Article
Obstetrics & Gynecology
Antonio Raffone, Antonio Travaglino, Francesco Maria Zullo, Annarita Gencarelli, Mariacarolina Micheli, Sergio Miranda, Pasquale De Franciscis, Luigi Insabato, Attilio Di Spiezio Sardo, Fulvio Zullo, Giuseppe Bifulco
Summary: The immunohistochemical expression of isoform B of the progesterone receptor (PRB) can be a predictive marker for the treatment outcome of atypical endometrial hyperplasia (AEH) and early endometrial cancer (EEC), especially when there is weak stromal expression, indicating a high sensitivity in predicting both no response and recurrence.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Ikuko Ota, Fuminori Taniguchi, Yoshiaki Ota, Hiroki Nagata, Ikumi Wada, Takaya Nakaso, Ai Ikebuchi, Eri Sato, Yukihiro Azuma, Tasuku Harada
Summary: The study found that LNG-IUS and DNG were similarly effective in reducing pain scores for patients with adenomyosis. However, DNG showed superior efficacy in pain control and reducing days of bleeding compared to LNG-IUS.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Isabella A. Chaves, Thais Baeta, Gabriella B. Dolabella, Luma R. Barbosa, Natalia M. Almeida, Flavia R. Oliveira, Elaine C. Oliveira, Agnaldo L. Silva-Filho, Ana Luiza Lunardi Rocha
Summary: This study aimed to assess pain scores at the insertion of the 52 mg levonorgestrel-releasing intrauterine system (LNG-IUS) among different groups of women. Results showed that nulligravidas experienced higher pain scores compared to women with previous vaginal delivery or elective caesarean-delivery without previous labor.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2021)
Review
Medicine, General & Internal
Yu Zheng, Ruyue Ma, Hong Xu, Lian Wang, Lei Zhang, Huiqun Mao, Ruiheng Zhao
Summary: This study aimed to evaluate the efficacy and safety of dienogest, leuprolide, danazol, gestrinone, mifepristone and levonorgestrel intrauterine system (LNG-IUS) in relieving symptoms and delaying the recurrence of endometriosis (EMT) cysts after fertility preservation surgery. The results showed that dienogest and LNG-IUS were effective in relieving symptoms and delaying cyst recurrence, with LNG-IUS having the highest potential for improving EMT symptoms.
Article
Obstetrics & Gynecology
Giovanni Campo, Agnese Rebecchi, Valeria S. Vanni, Luca Pagliardini, Carola Patruno, Enrico Papaleo, Massimo Candiani, Paolo Giardina
Summary: The research found that LNG-IUS has a better effect on regression of endometrial hyperplasia in infertile women compared to oral MPA, while the live birth rates following ART are comparable between the two groups.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Public, Environmental & Occupational Health
Kendal Danna, Grace Jaworski, Bakoly Rahaivondrafahitra, Francia Rasoanirina, Anthony Nwala, Masauso Nqumayo, Gina Smith, Pierre Moon, Ashley Jackson, Sarah Thurston, Amanda Kalamar
Summary: This study investigates the profiles and satisfaction levels of hormonal IUD users in low- and middle-income countries over a 12-month period. The findings suggest high rates of satisfaction and continuation among users in these countries, indicating that the hormonal IUD could be a well-received and effective contraceptive option in lower resource settings.
REPRODUCTIVE HEALTH
(2022)
Article
Obstetrics & Gynecology
Ahmed T. Hashem, Mostafa Mahmoud, Bassem Aly Islam, Mohamed Ibrahem Eid, Nancy Ahmed, Ahmed Mohamed Mamdouh, Rasha Elkomy, Amira Fouad Elgamel, A. A. Ali Hamada, Eman M. Khalil, Ahmed S. A. Ashour, Ahmed Said Ali, Ayman Taher, Amr Hasan Hussein, Iman Elzahaby, Mohamed Hafez Mohamed Younes, Emad Salah, Eman M. Mojahed, Bassem Talaat, Mohamed ElHodiby, Nada Kamal Osman, Dalia Adel Nour, Yasser Khamis, Ayman Aly Hamed Elsallamy, Mahmoud Ahmed Gehad, Mohamed Mahmoud Mohamed Kotb, Sherine H. Gad Allah
Summary: In parous women delivered only by elective cesarean delivery, lidocaine-prilocaine cream and 200 micrograms of vaginal misoprostol effectively reduced pain during and 10 minutes after LNG-IUD insertion, with easier insertions, high patient satisfaction, and tolerable side effects.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Oncology
Ning Hai, Qingxiang Hou, Ruijun Guo
Summary: The combination of transvaginal ultrasound-guided radiofrequency ablation (RFA) and a levonorgestrel-releasing intrauterine system (LNG-IUS) has been shown to be a simple, safe, and effective alternative for treating symptomatic uterine adenomyosis, with significant reductions in symptoms and uterine volume observed in the study.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Surgery
Mahdi Amini, Dag Wide-Swensson, Andreas Herbst
Summary: This study compares the efficacy and safety of sublingually administered misoprostol and orally administered misoprostol for labor induction. The results show that oral administration is associated with a higher rate of vaginal delivery, while sublingual administration is associated with a shorter time to delivery.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Yan Peng, Yu Dai, Guiyuan Yu, Xiaorong Yang, Cuili Wen, Ping Jin
Summary: The study demonstrated that high intensity focused ultrasound combined with gonadotropin-releasing hormone agonist and levonorgestrel-releasing intrauterine system is a safe and effective alternative treatment option for adenomyosis patients who failed to respond to drug therapies, with a high clinical success rate and significant improvement in symptoms.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Surgery
Salvatore Giovanni Vitale, Attilio Di Spiezio Sardo, Gaetano Riemma, Pasquale De Franciscis, Luis Alonso Pacheco, Jose Carugno
Summary: This study investigated the opinions of gynecologists on the in-office hysteroscopic removal of retained or fragmented intrauterine devices (IUDs) without anesthesia. The majority of gynecologists considered this procedure to be feasible and easy, with the Levonorgestrel-based IUD being the most commonly available and Copper T IUDs being the most frequently retained or fragmented types.
