Article
Medicine, General & Internal
Itay Lavy, Nir Erdinest, Ayala Katzir, Naomi London, Eleanor Ngwe Nche, David Smadja
Summary: A novel technique for handling and centration of DMEK grafts is presented, which can reduce surgery time and endothelial cell loss. The technique was successfully used in 27 cases with complex ocular pathology, resulting in improved visual acuity and decreased central corneal thickness post-operatively.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Pranita Sahay, Rajesh Fogla, Namrata Sharma
Summary: This study investigated the preferred surgical technique of Descemet membrane endothelial keratoplasty (DMEK) among corneal surgeons in India, as well as barriers faced by non-DMEK surgeons in performing this procedure. The results showed that DMEK was the most commonly used technique, but lack of training was the main reason for not performing DMEK among non-DMEK surgeons. The study also found that most DMEK surgeons found unrolling the graft in the anterior chamber to be the most difficult step, and they were more comfortable with using DSEK or DSAEK techniques.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Takahiko Hayashi, Wei Zhang, Deniz Hos, Silvia Schrittenlocher, Viet Nhat Hung Le, Sebastian Siebelmann, Mario Matthaei, Felix Bock, Bjoern Bachmann, Claus Cursiefen
Summary: The study demonstrates that DMEK is a feasible option for treating endothelial dysfunction in vascularized eyes, leading to significant improvement in visual acuity and corneal conditions. Continuous monitoring and appropriate management of neovascularization can effectively reduce the risk of transplant rejection.
Article
Ophthalmology
Takahiko Hayashi, Wei Zhang, Deniz Hos, Silvia Schrittenlocher, Viet Nhat Hung Le, Sebastian Siebelmann, Mario Matthaei, Felix Bock, Bjoern Bachmann, Claus Cursiefen
Summary: The study included 24 eyes of 24 patients who underwent Descemet membrane endothelial keratoplasty (DMEK) for vascularized eyes, showing improved visual acuity and decreased central corneal thickness postoperatively. DMEK is considered a feasible option for treating endothelial dysfunction in vascularized eyes with high graft survival rate.
Review
Ophthalmology
Weinel Luke, Golding-holbrook Tamme, Jern Yee Chen, Mills Richard
Summary: The influence of donor characteristics on preoperative DMEK preparation and intraoperative graft manipulation has not been extensively studied, but there is evidence suggesting that donors with diabetes may increase the risk of tearing, and younger donors may produce tighter scrolls that complicate intraoperative graft unfolding. Further research is needed to better understand how donor characteristics impact these processes.
Article
Ophthalmology
Myriam S. Bohm, Adam Wylegala, Pia Leon, Stephan Ong Tone, Joseph B. Ciolino, Ula Jurkunas
Summary: The one-year outcomes of preloaded Descemet membrane endothelial keratoplasty (pDMEK) and non-preloaded DMEK (n-pDMEK) in patients with Fuchs endothelial corneal dystrophy were found to be similar. There were no significant differences in postoperative visual acuity, central corneal thickness, endothelial cell count, and complication rates between the two procedures. The study suggests that eye bank-prepared pDMEK tissues are a useful tool in treating endothelial dysfunction.
Article
Ophthalmology
Antonio Moramarco, Vito Romano, Rocco Luigi Modugno, Giulia Coco, Pietro Viola, Luigi Fontana
Summary: The purpose of this study was to evaluate the effectiveness and safety of the Yogurt technique for DMEK graft preparation. The results showed that the DMEK Tzamalis punch can be used as an effective and safe method for DMEK graft preparation, and it can be performed successfully by relatively inexperienced surgeons.
Article
Ophthalmology
Indre Vasiliauskaite, Ruth Quilendrino, Lamis Baydoun, Korine van Dijk, Gerrit R. J. Melles, Silke Oellerich
Summary: The study found that 6-month endothelial cell density (ECD) affects DMEK graft survival, with early cell loss after DMEK negatively impacting long-term ECD outcomes and graft survival. Grafts with low 6-month ECD are at higher risk of failure within 5 years after DMEK.
Article
Ophthalmology
Marc B. Muijzer, Heleen Delbeke, Mor M. Dickman, Rudy M. M. A. Nuijts, Hanad Jimale, Chantal M. van Luijk, Saskia M. Imhof, Robert P. L. Wisse
Summary: The study aimed to explore the video-graded intraoperative risk factors for graft detachment and rebubbling in Descemet membrane endothelial keratoplasty surgery. The results revealed that gas-bubble size and graft shape/geometry are relevant factors for graft detachment and rebubbling, while other factors were not associated with an increased risk.
Article
Ophthalmology
Chandradevi Shanmugam, Rinky Agarwal, Mohamed Ibrahime Asif, Rahul Kumar Bafna, Prafulla Kumar Maharana, Tushar Agarwal, Rajesh Sinha, Jeewan Singh Titiyal, Namrata Sharma
Summary: The purpose of this study was to compare the outcomes of pre-Descemet endothelial keratoplasty (PDEK) and Descemet membrane endothelial keratoplasty (DMEK) in cases of endothelial decompensation. The patients were followed up for 6 months after surgery and it was found that both surgeries had comparable visual and graft survival outcomes.
