Article
Medicine, General & Internal
Christine M. Bourke, Brendan K. Cummings, Daire J. Hurley, Conor C. Murphy, Sarah Chamney
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are mucocutaneous reactions that can lead to severe ocular complications. This case report describes a rare presentation of isolated ocular SJS in a patient with ulcerative colitis being treated with Infliximab. The diagnosis was challenging as the causative agent had already been discontinued, but a conjunctival biopsy helped confirm the diagnosis. The treatment involved high-dose IV steroids and dual immunosuppression. This case contributes to the evidence supporting intensive ophthalmic management of SJS to prevent long-term vision loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Maria Efenesia Baffa, Roberto Maglie, Neri Giovannozzi, Francesca Montefusco, Stefano Senatore, Daniela Massi, Emiliano Antiga
Summary: Vaccines are crucial in combating the Sars-CoV-2 pandemic, but they can also lead to various cutaneous reactions like Sweet's syndrome. This case study highlights a 52-year-old Caucasian male who developed Sweet's syndrome shortly after receiving the BNT162b2 vaccine, suggesting a potential link between the vaccine and the syndrome.
Article
Rheumatology
Nur Beyza Tukek, Sinem Nihal Esatoglu, Gulen Hatemi, Elif Buse Caliskan, Yilmaz Ozyazgan, Didar Ucar, Yesim Ozguler, Emire Seyahi, Melike Melikoglu, Ugur Uygunoglu, Aksel Siva, Zekayi Kutlubay, Ibrahim Hatemi, Aykut Ferhat Celik, Serdal Ugurlu, Izzet Fresko, Sebahattin Yurdakul, Hasan Yazici, Vedat Hamuryudan
Summary: By reviewing patient data, we found that about 7% of patients with Behcet's syndrome developed new manifestations during treatment with IFX. Vascular involvement was more common in patients with new manifestations. For the majority of these patients, intensifying IFX treatment or adding other agents proved effective in managing the symptoms.
Article
Immunology
Gulen Hatemi, Nur Beyza Tukek, Sinem Nihal Esatoglu, Yesim Ozguler, Sitki Safa Taflan, Ugur Uygunoglu, Melike Melikoglu, Serdal Ugurlu, Izzet Fresko, Aksel Siva, Zekayi Kutlubay, Sebahattin Yurdakul, Hasan Yazici, Vedat Hamuryudan
Summary: The objective of the study was to investigate the efficacy and safety of infliximab in BS patients with vascular involvement. Among the 127 patients treated with infliximab, the remission rate was 73% at Month 6 and 63% at Month 12. Patients with pulmonary artery involvement and venous thrombosis had better remission rates compared to those with non-pulmonary artery involvement and venous ulcers.
CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Maria Carmo-Fonseca
Summary: This article reveals that, in addition to being the main energy source for cells, glucose also plays a role in regulating alternative splicing during epidermal differentiation. Glucose binds to the RNA-binding protein DDX21 and alters its interaction properties, thereby modulating splicing decisions.
Article
Public, Environmental & Occupational Health
Yazhini Madurapandian, Polani Rubeshkumar, Mohankumar Raju, Aishwarya Janane, Parasuraman Ganeshkumar, T. S. Selvavinayagam, Prabhdeep Kaur
Summary: The study found an outbreak of acute conjunctivitis in a visually impaired school, which was associated with close contact with a case and staying inside the campus.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Aws Waleed M. Al-Hayani, Iris Martinez Alemany, Carlos Santonja, Alfonso Cabello Ubeda, Laura Prieto Perez, Maria Carmen Ceballos-Rodriguez, Irene Carrillo Acosta, Miguel de Gorgolas Hernandez-Mora, Beatriz Alvarez Alvarez
Summary: Sweet Syndrome is a neutrophilic dermatosis and a rare variant, Histiocytoid Sweet Syndrome (HSS), can be associated with various conditions such as cancer, infections, and drug toxicity. This study presents a case of HSS in an HIV-positive patient in an infectious disease setting.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Miriam B. Barshak, Caitlin M. Dugdale, Roberto Pineda
Summary: A 31-year-old man sought medical attention for redness and pain in his right eye. He had been diagnosed with chickenpox and was taking tecovirimat. A diagnosis was reached.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yamini Mathur, Venkata Subramanian Krishnaraju, Harmandeep Singh, Rajender Kumar, Pinaki Dutta
Summary: Von Hippel-Lindau syndrome is an autosomal dominant disorder associated with a spectrum of tumors. This case report demonstrates the tracer avidity in bilateral swollen eyelids of a patient with suspected Von Hippel-Lindau syndrome using Ga-68-DOTANOC PET/CT.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Chemistry, Multidisciplinary
Carina I. C. Crucho, Maria Teresa Barros
Summary: This article discusses the rich chemistry of sucrose, a carbohydrate that enhances the sweetness of life.
Review
Medicine, General & Internal
Tzu-Chen Lo, Yu-Yen Chen
Summary: This study aimed to better understand the epidemiological and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) following COVID-19. Research found that MIS-C associated with COVID-19 shares features similar to Kawasaki disease and may be related to post-infective immune dysregulation. Further studies are needed to elucidate the underlying pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biology
Catalina Roxana Ferea, Stejara Nicoleta Mihai, Gabriela Balan, Minerva Codruta Badescu, Dana Tutunaru, Alin Laurentiu Tatu
Summary: Sweet syndrome is a rare disease characterized by sudden onset of skin lesions accompanied by fever, leukocytosis, and neutrophilia. It is responsive to systemic steroids. Sweet syndrome can have extracutaneous manifestations affecting various organs, and it is often associated with hematological malignancies such as myelodysplastic syndrome (MDS). In this article, the authors propose an algorithm for evaluating patients with MDS-related Sweet syndrome.
Article
Ophthalmology
Apurva Hardas, Neera Singh, Amrita Mohanty, Srikant Kumar Sahu
Summary: Montelukast was found to be effective and safe in treating pediatric patients with vernal keratoconjunctivitis, showing significant improvements in symptoms and signs without adverse events. It can be considered as a long-term therapy option for preventing relapse in moderate to severe cases of vernal keratoconjunctivitis.
Article
Gastroenterology & Hepatology
Joseph Sleiman, Asif A. Hitawala, Benjamin Cohen, Katie Falloon, Marian Simonson, Benjamin Click, Urmi Khanna, Anthony P. Fernandez, Florian Rieder
Summary: The study revealed that Sweet syndrome may precede or occur concurrently with inflammatory bowel disease in a significant proportion of cases. Azathioprine-associated Sweet syndrome and IBD-related Sweet syndrome present distinct clinical characteristics and treatment responses.
JOURNAL OF CROHNS & COLITIS
(2021)
News Item
Biochemistry & Molecular Biology
Lucy I. Crouch
Summary: This article describes the mechanism of consumption of high-mannose N-glycans in Bifidobacterium species, which is important for understanding their role in human gut microbiota.
NATURE CHEMICAL BIOLOGY
(2023)