UPDATES IN SURGERY
(2022)
Review
Obstetrics & Gynecology
Ting-Ting Zhao, Li-Li Pang, Lei-Lei Yang, Ruo-Nan Li, Ling-Xiu Fan, Yi Wen
Summary: The combination of HIFU and LNG-IUS for the treatment of adenomyosis has shown advantages in alleviating symptoms and reducing the volumes of the uterine and adenomyotic lesions.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Review
Oncology
Fabio R. Silva, Antonio Jose Grande, Ana Cristina Lacerda Macedo, Tamy Colonetti, Marina C. Rocha, Maria Laura Rodrigues Uggioni, Bruno R. Silva, Maria Ines da Rosa
Summary: A systematic review and meta-analysis were conducted to assess the association between the levonorgestrel-releasing intrauterine system (LNG-IUS) and breast cancer. The findings indicated that there was no evidence of an increased risk of breast cancer among LNG-IUS users based on the included observational studies.
CLINICAL BREAST CANCER
(2021)
Article
Obstetrics & Gynecology
Eliza Brull, Helymar Costa Machado, Luis Bahamondes, Cassia R. T. Juliato
Summary: Nulligravid and parous participants who used the 52 mg LNG-IUS exhibited similar rates of expulsion and continuation over a five-year period.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Jyotsna Sharma, Haritha Sagili, Anish Keepanasseril
Summary: The combination of transcervical Foley catheter and sublingual misoprostol was more effective than sublingual misoprostol alone for inducing vaginal birth within 24 hours in women with pre-eclampsia between 28 and 34 weeks of pregnancy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Public, Environmental & Occupational Health
Tuire Saloranta, Frida Gyllenberg, Anna But, Mika Gissler, Merja K. Laine, Oskari Heikinheimo
Summary: Young women are more likely to use free-of-charge family planning services, while young women speaking a foreign native language are underrepresented among service users. Women with a history of delivery, induced abortion or sexually transmitted infections, or with a lower socioeconomic or educational status are more likely to use these services.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Obstetrics & Gynecology
Ingela Lindh, Finn Egil Skjeldestad, Oskari Heikinheimo, Helena Hognert, Ojvind Lidegaard, Christina Bergh, Kristina Gemzell-Danielsson
Summary: The reproductive pattern of married women in Scandinavia has changed, with an increase in the use of hormonal contraceptives among women aged 40-49. Sweden had the highest induced abortion rate, while birth rates increased continuously in Denmark and Sweden. The use of assisted reproductive technology doubled in all three countries.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Medicine, General & Internal
Elena Toffol, Timo Partonen, Oskari Heikinheimo, Anna But, Antti Latvala, Jari Haukka
Summary: This study examines the relationship between the use of contraception and psychiatric medications. The findings suggest that women who use psychiatric medications are more likely to use hormonal contraception, with a specific pattern in the type of contraceptives used. Further research is needed to determine if this indicates a reduction in unwanted pregnancies among women with psychiatric disorders.
