Review
Pharmacology & Pharmacy
Eren Aytekin, Sibel Bozdag Pehlivan
Summary: Current treatment approaches for keratoconus include options such as penetrating keratoplasty, deep anterior lamellar keratoplasty, and corneal collagen cross-linking. Early diagnosis and halting the disease with CXL methods are becoming crucial in clinical practice.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Ophthalmology
Siddharth Nath, Carl Shen, Alex Koziarz, Laura Banfield, Behnam Nowrouzi-Kia, Mark A. Fava, William G. Hodge
Summary: Transepithelial and epithelium-off corneal cross-linking show significant differences in corneal ectasia treatment, with the latter being more effective but less safe in comparison.
Article
Ophthalmology
Daniel F. P. Larkin, Kashfia Chowdhury, Jennifer M. Burr, Mathew Raynor, Matthew Edwards, Stephen J. Tuft, Catey Bunce, Emilia Caverly, Caroline Dore
Summary: The study demonstrates that corneal cross-linking (CXL) can effectively halt the progression of keratoconus in the majority of young patients, positioning it as a first-line treatment for progressive disease and potentially offering the benefit of avoiding later need for contact lens wear or corneal transplantation.
Article
Ophthalmology
Christian Enders, Diana Vogel, Jens Dreyhaupt, Waltraud Wolf, Aylin Garip-Kuebler, Jonathan Hall, Lukas Neuhann, Jens Ulrich Werner
Summary: According to this study, corneal collagen cross-linking (CXL) is found to be safe and effective in treating patients with keratoconus. Significant improvements in visual acuity and keratometric measurements were observed after 1, 5, and 10 years. Although there were no significant changes after 13 years, CXL can slow down the progression of keratoconus.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Rong Shi, Weize Wang, Yu Che, Shaorong Linghu, Taixiang Liu
Summary: This study investigated the effects of corneal stromal lens collagen cross-linking regraft on corneal biomechanics. The results showed that regraft with cross-linking significantly increased the biomechanical properties of the cornea.
JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Nicolas Alejandre, Pablo Perez-Merino, Gonzalo Velarde, Ignacio Jimenez-Alfaro, Susana Marcos
Summary: The purpose of this study was to assess the impact of different combinations of intracorneal ring segments (ICRS) on corneal morphology and visual performance in patients with keratoconus. The study found that ICRS combinations implanted within a 5mm diameter zone were more effective in flattening the cornea, while those implanted within a 6mm diameter zone were more effective in reducing astigmatism. This study has important implications for surgical treatment options for patients with corneal diseases.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Farhad Hafezi, Nan-Ji Lu, Jad F. Assaf, Nikki L. Hafezi, Carina Koppen, Riccardo Vinciguerra, Paolo Vinciguerra, Mark Hillen, Shady T. Awwad
Summary: This study aimed to evaluate the depth of the demarcation line following accelerated epithelium-off corneal cross-linking (A-CXL) performed at the slit lamp with the patient sitting in an upright position. The results showed that the demarcation line depth achieved with patients sitting upright, receiving CXL at the slit lamp, is similar to published data on CXL performed in the supine position.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Ophthalmology
Jorge L. Alio del Barrio, Maninder Bhogal, Marcus Ang, Mohammed Ziaei, Scott Robbie, Andrea Montesel, Daniel M. Gore, Jodhbir S. Mehta, Jorge L. Alio
Summary: Corneal transplantation is a common procedure worldwide, but corneal graft failure has become a common indication for re-transplantation. Lamellar transplant techniques have introduced new complications for graft failure, but also offer advantages over penetrating keratoplasty in terms of reducing intra-operative risks and faster visual recovery.
SURVEY OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Julia Friedrich, Alexandra Sandner, Ali Nasseri, Mathias Maier, Daniel Zapp
Summary: The study showed that accelerated corneal cross-linking (ACXL) is an effective and safe treatment for patients with progressive keratoconus. Long-term follow-ups (56 months) demonstrated improvements in functional and tomographical outcomes, with stability observed during the final year. The treatment failure rate was 4%.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Magdalena Krok, Ewa Wroblewska-Czajka, Joanna Kokot, Anna Micinska, Edward Wylegala, Dariusz Dobrowolski
Summary: The objective of this paper is to analyze the occurrence of sterile infiltrate in patients with keratoconus after corneal collagen cross-linking (CXL) and evaluate possible risk factors. The study found that the occurrence of sterile infiltrates after CXL was relatively low, but damage to the epithelium and the phototoxic effect of the procedure were significant factors. Appropriate classification and selection of CXL procedures, along with protective measures, can have a significant impact on reducing the incidence of this complication.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Ophthalmology
Mohammad Karam, Abdulmalik Alsaif, Ahmed Aldubaikhi, Meshaal Aljebreen, Rand Alazaz, Nahlaa Alkhowaiter, Tariq Almudhaiyan, Faisal Aljassar
Summary: The aim of this study was to compare the outcomes of 18 mW/cm(2) (5 minutes) versus 9 mW/cm(2) (10 minutes) accelerated corneal collagen cross-linking protocols in patients with progressive keratoconus. The study found that the 10-minute protocol had better outcomes in terms of K1, K2, and HOA compared to the 5-minute protocol, but there were no statistically significant differences in other outcomes.
Article
Ophthalmology
Corina M. Chilibeck, Nigel H. Brookes, Akilesh Gokul, Bia Z. Kim, Helen C. Twohill, S. Louise Moffatt, David G. Pendergrast, Charles N. J. McGhee
Summary: The primary indication for keratoplasty has changed in New Zealand/Aotearoa due to population growth and advancements in surgical techniques. This study shows a decline in penetrating keratoplasty and an increase in regraft, keratoconus, and corneal dystrophy as the primary diagnoses. The use of different keratoplasty techniques has also evolved over time.
Article
Ophthalmology
Ahmed Ibrahim Basiony, Moataz Fayez ElSawy, Mahmoud Mohamed Ismail, Mohamed Samy Abd ElAziz, Mahmoud Tawfik KhalafAllah, Adel Galal Zaky
Summary: The study compared the outcomes of Myoring implantation using femtoassisted or manual dissection techniques, and found that femtoassisted technique was more effective in preventing ring extrusion.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Guilherme Rocha, Bruna Viana Vieira, Barbara Mirian Silva Mendes, Camila Ishii Iguma, Thairis Cassia Santana Silva, Luciene Barbosa de Sousa, Patrick Frensel Tzelikis
Summary: This study compared VA outcomes in patients with advanced keratoconus wearing SCL, those after ICRS or DALK surgeries. Patients after DALK and ICRS showed significant improvement in UDVA and CDVA, with additional treatment often involving fitting a SCL. The best visual acuity improvement was seen in patients who had DALK surgery followed by SCL fitting.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Engineering, Biomedical
Ayesha Gulzar, Erdost Yildiz, Humeyra N. Kaleli, Muhammad A. Nazeer, Noushin Zibandeh, Anjum N. Malik, Ayse Y. Tas, Ismail Lazoglu, Afsun Sahin, Seda Kizilel
Summary: This study proposes a new method for corneal crosslinking using a ruthenium-based water-soluble photoinitiator and visible light. The results demonstrate that the ruthenium-based approach has superior biomechanical properties, biocompatibility, and optical transparency compared to the riboflavin/UV-A method. It offers a promising non-surgical therapy option for all ectatic corneal pathologies.
ACTA BIOMATERIALIA
(2022)
