Article
Chemistry, Inorganic & Nuclear
Lakshay Kathuria, Ashoka G. Samuelson
Summary: The enantioselective reduction of imines to chiral secondary amines was studied using chiral half-sandwich iridium complexes with N-heterocyclic carbene ligands. The optimized conditions showed good yields for ketimines with moderate enantiomeric excess. The Ir complex with phenylglycine-derived chiral NHC exhibited the highest catalytic activity and enantiomeric excess compared to other NHCs in the series.
Article
Chemistry, Multidisciplinary
Ludivine Poyac, Stefano Scoditti, Xavier Dumail, Michel Granier, Sebastien Clement, Rafael Gramage-Doria, Charles H. Devillers, Sebastien Richeter
Summary: The electronic and steric properties of NHC ligands functionalized with porphyrins were investigated. It was found that when porphyrins are used as NHC-wingtips, the catalytic activity of the neighboring NHC-Rh(I) complex in the conjugate addition reaction is significantly improved.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Tereza Duskova, Dharmendra S. Prajapati, Pavel Kaule, Lucie Cervenkova Stastna, Tomas Strasak, Jan Cermak
Summary: A series of imidazolium salts with specific substituents were synthesized and used as precursors for the synthesis of rhodium and iridium complexes. The complexes exhibited high fluorophilicity, making them suitable for organic-organic and organic-fluorous phase separation.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yaru Jing, Jingxing Jiang, Yan Liu, Zhuofeng Ke
Summary: This study presents a theoretical evaluation of the electronic and steric properties of various N-Heterocyclic boryl (NHB) ligands using NHB-Ir(CO)(3) as the model complex. The results reveal the influence of substitution, backbone saturation, ring size, and heteroatoms on the NHB properties. The findings suggest that these scales are crucial for the design, application, and mechanistic understanding of NHB-based complexes or molecules.
Review
Chemistry, Multidisciplinary
Rajendra S. Ghadwal
Summary: This review article aims to highlight recent advances in accessing stable iMICs, quantifying their properties, and exploring their applications in synthesis and catalysis. The synthetic viability and use of vicinal C4,C5-anionic dicarbenes (ADCs) based on a 1,3-imidazole framework are also presented. iMICs and ADCs have the potential to push the limit of classical NHCs by enabling access to conceptually new main-group heterocycles, radicals, molecular catalysts, ligand sets, and more.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Niklas F. Both, Anke Spannenberg, Haijun Jiao, Kathrin Junge, Matthias Beller
Summary: The use of bis(NHC) manganese(I) complexes 3 as catalysts for the hydrogenation of esters was investigated. Various aromatic and aliphatic esters were successfully hydrogenated at mild temperatures and low catalyst loadings using complexes 3 with KHBEt3 as additive, highlighting the efficiency of the novel catalytic system. Additionally, the versatility of the developed catalytic system was demonstrated by the hydrogenation of other substrate classes like ketones, nitriles, N-heteroarenes, and alkenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Medicinal
Tao Jia, Oumar Diane, Deepanjan Ghosh, Myriem Skander, Gaelle Fontaine, Pascal Retailleau, Joel Poupon, Jerome Bignon, Ytabelle Maga Moulai Siasia, Vincent Servajean, Nathalie Hue, Jean-Francois Betzer, Angela Marinetti, Sophie Bombard
Summary: This article introduces a new series of bimetallic platinum-(II) complexes with NHC-type bridging ligands, which exhibit cytotoxicity, cell accumulation, and DNA binding properties in cancerous cells. These complexes demonstrate significant radiosensitizing effects by inhibiting DNA repair mechanisms, leading to persistent accumulation of irradiation-induced DNA damages. This study provides the first in vitro evidence for the radiosensitizing properties of NHC-platinum complexes, suggesting their potential use in combined chemo-radiotherapy protocols.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Shelby L. Strausser, David M. Jenkins
Summary: N-Heterocyclic carbenes (NHCs) are important auxiliary ligands in organometallic chemistry, with the most common variants based on five-membered rings. Research on six-membered-ring NHC variants has mainly focused on nonconjugated versions, with limited reports on conjugated six-membered ring NHCs.
Article
Chemistry, Applied
Andrea Longhi, Marco Baron, Marzio Rancan, Gregorio Bottaro, Laura Orian, Claudia Graiff, Marco Roverso, Ileana Menegazzo, Lidia Armelao, Sara Bogialli, Cristina Tubaro
Summary: This study explored the coordinating properties of the bis(1,4-dimethyl-1,2,4-triazol-5-ylidene) ligand (bitz) towards silver(I) and gold(I) centers. Results showed that bitz behaves as a bridging ligand, forming both dinuclear and trinuclear complexes, which were supported by X-ray diffraction analysis, NMR spectroscopy, and mass spectrometry evidence.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemical Research Methods
Fady Nahra, Nikolaos Tzouras, Alba Collado, Steven P. Nolan
Summary: N-heterocyclic carbene gold(I) chloride and hydroxide complexes are commonly used as synthetic reagents and efficient catalysts. This study describes a straightforward and practical method for synthesizing mononuclear gold complexes with high yields, as well as the synthesis of a mononuclear gold(I) hydroxide complex and an improved synthesis method for a dinuclear gold(I) hydroxide complex. This methodology offers advantages such as the use of sustainable reaction solvents and commercially available starting materials.
