Article
Medicine, General & Internal
Dario Romano, Valentino De Ruvo, Paolo Fogagnolo, Roberta Farci, Luca Mario Rossetti
Summary: The study aimed to evaluate the impact of glaucoma surgery on the ocular surface in patients who received trabeculectomy. The results showed that patients with successful trabeculectomy had better ocular surface parameters compared to fellow medically treated eyes, including higher Tear break-up time and lower conjunctival hyperemia and corneal staining scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Pablo Argueso
Summary: Mucins are a type of ancient glycoproteins that provide viscoelastic, lubricating, and hydration properties to wet surfaced epithelia. They form a barrier with selective permeability to protect underlying tissues. In the eye, mucins are expressed, processed, and spatially distributed based on specific organ requirements to protect against environmental insults while allowing the passage of light. The adaptation of human ocular surface epithelia includes the production of a thin and watery tear film containing soluble mucin. Transmembrane mucins play a significant role in the tear film, occupying up to one-quarter of its total thickness. Understanding the properties and functions of ocular mucins is crucial for developing applications with potential biological and clinical impact.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Ophthalmology
Judy Weng, Christopher Ross, Jacob Baker, Saleh Alfuraih, Kiumars Shamloo, Ajay Sharma
Summary: Short-term hyperglycemia in diabetes mellitus can cause rapid-onset damage to the ocular surface, leading to compromised tear film, goblet cells, and glycocalyx, as well as activation of an inflammatory cascade or cellular stress response in the cornea.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Sunil Shah, Debarun Dutta, Ankur Barua, Ludger Hanneken, Shehzad A. Naroo
Summary: The study aimed to determine the effects of Tixel (R) treatment on dry eye disease. The results showed that Tixel treatment significantly improved dry eye symptoms and had no adverse events.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Ophthalmology
Gloria Gambini, Matteo Mario Carla, Federico Giannuzzi, Alfonso Savastano, Tomaso Caporossi, Antonio Baldascino, Danilo Iannetta, Lorenzo Vielmo, Stanislao Rizzo
Summary: This study evaluated the impact of PreserFlo Microshunt on the ocular surface and found that it improved subjective symptoms, increased tear film stability, and reduced fluorescein staining. Additionally, significant improvements were observed in tear osmolarity and corneal epithelium.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Veterinary Sciences
Francesca Corsi, Kevin Arteaga, Flavia Corsi, Marco Masi, Alexia Cattaneo, Paolo Selleri, Manuela Crasta, Claudio Peruccio, Adolfo Guandalini
Summary: This study provides normative data for tear film examination in healthy Holland Lop rabbits, showing associations between tear osmolarity and interferometry grades with age and sex.
BMC VETERINARY RESEARCH
(2022)
Article
Ophthalmology
Anastasios-Georgios Konstas, Konstadinos G. Boboridis, Georgios P. Athanasopoulos, Anna-Bettina Haidich, Irini C. Voudouragkaki, Eirini Pagkalidou, Andreas Katsanos, L. Jay Katz
Summary: Switching to preservative-free glaucoma medications improves ocular surface health and IOP control. The use of 0.1% cyclosporine eye drops further reverses glaucoma therapy-related ocular surface disease (GTR-OSD).
Review
Ophthalmology
Hugo Pena-Verdeal, Carlos Garcia-Resua, Jacobo Garcia-Queiruga, Belen Sabucedo-Villamarin, Eva Yebra-Pimentel, Maria Jesus Giraldez
Summary: The osmolarity of tear film varies throughout the day and can be influenced by factors such as time, health condition, and environment. Clinicians should consider the diurnal variations in tear film osmolarity when making diagnoses to ensure accuracy.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Article
Medicine, General & Internal
Dominika Szkodny, Adam Wylegala, Edyta Chlasta-Twardzik, Edward Wylegala
Summary: This study aimed to evaluate the ocular surface parameters of post-COVID-19 patients when compared to healthy controls. The results showed no significant differences between the post-COVID group and control group in the objective measurements of ocular surface conditions, when performed after the acute phase of COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Swati Singh, Saumya Srivastav, Ashik Mohamed, Sayan Basu
Summary: This study investigated age- and sex-related differences in tear film parameters of a normal Indian population and examined their interparametric relationships. The findings suggest that tear meniscus height is minimally affected by age and independent of sex, non-invasive tear breakup time, and tear osmolarity. Tear breakup time and osmolarity show no significant age- and sex-related variation.
