Article
Biochemistry & Molecular Biology
Karla M. S. Braga, Eugenio G. Araujo, Frank W. Sellke, M. Ruhul Abid
Summary: The ethanolic extract from the fruit bark of Brazilian-native pequi has been found to reduce ROS levels in human coronary artery endothelial cells, promote cell proliferation, and upregulate antioxidative enzyme expression, indicating a protective effect against oxidative stress.
Review
Biochemistry & Molecular Biology
Diana Jhoseline Medina-Leyte, Oscar Zepeda-Garcia, Mayra Dominguez-Perez, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina, Leonor Jacobo-Albavera
Summary: The development of coronary artery disease (CAD) is closely tied to endothelial dysfunction and inflammation activation. Identifying new biomarkers and therapeutic strategies is crucial in preventing atherosclerosis and CAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Hematology
Shigeo Godo, Akira Suda, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa
Summary: Accumulating evidence over the past few decades has shown that structural and functional abnormalities of coronary microvasculature are highly prevalent and associated with adverse clinical outcomes in patients with various cardiovascular diseases. CMD has been recognized as an important clinical entity, with potential mechanisms including enhanced coronary vasoconstrictive reactivity at the microvascular level.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
Lars Saemann, Lena Wernstedt, Sabine Pohl, Markus Stiller, Jan Willsch, Britt Hofmann, Gabor Veres, Andreas Simm, Gabor Szabo
Summary: This study found that endothelial function of saphenous vein grafts decreases with age in patients treated with coronary artery bypass grafting. Age should be taken into consideration when maintaining grafts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Weronika Frak, Armanda Wojtasinska, Wiktoria Lisinska, Ewelina Mlynarska, Beata Franczyk, Jacek Rysz
Summary: Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory system, with atherosclerosis as its underlying cause. CVDs are the leading cause of morbidity and mortality globally, creating a significant public health concern. This review summarizes the pathophysiological implications of CVDs, focusing on coronary artery disease and atherosclerosis. Inflammatory factors and genetic risk factors have been identified in association with CVDs.
Article
Oncology
Jihong Zhang, Ying Gong, Juan Peng, Junling Han, Fuqiang Li, Liqin Song, Cuifeng Qiao
Summary: The objective of this study was to analyze the changes of blood lipids and endothelial cell function in patients with coronary heart disease complicated with hyperlipidemia after treatment with rosuvastatin. The results showed that rosuvastatin can reduce blood lipid levels and improve hemorheology indexes and cardiac function in patients.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Cell Biology
Chang Chen, Yequn Chen, Jiaxin Xiao, Yanhong Zhang, Zhaorui Yang, Peixuan Yang, Nan Lu, Kaihong Yi, Xiaojun Chen, Shaoxin Chen, Mary Clare O'Gara Msc, Michael O'Meara, Shu Ye, Xuerui Tan
Summary: There is an association between impaired fasting glucose level and a predisposition to severe coronary artery disease indicated by triple vessel disease or myocardial infarction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Wen-Tao Sun, Hai-Tao Hou, Huan-Xin Chen, Hong-Mei Xue, Jun Wang, Guo-Wei He, Qin Yang
Summary: The study investigated the expression and contribution of calcium-activated potassium channels in commonly used coronary artery bypass grafts, finding that BKCa subtype plays a significant role in vasodilatation in the internal thoracic artery. Differences were observed in the distribution of KCa channel subtypes between the two types of grafts.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Review
Medicine, General & Internal
Arnav Katira, Ravish Katira
Summary: Colchicine may play a key role in the prevention of cardiovascular events in patients with stable and unstable coronary artery disease, as it is associated with a reduction in the rate of myocardial infarction and other major cardiovascular outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Barbara Radovani, Frano Vuckovic, Aldo P. Maggioni, Ele Ferrannini, Gordan Lauc, Ivan Gudelj
Summary: This study investigated the association between N-glycosylation of immunoglobulin G (IgG) and coronary artery disease (CAD). The analysis revealed differences in IgG N-glycome composition between CAD+ and CAD- cases, particularly in women, where sialylated N-glycan structures were negatively associated with CAD.
Review
Cardiac & Cardiovascular Systems
Bo Liang, Xin-Yi Cai, Ning Gu
Summary: Coronary artery disease is a major cause of mortality worldwide, with pharmacological interventions like antiplatelet drugs, anticoagulant drugs, and statins commonly used to manage symptoms and prevent cardiovascular events. However, existing drugs have limitations and adverse effects, highlighting the need for new drug development. Marine natural products, known for their chemical diversity and biological activities, show promise in treating coronary artery disease, with substances like organic small molecules, polysaccharides, proteins, and lipids showing efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Health Care Sciences & Services
Wojciech Jan Skorupski, Marta Kaluzna-Oleksy, Maciej Lesiak, Aleksander Araszkiewicz, Wlodzimierz Skorupski, Stefan Grajek, Przemyslaw Mitkowski, Malgorzata Pyda, Marek Grygier
Summary: The study evaluates the outcomes of left main percutaneous coronary interventions in patients who are not suitable for coronary artery bypass graft surgery. The results show that these patients have higher complexity of disease and lower ejection fraction, but the procedure is successful with low complication rates. However, long-term all-cause mortality rate is slightly higher in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biology
Yash T. Katakia, Satyadevan Kanduri, Ritobrata Bhattacharyya, Srinandini Ramanathan, Ishan Nigam, Bhanu Vardhan Reddy Kuncharam, Syamantak Majumder
Summary: The angle of blood vessel bifurcation is an important determinant of atherosclerosis and endothelial dysfunction, as it can alter hemodynamics and impact endothelial structure and function.
COMMUNICATIONS BIOLOGY
(2022)
Article
Urology & Nephrology
Monika Misian, Ewa Baum, Andrzej Breborowicz
Summary: Serum and dialysate from patients undergoing peritoneal dialysis can induce inflammatory and prothrombotic reactions in coronary artery endothelial cells, and Sulodexide can reduce these effects.
Article
Multidisciplinary Sciences
Wonjae Lee, Yeonyee E. Yoon, Sang-Young Cho, In-Chang Hwang, Sun-Hwa Kim, Heesun Lee, Hyo Eun Park, Eun Ju Chun, Hyung-Kwan Kim, Su-Yeon Choi, Sung Hak Park, Hae-Won Han, Jidong Sung, Hae Ok Jung, Goo-Yeong Cho, Hyuk-Jae Chang
Summary: The progression of coronary artery calcium (CAC) is higher in men compared to women, but the difference between sexes diminishes as the 10-year ASCVD risk increases.