: Soil washing using FeCl3 was effective in reducing heavy metal concentrations, particularly for Pb, with the lowest concentrations achieved with a 1 M FeCl3 washing solution. However, the reduction in Cu and Zn was limited due to their initial concentrations being below regulatory standards. Sequential extraction results showed significant reductions in exchangeable and weak acid-soluble fractions of Pb upon FeCl3 washing.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2021)
Article
Ophthalmology
Rodrigo Barbosa de Souza, Isabela Gerdes Gyuricza, Luara Lucena Cassiano, Luis Ernesto Farinha-Arcieri, Ana Maria Alvim Liberatore, Sheila Schuindt do Carmo, Waldir Caldeira, Marcio Cruz, Alberto F. Ribeiro, Roberto Carlos Tedesco, Dieter P. Reinhardt, Ricardo Smith, Ivan Hong Jun Koh, Lygia Pereira
Summary: A study found that a heterozygous dominant-negative mutation in the Fbn1 gene in mice leads to disruption of microfibrils in the zonule, causing lens dislocation and enlargement of the anterior chamber.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Materials Science, Paper & Wood
Arthur M. Garcia, Tereza S. Martins, Fernanda F. Camilo
Summary: Renewable non-modified cellulose has been used as a matrix to support silver nanoparticles for catalytic reduction of 4-nitrophenol. The cellulose membranes containing AgNPs showed high thermal stability, water-resistance, and excellent catalytic performance without additional stabilizers. The dispersion and distribution of silver nanoparticles in the polymeric matrix contribute to the good catalytic performance of the membranes.
Article
Plant Sciences
Vinicius S. Londero, Thais A. Costa-Silva, Guilherme M. Antar, Joao B. Baitello, Larissa V. F. de Oliveira, Fernanda F. Camilo, Andrea N. L. Batista, Joao M. Batista, Andre G. Tempone, Joao Henrique G. Lago
Summary: In this study, compounds were extracted from Nectandra barbellata using an ionic liquid assisted by microwave. One sesquiterpene and three new lactones were isolated and tested against Trypanosoma cruzi. The bioactive compounds were found to act on the plasma membrane, mitochondria, and other cellular components, with no resemblance to interferent compounds predicted in silico.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biology
M. I. O. Milanez, A. M. A. Liberatore, E. E. Nishi, C. T. Bergamaschi, R. R. Campos, I. H. J. Koh
Summary: Sepsis can cause long-term disability, including immune dysfunction, neuropsychological disorders, persistent inflammation, catabolism, and immunosuppression. This experimental study in rats revealed that sepsis can lead to long-term alterations in renal and splanchnic sympathetic nerve activity, as well as baroreflex sensitivity. These findings suggest that impairment of sympathetic vasomotor response may contribute to the high risk of post-sepsis morbidity in survivors.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Chemistry, Applied
Laura C. Crapina, Sang W. Han, Marcos A. Bizeto
Summary: Efforts are being made to develop gene therapy delivery systems using inorganic nanoparticles such as mesoporous silica for safer and more efficient delivery. In this study, mesoporous silica nanoparticles were functionalized with different alkyl-amino groups and conjugated with plasmid vector pEGFP-N3. The conjugates showed acceptable cytotoxicity to HeLa cells, but low transfection efficiency, possibly due to aggregation in the cell culture medium.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Physical
Sinval Braz da Silva Filho, Larissa Verena F. de Oliveira, Roselaine da Silva Oliveira, Roselena Faez, Vitor L. Martins, Fernanda Ferraz Camilo
Summary: This study presents a facile method to fabricate free-standing solid polymer electrolytes using PEBA, IL, and lithium salt, characterized by various techniques. By incorporating different ILs, the membranes showed significantly improved ionic conductivity, making it a breakthrough in the research of solid electrolytes.
SOLID STATE IONICS
(2022)
Article
Biochemistry & Molecular Biology
Sidneia Sousa Santos, Milena Karina Colo Brunialti, Larissa de Oliveira Cavalcanti Peres Rodrigues, Ana Maria Alvim Liberatore, Ivan Hong Jun Koh, Vanessa Martins, Francisco Garcia Soriano, Csaba Szabo, Reinaldo Salomao
Summary: This study evaluated the effects of the PARP1 inhibitor olaparib on white blood cells from healthy volunteers in response to various challenges, showing that olaparib has cytoprotective effects, reduces inflammatory cytokine production, and does not inhibit the cells' ability to phagocytose or eradicate pathogens.