FRONTIERS IN MEDICINE
(2022)
Review
Ophthalmology
Barbara Burgos-Blasco, Pedro Arriola-Villalobos, Jose Ignacio Fernandez-Vigo, Carlos Oribio-Quinto, Mayte Arino-Gutierrez, David Diaz-Valle, Jose Manuel Benitez-del-Castillo
Summary: During the COVID-19 period, the use of face masks has significantly increased. Studies have shown that the rise in ocular discomfort symptoms, known as mask-associated dry eye (MADE), is mainly due to the effect of face masks. Wearing a face mask can create an unnatural upward airflow towards the eyes during expiration, leading to dry eye disease. Other factors such as increased temperature, humidity, carbon dioxide levels, stress, increased use of video display terminals, and changes in the ocular microbiota may also contribute to ocular discomfort. It is important to understand the effects and consequences of mask use on the ocular surface, especially considering the potential prolonged use of masks in the future.
Article
Ophthalmology
Tai-Yuan Su, Shu-Wen Chang
Summary: By constructing normalized ocular surface temperature (NOST) models for different tear film characteristics, it is possible to differentiate tear film types and potentially use them for dry-eye screening. The study found that in dry-eye screening, the NOST order was normal > short-BUT > short BUT with SPK.
Review
Ophthalmology
Cem Simsek, Murat Dogru
Summary: Sjogren syndrome is a chronic inflammatory autoimmune disease affecting the lacrimal and salivary glands. Tears may contain biomarkers for diagnosis and treatment assessment. The aim of the review is to identify reliable, sensitive, and specific biomarkers for guiding treatment decisions.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Multidisciplinary Sciences
Marcela Minarikova, Zdenek Fik, Josef Storm, Katerina Helisova, Kvetoslava Ferrova, Gabriela Mahelkova
Summary: The preocular tear film plays a critical role in maintaining a healthy ocular surface. This study aimed to investigate the potential utility of measuring tear film levels of MMP-9, a marker of ocular surface damage and inflammation, in patients with lagophthalmos. The results showed that patients with lagophthalmos had higher Oxford scores and lower TBUT and corneal sensitivity compared to healthy eyes. Tear MMP-9 levels were also higher in lagophthalmic eyes and were associated with increased fluorescein staining and decreased TBUT. These findings suggest that tear MMP-9 may be a useful biomarker for monitoring ocular surface damage and inflammation progression in patients with lagophthalmos.
Article
Ophthalmology
Swati Singh, Christian M. Hammer, Friedrich Paulsen
Summary: Urea is present in the tear film, aqueous humor, and vitreous of the eye. Urea transporters and synthesizing enzymes are found at the ocular surface, indicating ureagenesis occurs there. Urea plays a role in tear film stability and protecting the ocular surface.
Article
Ophthalmology
Yunjin Lee, Joon Young Hyon, Hyun Sun Jeon
Summary: The study investigated the characteristics of eyes with dry eye disease (DED) whose lipid layer thickness (LLT) measured 100 nm, revealing differences in some parameters compared to eyes with LLT below 100 nm. Age, ocular surface staining, and ocular surface disease index showed a positive correlation with LLT.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Youngsub Eom, Joon Young Hyon, Hyung Keun Lee, Jong Suk Song, Hyo Myung Kim
Summary: This study demonstrated high concordance between Korean and ADES diagnostic guidelines for dry eye patients, with most patients showing tear film instability. Evaporative dry eye was more common than aqueous-deficient dry eye, and VDTV users had significantly higher bothersome ocular symptoms scores.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jeongah Shin, Chang Rae Rho, Joon Young Hyon, Tae-Young Chung, Kyung Chul Yoon, Choun-Ki Joo
Summary: The study found that HU00701 and HU007 have good safety profiles and some efficacy for patients with moderate to severe dry eye disease. However, there were no significant differences between HU00701 and HU007 compared to placebo in terms of the primary and secondary endpoints.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Jayoon Moon, Sang-Mok Lee, Joon Young Hyon, Mee Kum Kim, Joo Youn Oh, Hyuk Jin Choi
Summary: The use of large diameter scleral lenses in Asian subjects with intractable ocular surface diseases improves visual acuity, alleviates signs and symptoms of ocular surface diseases, and does not cause significant adverse effects.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Bong Jik Kim, Hyoung Won Jeon, Woosung Jeon, Jin Hee Han, Jayoung Oh, Nayoung Yi, Min Young Kim, Minah Kim, Justin Namju Kim, Bo Hye Kim, Joon Young Hyon, Dongsup Kim, Ja-Won Koo, Doo-Yi Oh, Byung Yoon Choi
Summary: The study examined the role and genotype-phenotype correlation of LOXHD1 in down-sloping sensorineural hearing loss (SNHL) in teenagers and young adults, revealing that LOXHD1 accounts for a significant proportion of genetically diagnosed cases in this age group. The findings suggest that LOXHD1 may play a signature causative role in down-sloping SNHL in young adults, with potential interesting genotype-phenotype correlations.