Article
Obstetrics & Gynecology
Oskari Heikinheimo, Elena Toffol, Timo Partonen, Anna But, Antti Latvala, Jari Haukka
Summary: This study aimed to assess the associations between the patterns of use of different hormonal contraceptives and the risk of venous thromboembolism. The results showed that ethinylestradiol-containing combined preparations were associated with increased risk, while estradiol-containing combined preparations only had a slightly increased risk, and progestin-only contraception was not associated with venous thromboembolism risk.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Endocrinology & Metabolism
Annina Haverinen, Kaisu K. Luiro, Marika H. Kangasniemi, Terhi T. Piltonen, Steinar Hustad, Oskari Heikinheimo, Juha S. Tapanainen
Summary: Limited studies have compared the effects of combined oral contraceptives (COCs) containing natural estrogens and synthetic ethinylestradiol (EE) on reproductive hormones. This study compared the effects of estradiol valerate (EV)+dienogest (DNG), EE+DNG, and DNG alone (active control) on levels of follicle stimulating hormone (FSH), luteinizing hormone, Anti-Mullerian hormone (AMH), ovarian steroids, sex hormone binding globulin (SHBG), and the Free Androgen Index (FAI). The results suggest that treatment with EV+DNG may have more beneficial health effects compared to EE+DNG.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Annina H. Haverinen, Kaisu M. Luiro, Timea Szanto, Marika H. Kangasniemi, Leena Hiltunen, Susanna Sainio, Terhi T. Piltonen, Riitta Lassila, Juha S. Tapanainen, Oskari Heikinheimo
Summary: Oral contraceptives containing ethinylestradiol (EE) are associated with a risk of venous thromboembolism. This study compared the effects of different estrogen components in combined oral contraceptives on coagulation biomarkers and found that ethinylestradiol valerate (EV) + dienogest (DNG) had a smaller impact on thrombin generation compared to EE + DNG, suggesting that EV may be a more favorable component.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
Elina Rasp, Liisu Saavalainen, Anna But, Mika Gissler, Paivi Harkki, Oskari Heikinheimo, Kristiina Rono
Summary: This study investigated the subtypes of endometriosis in adolescents as well as trends in incidence rates and related procedures from 1987 to 2012. The results showed that peritoneal endometriosis was the most common type, and the incidence rate of surgical diagnosis of endometriosis peaked in 2001-2005 and decreased thereafter. There was an increase in procedures for ovarian and deep endometriosis, as well as the use of laparoscopy and day surgery.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
Nea Helle, Maarit Niinimaki, Reetta Linnakaari, Anna But, Mika Gissler, Oskari Heikinheimo, Maarit Mentula
Summary: Despite the high prevalence of miscarriages, there is a lack of systematic registration and research. By validating the Finnish health registry data, we found that it is reliable and feasible for identifying miscarriages, different types of miscarriages, and non-surgical treatment.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
M. H. Kangasniemi, R. K. Arffman, S. Joenvaara, A. Haverinen, K. Luiro, T. Tohmola, R. Renkonen, O. Heikinheimo, J. S. Tapanainen, T. T. Piltonen
Summary: This study compares the effects of an estradiol-based combined oral contraceptive (COC) with an ethinylestradiol-based COC and a dienogest-only preparation on the serum proteome. The results demonstrate that the synthetic COC has a wider range of effects on the serum proteome compared to the natural estrogen COC and the progestin-only preparation, involving multiple biological functions.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
A. Tuominen, L. Saavalainen, M. Niinimaki, M. Gissler, A. But, P. Harkki, O. Heikinheimo
Summary: This study found that the incidence of first live birth was lower in women before surgical verification of endometriosis, regardless of the type of endometriosis.
HUMAN REPRODUCTION
(2023)
Article
Clinical Neurology
Timo Partonen, Elena Toffol, Antti Latvala, Oskari Heikinheimo, Jari Haukka
Summary: Limited evidence suggests that the use of hormonal contraception may be associated with insomnia. A nationwide study of women aged 15-49 found significant associations between hormonal contraception use and insomnia. Specific products, such as drospirenone and ethinylestradiol, were associated with decreased odds of insomnia, while levonorgestrel-releasing intrauterine devices and vaginal rings with etonogestrel and ethinylestradiol were associated with increased odds of insomnia.
Article
Family Studies
Janina Bosas, Elena Toffol, Elina Pohjoranta, Maarit J. Mentula, Ritva Hurskainen, Satu Suhonen, Oskari Heikinheimo
Summary: Sexual well-being is closely associated with general well-being, with lower anxiety levels and higher quality of life contributing to stable and higher levels of sexual well-being in fertile-aged women. The method of contraception or relationship status did not have a significant impact on sexual well-being during long-term follow-up.
BMJ SEXUAL & REPRODUCTIVE HEALTH
(2023)
Article
Obstetrics & Gynecology
Venla Kemppainen, Maarit Mentula, Tomi Seppala, Mika Gissler, Hanna Rouhe, Saisto Terhi, Oskari Heikinheimo, Maarit Niinimaki
Summary: Through a population-based register study in Finland, we found that a history of induced abortion is associated with an increased incidence of fear of childbirth in subsequent pregnancies, while a history of psychiatric diagnosis and advanced maternal age (especially 40 years old and above) are more strongly associated with fear of childbirth.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Elina Pohjoranta, Satu Suhonen, Maarit Mentula, Mika Gissler, Oskari Heikinheimo
Summary: Routine provision of IUD after induced abortion can reduce the risk of subsequent abortion, but has no impact on delivery or miscarriage rates.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Christian M. Becker, Attila Bokor, Oskari Heikinheimo, Andrew Horne, Femke Jansen, Ludwig Kiesel, Kathleen King, Marina Kvaskoff, Annemiek Nap, Katrine Petersen, Ertan Saridogan, Carla Tomassetti, Nehalennia van Hanegem, Nicolas Vulliemoz, Nathalie Vermeulen
Summary: This guideline provides clinicians with evidence-based recommendations for the diagnosis and management of endometriosis. It covers various aspects including diagnosis, treatment of pain symptoms, management of infertility, and discusses different treatment options. Despite some limitations, this guideline is important for improving the care of patients with endometriosis.
HUMAN REPRODUCTION OPEN
(2022)