Article
Chemistry, Multidisciplinary
Vinicius Cavalheiro Maeda, Cintia Marques Correa, Marcos Henrique Mamoru Otsuka Hamanaka, Viviane Nogueira Hamanaka, Celso Molina, Fernanda F. Camilo
Summary: The purpose of this work was to develop a simple method to produce self-supported films composed of hydroxypropyl methylcellulose (HPMC) and polyaniline (PANI) by the direct mixture of aqueous dispersions of both polymers with subsequent drying. The addition of HPMC, a cellulose derivative with an excellent film-forming capacity, was fundamental to overcoming the poor processability of PANI, which impairs its use in many technological applications. All films showed conductivity in the order of 10(-2) to 10(-3) S cm(-1), which is in the range for metals or semiconductors. The typical electroactivity of PANI was also maintained in the hybrid films. The thermal stability and the mechanical properties of the pristine PANI were also improved with the addition of HPMC. Cellulose-containing conducting polymers can be considered a material of the future, with possible applications in several areas, such as smart wallpapers, e-papers, and sensors.
Article
Chemistry, Multidisciplinary
Matheus L. Silva, Leila Gimenes, Paulete Romoff, Marisi G. Soares, Fernanda F. Camilo, Erica Valadares de. C. Levatti, Andre G. Tempone, Joao Henrique G. Lago
Summary: Microwave assisted extraction and chromatographic steps were used to obtain various compounds from the dried aerial parts of Baccharis ligustrina, some of which showed activity against Trypanosoma cruzi and low toxicity towards cells.
Article
Chemistry, Multidisciplinary
Lister P. Bianconi, Christine Taviot-Gueho, Vera Regina L. Constantino, Marcos Augusto Bizeto
Summary: Heterostructures composed of mesoporous silica and layered double hydroxides were prepared and characterized in this study. The removal of the organic template used in the synthesis process was found to be critical for maintaining the integrity of the heterostructure. Calcination and solvent extraction methods yielded different structural changes in the components of the heterostructure.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Green & Sustainable Science & Technology
Larissa V. F. Oliveira, Lionel Limousy, Simona Bennici, Ludovic Josien, Samar Hajjar-Garreau, Mary-Lorene Goddard, Marcos A. Bizeto, Fernanda F. Camilo
Summary: In this study, a simple method for preparing wet cellulose films containing manganese oxide nanoparticles was developed. The films were produced using a 3D printed mold made from cellulose dissolved in an ionic liquid, allowing for the production of thin and homogeneous films with different shapes and designs. The cellulose-based catalysts showed potential for dye removal from wastewater through the decomposition of indigo carmine in acidic conditions.
CLEAN TECHNOLOGIES
(2021)
Article
Chemistry, Multidisciplinary
Marconi C. Santos, Marcos A. Bizeto, Fernanda F. Camilo
Summary: The study reports the production of hybrid materials of polyaniline and niobium oxide, showing polyaniline in its most conductive form and Nb2O5 nanoparticles uniformly dispersed in the matrix. The materials exhibited improved electrical conductivity and photocatalytic activity compared to neat Nb2O5, with better MB adsorption capacity and decolorization efficiency under visible light irradiation.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Flavia T. da Silva, Kaio S. Gomes, Fabricio C. Machado, Leticia L. Loureiro, Luiz R. Travassos, Tereza S. Martins, Joao Henrique G. Lago, Fernanda F. Camilo
Summary: Electrochemical synthesis of biseugenol in methanol yielded a new oxidized derivative characterized as methoxyloxo-biseugenol (MOB). MOB exhibited significant cytotoxicity against tumoral cells, with higher selectivity index values compared to biseugenol, potentially attributed to its unique chemical structure.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Luisa D. Chiavassa, Fernanda F. Camilo, Mauro A. La Scalea
Summary: The electrochemical reduction of nitrofurazone was studied in non-aqueous medium using three different ionic liquids. Two reversible cathodic peaks were observed for NF in all ILs, with only one peak recorded under higher frequency values. The systems reversibility was confirmed by CV, showing a reversible redox couple for this reduction. The EC mechanism was considered for the systems in aprotic medium, with a second-order chemical reaction after the charge transfer process.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2021)