Article
Chemistry, Inorganic & Nuclear
Lachlan J. Watson, Anthony F. Hill
Summary: The pro-ligands react with [RhCl(CE)(PPh3)2] to form bimetallic complexes, which undergo double C-H activation to form N-heterocyclic carbene (NHC) pincer complexes. Reduction and treatment with tritylium, ferrocenium or triphenylcyclopropenium tetrafluoroborates result in the formation of mononuclear NHC pincer complex salts. Treatment with lithium (trimethylsilyl)acetylide provides another bimetallic species, which can be obtained from [RhCl(RPm)] and LiCuCSiMe3.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Mert Olgun Karatas, Tuba Keskin, Namik Ozdemir, Hasan Kucukbay, Suat Tekin, Ahmet Mansur, Selami Gunal, Suleyman Sandal
Summary: In this study, Ag, Rh, and Ir complexes of a silyl-substituted NHC ligand were synthesized and their biological properties were investigated. The results showed that these complexes exhibited comparable or better cytotoxicity against cancer cells and antimicrobial activity compared to standard drugs.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Chemistry, Inorganic & Nuclear
Yidan Wang, Bo Zhang, Shuai Guo
Summary: The combination of NHC and pincer framework in transition metal complexes has been widely studied and applied in various fields, including catalysis and optical material chemistry. This minireview focuses on the synthesis, reactivity study and applications of metal pincer NHCs.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Angela Vivancos, Adrian Jimenez-Garcia, Delia Bautista, Pablo Gonzalez-Herrero
Summary: A series of bis-cyclometalated Pt(IV) complexes incorporating mesoionic aryl-NHC ligand trz with either 1-phenylpyrazole or 2-arylpyridine ligands are reported, showing phosphorescent emissions in the blue to yellow color range with high quantum yields. The addition of trz ligand leads to lower nonradiative decay rates and higher quantum efficiencies compared to homologous species with two equal 2-arylpyridine ligands. Computational calculations substantiate the effect of the carbene ligand on the energy levels and emissive properties of the complexes.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Abdollah Neshat, Shiva Akbari-Birgani, Mahdi Cheraghi, Shirin Gilanchi, Mohammad Reza Yousefshahi
Summary: A novel heteroleptic gold(I) complex has been synthesized and characterized, with higher anticancer activity compared to cisplatin.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Organic
Guang-Zhen Zhao, Daven Foster, Gellert Sipos, Pengchao Gao, Brian W. Skelton, Alexandre N. Sobolev, Reto Dorta
JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Inorganic & Nuclear
Pengchao Gao, Daven Foster, Gellert Sipos, Brian W. Skelton, Alexandre N. Sobolev, Stephen A. Moggach, Reto Dorta
Article
Chemistry, Inorganic & Nuclear
Pengchao Gao, Daven Foster, Gellert Sipos, Brian W. Skelton, Alexandre N. Sobolev, Reto Dorta
Article
Chemistry, Inorganic & Nuclear
Jeremy Duczynski, Alexandre N. Sobolev, Stephen A. Moggach, Reto Dorta, Scott G. Stewart
Article
Biochemistry & Molecular Biology
Michal Pieczykolan, Justyna Czaban-Jozwiak, Maura Malinska, Krzysztof Wozniak, Reto Dorta, Anna Rybicka, Anna Kajetanowicz, Karol Grela
Article
Chemistry, Organic
Michaela Wernik, Peter E. Hartmann, Gellert Sipos, Ferenc Darvas, A. Daniel Boese, Doris Dallinger, C. Oliver Kappe
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Review
Chemistry, Multidisciplinary
Reka Adamik, Balazs Buchholcz, Ferenc Darvas, Gellert Sipos, Zoltan Novak
Summary: This review provides a conceptual and critical summary of micellar synthesis possibilities that are well suited to DEL synthesis, as well as discussion of existing examples of micellar DEL approaches and selection of micellar organic transformations fundamentally suitable for DEL.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Michaela Wernik, Gellert Sipos, Balazs Buchholcz, Ferenc Darvas, Zoltan Novak, Sandor B. Oetvoes, C. Oliver Kappe
Summary: The study demonstrates the successful application of an oscillatory plug flow reactor in enabling heterogeneous catalytic reductive aminations in aqueous micellar media, enhancing mass transport and facilitating process simplicity, stability, and scalability. The method allows for the successful transformation of a broad range of substrates, including amino acid derivatives, under relatively mild conditions, utilizing only small amounts of Pd/C as a readily available heterogeneous catalyst, with the recyclability of the catalyst and reaction media also demonstrated.
Article
Chemistry, Multidisciplinary
Daven Foster, Pengchao Gao, Ziyun Zhang, Gellert Sipos, Alexandre N. Sobolev, Gareth Nealon, Laura Falivene, Luigi Cavallo, Reto Dorta
Summary: Chiral, cationic NHC-iridium complexes have been introduced as catalysts for the intramolecular hydroamination reaction of unactivated aminoalkenes, showing high activity and selectivity. By eliminating a major deactivation pathway, the efficiency of the reaction is improved. Through experimental and computational studies, valuable insights into the reaction mechanism have been gained.
Meeting Abstract
Chemistry, Multidisciplinary
Gellert Sipos, Gergo Ignacz, Balazs Fodi, Timothy Noel
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Meeting Abstract
Chemistry, Multidisciplinary
Gergo Ignacz, Timothy Noel, Gellert Sipos
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Organic
Tamas Foldesi, Gellert Sipos, Reka Adamik, Balint Nagy, Balazs L. Toth, Attila Benyei, Krisztina J. Szekeres, Gyozo G. Lang, Attila Demeter, Timothy J. Peelen, Zoltan Novak
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)