JOURNAL OF MEDICAL GENETICS
(2022)
Review
Chemistry, Multidisciplinary
Joon-Young Hyon, Sang-Beom Han
Summary: Dry eye disease is a common condition that can have adverse effects on the physical, functional, and psychological quality of life. Treatment strategies aimed at interrupting the inflammatory cycle and alleviating ocular surface inflammation, such as anti-inflammatory therapies, have shown improvements in signs and symptoms. Further studies are needed to establish treatment guidelines.
APPLIED SCIENCES-BASEL
(2021)
Article
Health Care Sciences & Services
Jae-Yong Kim, Hun Lee, Choun-Ki Joo, Joon-Young Hyon, Tae-Im Kim, Jin-Hyoung Kim, Jin-Kuk Kim, Eun-Young Cho, Ji-Eun Choi, Na-Rae Lee, Hung-Won Tchah
Summary: In a Korean population, myopic LASIK was shown to be effective and safe with high refractive predictability, although myopic regression may occur over time. Higher preoperative SE and lower preoperative BCVA are predictive of a low postoperative efficacy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Joo Young Na, Ki Young Huh, Kyung-Sang Yu, Joon Young Hyon, Hye Cheong Koo, Jong Ho Lee, Ji Chang You, Jae-Yong Chung
Summary: This study aimed to evaluate the safety and pharmacokinetics of imatinib mesylate eye drops in healthy subjects. The results showed that imatinib mesylate was well-tolerated in healthy subjects with minimal adverse effects in the body.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Ophthalmology
Hyun Sun Jeon, Seong Jun Byun, Joon Young Hyon, Kyu Hyung Park, Sang Jun Park
Summary: This population-based cohort study found that subconjunctival hemorrhage (SCH) itself is not a risk factor for stroke or acute myocardial infarction (AMI). Clinicians can reassure patients with SCH that it does not increase the risk of stroke or AMI. Evaluating underlying diseases in patients with SCH is recommended to identify risk factors for stroke or AMI.
OPHTHALMIC EPIDEMIOLOGY
(2022)
Article
Ophthalmology
Joong Hyun Park, Yengwoo Son, Joon Young Hyon, Ji Yun Lee, Hyun Sun Jeon
Summary: This case report highlights the rare occurrence of isolated conjunctival myeloid sarcoma as a sign of AML relapse. Ophthalmologists may play a role in the early detection of AML through the identification of atypical conjunctival lesions.
Article
Ophthalmology
Yunjin Lee, Hyun Sun Jeon, Joon Young Hyon
Summary: This study aimed to investigate the impact of serum anti-La antibodies on clinical parameters of dry eye disease (DED) and evaluate the correlation between antibody titers and DED parameters. The results showed a significant correlation between anti-Ro titers and conjunctival staining score, while no statistical correlation was found between anti-La and clinical DED parameters. Additionally, anti-Ro titers and focus score were significantly higher in patients positive for both anti-Ro and anti-La.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Min Kyu Yang, Ho-Seok Sa, Namju Kim, Hyun Sun Jeon, Joon Young Hyon, Hokyung Choung, Sang In Khwarg
Summary: This study quantitatively analyzed morphological and functional alterations of the meibomian glands in eyes with marginal entropion and their changes after surgery. The results showed that eyes with marginal entropion had higher meibomian gland loss and thinner lipid layer thickness, and the average LLT increased after surgery.
Review
Chemistry, Multidisciplinary
Joon Young Hyon, Sang Beom Han
Summary: Dry eye disease is a global public health problem that impairs quality of life and poses economic burden. Inflammation plays a key role in the worsening of the disease, and besides anti-inflammatory medications, vitamin supplementation may also be effective.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Do Yeh Yoon, Jeon Hee Eun, Joon Young Hyon
Summary: This study aimed to evaluate the correlation between tear film lipid layer thickness and transepidermal water loss (TEWL) from the ocular area in patients with short tear break-up time (TBUT)-type dry eye and healthy controls. The results showed that tear film lipid layer thickness was significantly correlated with tear break-up time and ocular surface staining, while TEWL showed a positive correlation with the Schirmer I score.
Article
Ophthalmology
Myung Nam Lim, Jae Yeon Lee, Joon Young Hyon, Sang Beom Han
Summary: This study aimed to evaluate the association between dry eye disease (DED) and various psychiatric and systemic diseases in an adult Korean population aged 40 years or older. The results showed that DED was associated with self-reported psychiatric conditions and systemic diseases.