Journal
CONTRACEPTION
Volume 79, Issue 1, Pages 24-28Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.contraception.2008.07.012
Keywords
LNG-IUS; Progestins; Lipid metabolism
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Funding
- National University of Singapore
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Background: This Study aims to assess the effects of levonorgestrel-releasing intrauterine system (LNG-IUS) oil lipid metabolism in an Asian population using Ortho Gynae T380 copper containing (nonhormonal) intrauterine device (IUD) as a control. Study Design: Ninety-two healthy women requesting IUD for contraception were randomly allocated to the two groups and were followed Lip at 6-, 12- and 18-month intervals. Serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), apolipoprotein A-1 (Apo A-1) and apolipoprotein B were measured pre insertion and at each visit following insertion. Results: There was a marginally significant reduction in TC level ill the LNG-IUS group. HDL-C showed a significant reduction in the LNG-IUS group at 6 months but reverted back to its preinsertion value by I year. TG, LDL-C and the cholesterol ratios remained stable. Levels of Apo A-1 and B also showed no significant reduction in both groups, and their ratios remained stable and insignificant. Conclusion: In this randomized comparative study among our local Asian population, it is assuring to note that the LNG-IUS does not have any adverse effects oil lipid metabolism. (C) 2009 Elsevier Inc. All rights reserved.
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