Article
Medicine, General & Internal
Antonio Ballesteros-Sanchez, Jorge Peraza-Nieves, Anna Casablanca-Pinera, Marina Rodriguez-Calvo-De-Mora, Saray Catalan-Coronado, Josep Torras-Sanvicens, Davide Borroni, Jose-Maria Sanchez-Gonzalez, Carlos Rocha-De-Lossada
Summary: This study compared corneal densitometry patterns between DMEK and DSAEK procedures. The results showed that DMEK had significantly lower corneal density and CD values compared to DSAEK. Additionally, DMEK showed better BCDVA, CCT, and GT values.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Andreas Viberg, Branka Samolov, Berit Bystroem
Summary: The study compares the outcomes of different posterior lamellar corneal transplant procedures for Fuchs endothelial corneal dystrophy, taking into consideration preoperative patient characteristics. The results show that all three surgical methods improved visual acuity in the majority of patients, but DMEK and phacoemulsification plus DSAEK achieved higher levels of visual acuity after 2 years, and phacoemulsification plus DSAEK had a superior graft survival rate. The choice of surgical method should be personalized, considering not only the corneal condition but also each patient's complete medical status and postoperative medical care.
Article
Ophthalmology
Anna-Karina B. Maier, Daniel Pilger, Enken Gundlach, Sibylle Winterhalter, Necip Torun, Tina Dietrich-Ntoukas
Summary: This retrospective study evaluated the outcomes of DMEK in eyes with pre-existing glaucoma. The results showed a high risk of postoperative complications, particularly in cases of previous filtrating surgery and DMEK after graft failure.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Lior Or, Yonit Krakauer, Nir Sorkin, Boris Knyazer, Zach Ashkenazy, Kostya Gushansky, Biana Dubinsky-Pertzov, Inbal Gazit, Adi Einan-Lifshitz
Summary: The viscoelastic marking technique is a simple, approachable, and safe method for marking DMEK grafts while preserving the anterior cornea for additional surgeries. The technique showed significant improvement in best spectacle-corrected visual acuity, with low rates of graft detachment and failure, making it a viable option for eye surgeons.
Article
Ophthalmology
Marianne O. Price, Francis W. Price
Summary: The purpose of this study was to evaluate the 15-year outcomes of Descemet stripping endothelial keratoplasty (DSEK). The results showed that DSEK provided excellent long-term visual rehabilitation and graft survival in this early cohort.
Article
Ophthalmology
Friederike Schaub, Yanhong Hou, Wei Zhang, Felix Bock, Deniz Hos, Claus Cursiefen
Summary: The study showed that corneal crosslinking (CXL) is effective in reducing corneal neovascularization in patients requiring high-risk penetrating keratoplasty (PK) and in decreasing the risk of graft rejection. Combination of CXL with PK was found to be safe and resulted in clear transplants without immune reactions in the cases studied.
Letter
Virology
Rafael S. Grajewski, Alexander C. Rokohl, Martina Becker, Felix Dewald, Clara Lehmann, Gerd Faetkenheuer, Claus Cursiefen, Florian Klein, Ludwig M. Heindl
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Ophthalmology
Simona L. Schlereth, Deniz Hos, Mario Matthaei, Pedram Hamrah, Leopold Schmetterer, Olivia O'Leary, Christoph Ullmer, Jens Horstmann, Felix Bock, Katrin Wacker, Hannes Schroder, Maria Notara, Michel Haagdorens, Rudy M. M. A. Nuijts, Suryan Dunker, Mor Dickman, Sascha Fauser, Hendrik P. N. Scholl, Thomas Wheeler-Schilling, Claus Cursiefen
Summary: The article discussed new technologies for better diagnosing corneal diseases and limbal stem cell deficiency, including unmet needs and achievable new diagnostic technologies in areas such as dry eye, ocular surface inflammation, imaging, corneal neovascularization, and corneal grafting.
OPHTHALMIC RESEARCH
(2021)
Article
Ophthalmology
Agathe Hribek, Thomas Clahsen, Jens Horstmann, Sebastian Siebelmann, Niklas Loreck, Ludwig M. Heindl, Bjorn O. Bachmann, Claus Cursiefen, Mario Matthaei
Summary: This study aimed to assess the correlation of CEC density with alterations of collagen composition of DM in FECD patients. The presence of a geographic pattern fibrillar layer in DEC was unveiled, which can be imaged by slit-lamp biomicroscopy, and the CEC density in the fibrillar layer region significantly decreased.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Sarah B. Zwingelberg, Frederike Buescher, Silvia Schrittenlocher, Alexander C. Rokohl, Niklas Loreck, Philomena Wawer-Matos, Anne Fassin, Friederike Schaub, Sigrid Roters, Mario Matthaei, Ludwig M. Heindl, Bjorn O. Bachmann, Claus Cursiefen
Summary: This study compares the long-term outcome of Descemet membrane endothelial keratoplasty (DMEK) in patients with Fuchs endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK). The results suggest that visual acuity after DMEK is comparable in PBK and FECD patients during long-term follow-up, but corneal edema recurs faster in PBK patients.
Editorial Material
Ophthalmology
Alexander C. Rokohl, Ludwig M. Heindl, Claus Cursiefen
Article
Ophthalmology
Lebriz Altay, Julia Lemke, Jutta Schroeder-Braunstein, Caroline Gietzelt, Vasilena Sitnilska, Friederike Schaub, Claus Cursiefen, Philip Enders, Sascha Fauser
Summary: The aim of this study was to investigate the influence of dietary supplementation using Age-Related Eye Disease Study 2 (AREDS2) on complement activation in patients with neovascular age-related macular degeneration (nAMD) under ongoing treatment. The results showed that short-term dietary AREDS2 supplementation leads to a significant increase in systemic zinc levels without any influence on complement activation levels.
Article
Biology
Thomas Volatier, Bjorn Schumacher, Claus Cursiefen, Maria Notara
Summary: The aim of this study was to document and compare the similarities and differences between the skin and the eye in terms of their protection mechanisms against ultraviolet radiation. The study found that the cornea, lacking the protective pigmentation of the skin, primarily relies on nucleotide excision repair to remove UV-induced DNA lesions. However, the mechanisms involved in the clearance of damaged material in the eye are poorly understood.
Article
Ophthalmology
Jeany Q. Li, Alexander C. Rokohl, Katharina Puetz, Alexander Haendel, Ludwig M. Heindl, Claus Cursiefen
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Verena Schoeneberger, Somaie Eberhardt, Leonie Menghesha, Philip Enders, Claus Cursiefen, Friederike Schaub
Summary: This study investigated the association between anatomical features of rhegmatogenous retinal detachment (RRD) and the extent of blood-aqueous barrier disorder. The results showed that lens status and the extent of retinal detachment can influence the level of objective tyndallometry in RRD.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Orlando Oezer, Mert Mestanoglu, Antonia Howaldt, Thomas Clahsen, Petra Schiller, Sebastian Siebelmann, Niklas Reinking, Claus Cursiefen, Bjoern Bachmann, Mario Matthaei
Summary: This study investigated the association of central subendothelial geographic deposits (FL) with edema formation in advanced Fuchs endothelial corneal dystrophy (FECD) and analyzed their localization. The results showed that the FL was associated with increased corneal thickness primarily in the central and inferotemporal region. These findings provide important information for the evaluation and treatment decision-making for FECD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Verena Schoeneberger, Leonie Menghesha, Stefanie Gerlach, Caroline Gietzelt, Somaie Eberhardt, Claus Cursiefen, Friederike Schaub
Summary: This study investigated the association between lens opacity and flare value in a large cohort of phakic eyes, and found that lens status, degree of lens opacity, and age are correlated with objective tyndallometry measurements.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biology
Thomas Volatier, Bjoern Schumacher, Berbang Meshko, Karina Hadrian, Claus Cursiefen, Maria Notara
Summary: Ultraviolet light from the sun causes DNA damage, especially to the skin and eyes of humans. Two repair enzymes from the kangaroo rat and an anti-bacterial virus show potential in repairing UV-induced lesions. While research and commercial products exist for skin repair, there is little research and no available products for eye protection. Our study aims to offer new options for protecting the eyes, which are particularly sensitive to UV rays and require rapid repair.
Article
Cell Biology
Berbang Meshko, Thomas L. A. Volatier, Karina Hadrian, Shuya Deng, Yanhong Hou, Mark Andreas Kluth, Christoph Ganss, Markus H. Frank, Natasha Y. Frank, Bruce Ksander, Claus Cursiefen, Maria Notara
Summary: The limbal epithelial stem cell (LESC) marker ABCB5 was used to investigate its role in corneal neovascularization. It was found that ABCB5 caused an increase in limbal lymphatic and blood vessel complexity in developing mice, but not in adult mice. Furthermore, in an inflammatory challenge, ABCB5 had a pro-lymphangiogenic effect. In addition, ABCB5-positive cells stimulated blood and lymphatic endothelial cell proliferation and migration, and had both pro-(lymph) angiogenic and anti-inflammatory properties.
Article
Ophthalmology
Alexander C. Rokohl, Rafael S. Grajewski, Philomena A. Wawer Matos, Adam Kopecky, Ludwig M. Heindl, Claus Cursiefen
Summary: COVID-19 has had impacts on ophthalmology, with potential ocular symptoms and complications in patients and even ophthalmologists possibly being infected. Common ocular complications include conjunctivitis and dry eye disease, but there are currently no evidence-based therapy recommendations.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2021)